Screening the whole genome of a pathogen in vivo for individual protective antigens

Vaccine

Volumn 23, Issue 23, 2005, Pages 3016-3025

  Stemke Hale, Katherine ^a   Kaltenboeck, Bernhard ^b   DeGraves, Fred J ^b   Sykes, Kathryn F ^a   Huang, Jin ^b   Bu, Chun Hui ^a   Johnston, Stephen Albert ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b AUBURN UNIVERSITY   (United States)

Author keywords

Chlamydia; Expression library immunization; Vaccine

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL VACCINE; DNA VACCINE; LIVE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PURIFICATION; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; BIOINFORMATICS; CHLAMYDIASIS; CHLAMYDOPHILA PSITTACI; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; EXPERIMENTAL MODEL; FEMALE; GENE FUNCTION; GENE ISOLATION; GENETIC ANALYSIS; GENETIC SCREENING; GENOME ANALYSIS; IMMUNIZATION; IN VIVO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE THERAPY; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PROTECTION; PROVOCATION TEST;

EID: 16244370701     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2004.12.013     Document Type: Article

References (53)

1. V. Piguet, and D. Trono Living in oblivion: HIV immune evasion Semin Immunol 13 2001 51 57
2. R. Grifantini, E. Bartolini, and A. Muzzi Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays Nat Biotechnol 20 2002 914 921
3. G. Grandi Antibacterial vaccine design using genomics and proteomics Trends Biotechnol 19 2001 181 188
4. M. Pizza, V. Scarlato, and V.E.A. Masignani Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing Science 287 2000 1816 1820
5. S. Montigiani, F. Falugi, and M. Scarselli Genomic approach for analysis of surface proteins in Chlamydia pneumoniae Infect Immun 70 2002 368 379
6. K.D. Everett, R.M. Bush, and A.A. Anderson Emended description of the order Chlamydiales, proposal of Parachlemydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms Int J Syst Bacteriol 49 1999 415 440
7. M.A. Barry, W.C. Lai, and S.A. Johnston Protection against mycoplasma infection using expression-library immunization Nature 377 6550 1995 632 635
8. D.C. Tang, M. DeVit, and S.A. Johnston Genetic immunization is a simple method for eliciting an immune response Nature 356 6365 1992 152 154
9. E. Alberti, A. Acosta, and C. Hidalgo Specific cellular and humoral immune response in balb/c mice immunised with an expression genomic library of Trypanosoma cruzi Vaccine 16 1998 608 612
10. K.A. Brayton, S.W. Vogel, and B.A. Allsopp Expression library immunization to identify protective antigens from Cowdria ruminantium Ann N Y Acad Sci 849 1998 369 371
11. F.D. Ivey, D.M. Magee, M.D. Woitaske, S.A. Johnston, and R.A. Cox Identification of a protective antigen of Coccidioides immitis by expression library immmunization Vaccine 21 2003 4359 4367
12. K. Manoutcharian, L.I. Terrazas, G. Gevorkian, and T. Govezensky Protection against murine cysticercosis using cDNA expression library immunization Immunol Lett 62 3 1998 131 136
13. R.J. Moore, C. Lenghaus, S.A. Sheedy, and T.J. Doran Improved vectors for expression library immunization - applications to Mycoplasma hyopneumoniae infection in pigs Vaccine 20 2001 115 120
14. D. Piedrafita, D. Xu, D. Hunter, R.A. Harrison, and F.Y. Liew Protective immune responses induced by vaccination with an expression genomic library of Leishmania major J Immunol 163 3 1999 1467 1472
15. A. Rainczuk, T. Scorza, P.M. Smooker, and T.W. Spithill Induction of specific T-cell responses, opsonizing antibodies, and protection against Plasmodium chabaudi adami infection in mice vaccinated with genomic expression libraries expressed in targeted and secretory DNA vectors Infect Immun 71 2003 4506 4515
16. P.M. Smooker, Y.Y. Setiady, A. Rainczuk, and T.W. Spithill Expression library immunization protects mice against a challenge with virulent rodent malaria Vaccine 18 23 2000 2533 2540
17. T.M. Wizemann, J.H. Heinrichs, and J.E. Adamou Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection Infect Immun 69 2001 1593 1598
18. J. Danesh, R. Collins, and R. Peto Chronic infections and coronary heart disease: is there a link? Lancet 350 9075 1997 430 436 [see comments]
19. L.A. Campbell, C.C. Kuo, and J.T. Grayston Chlamydia pneumoniae and cardiovascular disease Emerg Infect Dis 4 4 1998 571 579
20. J.B. Muhlestein Bacterial infections and atherosclerosis J Invest Med 46 8 1998 396 402
21. J. Schachter Infection and disease epidemiology R.S. Stephens Chlamydia: intracellular biology, pathogenesis, and immunity 1999 American Society for Miocrbiology Washington, DC 139 170
22. J.S. Schachter, and C.R. Dawson Human chlamydial infections 1978 PSG Publishing Company Inc. Littleton, MA
23. Quinn, 1998. Does Chlamydia pneumoniae cause coronary heart disease? Curr Opin Infect Dis 11, 301-307.
24. B. Kaltenboeck, K.G. Kousoulas, and J. Storz Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species J Bacteriol 175 2 1993 487 502
25. J. Storz Antigenic structures and interrelations of PL agents associated with polyarthritis, enzootic abortion, intrauterine and latent intestinal infections J Comp Pathol 76 1966 351
