How reliable is current imaging in restaging rectal cancer after neoadjuvant therapy?

World Journal of Gastroenterology

Volumn 19, Issue 36, 2013, Pages 5964-5972

  De Nardi, Paola ^a   Carvello, Michele ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Complete pathological response; Diagnostic accuracy; Neoadjuvant therapies; Rectal cancer; Restaging

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADJUVANT CHEMORADIOTHERAPY; ADJUVANT THERAPY; CANCER RECURRENCE; CANCER STAGING; CLINICAL EXAMINATION; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DIGITAL RECTAL EXAMINATION; FIBROSIS; FOLLOW UP; HISTOLOGY; HUMAN; IMAGING; LYMPH NODE METASTASIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFUSION WEIGHTED IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIMARY TUMOR; RECTUM CANCER; REVIEW; TRANSRECTAL ULTRASONOGRAPHY; TUMOR VASCULARIZATION;

COMPLETE PATHOLOGICAL RESPONSE; DIAGNOSTIC ACCURACY; NEOADJUVANT THERAPIES; RECTAL CANCER; RESTAGING;

CHEMOTHERAPY, ADJUVANT; DIAGNOSTIC IMAGING; HUMANS; LYMPHATIC METASTASIS; MAGNETIC RESONANCE IMAGING; NEOADJUVANT THERAPY; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; RECTAL NEOPLASMS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 84885636473     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i36.5964     Document Type: Review

References (91)

1. Arnoletti JP, Bland KI. Neoadjuvant and adjuvant therapy for rectal cancer. Surg Oncol Clin N Am 2006; 15: 147-157 [PMID: 16389155 DOI: 10.1016/j.soc.2005.08.001]
2. Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351: 1731-1740 [PMID: 15496622 DOI: 351/17/1731]
3. Janjan NA, Crane CN, Feig BW, Cleary K, Dubrow R, Curley SA, Ellis LM, Vauthey J, Lenzi R, Lynch P, Wolff R, Brown T, Pazdur R, Abbruzzese J, Hoff PM, Allen P, Brown B, Skibber J. Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2000; 47: 713-718 [PMID: 10837955 DOI: 10.1016/ S0360-3016(00)00418-1]
4. Madoff RD. Chemoradiotherapy for rectal cancer--when, why, and how? N Engl J Med 2004; 351: 1790-1792 [PMID: 15496630]
5. Janjan NA, Khoo VS, Abbruzzese J, Pazdur R, Dubrow R, Cleary KR, Allen PK, Lynch PM, Glober G, Wolff R, Rich TA, Skibber J. Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the M. D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 1999; 44: 1027-1038 [PMID: 10421535 DOI: 10.1016/S0360-3016(99)00099-1]
6. Janjan NA, Crane C, Feig BW, Cleary K, Dubrow R, Curley S, Vauthey JN, Lynch P, Ellis LM, Wolff R, Lenzi R, Abbruzzese J, Pazdur R, Hoff PM, Allen P, Brown T, Skibber J. Improved overall survival among responders to preoperative chemoradiation for locally advanced rectal cancer. Am J Clin Oncol 2001; 24: 107-112 [PMID: 11319280]
7. Valentini V, Coco C, Cellini N, Picciocchi A, Genovesi D, Mantini G, Barbaro B, Cogliandolo S, Mattana C, Ambesi-Impiombato F, Tedesco M, Cosimelli M. Preoperative chemoradiation for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, and sphincter preservation. Int J Radiat Oncol Biol Phys 1998; 40: 1067-1075 [PMID: 9539561 DOI: 10.1016/S0360-3016(97)00918-8]
8. Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1986; 1: 1479-1482 [PMID: 2425199 DOI: 10.1016/S0140-6736(86)91510-2]
9. Quirke P, Durdey P, Dixon MF, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 1986; 2: 996-999 [PMID: 2430152]
10. Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 2008; 26: 303-312 [PMID: 18182672]
