Discovery of a Protective Rickettsia prowazekii Antigen Recognized by CD8+ T Cells, RP884, Using an In Vivo Screening Platform

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Gazi, Michal ^a   Caro Gomez, Erika ^a   Goez, Yenny ^a   Cespedes, Maria A ^a   Hidalgo, Marylin ^b   Correa, Paula ^c   Valbuena, Gustavo ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^c UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; BACTERIAL ANTIGEN; BACTERIAL ANTIGEN RP884; BACTERIAL VACCINE; CD137 LIGAND; CD3 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; FERROCHELATASE; GAMMA INTERFERON; GRANZYME B; HERMES ANTIGEN; INTERLEUKIN 7 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL LOAD; CD8+ T LYMPHOCYTE; CELL BASED GENE THERAPY; CONTROLLED STUDY; CROSS PROTECTION; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; GENE EXPRESSION; GENE TRANSFER; GENETIC CONSERVATION; IC 50; IN VIVO STUDY; MOLECULAR CLONING; MOUSE; NONHUMAN; OPEN READING FRAME; PROTEIN DENATURATION; PROTEIN EXPRESSION; RICKETTSIA PROWAZEKII; SURVIVAL RATE; T LYMPHOCYTE SUBPOPULATION; TYPHUS; VACCINATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENETIC VECTORS; MICE; REPRODUCIBILITY OF RESULTS; RICKETTSIA PROWAZEKII; RICKETTSIAL VACCINES; TYPHUS, EPIDEMIC LOUSE-BORNE;

EID: 84885715162     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076253     Document Type: Article

References (41)

