Amplification of the c-erbB-2 gene detected by FISH in gastric cancers

Pathology International

Volumn 47, Issue 2-3, 1997, Pages 179-182

  Sato, Toshihiko ^a   Abe, Kaoru ^b   Kurose, Akira ^b   Uesugi, Noriyuku ^b   Todoroki, Takeshi ^c   Sasaki, Kohsuke ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

c erbB 2; DNA ploidy; flow cytometry; fluorescence in situ hybridization; gastric cancer

Indexed keywords

ANEUPLOIDY; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PLOIDY; PRIORITY JOURNAL; STOMACH CANCER; TUMOR DIFFERENTIATION;

EID: 0031003838     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1827.1997.tb03737.x     Document Type: Article

References (16)

1. Brison O. Gene amplification and tumor progression. Biochem. Biophys. Acta 1993; 1155: 25-41.
2. Gutman M, Ravia Y, Assf D, Yamamoto T, Rozin R, Shiloh Y. Amplification of c-myc and c-erbB-2 proto-oncogenes in human solid tumors: Frequency and clinical significance. Int. J. Cancer 1989; 44: 802-805.
3. Yamamoto T, Ikawa S, Akiyama T et al. Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor. Nature 1986; 319: 230-234.
4. Berchuck A, Kamei A, Whitaker R et al. Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res. 1990; 50: 4087-4091.
5. Nagai MA, Pacheco MM, Oshima CTF, Brentani MM. C-erbB-2 DNA amplification and mRNA expression in human primary breast tumors and its relationship to other prognostic factors. Cancer Biother. 1993; 8: 29-35.
6. Lemoine NR, Jain S, Silverstre F et al. Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer. Br. J. Cancer 1991; 64: 79-83.
7. Matsumura K, Kallioniemi O, Kallioniemi A et al. Deletion of chromosome 17p loci in breast cancer cells detected by fluorescence in situ hybridization. Cancer Res. 1992; 52: 3474-3477.
8. Sasaki K, Murakami T, Murakami T, Nakamura M. Intratumoral heterogeneity in DNA ploidy of esophageal squamous cell carcinomas. Cancer 1991; 68: 2403-2406.
9. Sauter G, Moch D, Morre P et al. Heterogeneity of erbB-2 gene amplification in bladder cancer. Cancer Res. 1993; 53: 2199-2203.
10. Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson SA. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 1987; 237: 178-182.
11. Yonemura Y, Ninomiya I, Yamaguchi A et al. Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer. Cancer Res. 1991; 51: 1034-1038.
12. Uchino S, Tsuda H, Maruyama K et al. Overexpression of c-erbB-2 protein in gastric cancer. Cancer 1993; 72: 3179-3184.
13. Jain S, Filipe I, Gullick WJ, Linehan J, Morris RW. C-erbB-2 protooncogene expression and its relationship to survival on gastric carcinoma: An immunohistological study on archival material. Int. J. Cancer 1991; 48: 668-671.
14. Kallioniemi O, Kallioniemi A, Kurisu W et al. C-erbB-2 oncogene amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc. Natl Acad. Sci. USA 1992; 89: 5321-5325.
15. Lemoine NR, Staddon S, Dickson C, Barnes DM, Gullick WJ. Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer. Oncogene 1990; 5: 237-239.
16. Tuzi NL, Venter DJ, Kumar S, Staddon SL, Lemoine NR, Gullick WJ. Expression of growth factor receptors in human brain tumours. Br. J. Cancer 1991; 63: 227-233.