11. Issa N, Murninkas A, Powsner E, Dreznick Z. Long-term outcome of local excision after complete pathological response to neoadjuvant chemoradiation therapy for rectal cancer. World J Surg 2012; 36: 2481-2487 [PMID: 22736345 DOI: 10.1007/s00268-012-1697-7]
12. Habr-Gama A, Perez RO. Non-operative management of rectal cancer after neoadjuvant chemoradiation. Br J Surg 2009; 96: 125-127 [PMID: 19160360 DOI: 10.1002/bjs.6470]
13. Habr-Gama A, Perez RO, Nadalin W, Sabbaga J, Ribeiro U, Silva e Sousa AH, Campos FG, Kiss DR, Gama-Rodrigues J. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg 2004; 240: 711-717; discussion 711-717 [PMID: 15383798]
14. Habr-Gama A, Perez R, Proscurshim I, Gama-Rodrigues J. Complete clinical response after neoadjuvant chemoradiation for distal rectal cancer. Surg Oncol Clin N Am 2010; 19: 829-845 [PMID: 20883957 DOI: 10.1016/j.soc.2010.08.001]
15. Habr-Gama A, Perez RO. The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy (Br J Surg 2012; 99: 993-1001). Br J Surg 2012; 99: 1601; author reply 1601-1602 [PMID: 23027080 DOI: 10.1002/bjs.8946]
16. Du C, Xue W, Li J, Cai Y, Gu J. Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy. Hum Pathol 2012; 43: 1061-1067 [PMID: 22204710 DOI: 10.1016/j.humpath.2011.07.026]
17. Lee CT, Chow NH, Liu YS, Lin SC, Lin PC, Wu YH, Lee JC, Tsai HM. Computed tomography with histological correlation for evaluating tumor regression of rectal carcinoma after preoperative chemoradiation therapy. Hepatogastroenterology 2012; 59: 2484-2489 [PMID: 22497951 DOI: 10.5754/hge12165]
18. Vecchio FM, Valentini V, Minsky BD, Padula GD, Venkatraman ES, Balducci M, Miccichè F, Ricci R, Morganti AG, Gambacorta MA, Maurizi F, Coco C. The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys 2005; 62: 752-760 [PMID: 15936556 DOI: 10.1016/ j.ijrobp.2004.11.017]
19. Guillem JG, Chessin DB, Shia J, Moore HG, Mazumdar M, Bernard B, Paty PB, Saltz L, Minsky BD, Weiser MR, Temple LK, Cohen AM, Wong WD. Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point. J Clin Oncol 2005; 23: 3475-3479 [PMID: 15908656]
20. Kahn H, Alexander A, Rakinic J, Nagle D, Fry R. Preoperative staging of irradiated rectal cancers using digital rectal examination, computed tomography, endorectal ultrasound, and magnetic resonance imaging does not accurately predict T0, N0 pathology. Dis Colon Rectum 1997; 40: 140-144 [PMID: 9075746]
21. Benzoni E, Cerato F, Cojutti A, Milan E, Pontello D, Chiaulon G, Sacco C, Bresadola V, Terrosu G. The predictive value of clinical evaluation of response to neoadjuvant chemoradiation therapy for rectal cancer. Tumori 2005; 91: 401-405 [PMID: 16459636]
22. Perez RO, Habr-Gama A, Gama-Rodrigues J, Proscurshim I, Julião GP, Lynn P, Ono CR, Campos FG, Silva e Sousa AH, Imperiale AR, Nahas SC, Buchpiguel CA. Accuracy of positron emission tomography/computed tomography and clinical assessment in the detection of complete rectal tumor regression after neoadjuvant chemoradiation: long-term results of a prospective trial (National Clinical Trial 00254683). Cancer 2012; 118: 3501-3511 [PMID: 22086847 DOI: 10.1002/ cncr.26644]
23. Hiotis SP, Weber SM, Cohen AM, Minsky BD, Paty PB, Guillem JG, Wagman R, Saltz LB, Wong WD. Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients. J Am Coll Surg 2002; 194: 131-135; discussion 131-135 [PMID: 11848629]
