Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction

Circulation

Volumn 128, Issue 16, 2013, Pages 1770-1780

  Cechova, Sylvia ^a   Zeng, Qing ^a   Billaud, Marie ^b   Mutchler, Stephanie ^b   Rudy, Christine K ^a   Straub, Adam C ^b   Chi, Liqun ^d   Chan, Fang R ^a   Hu, Jun ^e   Griffiths, Robert ^d   Howell, Nancy L ^a   Madsen, Kirsten ^e   Jensen, Boye L ^e   Palmer, Lisa A ^c   Carey, Robert M ^a   Sung, Sun Sang J ^a   Malakauskas, Sandra M ^f   Isakson, Brant E ^b   Le, Thu H ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^f Salem Veterans Administration   (United States)

Author keywords

arginine; hypertension; salt sensitivity; Tmem27 protein, mouse

Indexed keywords

AMINO ACID TRANSPORTER; ANGIOTENSIN CONVERTING ENZYME 2; ARGININE; COLLECTRIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SUPEROXIDE; TEMPOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CELL MEMBRANE; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPERTENSION; KNOCKOUT MOUSE; MALE; MOUSE; NATRIURESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; VASCULAR DISEASE; VASODILATATION;

ARGININE; HYPERTENSION; SALT SENSITIVITY; TMEM27 PROTEIN, MOUSE;

ANIMALS; ARGININE; ENDOTHELIAL CELLS; FEMALE; HYPERTENSION, RENAL; KIDNEY; LUNG; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; NATRIURESIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDYL-DIPEPTIDASE A; PRIMARY CELL CULTURE; SODIUM CHLORIDE, DIETARY; SUPEROXIDES;

EID: 84885837321     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.003301     Document Type: Article

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