Cytogenetic biodosimetry using the blood lymphocytes of astronauts

Acta Astronautica

Volumn 92, Issue 1, 2013, Pages 97-102

  George, Kerry A ^a   Rhone, Jordan ^b   Chappell, Lori J ^c   Cucinotta, Francis A ^d  

^a WYLE LABORATORIES   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c USRA   (United States)

^d NASA JOHNSON SPACE CENTER   (United States)

Author keywords

Biodosimetry; Chromosomal aberrations; HZE nuclei; Space radiation

Indexed keywords

BLOOD; CHROMOSOMES; DAMAGE DETECTION; DISEASES; HEALTH; HEALTH RISKS; HEAVY IONS; LYMPHOCYTES; MANNED SPACE FLIGHT; RADIATION; RADIATION DAMAGE; RADIATION EFFECTS; RADIATION SHIELDING; RADIOTHERAPY; RISK ASSESSMENT; RISK PERCEPTION;

BIODOSIMETRY; CHROMOSOMAL ABERRATION; HZE NUCLEI; INDIVIDUAL RADIOSENSITIVITY; PERIPHERAL BLOOD LYMPHOCYTES; QUANTITATIVE APPROACH; RISK ASSESSMENT MODELS; SPACE RADIATIONS;

NEUTRON IRRADIATION;

EID: 84885628649     PISSN: 00945765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actaastro.2012.05.001     Document Type: Article

References (25)

1. M.Y. Kim, K. George, F.A. Cucinotta, Book Chapter 2.5 Radiation in Principal of Safety Design for Space Systems, International Association for the Advancement of Space Safety, Elsevier, 2009 Book published March.
2. Radiation Protection Guidance for Activities in Low-Earth Orbit, NCRP Report No. 132, 2000 Bethesda, Maryland.
3. Operational Radiation Safety Program for Astronauts in Low-Earth Orbit: a Basic Framework, NCRP Report No. 142, 2002 Bethesda, Maryland.
4. F.A. Cucinotta, S. Hu, N.A. Schwadron, K. Kozarev, L.W. Townsend, M.Y. Kim, Space radiation risk limits and Earth-Moon-Mars environmental models, Space Weather 8 (2010) S00E09.
5. F.A. Cucinotta, L.J. Chappell, Updates to astronaut radiation limits: radiation risks for never-smokers, Radiat. Res. 176 (2011) 102-114.
6. F.A. Cucinotta, M.Y. Kim, L.J. Chappell, Space radiation cancer risk projections and uncertainties, NASA TP (2011) 2011-216155.
7. F.A. Cucinotta, M. Durante, Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings, Lancet Oncol. 7 (5) (2006) 431-435.
8. M. Durante, F.A. Cucinotta, Heavy ion carcinogenesis and human space exploration, Nat. Rev. Cancer 8 (2008) 465-472. (Pubitemid 351744960)
9. K. George, M. Durante, H. Wu, V. Willingham, G. Badhwar, F.A. Cucinotta, Chromosome aberrations in astronauts' blood lymphocytes after space flight, Radiat. Res. 156 (2001) 731-738. (Pubitemid 34024268)
10. Cytogenetic Analysis for Radiation Dose Assessment, IAEA. Technical report no 405, International Atomic Energy Agency, Vienna, 2001.
11. K. George, M. Durante, Chromosome Aberrations in Astronauts, Book Chapter 25, Chromosome Alterations: Methods, results, and importance in human health, Springer book published, 2007.
12. M. Durante, Biomarkers of space radiation risk, Radiat. Res. 164 (2005) 467-473. (Pubitemid 41368920)
13. K. George, H. Wu, V. Willingham, Y. Furusawa, T. Kawata, F.A. Cucinotta, High- and low-LET induced chromsome damage in human lymphocytes: a time course of aberrations in metaphase and interphase, Int. J. Radiat. Biol. 77 (2001) 175-183. (Pubitemid 32158364)
14. K. George, M. Durante, V. Willingham, H. Wu, T.C. Yang, F.A. Cucinotta, Biological effectiveness of accelerted particles for the induction of chomosome damage measured in metphase and interphase human lymphoyctes, Radiat. Res. 160 (2003) 425-435. (Pubitemid 37174510)
15. G. Obe, I. Johannes, C. Johannes, K. Hallman, G. Reitz, R. Facius, Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights, Int. J. Radiat. Biol. 72 (1997) 727-734. (Pubitemid 28020337)
16. L. Testard, M. Ricoul, F. Hoffschir, A. Flury-Herard, B. Dutrillaux, B. Federenko, V. Gerasimenko, L. Sabatier, Radiation-induced chromosome damage in astronauts' lymphocytes, Int. J. Radiat. Biol. 70 (1996) 403-411. (Pubitemid 26359806)
17. B. Federenko, S. Druzhinin, L. Yudaeva, V. Petrov, Y. Akatov, G. Snigiryova, N. Novitskaya, V. Shevchenko, V. Rubanovich, Cytoge- netic studies of blood lymphocytes from cosmonauts after long-term space flights on Mir station, Adv. Space Res. 27 (2) (2003) 355-359. (Pubitemid 32568906)
18. T.C. Yang, K. George, A.S. Johnson, M. Durante, B.S. Fedorenko, BS, Biodosimetry results from space flight Mir-18, Radiat. Res. 48 (1997) 17-23.
19. K. George, V. Willingham, F.A. Cucinotta, Stability of chromosome aberrations in the blood lymphocytes of astronauts after space flight by FISH chromosome painting, Radiat. Res. 164 (2005) 474-480. (Pubitemid 41368921)
20. F.A. Cucinotta, M.Y. Kim, V. Willingham, K.A. George, Physical and biological organ dosimetry analysis for international space station astronauts, Radiat. Res. 170 (2008) 127-138. (Pubitemid 351934246)
21. J.D. Tucker, FISH cytogenetics and the future of radiation biodosi- metry, Radiat. Prot. Dosim. 97 (2001) 55-60. (Pubitemid 33094854)
22. M. Durante, G. Snigiryova, E. Akaeva, S. Bogomazova, S. Druzhinin, B. Ferenfo, O. Greco, N. Novitskaya, A. Rubanovich, V. Shevchenko, U. von Recklinghausen, G. Obe, Chromosome aberration dosimetry in cosmonauts after single or multiple flights, Cytogenet Genome Res. 103 (1-2) (2003) 40-46. (Pubitemid 38353283)
23. K. George, L.J. Chappell, F.A. Cucinotta, Persistence of space radiation induced cytogenetic damage in the blood lymphocytes of astronauts, Mutat. Res. 701 (2010) 75-79.
24. S. Bonassi, et al., Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22, 358 subjects in 11 countries, Carcinogenesis 29 (2008) 1178-1183. (Pubitemid 351958697)
25. M. Durante, S. Bonassi, K. George, F.A. Cucinotta, Risk estimation based on chromosomal aberrations induced by radiation, Radiat. Res. 156 (2001) 662-667. (Pubitemid 33027545)