Effect of inhaled iloprost on the exercise function of Fontan patients: A demonstration of concept

International Journal of Cardiology

Volumn 168, Issue 3, 2013, Pages 2435-2440

  Rhodes, Jonathan ^a   Ubeda Tikkanen, Ana ^a   Clair, Mathieu ^a   Fernandes, Susan M ^a   Graham, Dionne A ^a   Milliren, Carly E ^a   Daly, Kevin P ^a   Mullen, Mary P ^a   Landzberg, Michael J ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Exercise testing; Fontan procedure; Heart defects, congenital; Vasodilation

Indexed keywords

ILOPROST; OXYGEN; PLACEBO; VASODILATOR AGENT;

ADOLESCENT; ADULT; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE; FEMALE; FONTAN PROCEDURE; HEART ATRIUM FLUTTER; HEART SINGLE VENTRICLE; HUMAN; HYPOPLASTIC LEFT HEART SYNDROME; MALE; NEBULIZER; OXYGEN TENSION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SORE THROAT; THORAX PAIN; TRICUSPID VALVE ATRESIA; EXERCISE TEST; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; PHYSIOLOGY; YOUNG ADULT;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; CHILD; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE; EXERCISE TEST; FEMALE; FONTAN PROCEDURE; HUMANS; ILOPROST; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; VASODILATOR AGENTS; YOUNG ADULT;

EID: 84885640563     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.03.014     Document Type: Article

References (31)

1. F. Fontan, and E. Baudet Surgical repair of tricuspid atresia Thorax 26 1971 240 248
2. Y. d'Udekem, A.J. Iyengar, and A.D. Cochrane The Fontan procedure: contemporary techniques have improved long-term outcomes Circulation 116 2007 I157 I164
3. P. Khairy, S.M. Fernandes, and J.E. Mayer Jr. Long-term survival, modes of death, and predictors of mortality in patients with Fontan surgery Circulation 117 2008 85 92
4. S.M. Paridon, P.D. Mitchell, and S.D. Colan A cross-sectional study of exercise performance during the first two decades of life following the Fontan operation J Am Coll Cardiol 52 2008 99 107
5. A. Giardini, A. Hager, C.P. Napoleone, and F.M. Picchio Natural history of exercise capacity after the Fontan operation: a longitudinal study Ann Thorac Surg 85 2008 818 822
6. S.M. Fernandes, D.B. McElhinney, P. Khairy, D.A. Graham, M.J. Landzberg, and J. Rhodes Serial cardiopulmonary exercise testing in patients with previous Fontan surgery Pediatr Cardiol 31 2010 175 180
7. Y.M. Law, J. Ettedgui, L. Beerman, A. Maisel, and S. Tofovic Comparison of plasma B-type natriuretic peptide levels in single ventricle patients with systemic ventricle heart failure versus isolated cavopulmonary failure Am J Cardiol 98 2006 520 524
8. L.G. Ekelund, and A. Holmgren Central hemodynamics during exercise Circ Res 20 and 21 Suppl. I 1967 I-33 I-43
9. A. D'Andrea, R. Naeije, and M. D'Alto Range in pulmonary artery systolic pressure among highly trained athletes Chest 139 2011 788 794
10. M.K. Stickland, R.C. Welsh, and S.R. Petersen Does fitness level modulate the cardiovascular hemodynamic response to exercise? J Appl Physiol 100 2006 1895 1901
11. A. La Gerche, and M. Gewillig What limits cardiac performance during exercise in normal subjects and in healthy Fontan patients? Int J Pediatr 2010 2010
12. M. Levy, C. Danel, A.M. Laval, F. Leca, P.R. Vouhe, and D. Israel-Biet Nitric oxide synthase expression by pulmonary arteries: a predictive marker of Fontan procedure outcome? J Thorac Cardiovasc Surg 125 2003 1083 1090
13. S. Khambadkone, J. Li, M.R. de Leval, S. Cullen, J.E. Deanfield, and A.N. Redington Basal pulmonary vascular resistance and nitric oxide responsiveness late after Fontan-type operation Circulation 107 2003 3204 3208
14. Z. Yin, Z. Wang, H. Zhu, R. Zhang, H. Wang, and X. Li Experimental study of effect of Fontan circuit on pulmonary microcirculation Asian Cardiovasc Thorac Ann 14 2006 183 188
15. B.H. Goldstein, C.E. Connor, L. Gooding, and A.P. Rocchini Relation of systemic venous return, pulmonary vascular resistance, and diastolic dysfunction to exercise capacity in patients with single ventricle receiving fontan palliation Am J Cardiol 105 2010 1169 1175
16. M.B. Mitchell, D.N. Campbell, and D. Ivy Evidence of pulmonary vascular disease after heart transplantation for Fontan circulation failure J Thorac Cardiovasc Surg 128 2004 693 702
17. A. Giardini, A. Balducci, S. Specchia, G. Gargiulo, M. Bonvicini, and F.M. Picchio Effect of sildenafil on haemodynamic response to exercise and exercise capacity in Fontan patients Eur Heart J 29 2008 1681 1687
18. D.J. Goldberg, B. French, and M.G. McBride Impact of oral sildenafil on exercise performance in children and young adults after the Fontan operation: a randomized, double-blind, placebo-controlled, crossover trial Circulation 123 2011 1185 1193
19. M. Guazzi, M. Casali, F. Berti, G. Rossoni, V.D. Colonna, and M.D. Guazzi Endothelium-mediated modulation of ergoreflex and improvement in exercise ventilation by acute sildenafil in heart failure patients Clin Pharmacol Ther 83 2008 336 341
20. K. Inai, Y. Saita, S. Takeda, M. Nakazawa, and H. Kimura Skeletal muscle hemodynamics and endothelial function in patients after Fontan operation Am J Cardiol 93 2004 792 797
21. Administration USFaD Revatio (sildenafil): drug safety communication - recommendation against use in children 2012
22. H. Olschewski, H.A. Ghofrani, and T. Schmehl Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group Ann Intern Med 132 2000 435 443
23. R. Wensel, C.F. Opitz, R. Ewert, L. Bruch, and F.X. Kleber Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension Circulation 101 2000 2388 2392
24. R. Ewert, S. Glaser, T. Bollmann, and C. Schaper Inhaled iloprost for therapy in pulmonary arterial hypertension Expert Rev Respir Med 5 2011 145 152
25. D.D. Ivy, A.K. Doran, and K.J. Smith Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension J Am Coll Cardiol 51 2008 161 169
26. K. Wasserman, J.E. Hansen, D.Y. Sue, R. Casaburi, and B.J. Whipp Principles of exercise testing and interpretation 1999 Lippincott Philadelphia 151
27. N.L. Jones Clinical Exercise Testing 1997 W.B. Saunders Philadelphia 135
28. J. Meadows, P. Lang, G. Marx, and J. Rhodes Fontan fenestration closure has no acute effect on exercise capacity but improves ventilatory response to exercise J Am Coll Cardiol 52 2008 108 113
29. S.M. Fernandes, M.E. Alexander, and D.A. Graham Ability of exercise testing to predict morbidity and mortality in adults with Fontan surgery Congenit Heart Dis 6 2011 294 303
30. A. Kempny, K. Dimopoulos, and A. Uebing Reference values for exercise limitations among adults with congenital heart disease. Relation to activities of daily life - single centre experience and review of published data Eur Heart J 33 2012 1386 1396
31. J. Rhodes, T.A. Ubeda, and K.J. Jenkins Exercise testing and training in children with congenital heart disease Circulation 122 2010 1957 1967