Methanol extract of Codonopsis pilosula inhibits inducible nitric oxide synthase and protein oxidation in lipopolysaccharide-stimulated raw cells

Tropical Journal of Pharmaceutical Research

Volumn 12, Issue 5, 2013, Pages 705-710

  Yoo, Chang Seon ^a   Kim, Sung Jin ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Codonopsis pilosula; Cyclooxygenase 2 (COX 2); Free radicals; Inducible nitric oxide synthase (iNOS); Lipopolysaccharide; Nitric oxide (NO)

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTHOCYANIN; CODONOPSIS PILOSULA EXTRACT; CYCLOOXYGENASE 2; FLAVONOID; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; METHANOL; NITRIC OXIDE; PHENOL; SCAVENGER;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; ENZYME SYNTHESIS; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SYNTHESIS INHIBITION;

EID: 84885699912     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v12i5.7     Document Type: Article

References (27)

1. Qi HY, Wang R, Liu Y, Shi YP. Studies on the chemical constituents of Codonopsis pilosula. Zhong Yao Cai 2011; 34: 546-548.
2. Wakana D, Kawahara N, Goda Y. Three new triterpenyl esters, codonopilates A-C, isolated from Codonopsis pilosula. J Nat Med 2011; 65: 18-23.
3. Mizutani K, Yuda M, Tanaka O, Saruwatari Y, Jia MR, Ling YK, Pu XF. Tangshenosides I and II from Chun-Dangshen, the root of Codonopsis tangshen Oliv. Chem Pharm Bull 1998; 36: 2726-2729.
4. Liu T, Liang W, Tu G. Perlolyrine: a β-carboline alkaloid from Codonopsis pilosula. Planta Medica 1988; 54: 472-473.
5. Xu QP. Ed. Pharmacology of Chinese Herbs (Chinese): Guizhou Science and Technology Publishing Company, Guiyang, Guozhou Province, P.R. China, 1994.
6. Singh B, Song H, Liu XD, Hardy M, Liu GZ, Vinjamury S, Martirosian CD. Dangshen (Codonopsis Pilosula) and Bai Guo (Gingko Biloba) enhance learning and memory. Alternative Therapies 2004; 10: 52-56.
7. Fridovich I. The biology of oxygen radicals. Science 1978; 201: 875-880.
8. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. Lebenson Wiss Technol 1995; 28: 25-30.
9. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahz BW, Shaltiel S, Stadtman ER. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990; 186: 464-478.
10. Oyaizu M. Studies on products of browning reaction: Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn J Nutr 1986; 44: 307-314.
11. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 722: 248-254.
12. Towbin H, Staehelin J, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application. Proc Natl Acad Sci USA 1979; 76: 4350-4354.
13. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic reagents. Am J Enol Vitic 1965; 16: 144-158.
14. Miliauskasa G, Venskutonis PR, van Beekb TA. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem 2004; 85: 231-237.
15. Piccolella S, Fiorentino A, Pacifico S, D'Abrosca B, Uzzo P, Monaco P. Antioxidant properties of sour cherries (Prunus cerasus L.): Role of colorless phytochemicals from the methanolic extract of ripe fruits. J Agric Food Chem 2008; 56: 1928-1935.
16. Kim BJ, Kim JH, Kim HP, Heo MY. Biological screening of 100 plant extracts for cosmetic use (II): Anti-oxidative activity and free radical scavenging activity. Int J Cosmet Sci 1997; 19: 299-307.
17. Evereklioglu C, Er H, Doganay S, Cekmen M, Turkoz Y, Otlu B, Ozerol E. Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration. Doc Ophthalmol 2003; 106: 129-136.
18. Avery SV. Molecular targets of oxidative stress. Biochem J 2011; 434: 201-210.
19. Martínez A, Portero-Otin M, Pamplona R, Ferrer I. Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates. Brain Pathol 2010; 20: 281-297.
20. Costa WMV, Amorim MA, Quintanilha A, Moradas-Ferreira P. Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cervisiae: the involvement of the oxidative stress response regulators Yap 1 and Skn7. Free radical Biol. 2002; 33: 1507-1515.
21. Ndengele MM, Cuzzocrea S, Esposito E, Mazzon E, Di Paola R, Matuschak GM, Salvemini D. Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. FASEB J. 2008; 22: 3154-64.
22. Condoner-Frnach P, Travarez-Alonso S, Murria-Estal R, Megias-Vericat J, Tortajada-Girbes M, Alonso-Iglesias E. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atheroscrelosis, 2011. Epub ahead of print.
23. Conforti F, Menichini F. Phenolic compounds from plants as nitric oxide production inhibitors. Curr. Med. Chem. 2011; 18: 1137-1145.
24. Handunnetti SM, Kumara RR, Deraniyagala SA, Ratnasooriya WD. Anti-inflammatory activity of Ixora coccinea methanolic leaf extract. Pharmacogn Res 2009; 1: 80-90.
25. Gambhire MN, Wankhede SS, Juvekar AR. Antiinflammatory activity of aqueous extract of Barleria cristata leaves. J Young Pharm 2009; 1: 220-224.
26. Kumar D, Kumar S, Singh J, Narender, Rashmi, Vashistha BD, et al. Free radical scavenging and analgesic activities of Cucumis sativus L. fruit extract. J Young Pharm 2010; 2: 365-368.
27. Kähkönen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, Heinonen M. Antioxidant Activity of Plant Extracts Containing Phenolic Compounds. J. Agric. Food. Chem. 1999; 47: 3954-3962