26. R.G. Rank Models of immunity R.S. Stephens Chlamydia: intracellular biology, pathogenesis, and immunity 1999 American Society for Microbiology Washington, DC 239 296
27. M.E. Ward Mechanism of Chlamydia-induced disease R.S. Stephens Chlamydia: intracellular biology, pathogenesis, and immunity 1999 American Society for Microbiology Washington, DC 171 210
28. S. Pal, K.M. Barnhart, Q. Wei, A.M. Abai, E.M. Peterson, and L.M. de la Maza Vaccination of mice with DNA plasmids coding for the Chlamydia trachomatis major outer membrane protein elicits an immune response but fails to protect against a genital challenge Vaccine 17 5 1999 459 465
29. D. Vanrompay, E. Cox, and P. Kaiser Protection of turkeys against Chlamydophila psittaci challenge by parenteral and mucosal inoculations and the effect of turkey interferon-gamma on genetic immunization Immunology 103 1 2001 106 112
30. J. Sandbulte, J. TerWee, K. Wigington, and M. Sabara Evaluation of Chlamydia psittaci subfraction and subunit preparations for their protective capacities Vet Microbiol 48 3-4 1996 269 282
31. T.W. Tan, A.J. Herring, I.E. Anderson, and G.E. Jones Protection of sheep against Chlamydia psittaci infection with a subcellular vaccine containing the major outer membrane protein Infect Immun 58 9 1990 3101 3108
32. J. Huang, M.D. Wang, S. Lenz, D. Gao, and B. Kaltenboeck Interleukin-12 administered during Chlamydia psittaci lung infection in mice confers immediate and long-term protection and reduces MIP-2 level and neutrophil infiltration in lung tissue J Immunol 162 4 1999 2217 2226
33. J. Huang, F.J. DeGraves, and S.D. Lenz The quantity of nitric oxide released by macrophages regulates Chlamydia-induced disease Proc Natl Acad Sci USA 99 2002 3914 3919
34. J. Huang, F.J. DeGraves, D. Gao, P. Feng, T. Schlapp, and B. Kaltenboeck Quantitative detection of Chlamydia spp. by fluorescent PCR in the LightCycler Biotechniques 30 1 2001 150 157
35. L. Cheng, P.R. Ziegelhoffer, and N.S. Yang In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment Proc Natl Acad Sci USA 90 10 1993 4455 4459
36. K.F. Sykes, and S.A. Johnston Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses DNA Cell Biol 18 7 1999 521 531
37. M.E. Rottenberg, A.C. Gigliotti Rothfuchs, D. Gigliotti, C. Svanholm, L. Bandholtz, and H. Wigzell Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice J Immunol 162 5 1999 2829 2836
38. R.P. Morrison, K. Feilzer, and D.B. Tumas Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection Infect Immun 63 12 1995 4661 4668
39. D.M. Feltquate, S. Heaney, R.G. Webster, and H.L. Robinson Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization J Immunol 158 5 1997 2278 2284
40. K.A. Kelly, E.A. Robinson, and R.G. Rank Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection Infect Immun 64 12 1996 4976 4983
41. S. Kalman, W. Mitchell, and R. Marathe Comparative genomes of Chlamydia pneumoniae and C. trachomatis Nat Genet 21 4 1999 385 389
42. D. Longbottom, M. Russell, S.M. Dunbar, G.E. Jones, and A.J. Herring Molecular cloning and characterization of the genes coding for the highly immunogenic cluster of 90-kilodalton envelope proteins from the Chlamydia psittaci subtype that causes abortion in sheep Infect Immun 66 4 1998 1317 1324
43. D. Longbottom, M. Russell, G.E. Jones, F.A. Lainson, and A.J. Herring Identification of a multigene family coding for the 90 kDa proteins of the ovine abortion subtype of Chlamydia psittaci FEMS Microbiol Lett 142 2-3 1996 277 281
44. T.D. Read, G.S. Myers, R.C. Brunham, and E.A. Nelson Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae Nucleic Acids Res 31 2003 2134 2147
45. P.A. Reche, J.P. Glutting, and E.L. Reinherz Prediction of MHC Class I binding peptides using profile motifs Hum Immunol 63 2002 701 709
46. MacVectorTM, 6.5 User Guide, Oxford Molecular Ltd., 1999 [Section 14-19].
47. L.J. McGuffin, K. Bryson, and D.T. Jones The PSIPRED protein structure prediction server Bioinfomatics 16 2000 404 405
48. K.F. Sykes, and S.A. Johnston Linear expression elements: a rapid, in vivo, method to screen for gene functions Nat Biotechnol 17 4 1999 355 359
49. F.J. DeGraves, T.Y. Kim, J.B. Jee, T. Schlapp, H.-R. Hehnen, and B. Kaltenboeck Re-infection with Chlamydophila abortus by uterine and indirect cohort routes reduces fertility in cattle pre-exposed to Chlamydophila Infect Immun 72 5 2004 2538 2545
50. W.P. Stemmer, A. Crameri, K.D. Ha, T.M. Brennan, and H.L. Heyneker Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides Gene 164 1 1995 49 53
51. T. Nagata, M. Uchijima, A. Yoshida, M. Kawashima, and Y. Koide Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganisms Biochem Biophys Res Commun 261 2 1999 445 451
52. DeGraves FJ, Stemke-Hale K, Huang J, et al. Vaccine identified by in vivo genomic screening enhances fertility in cattle during environmental challenge with Chlamydia. In: Schachter J, e.a., editor. Chlamydial Infections: Proceedings of the 10th International Symposium on Human Chlamydial Infection, Antalya, Turkey, 2002. p. 265-68.
53. F.J. DeGraves, D. Gao, H.-R. Hehnen, T. Schlapp, and B. Kaltenboeck High prevalence of Chlamydia psittaci and C. pecorum vaginal infection in cattle quantitatively detected by high-sensitivity real-time PCR J Clin Microbiol 41 2003 1726 1729