Development of a Stress-Inducible Controlled Expression (SICE) system in Lactococcus lactis for the production and delivery of therapeutic molecules at mucosal surfaces

Journal of Biotechnology

Volumn 168, Issue 2, 2013, Pages 120-129

  Benbouziane, Bouasria ^a,b   Ribelles, Pedro ^a   Aubry, Camille ^a   Martin, Rebeca ^a   Kharrat, Pascale ^a   Riazi, Ali ^b   Langella, Philippe ^a   Bermúdez Humarán, Luis G ^a  

^a UMR1319 MICALIS   (France)

^b UNIVERSITY OF MOSTAGANEM   (Algeria)

Author keywords

Immunomodulation; Lactic acid bacteria; Lactococcus lactis; Recombinant heterologous production; Stress inducible system

Indexed keywords

HETEROLOGOUS PRODUCTION; IMMUNO MODULATIONS; LACTIC ACID BACTERIA; LACTOCOCCUS LACTIS; STRESS-INDUCIBLE SYSTEM;

BACTERIA; LACTIC ACID; VACCINES;

DISEASE CONTROL;

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; MITOMYCIN; PROTEIN E7; VACCINE; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; COLITIS; CYTOKINE PRODUCTION; DNA DEGRADATION; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; FEMALE; HEAT SHOCK; HUMAN PAPILLOMAVIRUS TYPE 16; LACTOCOCCUS LACTIS; MALE; MOLECULE; MOUSE; MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SALT STRESS; SPLEEN CELL; STRESS; STRESS INDUCIBLE CONTROLLED EXPRESSION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; VACCINATION; WART VIRUS; WESTERN BLOTTING;

HUMAN PAPILLOMAVIRUS TYPE 16; LACTOCOCCUS LACTIS; MURINAE;

IMMUNOMODULATION; LACTIC ACID BACTERIA; LACTOCOCCUS LACTIS; RECOMBINANT HETEROLOGOUS PRODUCTION; STRESS-INDUCIBLE SYSTEM;

ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; FEMALE; GENETIC VECTORS; HUMAN PAPILLOMAVIRUS 16; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; LACTOCOCCUS LACTIS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUCOUS MEMBRANE; ORGAN SPECIFICITY; PAPILLOMAVIRUS INFECTIONS; PAPILLOMAVIRUS VACCINES; PLASMIDS; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; STRESS, PHYSIOLOGICAL; VACCINES, SYNTHETIC;

EID: 84885839639     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2013.04.019     Document Type: Article

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