Delivery Rate Affects Uptake of a Fluorescent Glucose Analog in Murine Metastatic Breast Cancer

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Rajaram, Narasimhan ^a   Frees, Amy E ^a   Fontanella, Andrew N ^a   Zhong, Jim ^b   Hansen, Katherine ^b   Dewhirst, Mark W ^a,b   Ramanujam, Nirmala ^a  

^a Duke University   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [N (7 NITROBENZ 2 OXA 1,3 DIAXOL 4 YL)AMINO] 2 DEOXYGLUCOSE; DEOXYHEMOGLOBIN; GLUCOSE DERIVATIVE; OXYGEN; OXYHEMOGLOBIN; UNCLASSIFIED DRUG;

ABSORPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST METASTASIS; CANCER CELL; CONTROLLED STUDY; FEMALE; FLUORESCENCE; GLUCOSE TRANSPORT; HYPOXEMIA; IN VITRO STUDY; IN VIVO STUDY; MICROVASCULARIZATION; MOUSE; NONHUMAN; SKIN FLAP; SURVIVAL; TISSUE OXYGENATION; TUMOR BLOOD FLOW; TUMOR VASCULARIZATION;

4-CHLORO-7-NITROBENZOFURAZAN; ANIMALS; ANOXIA; BREAST NEOPLASMS; CELL LINE, TUMOR; DEOXYGLUCOSE; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT DYES; KINETICS; MICE; NEOPLASM METASTASIS; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW; SULFUR DIOXIDE; TIME FACTORS;

EID: 84885701301     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076524     Document Type: Article

References (35)