24. Habr-Gama A, Perez RO, Wynn G, Marks J, Kessler H, Gama-Rodrigues J. Complete clinical response after neoadjuvant chemoradiation therapy for distal rectal cancer: characterization of clinical and endoscopic findings for standardization. Dis Colon Rectum 2010; 53: 1692-1698 [PMID: 21178866 DOI: 10.1007/DCR.0b013e3181f42b89]
25. Kikuchi S, Kida M, Kobayashi K, Yano T, Sakuramoto S, Watanabe M, Kubota K, Isobe Y. New diagnostic imaging of gastointestinal tumors: a preliminary study of three-dimensional tumor structure and volumetry. Anticancer Res 2005; 25: 2935-2941 [PMID: 16080547]
26. Bhutani MS. Recent developments in the role of endoscopic ultrasonography in diseases of the colon and rectum. Curr Opin Gastroenterol 2007; 23: 67-73 [PMID: 17133088 DOI: 10.1097/MOG.0b013e328011630b]
27. Huh JW, Park YA, Jung EJ, Lee KY, Sohn SK. Accuracy of endorectal ultrasonography and computed tomography for restaging rectal cancer after preoperative chemoradiation. J Am Coll Surg 2008; 207: 7-12 [PMID: 18589355]
28. Mezzi G, Arcidiacono PG, Carrara S, Perri F, Petrone MC, De Cobelli F, Gusmini S, Staudacher C, Del Maschio A, Testoni PA. Endoscopic ultrasound and magnetic resonance imaging for re-staging rectal cancer after radiotherapy. World J Gastroenterol 2009; 15: 5563-5567 [PMID: 19938195]
29. Gavioli M, Bagni A, Piccagli I, Fundaro S, Natalini G. Usefulness of endorectal ultrasound after preoperative radiotherapy in rectal cancer: comparison between sonographic and histopathologic changes. Dis Colon Rectum 2000; 43: 1075-1083 [PMID: 10950005]
30. Rau B, Hünerbein M, Barth C, Wust P, Haensch W, Riess H, Felix R, Schlag PM. Accuracy of endorectal ultrasound after preoperative radiochemotherapy in locally advanced rectal cancer. Surg Endosc 1999; 13: 980-984 [PMID: 10526031]
31. Martellucci J, Scheiterle M, Lorenzi B, Roviello F, Cetta F, Pinto E, Tanzini G. Accuracy of transrectal ultrasound after preoperative radiochemotherapy compared to computed tomography and magnetic resonance in locally advanced rectal cancer. Int J Colorectal Dis 2012; 27: 967-973 [PMID: 22297865 DOI: 10.1007/s00384-012-1419-5]
32. Vanagunas A, Lin DE, Stryker SJ. Accuracy of endoscopic ultrasound for restaging rectal cancer following neoadjuvant chemoradiation therapy. Am J Gastroenterol 2004; 99: 109-112 [PMID: 14687151]
33. Marone P, de Bellis M, Avallone A, Delrio P, di Nardo G, D' Angelo V, Tatangelo F, Pecori B, Di Girolamo E, Iaffaioli V, Lastoria S, Battista Rossi G. Accuracy of endoscopic ultrasound in staging and restaging patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation. Clin Res Hepatol Gastroenterol 2011; 35: 666-670 [PMID: 21782549]
34. Radovanovic Z, Breberina M, Petrovic T, Golubovic A, Radovanovic D. Accuracy of endorectal ultrasonography in staging locally advanced rectal cancer after preoperative chemoradiation. Surg Endosc 2008; 22: 2412-2415 [PMID: 18622554 DOI: 10.1007/s00464-008-0037-3]
35. Maor Y, Nadler M, Barshack I, Zmora O, Koller M, Kundel Y, Fidder H, Bar-Meir S, Avidan B. Endoscopic ultrasound staging of rectal cancer: diagnostic value before and following chemoradiation. J Gastroenterol Hepatol 2006; 21: 454-458 [PMID: 16509874]
36. Radovanović Z, Radovanović D, Breberina M, Petrović T, Golubović A, Bokorov B. [The value of endorectal ultrasonography in rectal cancer staging]. Med Pregl 2008; 61: 557-561 [PMID: 19368271]
37. Pomerri F, Pucciarelli S, Maretto I, Zandonà M, Del Bianco P, Amadio L, Rugge M, Nitti D, Muzzio PC. Prospective assessment of imaging after preoperative chemoradiotherapy for rectal cancer. Surgery 2011; 149: 56-64 [PMID: 20452636 DOI: 10.1016/j.surg.2010.03.025]
