Tissue-specific alterations in zinc transporter expression in intestine and liver reflect a threshold for homeostatic compensation during dietary zinc deficiency in weanling rats

Journal of Nutrition

Volumn 139, Issue 5, 2009, Pages 835-841

  Jou, Ming Yu ^a   Hall, Andrew G ^a   Philipps, Anthony F ^b   Kelleher, Shannon L ^c   Lönnerdal, Bo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER; ZIP1 PROTEIN; ZIP4 PROTEIN; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; MEMBRANE PROTEIN; SLC30A1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CIRCULATION; CONTROLLED STUDY; DIET; GENE; GENE EXPRESSION; HOMEOSTASIS; INTESTINE; INTESTINE VILLUS; JEJUNUM; LIVER; NONHUMAN; PROTEIN EXPRESSION; RAT; TISSUE SPECIFICITY; ZINC DEFICIENCY; ZIP1 GENE; ZIP4 GENE; ANIMAL; CHEMISTRY; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; WEANING;

MAMMALIA; RATTUS;

ANIMALS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; DIET; HOMEOSTASIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINES; LIVER; MEMBRANE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TISSUE DISTRIBUTION; WEANING; ZINC;

EID: 65349176447     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.100974     Document Type: Article

References (31)

1. Hall AG, Kelleher SL, Lonnerdal B, Philipps AF. A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats. J Pediatr Gastroenterol Nutr. 2005;41:72-80.
2. Rivera J, Brown KH, Hotz C, Ruel M. Zinc deficiency: issues for public health, assessment, and prevention. Forum Nutr. 2003;56:59-61.
3. King JC, Shames DM, Woodhouse LR. Zinc homeostasis in humans. J Nutr. 2000;130:S1360-6.
4. Krebs NF, Hambidge KM, Westcott JE, Miller LV, Sian L, Bell M, Grunwald G. Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis. J Nutr. 2003;133:S1498-501.
5. Hambidge KM, Krebs NF, Westcott JE, Miller LV. Changes in zinc absorption during development. J Pediatr. 2006;149:S64-8.
6. Kelleher SL, Lönnerdal B. Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J Nutr. 2003;133:3378-85.
7. King JC, Shames DM, Lowe NM, Woodhouse LR, Sutherland B, Abrams SA, Turnlund JR, Jackson MJ. Effect of acute zinc depletion on zinc homeostasis and plasma zinc kinetics in men. Am J Clin Nutr. 2001;74:116-24.
8. Taylor CM, Bacon JR, Aggett PJ, Bremner I. Homeostatic regulation of zinc absorption and endogenous losses in zinc-deprived men. Am J Clin Nutr. 1991;53:755-63.
9. Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch. 2004;447:796-800.
10. Kury S, Dreno B, Bezieau S, Giraudet S, Kharfi M, Kamoun R, Moisan JP. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet. 2002;31:239-40.
11. Dufner-Beattie J, Wang F, Kuo YM, Gitschier J, Eide D, Andrews GK. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. J Biol Chem. 2003;278:33474- 81.
12. Liuzzi JP, Cousins RJ. Mammalian zinc transporters. Annu Rev Nutr. 2004;24:151-72.
13. Yu YY, Kirschke CP, Huang L. Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract. J Histochem Cytochem. 2007;55:223-34.
14. Jackson KA, Helston RM, McKay JA, O'Neill ED, Mathers JC, Ford D. Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability. J Biol Chem. 2007;282:10423-31.
15. Valentine RA, Jackson KA, Christie GR, Mathers JC, Taylor PM, Ford D. ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells. J Biol Chem. 2007;282:14389-93.
16. Yu Y, Lu L, Luo XG, Liu B. Kinetics of zinc absorption by in situ ligated intestinal loops of broilers involved in zinc transporters. Poult Sci. 2008;87:1146-55.
17. Dufner-Beattie J, Huang ZL, Geiser J, Xu W, Andrews GK. Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy. Genesis. 2006;44:239-51.
18. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
19. Kelleher SL, Lonnerdal B. Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. J Nutr. 2002;132:3280-5.
20. Kelleher SL, Lonnerdal B. Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin. Am J Physiol Cell Physiol. 2005;288:C1042-7.
21. Liuzzi JP, Bobo JA, Cui L, McMahon RJ, Cousins RJ. Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation. J Nutr. 2003;133:342-51.
22. Gitan RS, Luo H, Rodgers J, Broderius M, Eide D. Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocy- tosis and vacuolar degradation. J Biol Chem. 1998;273:28617-24.
23. Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet. 2002;71:66-73.
24. Liuzzi JP, Blanchard RK, Cousins RJ. Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. J Nutr. 2001;131:46-52.
25. Huang ZL, Dufner-Beattie J, Andrews GK. Expression and regulation of SLC39A family zinc transporters in the developing mouse intestine. Dev Biol. 2006;295:571-9.
26. Roy CN, Enns CA. Iron homeostasis: new tales from the crypt. Blood. 2000;96:4020-7.
27. Paski SC, Covery L, Kummer A, Xu Z. Role of metallothionein in regulating the abundance of histochemically reactive zinc in rat tissues. Can J Physiol Pharmacol. 2003;81:815-24.
28. Zhao H, Butler E, Rodgers J, Spizzo T, Duesterhoeft S, Eide D. Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements. J Biol Chem. 1998;273:28713-20.
29. Gitan RS, Shababi M, Kramer M, Eide DJ. A cytosolic domain of the yeast Zrt1 zinc transporter is required for its post- translational inactivation in response to zinc and cadmium. J Biol Chem. 2003; 278:39558-64.
30. Atkinson SA, Whelan D, Whyte RK, Lonnerdal B. Abnormal zinc content in human milk. Risk for development of nutritional zinc deficiency in infants. Am J Dis Child. 1989;143:608-11.
31. Chowanadisai W, Lonnerdal B, Kelleher SL. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem. 2006; 281:39699-707.