1. Kunkel M, Forster GJ, Reichert TE, Kutzner J, Benz P, et al. (2003) Radiation response non-invasively imaged by [18F]FDG-PET predicts local tumor control and survival in advanced oral squamous cell carcinoma. Oral Oncol 39: 170-177.
2. Kunkel M, Helisch A, Reichert TE, Jeong JH, Buchholz HG, et al. (2006) Clinical and prognostic value of [(18)F]FDG-PET for surveillance of oral squamous cell carcinoma after surgical salvage therapy. Oral Oncol 42: 297-305.
3. Thorwarth D, Eschmann SM, Holzner F, Paulsen F, Alber M, (2006) Combined uptake of [18F] FDG and [18F] FMISO correlates with radiation therapy outcome in head-and-neck cancer patients. Radiotherapy and oncology 80: 151-156.
4. Van den Abbeele AD, Ertuk M, (2008) FDG-PET to measure response to targeted therapy: the example of gastrointestinal stromal tumor and imatinib mesylate (Gleevec). PET Clinics 3: 77-87.
5. Mankoff DA, Dunnwald LK, Gralow JR, Ellis GK, Charlop A, et al. (2002) Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy. Journal of Nuclear Medicine 43: 500-509.
6. Shankar LK, Hoffman JM, Bacharach S, Graham MM, Karp J, et al. (2006) Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute Trials. Journal of Nuclear Medicine 47: 1059-1066.
7. Zasadny KR, Tatsumi M, Wahl RL, (2003) FDG metabolism and uptake versus blood flow in women with untreated primary breast cancers. European journal of nuclear medicine and molecular imaging 30: 274-280.
8. Nitin N, Carlson A, Muldoon T, El Naggar A, Gillenwater A, et al. (2009) Molecular imaging of glucose uptake in oral neoplasia following topical application of fluorescently labeled deoxy glucose. International Journal of Cancer 124: 2634-2642.
9. O'Neil RG, Wu L, Mullani N, (2005) Uptake of a fluorescent deoxyglucose analog (2-NBDG) in tumor cells. Molecular Imaging and Biology 7: 388-392.
10. Yamada K, Saito M, Matsuoka H, Inagaki N, (2007) A real-time method of imaging glucose uptake in single, living mammalian cells. Nature protocols 2: 753-762.
11. Yoshioka K, Oh K, Saito M, Nemoto Y, Matsuoka H, (1996) Evaluation of 2-[N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino]-2-deoxy-D-glucose, a new fluorescent derivative of glucose, for viability assessment of yeast Candida albicans. Applied microbiology and biotechnology 46: 400-404.
12. Yoshioka K, Takahashi H, Homma T, Saito M, Oh KB, et al. (1996) A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli. Biochimica et Biophysica Acta (BBA)-General Subjects 1289: 5-9.
13. Millon S, Ostrander J, Brown J, Raheja A, Seewaldt V, et al. (2010) Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines. Breast Cancer Research and Treatment: 1-8.
14. Tseng JC, Wang Y, Banerjee P, Kung AL (2012) Incongruity of Imaging Using Fluorescent 2-DG Conjugates Compared to 18 F-FDG in Preclinical Cancer Models. Molecular Imaging and Biology: 1-8.
15. Palmer GM, Fontanella AN, Zhang G, Hanna G, Fraser CL, et al. (2010) Optical imaging of tumor hypoxia dynamics. J Biomed Opt 15: 066021.
16. Sorg BS, Moeller BJ, Donovan O, Cao Y, Dewhirst MW, (2005) Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. J Biomed Opt 10: 44004.
17. Heppner GH, Miller FR, Shekhar PVM, (2000) Nontransgenic models of breast cancer. Breast Cancer Res 2: 331-334.
18. Young CD, Lewis AS, Rudolph MC, Ruehle MD, Jackman MR, et al. (2011) Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS One 6: e23205.
19. Tao K, Fang M, Alroy J, Sahagian GG, (2008) Imagable 4T1 model for the study of late stage breast cancer. BMC cancer 8: 228.
20. Lu X, Bennet B, Mu E, Rabinowitz J, Kang Y, (2010) Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. Journal of Biological Chemistry 285: 9317.
21. Moeller BJ, Cao Y, Li CY, Dewhirst MW, (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors:: Role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441.
22. Palmer GM, Fontanella AN, Zhang G, Hanna G, Fraser CL, et al. (2010) Optical imaging of tumor hypoxia dynamics. Journal of Biomedical Optics 15.
23. Dunn T, Braun R, Rhemus W, Rosner G, Secomb T, et al. (1999) The effects of hyperoxic and hypercarbic gases on tumour blood flow. British journal of cancer 80: 117.
24. Kruuv J, Inch W, McCredie J, (1967) Blood flow and oxygenation of tumors in mice. I. Effects of breathing gases containing carbon dioxide at atmospheric pressure. Cancer 20: 51-59.
25. Kallinowski F, Schlenger K, Kloes M, Stohrer M, Vaupel P, (1989) Tumor blood flow: the principal modulator of oxidative and glycolytic metabolism, and of the metabolic micromilieu of human tumor xenografts in vivo. International journal of cancer 44: 266-272.
26. King LM, Opie LH, (1998) Glucose delivery is a major determinant of glucose utilisation in the ischemic myocardium with a residual coronary flow. Cardiovascular research 39: 381-392.
27. Semple SI, Gilbert FJ, Redpath TW, Staff RT, Ahearn TS, et al. (2004) The relationship between vascular and metabolic characteristics of primary breast tumours. European radiology 14: 2038-2045.
28. Mankoff DA, Dunnwald LK, Gralow JR, Ellis GK, Schubert EK, et al. (2003) Changes in blood flow and metabolism in locally advanced breast cancer treated with neoadjuvant chemotherapy. Journal of Nuclear Medicine 44: 1806-1814.
29. Komar G, Kauhanen S, Liukko K, Seppänen M, Kajander S, et al. (2009) Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clinical Cancer Research 15: 5511-5517.
30. Hermans R, Meijerink M, Van den Bogaert W, Rijnders A, Weltens C, et al. (2003) Tumor perfusion rate determined noninvasively by dynamic computed tomography predicts outcome in head-and-neck cancer after radiotherapy. International Journal of Radiation Oncology* Biology* Physics 57: 1351-1356.
31. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, et al. (2004) Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature medicine 10: 145-147.
32. Fokas E, Im JH, Hill S, Yameen S, Stratford M, et al. (2012) Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature. Cancer research 72: 239-248.
33. Moeller BJ, Cao Y, Li CY, Dewhirst MW, (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441.
34. Moeller BJ, Dreher MR, Rabbani ZN, Schroeder T, Cao Y, et al. (2005) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer cell 8: 99-110.
35. Zhong J, Rajaram N, Brizel DM, Frees AE, Ramanujam N, et al. (2013) Radiation induces aerobic glycolysis through reactive oxygen species. Radiotherapy and Oncology 106: 390-396.