38. Maretto I, Pomerri F, Pucciarelli S, Mescoli C, Belluco E, Burzi S, Rugge M, Muzzio PC, Nitti D. The potential of restaging in the prediction of pathologic response after preoperative chemoradiotherapy for rectal cancer. Ann Surg Oncol 2007; 14: 455-461 [PMID: 17139456 DOI: 10.1245/s10434-006-9269-4]
39. Brown G, Richards CJ, Bourne MW, Newcombe RG, Radcliffe AG, Dallimore NS, Williams GT. Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison. Radiology 2003; 227: 371-377 [PMID: 12732695 DOI: 10.1148/radiol.2272011747227/2/371]
40. Kim JH, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG. Highresolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol 2004; 52: 78-83 [PMID: 15380850 DOI: 10.1016/j.ejrad.2003.12.005]
41. Iafrate F, Laghi A, Paolantonio P, Rengo M, Mercantini P, Ferri M, Ziparo V, Passariello R. Preoperative staging of rectal cancer with MR Imaging: correlation with surgical and histopathologic findings. Radiographics 2006; 26: 701-714 [PMID: 16702449]
42. Reerink O, Verschueren RC, Szabo BG, Hospers GA, Mulder NH. A favourable pathological stage after neoadjuvant radiochemotherapy in patients with initially irresectable rectal cancer correlates with a favourable prognosis. Eur J Cancer 2003; 39: 192-195 [PMID: 12509951 DOI: 10.1016/ S0959-8049(02)00557-9]
43. Vliegen RF, Beets GL, Lammering G, Dresen RC, Rutten HJ, Kessels AG, Oei TK, de Bruïne AP, van Engelshoven JM, Beets-Tan RG. Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction. Radiology 2008; 246: 454-462 [PMID: 18227541]
44. Brown G, Daniels IR, Richardson C, Revell P, Peppercorn D, Bourne M. Techniques and trouble-shooting in high spatial resolution thin slice MRI for rectal cancer. Br J Radiol 2005; 78: 245-251 [PMID: 15730990]
45. Vliegen RF, Beets GL, von Meyenfeldt MF, Kessels AG, Lemaire EE, van Engelshoven JM, Beets-Tan RG. Rectal cancer: MR imaging in local staging--is gadolinium-based contrast material helpful? Radiology 2005; 234: 179-188 [PMID: 15550372]
46. Kuo LJ, Chern MC, Tsou MH, Liu MC, Jian JJ, Chen CM, Chung YL, Fang WT. Interpretation of magnetic resonance imaging for locally advanced rectal carcinoma after preoperative chemoradiation therapy. Dis Colon Rectum 2005; 48: 23-28 [PMID: 15690653]
47. Chen CC, Lee RC, Lin JK, Wang LW, Yang SH. How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy? Dis Colon Rectum 2005; 48: 722-728 [PMID: 15747073 DOI: 10.1007/s10350-004-0851-1]
48. Kim DJ, Kim JH, Lim JS, Yu JS, Chung JJ, Kim MJ, Kim KW. Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy. Radiographics 2010; 30: 503-516 [PMID: 20228331]
49. Torkzad MR, Lindholm J, Martling A, Cedermark B, Glimelius B, Blomqvist L. MRI after preoperative radiotherapy for rectal cancer; correlation with histopathology and the role of volumetry. Eur Radiol 2007; 17: 1566-1573 [PMID: 17265052 DOI: 10.1007/s00330-006-0518-5]
50. Kim YH, Kim DY, Kim TH, Jung KH, Chang HJ, Jeong SY, Sohn DK, Choi HS, Ahn JB, Kim DH, Lim SB, Lee JS, Park JG. Usefulness of magnetic resonance volumetric evaluation in predicting response to preoperative concurrent chemoradiotherapy in patients with resectable rectal cancer. Int J Radiat Oncol Biol Phys 2005; 62: 761-768 [PMID: 15936557 DOI: 10.1016/j.ijrobp.2004.11.005]
