Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver

British Journal of Nutrition

Volumn 109, Issue 3, 2013, Pages 425-432

  Kotani, Megumi ^a   Kim, Ki Hyun ^a   Ishizaki, Natsumi ^a   Funaba, Masayuki ^a   Matsui, Tohru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Calcium deficiency; Liver zinc; Magnesium deficiency; Metallothionein; Rats; Zinc transporter

Indexed keywords

METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; ZINC; ZINC TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM DEFICIENCY; CONTROLLED STUDY; DIETARY INTAKE; FEMUR; GENE EXPRESSION; LIVER; LIVER WEIGHT; MAGNESIUM DEFICIENCY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BLOOD LEVEL; RAT; UPREGULATION; WEIGHT GAIN; ZINC BLOOD LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BONE RESORPTION; CALCIUM; CATION TRANSPORT PROTEINS; DERMATITIS; FEMUR; LIVER; MAGNESIUM DEFICIENCY; MALE; METALLOTHIONEIN; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SKIN; SPECIFIC PATHOGEN-FREE ORGANISMS; UP-REGULATION; ZINC;

EID: 84885750938     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512001195     Document Type: Article

References (39)

1. Kimura M & Itokawa Y (1998) Inefficient utilization of ir on and minerals in magnesium deficient rats. In Magnesium in Health and Disease, pp. 95-102 [Y Itokawa and J Durlach, editors]. London: John Libbey.
2. Mills BJ, Broghamer WL, Higgins PJ, et al. (1984) Inhibition of tumor growth by magnesium depletion of rats. J Nutr 114, 739-745. (Pubitemid 14135457)
3. Vormann J, Gunther T, Hollriegl V, et al. (1995) Effect of various degrees and duration of magnesium deficienc y on lipid peroxidation and mineral metabolism in rats. J Nutr Biochem 6, 681-688. (Pubitemid 3006860)
4. Andersen RD, Taplitz SJ, Birren BW, et al. (1987) Rat metallothionein multigene family. Experientia SUPPL. 52, 373-384.
5. Vasák M (2005) Advances in metallothionein structure and functions. J Trace Elem Med Biol 19, 13-17. (Pubitemid 41253912)
6. Andrews GK (2000) Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 59, 95-104.
7. Calviello G, Ricci P, Lauro L, et al. (1994) Mg deficiency induces mineral content changes and o xidative stress in rats. Biochem Mol Biol Int 32, 903-911. (Pubitemid 24133333)
8. Martin H, Uring-Lambert B, Adrian M, et al. (2008) Effects of long-term dietary intake of magnesium on oxidative stress, apoptosis an d ageing in rat liver. Magnes Res 21, 124-130.
9. Jou MY, Hall AG, Philipps AF, et al. (2009) Tissue-specific alterations in zinc transporter expression in intestine and liver reflect a threshold for homeostatic compensation during dietary zinc deficiency in weanling rats. J Nutr 139, 835-841.
10. Wang F, Kim BE, Petris MJ, et al. (2004) The mammalian Zip5 protein is a zinc transporter t hat localizes to the basolateral surface of polarized cells. J Biol Chem 279, 51433-51441. (Pubitemid 40017891)
11. Liuzzi JP, Lichten LA, Rivera S, et al. (2005) Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A 102, 6843-6848. (Pubitemid 40675404)
12. Langmade SJ, Ravindra R, Daniels PJ, et al. (2000) The transcription factor MT F-1 mediates metal regulation of the mouse ZnT1 gene. J Biol Chem 275, 34803-34809.
13. Kambe T, Narita H, Yamaguchi-Iwai Y, et al. (2002) Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem 277, 19049-19055. (Pubitemid 34952469)
14. Huang L, Kirschke CP & Gitschier J (2002) Functional characterization of a novel mammalian zinc transporter, ZnT6. J Biol Chem 277, 26389-26395. (Pubitemid 34967132)
15. Lichten LA & Cousins RJ (2009) Mammalian zinc transporters: Nutritional and physiologic regulation. Annu Rev Nutr 29, 153-176.
16. Iseri LT & French JH (1984) Magnesium: Nature?s physiologic calcium blocker. Am Heart J 108, 188-193. (Pubitemid 14087995)
