Imaging: What can it tell us about parkinsonian gait?

Movement Disorders

Volumn 28, Issue 11, 2013, Pages 1492-1500

  Bohnen, Nicolaas I ^a,b   Jahn, Klaus ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acetylcholine; Amyloid; Cerebellum; Dopamine; Gait; MRI; Network; Parkinson's disease; Pedunculopontine nucleus; PET; Progressive supranuclear palsy; SPECT

Indexed keywords

1 METHYLPIPERIDIN 4 YL PROPIONIC ACID C 11; 6 FLUORODOPA F 18; CARBOXYLYASE; CHOLINERGIC RECEPTOR; DOPAMINE; DOPAMINE DECARBOXYLASE; DOPAMINE TRANSPORTER; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; IOFETAMINE I 123; NEUROTRANSMITTER; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; WATER O 15; XENON 133;

AMYLOIDOSIS; ATTENTION; AUTONOMIC DENERVATION; BRAIN BLOOD FLOW; BRAIN DEPTH STIMULATION; COGNITION; CORPUS STRIATUM; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DOPAMINERGIC NERVE CELL; ELECTROENCEPHALOGRAPHY; FREEZING; FREEZING OF GAIT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; GAIT; GAIT DISORDER; HUMAN; LOCOMOTION; MAGNETOENCEPHALOGRAPHY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL NETWORK; NERVE PROJECTION; NEUROPATHOLOGY; NEUROTRANSMITTER RELEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; POSITRON EMISSION TOMOGRAPHY; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPINAL CORD; SUBTHALAMIC NUCLEUS; THALAMUS;

ACETYLCHOLINE; AMYLOID; CEREBELLUM; DOPAMINE; GAIT; MRI; NETWORK; PARKINSON'S DISEASE; PEDUNCULOPONTINE NUCLEUS; PET; PROGRESSIVE SUPRANUCLEAR PALSY; SPECT;

BRAIN; GAIT DISORDERS, NEUROLOGIC; HUMANS; NEUROIMAGING; NEUROTRANSMITTER AGENTS; PARKINSONIAN DISORDERS;

EID: 84885709284     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25534     Document Type: Review

References (72)