1. Bechah Y, Capo C, Mege JL, Raoult D, (2008) Epidemic typhus. Lancet Infect Dis 8: 417-426.
2. Azad AF, (2007) Pathogenic rickettsiae as bioterrorism agents. Clin Infect Dis 45Suppl 1: S52-S55.
3. Walker DH, (2009) The realities of biodefense vaccines against Rickettsia. Vaccine 27Suppl 4: D52-D55.
4. Azad AF (1988) Relationship of vector biology and epidemiology of louse- and flea-borne rickettsioses. In: Biology of rickettsial diseases. CRC Press. 51-62.
5. Moutaftsi M, Bui HH, Peters B, Sidney J, Salek-Ardakani S, et al. (2007) Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol 178: 6814-6820.
6. Sette A, Rappuoli R, (2010) Reverse vaccinology: developing vaccines in the era of genomics. Immunity 33: 530-541.
7. Sykes K, (2008) Progress in the development of genetic immunization. Expert Rev Vaccines 7: 1395-1404.
8. Stemke-Hale K, Kaltenboeck B, DeGraves FJ, Sykes KF, Huang J, et al. (2005) Screening the whole genome of a pathogen in vivo for individual protective antigens. Vaccine 23: 3016-3025.
9. Walker DH, Cain BG, (1980) The rickettsial plaque. Evidence for direct cytopathic effect of Rickettsia rickettsii. Lab Invest 43: 388-396.
10. Walker DH, Popov VL, Feng HM, (2000) Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes. Lab Invest 80: 1361-1372.
11. Valbuena G, Jordan JM, Walker DH, (2004) T cells mediate cross-protective immunity between spotted fever group rickettsiae and typhus group rickettsiae. J Infect Dis 190: 1221-1227.
12. Li Z, Díaz-Montero CM, Valbuena G, Yu XJ, Olano JP, et al. (2003) Identification of CD8 T-lymphocyte epitopes in OmpB of Rickettsia conorii. Infect Immun 71: 3920-3926.
13. Katzen F, (2007) Gateway® recombinational cloning: a biological operating system. Expert Opinion on Drug Discovery 2: 571-589.
14. Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, et al. (2007) Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. Blood 110: 1448-1457.
15. Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ, (2006) A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126: 995-1004.
16. Sette A, Moutaftsi M, Moyron-Quiroz J, McCausland MM, Davies DH, et al. (2008) Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity 28: 847-858.
17. Jing L, Davies DH, Chong TM, Chun S, McClurkan CL, et al. (2008) An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling. J Virol 82: 7120-7134.
18. Foster B, Prussin C, Liu F, Whitmire JK, Whitton JL (2007) Detection of intracellular cytokines by flow cytometry. Curr Protoc Immunol Chapter 6: Unit 6.24.
19. Hufford MM, Kim TS, Sun J, Braciale TJ, (2011) Antiviral CD8+ T cell effector activities in situ are regulated by target cell type. J Exp Med 208: 167-180.
20. Moe JB, Pedersen CE, (1980) The impact of rickettsial diseases on military operations. Mil Med 145: 780-785.
21. Raoult D, Woodward T, Dumler JS, (2004) The history of epidemic typhus. Infect Dis Clin North Am 18: 127-140.
22. Zinsser H, Castaneda MR, (1933) On the isolation from a case of Brill's disease of a typhus strain resembling the European type. N. Engl. J. Med 209: 815-819.
23. Woodward TE (1986) Rickettsial vaccines with emphasis on epidemic typhus. Initial report of an old vaccine trial. S Afr Med J Suppl: 73-76.
24. Mason RA, Wenzel RP, Seligmann EB, Ginn RK, (1976) A reference, inactivated, epidemic typhus vaccine: clinical trials in man. J Biol Stand 4: 217-224.
25. Sumner JW, Sims KG, Jones DC, Anderson BE, (1995) Protection of guinea-pigs from experimental Rocky Mountain spotted fever by immunization with baculovirus-expressed Rickettsia rickettsii rOmpA protein. Vaccine 13: 29-35.
26. Crocquet-Valdes PA, Díaz-Montero CM, Feng HM, Li H, Barrett AD, et al. (2001) Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis. Vaccine 20: 979-988.
27. Churilla A, Ching WM, Dasch GA, Carl M, (1990) Human T lymphocyte recognition of cyanogen bromide fragments of the surface protein of Rickettsia typhi. Ann N Y Acad Sci 590: 215-220.
28. Mason D, (1998) A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol Today 19: 395-404.
29. Sewell AK, (2012) Why must T cells be cross-reactive? Nat Rev Immunol 12: 669-677.
30. Stuehler C, Khanna N, Bozza S, Zelante T, Moretti S, et al. (2011) Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans. Blood 117: 5881-5891.
31. Pica N, Palese P, (2013) Toward a Universal Influenza Virus Vaccine: Prospects and Challenges. Annu Rev Med 64: 189-202.
32. Feng H, Popov VL, Yuoh G, Walker DH, (1997) Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae. J Immunol 158: 5314-5320.
33. Walker DH, Olano JP, Feng HM, (2001) Critical role of cytotoxic T lymphocytes in immune clearance of rickettsial infection. Infect Immun 69: 1841-1846.
34. Feng HM, Walker DH, (2003) Cross-protection between distantly related spotted fever group rickettsiae. Vaccine 21: 3901-3905.
35. Riedl P, Wieland A, Lamberth K, Buus S, Lemonnier F, et al. (2009) Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential. J Immunol 183: 370-380.
36. Ruckwardt TJ, Luongo C, Malloy AM, Liu J, Chen M, et al. (2010) Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope. J Immunol 185: 4673-4680.
37. Im EJ, Hong JP, Roshorm Y, Bridgeman A, Létourneau S, et al. (2011) Protective efficacy of serially up-ranked subdominant CD8 T cell epitopes against virus challenges. PLoS Pathog 7: e1002041.
38. Li H, Jerrells TR, Spitalny GL, Walker DH, (1987) Gamma interferon as a crucial host defense against Rickettsia conorii in vivo. Infect Immun 55: 1252-1255.
39. Feng HM, Popov VL, Walker DH, (1994) Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease. Infect Immun 62: 1952-1960.
40. Abdulhaqq SA, Weiner DB, (2008) DNA vaccines: developing new strategies to enhance immune responses. Immunol Res 42: 219-232.
41. Halling-Brown M, Sansom CE, Davies M, Titball RW, Moss DS, (2008) Are bacterial vaccine antigens T-cell epitope depleted? Trends Immunol 29: 374-379.