51. Devries AF, Griebel J, Kremser C, Judmaier W, Gneiting T, Kreczy A, Ofner D, Pfeiffer KP, Brix G, Lukas P. Tumor microcirculation evaluated by dynamic magnetic resonance imaging predicts therapy outcome for primary rectal carcinoma. Cancer Res 2001; 61: 2513-2516 [PMID: 11289123]
52. DeVries AF, Kremser C, Hein PA, Griebel J, Krezcy A, Ofner D, Pfeiffer KP, Lukas P, Judmaier W. Tumor microcirculation and diffusion predict therapy outcome for primary rectal carcinoma. Int J Radiat Oncol Biol Phys 2003; 56: 958-965 [PMID: 12829130 DOI: 10.1016/S0360-3016(03)00208-6]
53. Kremser C, Trieb T, Rudisch A, Judmaier W, de Vries A. Dynamic T(1) mapping predicts outcome of chemoradiation therapy in primary rectal carcinoma: sequence implementation and data analysis. J Magn Reson Imaging 2007; 26: 662-671 [PMID: 17729365 DOI: 10.1002/jmri.21034]
54. Hein PA, Kremser C, Judmaier W, Griebel J, Pfeiffer KP, Kreczy A, Hug EB, Lukas P, DeVries AF. Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: preliminary results of a prospective study. Eur J Radiol 2003; 45: 214-222 [PMID: 12595106 DOI: 10.1016/ S0720-048X(02)00231-0]
55. Dzik-Jurasz A, Domenig C, George M, Wolber J, Padhani A, Brown G, Doran S. Diffusion MRI for prediction of response of rectal cancer to chemoradiation. Lancet 2002; 360: 307-308 [PMID: 12147376 DOI: 10.1016/S0140-6736(02)09520-X]
56. Hussain SM, Outwater EK, Siegelman ES. Mucinous versus nonmucinous rectal carcinomas: differentiation with MR imaging. Radiology 1999; 213: 79-85 [PMID: 10540644]
57. Oberholzer K, Menig M, Kreft A, Schneider A, Junginger T, Heintz A, Kreitner KF, Hötker AM, Hansen T, Düber C, Schmidberger H. Rectal cancer: mucinous carcinoma on magnetic resonance imaging indicates poor response to neoadjuvant chemoradiation. Int J Radiat Oncol Biol Phys 2012; 82: 842-848 [PMID: 21236593]
58. Stoker J, Rociu E, Wiersma TG, Laméris JS. Imaging of anorectal disease. Br J Surg 2000; 87: 10-27 [PMID: 10606906]
59. Beynon J, Mortensen NJ, Foy DM, Channer JL, Rigby H, Virjee J. Preoperative assessment of mesorectal lymph node involvement in rectal cancer. Br J Surg 1989; 76: 276-279 [PMID: 2655811]
60. Kim DJ, Kim JH, Ryu YH, Jeon TJ, Yu JS, Chung JJ. Nodal staging of rectal cancer: high-resolution pelvic MRI versus 18F-FDGPET/CT. J Comput Assist Tomogr 2011; 35: 531-534 [PMID: 21926843 DOI: 10.1097/RCT.0b013e318225720f]
61. Yasuda K, Adachi Y, Shiraishi N, Yamaguchi K, Hirabayashi Y, Kitano S. Pattern of lymph node micrometastasis and prognosis of patients with colorectal cancer. Ann Surg Oncol 2001; 8: 300-304 [PMID: 11352302]
62. Lahaye MJ, Engelen SM, Kessels AG, de Bruïne AP, von Meyenfeldt MF, van Engelshoven JM, van de Velde CJ, Beets GL, Beets-Tan RG. USPIO-enhanced MR imaging for nodal staging in patients with primary rectal cancer: predictive criteria. Radiology 2008; 246: 804-811 [PMID: 18195379]
63. Will O, Purkayastha S, Chan C, Athanasiou T, Darzi AW, Gedroyc W, Tekkis PP. Diagnostic precision of nanoparticleenhanced MRI for lymph-node metastases: a meta-analysis. Lancet Oncol 2006; 7: 52-60 [PMID: 16389184 DOI: 10.1016/ S1470-2045(05)70537-4]
64. Cho YB, Chun HK, Kim MJ, Choi JY, Park CM, Kim BT, Lee SJ, Yun SH, Kim HC, Lee WY. Accuracy of MRI and 18FFDG PET/CT for restaging after preoperative concurrent chemoradiotherapy for rectal cancer. World J Surg 2009; 33: 2688-2694 [PMID: 19823904 DOI: 10.1007/s00268-009-0248-3]
