Intestinal mucosal proliferation, apoptosis and oxidative stress in patients with liver cirrhosis

Annals of Hepatology

Volumn 12, Issue 2, 2013, Pages 301-307

  Assimakopoulos, Stelios F ^a   Tsamandas, Athanassios C ^a   Tsiaoussis, Georgios I ^a   Karatza, Elli ^a   Zisimopoulos, Dimitrios ^b   Maroulis, Ioannis ^a   Kontogeorgou, Eleni ^a   Georgiou, Christos D ^b   Scopa, Chrisoula D ^a   Thomopoulos, Konstantinos C ^a  

^a UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^b Department of Biology   (Greece)

Author keywords

Endotoxemia; Epithelial homeostasis; Intestinal permeability; Lipid peroxidation

Indexed keywords

ENDOTOXIN; LIPID PEROXIDE;

ADULT; APOPTOSIS; ARTICLE; CELL COUNT; CELL PROLIFERATION; CLINICAL ARTICLE; COMPENSATED LIVER CIRRHOSIS; CONTROLLED STUDY; DECOMPENSATED LIVER CIRRHOSIS; ENDOTOXEMIA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CELL; INTESTINE MUCOSA; LIPID PEROXIDATION; LIVER CIRRHOSIS; MALE; MITOSIS; OXIDATIVE STRESS; AGED; BIOPSY; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COMPARATIVE STUDY; DUODENUM; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MITOSIS INDEX; PATHOLOGY; PERMEABILITY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; APOPTOSIS; BIOPSY; CASE-CONTROL STUDIES; CELL PROLIFERATION; DUODENUM; ENDOTOXEMIA; ENDOTOXINS; ENTEROCYTES; FEMALE; HUMANS; INTESTINAL MUCOSA; LIPID PEROXIDATION; LIPID PEROXIDES; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MITOTIC INDEX; OXIDATIVE STRESS; PERMEABILITY;

EID: 84885640501     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31369-9     Document Type: Article

References (33)

