Mechanical approaches to oncological drug delivery

Therapeutic Delivery

Volumn 4, Issue 10, 2013, Pages 1213-1215

  Carlisle, Robert ^a   Coussios, Constantin C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

cavitation; delivery; extravasation; tumor; ultrasound

Indexed keywords

EID: 84885661134     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.13.94     Document Type: Review

References (23)

1. Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat. Rev. Cancer 6(8), 583-592 (2006).
2. Boucher Y, Salehi H, Witwer B, Harsh GRT, Jain RK. Interstitial fluid pressure in intracranial tumours in patients and in rodents. Br. J. Cancer 75(6), 829-836 (1997).
3. Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307(5706), 58-62 (2005).
4. Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc. Res. 37(1), 77-104 (1989).
5. Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics. Microvasc. Res. 40(2), 246-263 (1990).
6. Krol A, Maresca J, Dewhirst MW, Yuan F. Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery. Cancer Res. 59(16), 4136-4141 (1999).
7. Magzoub M, Jin S, Verkman AS. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 22(1), 276-284 (2008).
8. Pluen A, Boucher Y, Ramanujan S et al. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc. Natl Acad. Sci. USA 98(8), 4628-4633 (2001).
9. Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv. Enzyme Regul. 41, 189-207 (2001).
10. Laginha KM, Verwoert S, Charrois GJ, Allen TM. Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors. Clin. Cancer Res. 11(19 Pt 1), 6944-6949 (2005).
11. Loges S, Mazzone M, Hohensinner P, Carmeliet P. Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited. Cancer Cell. 15(3), 167-170 (2009).
12. Milosevic M, Fyles A, Hedley D et al. Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res. 61(17), 6400-6405 (2001).
13. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 64(11), 3731-3736 (2004).
14. Tailor TD, Hanna G, Yarmolenko PS et al. Effect of pazopanib on tumor microenvironment and liposome delivery. Mol. Cancer Ther. 9(6), 1798-1808 (2010).
15. Mo S, Coussios CC, Seymour L, Carlisle R. Ultrasound-enhanced drug delivery for cancer. Expert Opin. Drug Deliv. 9(12), 1525-1538 (2012).
16. Coussios CC, Roy RA. Applications of acoustics and cavitation to noninvasive therapy and drug delivery. Annu. Rev. Fluid Mech. 40, 395-420 (2008).
17. Rifai B, Arvanitis CD, Bazan-Peregrino M, Coussios CC. Cavitation-enhanced delivery of macromolecules into an obstructed vessel. J. Acoust. Soc. Am. 128(5), EL310-EL315 (2010).
18. Bazan-Peregrino M, Rifai B, Carlisle RC et al. Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound. J. Control. Release 169(1-2), 40-47 (2013).
19. Bazan-Peregrino M, Arvanitis CD, Rifai B, Seymour LW, Coussios CC. Ultrasound-induced cavitation enhances the delivery and therapeutic efficacy of an oncolytic virus in an in vitro model. J. Control. Release. 157(2), 235-242 (2012).
20. Rapoport N, Gao Z, Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J. Natl Cancer Inst. 99(14), 1095-1106 (2007).
21. Choi JJ, Coussios CC. Spatiotemporal evolution of cavitation dynamics exhibited by flowing microbubbles during ultrasound exposure. J. Acoust. Soc. Am. 132(5), 3538-3549 (2012).
22. Gyongy M, Coussios CC. Passive cavitation mapping for localization and tracking of bubble dynamics. J. Acoust. Soc. Am. 128(4), EL175-EL180 (2010).
23. Arvanitis CD, Livingstone MS, Vykhodtseva N, McDannold N. Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring. PLoS ONE 7(9), e45783 (2012).