HER-2/neu expression in resectable gastric cancer and its relationship with histopathologic subtype, grade, and stage

Iranian Journal of Basic Medical Sciences

Volumn 10, Issue 2, 2007, Pages 139-145

  Raziee, H R ^a   Kermani, A Taghizadeh ^a   Ghaffarzadegan, K ^a   Shakeri, M Taghi ^b   Ghavamnasiri, M R ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gastric cancer; Grade; HER 2 neu; Immunohistochemistry; Lauren s classification

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER STAGING; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ONCOGENE NEU; PROTEIN EXPRESSION; STOMACH CANCER; TISSUE MICROARRAY; TUMOR GROWTH; TUMOR VOLUME;

EID: 84885698705     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: 10.22038/IJBMS.2007.5281     Document Type: Article

References (34)

1. Press MF, Cordon-Cardo C, Slamon DJ. Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissue. Oncogene 1990; 5: 953-962.
2. Yamamoto T, Ikawa S, Akiyama T. Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor. Nature 1986; 319:230-236.
3. Bongiorno PF, Whyte RI, Lesser EJ. Alterations of K-ras, p53, and erbB-2/neu in human lung adenocarcinomas. J Thorac Cardiovasc Surg 1994; 107:590-595.
4. Mitra AB, Murty VVS, Pratap M. ERBB2 (HER-2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix. Cancer Res 1994; 54:637-639.
5. Slamon DJ, Clark GM, Wong SG. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/ neu oncogene. Sci 1987; 235:177-182.
6. Beckhardt RN, Kiyokawa N, Liu TJ. Neu oncogene in head and neck squamous cell carcinoma. Proc Am Assoc Cancer Res 1994; 35:153.
7. Hynes N, Stern D. The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 1994; 1198:165-184.
8. Slamon DJ, Clark GM, Wong SG. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/ neu oncogene. Sci 1987; 235:177-182.
9. Guerin M, Gabillot M, Mathieu MC. Structure and expression of c-erbB-2 and EGF receptor genes in inflammatory and non-inflammatory breast cancer: Prognostic significance. Int J Cancer 1989; 43:201-208.
10. Van de Vijiver MJ, Peterse JL, Mooi WJ. Neu protein overexpression in breast cancer: Association with comedo type-ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N Engl J Med 1988; 319:1239-1245.
11. Berger MS, Locher GW, Sauer S. Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading, Cancer Res 1988; 48:1238-1243.
12. Paik S, Bryant J, Tan-Chiu E, Yothers G, Park C, Wickerham DL, et al. HER2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-15. J Natl Cancer Inst 2000; 92:1991-1998.
13. Allgayer H, Babic R, Gruetzner UG, Tarabichi A, Schildberg FW, Heiss MA. C-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease system. J Clin Oncol 2000; 18: 2201-2209.
14. Hilton D, West K. c-erbB-2 oncogene product expression and prognosis in gastric carcinoma. J Clin Pathol 1992; 45:454-456.
15. Kolodziejczyk P, Yao T, Oya M. Long term follow-up study of patients with gastric adenomas with malignant transformation. Cancer 1994; 74:2896-2907.
16. Tateishi M, Toda T, Minamisono Y. Clinicopathological significance of c-erbB-2 protein expression in human gastric carcinoma. Surg Oncol 1992; 49:209-212.
17. Sasano H, Date F, Imatani A. Double immunostaining for c-erbB-2 and p53 in human stomach cancer cells. Hum Pathol 1993; 24:584-589.
18. Fornier M, Risio M, van Poznak C, Seidman A. HER2 testing and correlation with the efficacy of trastuzumab therapy. Oncol 2002; 16: 1340-1352.
19. Ross JS, McKenna B. The HER-2/neu oncogene in tumors of the gastrointestinal tract. Cancer Invest 2001; 19: 554-568.
20. Risio M, De Rosa G, Sarotto I, Casorzo L, Capussotti L, Torchio B et al. HER2 testing in gastric cancer:molecular morphology and storage time-related changes in archival samples. Int J Oncol 2003; 23(5):1381-7.
21. Tanner M, Hollmen M. Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIa gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol 2005; 16: 273-278.
22. Lin JT, Wu MS, Shun CT. Occurrence of microsatellite instability in gastric carcinoma is associated with enhanced expression of erbB-2 oncoprotein. Cancer Res 1995; 55:1428-1430.
23. Wu MS, Shun CT, Wang HP. Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection. Gastroenterol 1997; 112:1457-1465.
24. Polkowski W, van Sandick JW, Offerhaus GL. Prognostic value of Lauren’s classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction. Ann Surg Oncol 1999; 6: 290-297.
25. Motojima K, Furui J, Kohara N. ErbB-2 expression in well differentiated adenocarcinoma of the stomach predicts shorter survival after curative resection. Surg 1994; 115:349-354.
26. Shimada E, Kato M, Saito Y. Immunohistochemical study of the c-erbB-2 protein in human gastric carcinoma. Nippon Geka Gakkai Zasshi 1993; 94: 33-40.
27. Motojima K, Furui J, Kohara N, Izawa K, Kanematsu T, Shiku H. ErbB-2 expression in well-differentiated adenocarcinoma of the stomach predicts shorter survival after curative resection. Surg 1994; 115: 349-354.
28. Soto T, Abe K, Kurose A, Uesugi N, Todoroki T, Sasaki K. Amplification of the c-erbB-2 gene detected by FISH in gastric cancers, Pathol Int 1997;47:79-183.
29. Martin IG, Dixon MF, Sue-Ling H, Axon AT, Johnston D. Histological grading of gastric cancer is an important predictor of outcome. Gut 1994; 35: 758-763.
30. Yonemura Y, Sugiyama K, Fujimura T. Epidermal growth factor receptor status and S-phase fractions in gastric carcinoma. Oncol 1989; 46:158-61.
31. Iida A, Hirose K, Arai M, Yamaguchi A, Nakagawara G. Relationship among the expression of epidermal growth factor, proliferating cell nuclear antigen labelling index, and lymph node metastasis in gastric cancer. Oncol 1995; 52:189-95.
32. Koullias GJ, Kouraklis GP, Raftopoulos IS, Davaris PS, Papadopoulos SA, Golematis BC.Increased estrogen recepr and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas. J Surg Oncol 1996; 63:166-71.
33. Pegram MD, Finn RS, Arzoo K. The effect of Her-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells. Oncogene 1997; 15:537-547.
34. Pegram M, Hsu S, Lewis G. Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 1999;18:2241-2251.