65. Grassetto G, Marzola MC, Minicozzi A, Al-Nahhas A, Rubello D. F-18 FDG PET/CT in rectal carcinoma: where are we now? Clin Nucl Med 2011; 36: 884-888 [PMID: 21892038 DOI: 10.1097/RLU.0b013e318219b507]
66. Mak D, Joon DL, Chao M, Wada M, Joon ML, See A, Feigen M, Jenkins P, Mercuri A, McNamara J, Poon A, Khoo V. The use of PET in assessing tumor response after neoadjuvant chemoradiation for rectal cancer. Radiother Oncol 2010; 97: 205-211 [PMID: 20598390 DOI: 10.1016/j.radonc.2010.05.016]
67. Kalff V, Ware R, Heriot A, Chao M, Drummond E, Hicks RJ. Radiation changes do not interfere with postchemoradiation restaging of patients with rectal cancer by FDG PET/CT before curative surgical therapy. Int J Radiat Oncol Biol Phys 2009; 74: 60-66 [PMID: 18922649 DOI: 10.1016/ j.ijrobp.2008.06.1944]
68. Vriens D, de Geus-Oei LF, van der Graaf WT, Oyen WJ. Tailoring therapy in colorectal cancer by PET-CT. Q J Nucl Med Mol Imaging 2009; 53: 224-244 [PMID: 19293770]
69. Kubota K. [Cancer diagnosis with positron emission tomography (PET)]. Kaku Igaku 1996; 33: 207-212 [PMID: 8721109]
70. Capirci C, Rampin L, Erba PA, Galeotti F, Crepaldi G, Banti E, Gava M, Fanti S, Mariani G, Muzzio PC, Rubello D. Sequential FDG-PET/CT reliably predicts response of locally advanced rectal cancer to neo-adjuvant chemo-radiation therapy. Eur J Nucl Med Mol Imaging 2007; 34: 1583-1593 [PMID: 17503039 DOI: 10.1007/s00259-007-0426-1]
71. Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors. J Nucl Med 2009; 50 Suppl 1: 122S-150S [PMID: 19403881]
72. Cherry SR. The 2006 Henry N. Wagner Lecture: Of mice and men (and positrons)--advances in PET imaging technology. J Nucl Med 2006; 47: 1735-1745 [PMID: 17079804]
73. Capirci C, Rubello D, Pasini F, Galeotti F, Bianchini E, Del Favero G, Panzavolta R, Crepaldi G, Rampin L, Facci E, Gava M, Banti E, Marano G. The role of dual-time combined 18-fluorodeoxyglucose positron emission tomography and computed tomography in the staging and restaging workup of locally advanced rectal cancer, treated with preoperative chemoradiation therapy and radical surgery. Int J Radiat Oncol Biol Phys 2009; 74: 1461-1469 [PMID: 19419820 DOI: 10.1016/j.ijrobp.2008.10.064]
74. Heriot AG, Hicks RJ, Drummond EG, Keck J, Mackay J, Chen F, Kalff V. Does positron emission tomography change management in primary rectal cancer? A prospective assessment. Dis Colon Rectum 2004; 47: 451-458 [PMID: 14978612 DOI: 10.1007/s10350-003-0089-3]
75. Calvo FA, Domper M, Matute R, Martínez-Lázaro R, Arranz JA, Desco M, Alvarez E, Carreras JL. 18F-FDG positron emission tomography staging and restaging in rectal cancer treated with preoperative chemoradiation. Int J Radiat Oncol Biol Phys 2004; 58: 528-535 [PMID: 14751524 DOI: 10.1016/ j.ijrobp.2003.09.058]
76. Capirci C, Rubello D, Chierichetti F, Crepaldi G, Carpi A, Nicolini A, Mandoliti G, Polico C. Restaging after neoadjuvant chemoradiotherapy for rectal adenocarcinoma: role of F18-FDG PET. Biomed Pharmacother 2004; 58: 451-457 [PMID: 15464875]
77. Capirci C, Rubello D, Chierichetti F, Crepaldi G, Fanti S, Mandoliti G, Salviato S, Boni G, Rampin L, Polico C, Mariani G. Long-term prognostic value of 18F-FDG PET in patients with locally advanced rectal cancer previously treated with neoadjuvant radiochemotherapy. AJR Am J Roentgenol 2006; 187: W202-W208 [PMID: 16861513]
78. Huh JW, Min JJ, Lee JH, Kim HR, Kim YJ. The predictive role of sequential FDG-PET/CT in response of locally advanced rectal cancer to neoadjuvant chemoradiation. Am J Clin Oncol 2012; 35: 340-344 [PMID: 21422901 DOI: 10.1097/ COC.0b013e3182118e7d]
