Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation

Atherosclerosis

Volumn 215, Issue 2, 2011, Pages 475-480

  Codoñer Franch, Pilar ^a,b   Tavárez Alonso, Sandra ^b   Murria Estal, Rosa ^a   Megías Vericat, Javier ^c   Tortajada Girbés, Miguel ^a   Alonso Iglesias, Eulalia ^b  

^a HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Children; Nitric oxide; Obesity; Oxidative stress; Tumor necrosis factor

Indexed keywords

3 NITROTYROSINE; 8 ISOPROSTAGLANDIN F2 ALPHA; BIOLOGICAL MARKER; HOMOCYSTEINE; INSULIN; INTERLEUKIN 6; LEPTIN; MALONALDEHYDE; NITRATE; NITRIC OXIDE; NITRITE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; URIC ACID;

ABDOMINAL OBESITY; ADOLESCENT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE; BLOOD SAMPLING; CHILD; CHILDHOOD; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NITROSATIVE STRESS; NUTRITIONAL STATUS; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; URINE LEVEL; WAIST CIRCUMFERENCE;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; FEMALE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MALE; NITRATES; NITRIC OXIDE; NITRITES; OBESITY; OXIDATIVE STRESS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; URIC ACID; WAIST CIRCUMFERENCE;

EID: 79953034101     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.12.035     Document Type: Article

References (30)

1. Pacher P., Beckman J.S., Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007, 87:315-424.
2. Gustafson B. Adipose tissue, inflammation and atherosclerosis. J Atheroscler Thromb 2010, 17:332-341.
3. Kagota S., Yamaguchi Y., Tanaka N., et al. Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci 2006, 78:1187-1196.
4. Gomes V.A., Casella-Filho A., Chagas A.C., Tanus-Santos J.E. Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome. Nitric Oxide 2008, 19:345-350.
5. Gruber H.J., Mayer C., Mangge H., Fauler G., Grandits N., Wilders-Truschnig M. Obesity reduces the bioavailability of nitric oxide in juveniles. Int J Obes (Lond) 2008, 32:826-831.
6. Zahedi Asl S., Ghasemi A., Azizi F. Serum nitric oxide metabolites in subjects with metabolic syndrome. Clin Biochem 2008, 41:1342-1347.
7. Ghasemi A., Zahediasl S., Azizi F. Nitric oxide and clustering of metabolic syndrome components in pediatrics. Eur J Epidemiol 2010, 25:45-53.
8. Codoñer-Franch P., Boix-García L., Simó-Jordá R., del Castillo-Villaescusa C., Maset-Maldonado J., Valls-Bellés V. Is obesity associated with oxidative stress in children. Int J Pediatr Obes 2010, 5:56-63.
9. Serra-Majem L., Ribas L., Ngo J., et al. Food, youth and the Mediterranean diet in Spain. Development of KIDMED, Mediterranean Diet Quality Index in children and adolescents. Public Health Nutr 2004, 7:931-935.
10. Carrascosa Lezcano A., Fernández García J.M., Fernández Ramos C., et al. Spanish cross-sectional growth study 2008. Part II. Height, weight and body mass index values from birth to adulthood. An Pediatr (Barc) 2008, 68:552-569.
11. Fernández J.R., Redden D.T., Pietrobelli A., Allison D.B. Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents. J Pediatr 2004, 145:439-444.
12. McCarthy H.D., Cole T.J., Fry T., Jebb S.A., Prentice A.M. Body fat reference curves for children. Int J Obes (Lond) 2006, 30:598-602.
13. Cole T.J., Bellizzi M.C., Flegal K.M., Dietz W.H. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000, 320:1240-1243.
14. National high blood pressure education program working group on high blood pressure in children and adolescent. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-76.
15. Tsikas D., Gutzki F.-M., Stichtenoth D.O. Circulating and excretory nitrite and nitrate as indicators of nitric oxide synthesis in humans: methods of analysis. Eur J Clin Pharmacol 2006, 61:51-59.
16. Misko T.P., Schilling R.J., Salvemini D., Moore W.M., Currie M.G. A fluorometric assay for the measurement of nitrite in biological samples. Anal Biochem 1993, 214:11-16.
17. Moshage H., Kok B., Huizenga J.R., Jansen P.L. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem 1995, 41:892-896.
18. Ceriello A., Mercuri F., Quagliaro L., et al. Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress. Diabetologia 2001, 44:834-838.
19. Mateos R., Lecumberri E., Ramos S., Goya L., Bravo L. Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J Chromatogr B Analyt Technol Biomed Life Sci 2005, 827:76-82.
20. Witko-Sarsat V., Friedlander M., Capeillere-Blandin C., et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 1996, 49:1304-1313.
21. Codoñer-Fanch P., Tavárez-Alonso S., Murria-Estal R., Tortajada-Girbés M., Simó-Jordá R., Alonso-Iglesias E. Elevated advanced oxidation protein products (AOPPs) is indicative of metabolic risk in severe obese children. Nutr Metab Cardiovasc Dis 2010, doi:10.1016/j.numecd.2010.06.002.
22. Vignali D.A. Multiplexed particle-based flow cytometric assays. J Immunol Methods 2000, 243:243-255.
23. Zimmet P., Alberti K.G., Kaufman F., et al. The metabolic syndrome in children and adolescents-an IDF consensus report. Pediatr Diabetes 2007, 8:299-306.
24. Keskin M., Kurtoglu S., Kendirci M., Atabek M.E., Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005, 115:e500-e503.
25. Giannini C., de Giorgis T., Scarinci A., et al. Obese related effects of inflammatory markers and insulin resistance on increased carotid intima media thickness in pre-pubertal children. Atherosclerosis 2008, 197:448-456.
26. Lin L.Y., Lee W.J., Shen H.N., Yang W.S., Pai N.H., Su T.C., Liau C.S. Nitric oxide production is paradoxically decreased after weight reduction surgery in morbid obesity patients. Atherosclerosis 2007, 190:436-442.
27. Noronha B.T., Li J.M., Wheatcroft S.B., Shah A.M., Kearney M.T. Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity. Diabetes 2005, 54:1082-1089.
28. Koeck T., Willard B., Crabb J.W., Kinter M., Stuehr D.J., Aulak K.S. Glucose-mediated tyrosine nitration in adipocytes: targets and consequences. Free Radic Biol Med 2009, 46:884-892.
29. Choi J.W. Enhanced nitric oxide production is closely associated with serum lipid concentrations in adolescents. Clin Chem Acta 2004, 347:151-156.
30. O'Kane P.D., Jackson G., Ferro A. Whole body nitric oxide production is not decreased in patients with coronary atherosclerosis but is inversely related to plasma homocysteine. Atherosclerosis 2008, 196:574-579.