1. Mehal WZ. The gut-liver axis: a busy two-way street. Hepatology 2012; 55: 1647-9.
2. Ramos AR, Matte U, Goldani HA, Oliveira OL, Vieira SM, Silveira TR. Intestinal permeability assessed by 51Cr-EDTA in rats with CCl4-induced cirrhosis. Arq Gastroenterol 2010; 47: 188-92.
3. Scarpellini E, Valenza V, Gabrielli M, Lauritano EC, Perotti G, Merra G, Dal Lago A, et al. Intestinal permeability in cirrhotic patients with and without spontaneous bacterial peritonitis: is the ring closed? Am J Gastroenterol 2010; 105: 323-7.
4. Lee S, Son SC, Han MJ, Kim WJ, Kim SH, Kim HR, Jeon WK, et al. Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites. World J Gastroenterol 2008; 14: 3884-90.
5. Aldersley MA, Howdle PD. Intestinal permeability and liver disease. Eur J Gastroenterol Hepatol 1999; 11: 401-3.
6. Guarner C, Soriano G. Bacterial translocation and its consequences in patients with cirrhosis. Eur J Gastroenterol Hepatol 2005; 17: 27-31.
7. Venkat D, Venkat KK. Hepatorenal syndrome. South Med J 2010; 103: 654-61.
8. Yi HM, Wang GS, Cai CJ, Yang Y, Lu MQ, Hu B, Chen GH. Significance of lipopolysaccharides, toll-like receptor and inducible nitric oxide synthase in hepatopulmonary syndrome. Zhonghua Yi Xue Za Zhi 2009; 89: 1521-4.
9. Senzolo M, Fries W, Buda A, Pizzuti D, Nadal E, Sturniolo GC, Burroughs AK, et al. Oral propranolol decreases intestinal permeability in patients with cirrhosis: another protective mechanism against bleeding? Am J Gastroenterol 2009; 104: 3115-6.
10. Assimakopoulos SF, Scopa CD, Vagianos CE. Pathophysiology of increased intestinal permeability in obstructive jaundice. World J Gastroenterol 2007; 13: 6458-64.
11. Assimakopoulos SF, Tsamandas AC, Tsiaoussis GI, Karatza E, Triantos C, Vagianos CE, Spiliopoulou I, et al. Altered intestinal tight junctions' expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability. Eur J Clin Invest 2012; 42: 439-46.
12. Halliwell B, Gutteridge CMJ. Free Radicals in Biology and Medicine. Oxford; 1999.
13. Alexandris IH, Assimakopoulos SF, Vagianos CE, Patsoukis N, Georgiou C, Nikolopoulou V, Scopa CD. Oxidative state in intestine and liver after partial hepatectomy in rats. Effect of bombesin and neurotensin. Clin Biochem 2004; 37: 350-6.
14. Assimakopoulos SF, Scopa CD, Zervoudakis G, Mylonas PG, Georgiou C, Nikolopoulou V, Vagianos CE. Bombesin and neurotensin reduce endotoxemia, intestinal oxidative stress, and apoptosis in experimental obstructive jaundice. Ann Surg 2005; 241: 159-67.
15. Ancha HR, Kurella RR, McKimmey CC, Lightfoot S, Harty RF. Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats. Dig Dis Sci 2009; 54: 758-66.
16. Ozkan OV, Yuzbasioglu MF, Ciralik H, Kurutas EB, Yonden Z, Aydin M, Bulbuloglu E, et al. Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats. Tohoku J Exp Med 2009; 218: 251-8.
17. Ramachandran A, Prabhu R, Thomas S, Reddy JB, Pulimood A, Balasubramanian KA. Intestinal mucosal alterations in experimental cirrhosis in the rat: role of oxygen free radicals. Hepatology 2002; 35: 622-9.
18. Natarajan SK, Ramamoorthy P, Thomas S, Basivireddy J, Kang G, Ramachandran A, Pulimood AB, et al. Intestinal mucosal alterations in rats with carbon tetrachloride-induced cirrhosis: Changes in glycosylation and luminal bacteria. Hepatology 2006; 43: 837-46.
19. Georgiou CD, Zervoudakis G, Papapostolou I. Mechanism of Coomassie Brilliant Blue G-250 binding to proteins: a hydrophobic assay for ng quantities of proteins. Analytical and Bioanalytical Chemistry 2008; 391: 391-403.
20. Wollf P. Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. In: LP (ed.). Methods in Enzymology; 1994, p. 182-9.
21. Lee RG, Nakamura K, Tsamandas AC, Abu-Elmagd K, Furukawa H, Hutson WR, Reyes J, et al. Pathology of human intestinal transplantation. Gastroenterology 1996; 110: 1820-34.
22. Spahr L, Bresson-Hadni S, Amann P, Kern I, Golaz O, Frossard JL, Hadengue A. Allopurinol, oxidative stress and intestinal permeability in patients with cirrhosis: an open-label pilot study. Liver Int 2007; 27: 54-60.
23. Ersoz G, Aydin A, Erdem S, Yuksel D, Akarca U, Kumanlioglu K. Intestinal permeability in liver cirrhosis. Eur J Gastroenterol Hepatol 1999; 11: 409-12.
24. Czeczot H, Scibior D, Skrzycki M, Podsiad M. Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma. Acta Biochim Pol 2006; 53: 237-42.
25. Moustafa AH, Ali EM, Mohamed TM, Abdou HI. Oxidative stress and thyroid hormones in patients with liver diseases. Eur J Intern Med 2009; 20: 703-8.
26. Ishii Y, Suzuki S, Asai S, Murai I. Liver function assessment with three (13)C breath tests by two-point measurements. Isotopes Environ Health Stud 2012. In press [Epub ahead of print].
27. Szuster-Ciesielska A, Daniluk J, Kandefer-Szerszen M. Oxidative stress in the blood of patients with alcohol-related liver cirrhosis. Med Sci Monit 2002; 8: CR419-24.
28. Nalini G, Hariprasad C, Narayanan VA. Oxidative stress in alcoholic liver disease. Indian J Med Res 1999; 110: 200-3.
29. Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal 1999; 11: 1-14.
30. Rao RK, Basuroy S, Rao VU, Karnaky Jr KJ, Gupta A. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J 2002; 368: 471-81.
31. Margaritis VG, Filos KS, Michalaki MA, Scopa CD, Spiliopoulou I, Nikolopoulou VN, Vagianos CE. Effect of oral glutamine administration on bacterial tanslocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructive jaundice. World J Surg 2005; 29: 1329-34.
32. Lutgendorff F, Nijmeijer RM, Sandström PA, Trulsson LM, Magnusson KE, Timmerman HM, van Minnen LP, et al. Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis. PLoS One 2009; 4: e4512.
33. Assimakopoulos SF, Maroulis I, Patsoukis N, Vagenas K, Scopa CD, Georgiou CD, Vagianos CE. Effect of antioxidant treatments on the gut-liver axis oxidative status and function in bile duct-ligated rats. World J Surg 2007; 31: 2023-32.