17. Bussiere FI, Gueux E, Rock E, et al. (2002) Protective effect of calcium deficiency on the inflammatory response in magn esium-deficient rats. Eur J Nutr 41, 197-202. (Pubitemid 36056317)
18. Reeves PG (1997) Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127, S838-S841.
19. Loser K, Hansen W, Apelt J, et al. (2005) In vitro-generated regulatory T cells induced by Foxp3-retrovirus infection control murine contact allergy and systemic autoimmunity. Gene Ther 12, 1294-1304. (Pubitemid 43084485)
20. Bartsch R, Klein D & Summer KH (1990) The Cd-Chelex assay: A new sensitive method to determine metallothionein containing zinc and cadmium. Arch Toxicol 64, 177-180. (Pubitemid 20151259)
21. Kiyozumi M, Sakaguchi Y, Shiozuka E, et al. (1993) A rapid determination of metallothionein in animal tissues by Cd-Chelex method. Jpn J Toxicol Environ Health 39, 345-349. (Pubitemid 23288059)
22. Ishizaki N, Kotani M, Funaba M, et al. (2011) Hepcidin expression in the liver of rats fed a magnesium-deficient diet. Br J Nutr 106, 1169-1172.
23. Hollander M & Wolfe DA (1999) Nonparametric Statistical Methods. New York, NY: John Wiley & Sons.
24. Liuzzi JP, Aydemir F, Nam H, et al. (2006) Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A 103, 13612-13617. (Pubitemid 44413956)
25. Lichten LA, Liuzzi JP & Cousins RJ (2009) Interleukin-1b contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gas trointest Liver Physiol 296, G860-G867.
26. Weglicki WB, Phillips TM, Freedman AM, et al. (1992) Magnesium- deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol Cell Biochem 110, 169-173.
27. Onosaka S & Cherian MG (1982) The induced synthesis of metallothionein in various tissues of rats in response to metals. II. Influence of zinc status and specific effect on pancreatic metallothionein. Toxicology 23 , 11-20. (Pubitemid 12100540)
28. Kelly EJ, Quaife CJ, Froelick GJ, et al. (1996) Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr 126, 1782-1790. (Pubitemid 26231444)
29. Oh SH, Deagen JT, Whanger PD, et al. (1978) Biological function of metallothionein. V. Its induction in rats by various stresses. Am J Physiol 234, E282-E285. (Pubitemid 9159848)
30. Durnam DM, Hoffman JS , Quaife CJ, et al. (1984) Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones. Proc Natl Acad Sci U S A 81, 1053-1056. (Pubitemid 14168220)
31. Golden BE (1988) Zinc in cell division and tissue growth: Physiological aspects. In Zinc in Human Biology, pp. 119-128 [CF Mills, editor]. London: Springer-Verlag.
32. Min KS, Ueda H & Tanaka K (2008) Involvement of intestinal calcium transporter 1 and metallothionein in cadmium accumulation in the liver and kidney of mice fed a low-calcium diet. Toxicol Lett 176, 85-92. (Pubitemid 350251069)
33. King JC (1990) Assessment of zinc status. J Nutr 120, 1474-1479.
34. House WA & Wastney ME (1997) Compartmental analysis of zinc kinetics in mature male rats. Am J Physiol 273, R1117-R1125.
35. Mazur A, Maier JA, Rock E, et al. (2007) Magnesium and the inflammatory response: Potential physiopathological implications. Arch Biochem Biophys 458, 48-56. (Pubitemid 46201802)
36. Malpuech-Brugèr e C, Rock E, AstierC, et al. (1998) Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis. Life Sci 63, 1815-1822. (Pubitemid 28511614)
37. Wallach S (1988) Availability of body magnesium during magnesium deficiency. Magnesium 7, 262-270. (Pubitemid 19139164)
38. McAleese DM & Forbes RM (1961) The requirement and tissue distribution of magnesium in the rat as influenced by environmental temperature and dietary calcium. J Nutr 73, 94-106.
39. Nielsen FH (2010) Magnesium, inflammation, and obesity in chronic disease. Nutr Rev 68, 333-340.