79. Shanmugan S, Arrangoiz R, Nitzkorski JR, Yu JQ, Li T, Cooper H, Konski A, Farma JM, Sigurdson ER. Predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer using 18FDG-PET/CT. Ann Surg Oncol 2012; 19: 2178-2185 [PMID: 22395978 DOI: 10.1245/s10434-012-2248-z]
80. Denecke T, Rau B, Hoffmann KT, Hildebrandt B, Ruf J, Gutberlet M, Hünerbein M, Felix R, Wust P, Amthauer H. Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging? Eur Radiol 2005; 15: 1658-1666 [PMID: 15806369 DOI: 10.1007/s00330-005-2658-4]
81. Mohiuddin M, Hayne M, Regine WF, Hanna N, Hagihara PF, McGrath P, Marks GM. Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers. Int J Radiat Oncol Biol Phys 2000; 48: 1075-1080 [PMID: 11072165 DOI: 10.1016/S0360-3016(00)00732-X]
82. Theodoropoulos G, Wise WE, Padmanabhan A, Kerner BA, Taylor CW, Aguilar PS, Khanduja KS. T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 2002; 45: 895-903 [PMID: 12130878]
83. Luna-Pérez P, Rodríguez-Ramírez S, Hernández-Pacheco F, Gutiérrez De La Barrera M, Fernández R, Labastida S. Anal sphincter preservation in locally advanced low rectal adenocarcinoma after preoperative chemoradiation therapy and coloanal anastomosis. J Surg Oncol 2003; 82: 3-9 [PMID: 12501163 DOI: 10.1002/jso.10185]
84. Luna-Pérez P, Rodríguez-Ramírez S, Rodriguez-Coria DF, Fernández A, Labastida S, Silva A, López MJ. Preoperative chemoradiation therapy and anal sphincter preservation with locally advanced rectal adenocarcinoma. World J Surg 2001; 25: 1006-1011 [PMID: 11571965]
85. Habr-Gama A, de Souza PM, Ribeiro U, Nadalin W, Gansl R, Sousa AH, Campos FG, Gama-Rodrigues J. Low rectal cancer: impact of radiation and chemotherapy on surgical treatment. Dis Colon Rectum 1998; 41: 1087-1096 [PMID: 9749491]
86. Medich D, McGinty J, Parda D, Karlovits S, Davis C, Caushaj P, Lembersky B. Preoperative chemoradiotherapy and radical surgery for locally advanced distal rectal adenocarcinoma: pathologic findings and clinical implications. Dis Colon Rectum 2001; 44: 1123-1128 [PMID: 11535851]
87. Grann A, Minsky BD, Cohen AM, Saltz L, Guillem JG, Paty PB, Kelsen DP, Kemeny N, Ilson D, Bass-Loeb J. Preliminary results of preoperative 5-fluorouracil, low-dose leucovorin, and concurrent radiation therapy for clinically resectable T3 rectal cancer. Dis Colon Rectum 1997; 40: 515-522 [PMID: 9152176]
88. Habr-Gama A, Perez RO, São Julião GP, Proscurshim I, Gama-Rodrigues J. Nonoperative approaches to rectal cancer: a critical evaluation. Semin Radiat Oncol 2011; 21: 234-239 [PMID: 21645869]
89. Habr-Gama A, Oliva Perez R. [The strategy "wait and watch" in patients with a cancer of bottom stocking rectum with a complete clinical answer after neoadjuvant radiochemotherapy]. J Chir (Paris) 2009; 146: 237-239 [PMID: 19682685]
90. Perez RO, Habr-Gama A, São Julião GP, Gama-Rodrigues J, Sousa AH, Campos FG, Imperiale AR, Lynn PB, Proscurshim I, Nahas SC, Ono CR, Buchpiguel CA. Optimal timing for assessment of tumor response to neoadjuvant chemoradiation in patients with rectal cancer: do all patients benefit from waiting longer than 6 weeks? Int J Radiat Oncol Biol Phys 2012; 84: 1159-1165 [PMID: 22580120]
91. Singh-Ranger G, Kumar D. Current concepts in the nonoperative management of rectal cancer after neoadjuvant chemoradiation. Anticancer Res 2011; 31: 1795-1800 [PMID: 21617242]