Intestinal inflammation in postoperative ileus: Pathogenesis and therapeutic targets

Gut

Volumn 62, Issue 11, 2013, Pages 1534-1535

  Rychter, Jakub ^a   Clavé, Pere ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALTREXONE; ALVIMOPAN; CORTICOTROPIN RELEASING FACTOR; DOXANTRAZOLE; GSK 143; KETOTIFEN; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PROTEIN TYROSINE KINASE INHIBITOR; SEMAPIMOD; UNCLASSIFIED DRUG;

ABDOMINAL SURGERY; CLINICAL FEATURE; DISEASE COURSE; DRUG MECHANISM; ENTERIC FEEDING; ENTERITIS; EPIDURAL ANESTHESIA; GASTROINTESTINAL MOTILITY DISORDER; HUMAN; MACROPHAGE; MAST CELL; NONHUMAN; NOTE; PATHOGENESIS; POSTOPERATIVE ILEUS; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR;

COLORECTAL SURGERY; GASTROINTESTINAL MOTILITY; INFLAMMATORY MECHANISMS; MACROPHAGES; MAST CELLS;

ANILINE COMPOUNDS; ANIMALS; ILEUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; POSTOPERATIVE COMPLICATIONS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIMIDINES;

EID: 84885634564     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-304176     Document Type: Note

References (10)

1. Delaney CP, Kehlet H, Senagore AJ, et al. On behalf of the Postoperative Ileus Management Council (PIMC). Postoperative ileus: profiles, Risk factors and Definitions. A framework for Optimizing Surgical Outcomes in Patients Undergoing Major Abdominal and Colorectal Surgery. Clinical Consensus Update in General Surgery, May 1, 2006. http://www.clinicalwebcasts.com/pdfs/GenSurg-WEB. pdf (accessed 26 Dec 2012).
2. Holte K, Kehlet H. Postoperative ileus: a preventable event. Br J Surg 2000;87:1480-93.
3. Luckey A, Livingston E, Taché Y. Mechanisms and treatment of postoperative ileus. Arch Surg 2003;138:206-14. (Pubitemid 36216289)
4. Boeckxstaens GE, de Jonge WJ. Neuroimmune mechanisms in postoperative ileus. Gut 2009;58:1300-11.
5. Delaney CP, Wolff BG, Viscusi ER, et al. Alvimopan, for postoperative ileus following bowel resection: a pooled analysis of phase III studies. Ann Surg 2007;245:355-63. (Pubitemid 46673131)
6. Wehner S, Vilz TO, Stoffels B, et al. Immune mediators of postoperative ileus. Langenbecks Arch Surg 2012;397:591-601.
7. The FO, Buist MR, Lei A, et al. The role of mast cell stabilization in treatment of postoperative ileus: a pilot study. Am J Gastroenterol 2009;104: 2257-66.
8. Wehner S, Straesser S, Vilz TO, et al. Inhibition of p38 mitogen-activated protein kinase pathway as prophylaxis of postoperative ileus in mice. Gastroenterology 2009;136:619-29.
9. van Bree SH, Gomez-Pinilla PJ, van de Bovenkamp FS, et al. Inhibition of spleen tyrosine kinase as treatment of postoperative ileus. Gut 2013;62:1581-90.
10. Kehlet H, Slim K. The future of fast-track surgery. Br J Surg 2012;99:1025-6.