Angiotensin II-mediated up-regulation of connective tissue growth factor promotes atrial tissue fibrosis in the canine atrial fibrillation model

Europace

Volumn 14, Issue 8, 2012, Pages 1206-1214

  Kiryu, Michiro ^a   Niwano, Shinichi ^a   Niwano, Hiroe ^a   Kishihara, Jun ^a   Aoyama, Yuya ^a   Fukaya, Hidehira ^a   Masaki, Yoshihiko ^a   Izumi, Tohru ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin receptor blocker; Atrial fibrillation; Connective tissue growth factor; Rapid pacing

Indexed keywords

ANGIOTENSIN II; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OLMESARTAN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CENTRAL VENOUS PRESSURE; CYTOPLASM; DIASTOLIC BLOOD PRESSURE; EXPERIMENTAL DOG; EXTRACELLULAR MATRIX; FEMALE; HEART ATRIUM FIBRILLATION; HEART ATRIUM FIBROSIS; HEART ATRIUM PACING; HEART MUSCLE FIBROSIS; HEART OUTPUT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ARTERY PRESSURE; LUNG WEDGE PRESSURE; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SYSTOLIC BLOOD PRESSURE;

ANGIOTENSIN II; ANIMALS; ATRIAL FIBRILLATION; BLOTTING, WESTERN; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE MODELS, ANIMAL; DOGS; EXTRACELLULAR MATRIX; FEMALE; HEART ATRIA; IMIDAZOLES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TETRAZOLES; UP-REGULATION;

EID: 84864420871     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eus052     Document Type: Article

References (32)

1. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995;92: 1954-68.
2. Li D, Fareh S, Leung TK, Nattel S. Promotion of atrial fibrillation by heart failure in dogs. Circulation 1999;100:87-95.
3. Rupérez M, Lorenzo O, Blanco-Colio LM, Esteban V, Egido J, Ruiz-Ortega M. Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis. Circulation 2003;108:1499-505. (Pubitemid 37176458)
4. Ruiz-Ortega M, Rodŕiguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J. TGF-beta signaling in vascular fibrosis. Cardiovasc Res 2007;74:196-206.
5. Perbal B. CCN proteins: multifunctional signaling regulators. Lancet 2004;363:62-4. (Pubitemid 38076928)
6. Liu BC, Sun J, Chen Q, Ma KL, Ruan XZ, Phillips AO. Role of connective tissue growth factor in mediating hypertrophy of human proximal tubular cells induced by angiotensin II. Am J Nephrol 2003;23:429-37. (Pubitemid 37465106)
7. Adam O, Lavall D, Theobald K, Hohl M, Grube M, Ameling S et al. Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J Am Coll Cardiol 2010;55:469-82.
8. Dean RG, Balding LC, Candido R, Burns WC, Cao Z, Twigg SM et al. Connective tissue growth factor and cardiac fibrosis after myocardial infarction. J Histochem Cytochem 2005;53:1245-56. (Pubitemid 41331123)
9. Kato T, Yamashita T, Sekiguchi A, Tsuneda T, Sagara K, Takamura M et al. AGEs-RAGE system mediates atrial structural remodeling in the diabetic rat. J Cardiovasc Electrophysiol 2008;19:415-20. (Pubitemid 351457548)
10. Niwano S, Kojima J, Fukaya H, Sato D, Moriguchi M, Niwano H et al. Arrhythmo-genic difference between the left and right atria during rapid atrial activation in a canine model of atrial fibrillation. Circ J 2007;71:1629-35. (Pubitemid 47529668)
11. Niwano S, Ortiz J, Abe H, Gonzalez X, Rudy Y, Waldo AL. Characterization of the excitable gap in a functionally determined reentrant circuit. Studies in the sterile pericarditis model of atrial flutter. Circulation 1994;90:1997-2014. (Pubitemid 24320953)
12. Moriguchi M, Niwano S, Yoshizawa N, Kitano Y, Kojima J, Inuo K et al. Inhomo-geneity in the appearance of electrical remodeling during chronic rapid atrial pacing: evaluation of the dispersion of atrial effective refractoriness. Jpn Circ J 2001;65:335-40.
13. Kojima J, Niwano S, Moriguchi M, Ikeda K, Inuo K, Saito J et al. Effect of pilsicainide on atrial electrophysiologic properties in the canine rapid atrial stimulation model. Circ J 2003;67:340-6.
14. Moriguchi M, Niwano S, Yoshizawa N, Kojima J, Inuo K, Izumi T. Verapamil suppresses the inhomogeneity of electrical remodeling in a canine long-term rapid atrial stimulation model. Pacing Clin Electrophysiol 2003;26:2072-82. (Pubitemid 37433673)
15. Fukaya H, Niwano S, Satoh D, Masaki Y, Niwano H, Kojima J et al. Inhomogenic effect of bepridil on atrial electrical remodeling in a canine rapid atrial stimulation model. Circ J 2008;72:318-26. (Pubitemid 351413375)
16. Wakisaka Y, Niwano S, Niwano H, Saito J, Yoshida T, Hirasawa S et al. Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. Cardiovasc Res 2004;63:689-99. (Pubitemid 39078683)
17. Goette A, Staack T, Röcken C, Arndt M, Geller JC, Huth C et al. Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation. J Am Coll Cardiol 2000;35:1669-77. (Pubitemid 30307515)
18. Tsai CT, Tseng CD, Hwang JJ, Wu CK, Yu CC, Wang YC et al. Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor b1. Cardiovasc Res 2011;89:805-15.
19. Garrett Q, Khaw PT, Blalock TD, Schultz GS, Grotendorst GR, Daniels JT. Involvement of CTGF in TGF-beta1-stimulation of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress. Invest Ophthalmol Vis Sci 2004;45:1109-16. (Pubitemid 38869015)
20. Panek AN, Posch MG, Alenina N, Ghadge SK, Erdmann B, Popova E et al. Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload. PLoS One 2009; 4:e6743.
21. Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-b. Nat Cell Biol 2002; 4:599-604.
22. Xu J, Cui G, Esmailian F, Plunkett M, Marelli D, Ardehali A et al. Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation. Circulation 2004;109: 363-8. (Pubitemid 38133905)
23. Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circulation Res 1988;62:757-65.
24. Shimizu M, Umeda K, Sugihara N, Yoshio H, Ino H, Takeda R et al. Collagen remodelling in myocardia of patients with diabetes. J Clin Pathol 1993; 46:32-6. (Pubitemid 23039583)
25. Kumagai K, Nakashima H, Urata H, Gondo N, Arakawa K, Saku K. Effects of angio-tensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation. J Am Coll Cardiol 2003;41:2197-204. (Pubitemid 36724267)
26. Fukaya H, Niwano S, Niwano H, Masaki Y, Kiryu M, Hirasawa S et al. Combined effects of up-and downstream therapies on atrial fibrillation in a canine rapid stimulation model. Int J Cardiol 2010 Epub ahead of print.
27. Yang F, Chung AC, Huang XR, Lan HY. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and-independent Smad pathways: the role of Smad3. Hypertension 2009;54:877-84.
28. Bruins P, te Velthuis H, Yazdanbakhsh AP, Jansen PG, van Hardevelt FW, de Beaumont EM et al. Activation of the complement system during and after cardio-pulmonary bypass surgery. Circulation 1997;96:3542-8.
29. Chung MK, Martin DO, Sprecher D, Wazni O, Kanderian A, Carnes CA et al. C-reactive protein elevation in patients with atrial arrhythmias. Inflammatory mechanisms and persistence of atrial fibrillation. Circulation 2001; 104:2886-91. (Pubitemid 33139098)
30. On YK, Jeon ES, Lee SY, Shin DH, Choi JO, Sung J et al. Plasma transforming growth factor-b1 as a biochemical marker to predict the persistence of atrial fibrillation after the surgical maze procedure. J Thorac Cardiovasc Surg 2009;137: 1515-20.
31. Verheule S, Sato T, Everett T 4th, Engle SK, Otten D, Rubart-von der Lohe M et al. Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-b1. Circ Res 2004;94: 1458-65. (Pubitemid 38780318)
32. Nakajima H, Nakajima HO, Salcher O, Dittiè AS, Dembowsky K, Jing S et al. Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-beta(1) transgene in the heart. Circ Res 2000;86:571-9. (Pubitemid 30165049)