1. Baltadjieva R, Giladi N, Gruendlinger L, Peretz C, Hausdorff JM. Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease. Eur J Neurosci 2006;24:1815-1820.
2. Sethi K. Levodopa unresponsive symptoms in Parkinson disease. Mov Disord 2008;23(SUPPL 3):S521-S533.
3. Azulay JP, Van Den Brand C, Mestre D, et al. Automatic motion analysis of gait in patients with Parkinson disease: effects of levodopa and visual stimulations [article in French]. Rev Neurol (Paris) 1996;152:128-134.
4. Kemoun G, Defebvre L. Clinical description, analysis of posture, initiation of stabilized gait [article in French]. Presse Med 2001;30:452-459.
5. Factor SA. The clinical spectrum of freezing of gait in atypical parkinsonism. Mov Disord 2008;23(SUPPL 2):S431-S438.
6. Snijders AH, Leunissen I, Bakker M, et al. Gait-related cerebral alterations in patients with Parkinson's disease with freezing of gait. Brain 2011;134:59-72.
7. Bonnet AM, Loria Y, Saint-Hilaire MH, Lhermitte F, Agid Y. Does long-term aggravation of Parkinson's disease result from nondopaminergic lesions? Neurology 1987;37:1539-1542.
8. Greenstein JJ, Gastineau EA, Siegel BH, Macsata R, Conklin JJ, Maurer AH. Cerebral hemisphere activation during human bipedal locomotion [abstract]. Hum Brain Mapp 1995;3(SUPPL 1):320.
9. Fukuyama H, Ouchi Y, Matsuzaki S, et al. Brain functional activity during gait in normal subjects: a SPECT study. Neurosci Lett 1997;228:183-186.
10. Maillet A, Pollak P, Debu B. Imaging gait disorders in parkinsonism: a review. J Neurol Neurosurg Psychiatry 2012;83:986-993.
11. Miyai I, Tanabe HC, Sase I, et al. Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage 2001;14:1186-1192.
12. la Fougere C, Zwergal A, Rominger A, et al. Real versus imagined locomotion: a [18F]-FDG PET-fMRI comparison. Neuroimage 2010;50:1589-1598.
13. Wutte MG, Glasauer S, Jahn K, Flanagin VL. Moving and being moved: differences in cerebral activation during recollection of whole-body motion. Behav Brain Res 2012;227:21-29.
14. Shik ML, Orlovsky GN. Neurophysiology of locomotor automatism. Physiol Rev 1976;56:465-501.
15. Armstrong DM. The supraspinal control of mammalian locomotion. J Physiol 1988;405:1-37.
16. Jahn K, Deutschlander A, Stephan T, et al. Supraspinal locomotor control in quadrupeds and humans. Prog Brain Res 2008;171:353-362.
17. Pahapill PA, Lozano AM. The pedunculopontine nucleus and Parkinson's disease. Brain 2000;123:1767-1783.
18. Mori S, Matsuyama K, Mori F, Nakajima K. Supraspinal sites that induce locomotion in the vertebrate central nervous system. Adv Neurol 2001;87:25-40.
19. Inglis WL, Winn P. The pedunculopontine tegmental nucleus: where the striatum meets the reticular formation. Prog Neurobiol 1995;47:1-29.
20. Hashimoto T. Speculation on the responsible sites and pathophysiology of freezing of gait. Parkinsonism Rel Dis 2006;12:S55-S62.
21. Hanakawa T, Fukuyama H, Katsumi Y, Honda M, Shibasaki H. Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease. Ann Neurol 1999;45:329-336.
22. Hanakawa T, Katsumi Y, Fukuyama H, et al. Mechanisms underlying gait disturbance in Parkinson's disease: a single photon emission computed tomography study. Brain 1999;122:1271-1282.
23. del Olmo MF, Arias P, Furio MC, Pozo MA, Cudeiro J. Evaluation of the effect of training using auditory stimulation on rhythmic movement in Parkinsonian patients-a combined motor and [18F]-FDG PET study. Parkinsonism Relat Disord 2006;12:155-164.
24. Zwergal A, la Fougere C, Lorenzl S, et al. Functional disturbance of the locomotor network in progressive supranuclear palsy. Neurology 2013;80:634-641.
25. Wai YY, Wang JJ, Weng YH, et al. Cortical involvement in a gait-related imagery task: comparison between Parkinson's disease and normal aging. Parkinsonism Relat Disord 2012;18:537-542.
26. Bartels AL, Leenders KL. Brain imaging in patients with freezing of gait. Mov Disord 2008;23(SUPPL 2):S461-S467.
27. Shine JM, Matar E, Ward PB, et al. Exploring the cortical and subcortical functional magnetic resonance imaging changes associated with freezing in Parkinson's disease. Brain 2013;136:1204-1215.
28. Tessitore A, Amboni M, Esposito F, et al. Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait. Parkinsonism Relat Disord 2012;18:781-787.
29. Kostic VS, Agosta F, Pievani M, et al. Pattern of brain tissue loss associated with freezing of gait in Parkinson disease. Neurology 2012;78:409-416.
30. Shine JM, Matar E, Ward PB, et al. Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load [serial online]. PLoS One 2013;8:e52602.
31. Naismith SL, Lewis SJ. A novel paradigm for modelling freezing of gait in Parkinson's disease. J Clin Neurosci 2010;17:984-987.
32. Shine JM, Naismith SL, Lewis SJ. The pathophysiological mechanisms underlying freezing of gait in Parkinson's disease. J Clin Neurosci 2011;18:1154-1157.
33. Hill KK, Campbell MC, McNeely ME, et al. Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease. Exp Neurol 2012;241:105-112.
34. Doya K. Complementary roles of basal ganglia and cerebellum in learning and motor control. Curr Opin Neurobiol 2000;10:732-739.
35. Brudzynski SM, Houghton PE, Brownlee RD, Mogenson GJ. Involvement of neuronal cell bodies of the mesencephalic locomotor region in the initiation of locomotor activity of freely behaving rats. Brain Res Bull 1986;16:377-381.
36. Jenkinson N, Nandi D, Miall RC, Stein JF, Aziz TZ. Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey. Neuroreport 2004;15:2621-2624.
37. Milner KL, Mogenson GJ. Electrical and chemical activation of the mesencephalic and subthalamic locomotor regions in freely moving rats. Brain Res 1988;452:273-285.
38. Plaha P, Gill SS. Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease. Neuroreport 2005;16:1883-1887.
39. Moro E, Hamani C, Poon YY, et al. Unilateral pedunculopontine stimulation improves falls in Parkinson's disease. Brain 2010;133:215-224.
40. Ballanger B, Lozano AM, Moro E, et al. Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study. Hum Brain Mapp 2009;30:3901-3909.
41. Pirker W, Asenbaum S, Bencsits G, et al. [123I]beta-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. Mov Disord 2000;15:1158-1167.
42. Ouchi Y, Kanno T, Okada H, et al. Presynaptic and postsynaptic dopaminergic binding densities in the nigrostriatal and mesocortical systems in early Parkinson's disease: a double-tracer positron emission tomography study. Ann Neurol 1999;46:723-731.
43. Yarnall A, Rochester L, Burn DJ. The interplay of cholinergic function, attention, and falls in Parkinson's disease. Mov Disord 2011;26:2496-2503.
44. Bohnen NI, Mueller ML, Kotagal V, et al. Heterogeneity of cholinergic denervation in Parkinson disease J Cereb Blood Flow Metab 2012;32:1609-1617.
45. Bohnen NI, Muller ML, Koeppe RA, et al. History of falls in Parkinson disease is associated with reduced cholinergic activity. Neurology 2009;73:1670-1676.
46. Karachi C, Grabli D, Bernard FA, et al. Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease. J Clin Invest 2010;120:2745-2754.
47. Bohnen NI, Kotagal V, Albin RL, Koeppe RA, Frey KA, Muller MLTM. Gait speed is preserved in oligosystem compared to multisystem neurodegeneration in Parkinson disease [abstract]. Neurology 2013;80:P04165.
48. Halliday G, Hely M, Reid W, Morris J. The progression of pathology in longitudinally followed patients with Parkinson's disease. Acta Neuropathol 2008;115:409-415.
49. Lopez IC, Ruiz PJ, Del Pozo SV, Bernardos VS. Motor complications in Parkinson's disease: ten year follow-up study. Mov Disord 2010;25:2735-2739.
50. Muller ML, Frey KA, Petrou M, et al. β-Amyloid and postural instability and gait difficulty in Parkinson's disease at risk for dementia. Mov Disord 2013;28:296-301.
51. Hausdorff JM, Schaafsma JD, Balash Y, Bartels AL, Gurevich T, Giladi N. Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gait. Exp Brain Res 2003;149:187-194.
52. Takakusaki K, Tomita N, Yano M. Substrates for normal gait and pathophysiology of gait disturbances with respect to the basal ganglia dysfunction. J Neurol 2008;255(SUPPL 4):19-29.
53. Zwergal A, la Fougere C, Lorenzl S, et al. Postural imbalance and falls in PSP correlate with functional pathology of the thalamus. Neurology 2011;77:101-109.
54. Albin RL, Koeppe RA, Bohnen NI, Wernette K, Kilbourn MA, Frey KA. Spared caudal brainstem SERT binding in early Parkinson's disease. J Cereb Blood Flow Metab 2008;28:441-444.
55. Kotagal V, Bohnen NI, Muller JL, Koeppe RA, Frey KA, Albin RL. Cerebral amyloid deposition correlates inversely with serotoninergic innervation in Parkinson disease. Arch Neurol 2012;69:1628-1631.
56. Jahn K, Deutschlander A, Stephan T, Strupp M, Wiesmann M, Brandt T. Brain activation patterns during imagined stance and locomotion in functional magnetic resonance imaging. Neuroimage 2004;22:1722-1731.
57. Sen S, Kawaguchi A, Truong Y, Lewis MM, Huang X. Dynamic changes in cerebello-thalamo-cortical motor circuitry during progression of Parkinson's disease. Neuroscience 2010;166:712-719.
58. Camicioli R, Gee M, Bouchard TP, et al. Voxel-based morphometry reveals extra-nigral atrophy patterns associated with dopamine refractory cognitive and motor impairment in parkinsonism. Parkinsonism Relat Disord 2009;15:187-195.
59. Hazrati LN, Parent A. Projection from the deep cerebellar nuclei to the pedunculopontine nucleus in the squirrel monkey. Brain Res 1992;585:267-271.
60. Grimbergen YA, Langston JW, Roos RA, Bloem BR. Postural instability in Parkinson's disease: the adrenergic hypothesis and the locus coeruleus. Expert Rev Neurother 2009;9:279-290.
61. Moore RY, Bloom FE. Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems. Annu Rev Neurosci 1979;2:113-168.
62. Zarow C, Lyness SA, Mortimer JA, Chui HC. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch Neurol 2003;60:337-341.
63. Muller M, Bohnen N, Bhaumik A, Albin R, Frey K, Gilman S. Striatal dopaminergic denervation and cardiac post-ganglionic sympathetic denervation correlate independently with gait velocity in Parkinson disease [abstract]. Neurology 2011;76:A265.
64. Gallezot JD, Weinzimmer D, Nabulsi N, et al. Evaluation of [(11)C]MRB for assessment of occupancy of norepinephrine transporters: studies with atomoxetine in non-human primates. Neuroimage 2011;56:268-279.
65. Filippi M, Kulisevsky J. Advances with MRI in Parkinson disease: from freezing to festination. Neurology 2012;79:2222-2223.
66. Thevathasan W, Pogosyan A, Hyam JA, et al. Alpha oscillations in the pedunculopontine nucleus correlate with gait performance in parkinsonism. Brain 2012;135:148-160.
67. Handojoseno AM, Shine JM, Nguyen TN, Tran Y, Lewis SJ, Nguyen HT. The detection of freezing of gait in Parkinson's disease patients using EEG signals based on Wavelet decomposition. Conf Proc IEEE Eng Med Biol Soc 2012;2012:69-72.
68. Matsui H, Udaka F, Miyoshi T, et al. Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease. Mov Disord 2005;20:1272-1277.
69. Mito Y, Yoshida K, Yabe I, et al. Brain SPECT analysis by 3D-SSP and clinical features of Parkinson's disease. Hokkaido Igaku Zasshi 2006;81:15-23.
70. Bartels AL, de Jong BM, Giladi N, et al. Striatal dopa and glucose metabolism in PD patients with freezing of gait. Mov Disord 2006;21:1326-1332.
71. Imamura K, Okayasu N, Nagatsu T. Cerebral blood flow and freezing of gait in Parkinson's disease. Acta Neurol Scand 2012;126:210-218.
72. Gilman S, Koeppe RA, Nan B, et al. Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes. Neurology 2010;74:1416-1423.