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Volumn 12, Issue 10, 2013, Pages 2167-2175

Combining erlotinib and cetuximab is associated with activity in patients with non-small cell lung cancer (including squamous cell carcinomas) and wild-type EGFR or resistant mutations

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB;

EID: 84885621292     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-1208     Document Type: Article
Times cited : (33)

References (41)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011;61: 212-36.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350: 2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 4
    • 32944481596 scopus 로고    scopus 로고
    • Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
    • Riely GJ, Pao W, Pham D, Li AR, Rizvi N, Venkatraman ES, et al. Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 2006;12: 839-44.
    • (2006) Clin Cancer Res , vol.12 , pp. 839-844
    • Riely, G.J.1    Pao, W.2    Pham, D.3    Li, A.R.4    Rizvi, N.5    Venkatraman, E.S.6
  • 5
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • Mitsudomi T, Kosaka T, Endoh H, Horio Y, Hida T, Mori S, et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 2005;23: 2513-20.
    • (2005) J Clin Oncol , vol.23 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3    Horio, Y.4    Hida, T.5    Mori, S.6
  • 7
    • 33746034167 scopus 로고    scopus 로고
    • Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
    • Jackman DM, Yeap BY, Sequist LV, Lindeman N, Holmes AJ, Joshi VA, et al. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 2006;12: 3908-14.
    • (2006) Clin Cancer Res , vol.12 , pp. 3908-3914
    • Jackman, D.M.1    Yeap, B.Y.2    Sequist, L.V.3    Lindeman, N.4    Holmes, A.J.5    Joshi, V.A.6
  • 8
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003;21: 2787-99.
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 9
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002;7(Suppl 4): 2-8.
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 10
    • 73349096261 scopus 로고    scopus 로고
    • Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Hammerman PS, Janne PA, Johnson BE. Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2009;15: 7502-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 7502-7509
    • Hammerman, P.S.1    Janne, P.A.2    Johnson, B.E.3
  • 11
    • 82955240672 scopus 로고    scopus 로고
    • Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer
    • Mumenthaler SM, Foo J, Leder K, Choi NC, Agus DB, Pao W, et al. Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Mol Pharm 2011;8: 2069-79.
    • (2011) Mol Pharm , vol.8 , pp. 2069-2079
    • Mumenthaler, S.M.1    Foo, J.2    Leder, K.3    Choi, N.C.4    Agus, D.B.5    Pao, W.6
  • 12
    • 33947498978 scopus 로고    scopus 로고
    • Molecular predictors of response to epidermal growth factor receptor antagonists in nonsmall- cell lung cancer
    • Sequist LV, Bell DW, Lynch TJ, Haber DA. Molecular predictors of response to epidermal growth factor receptor antagonists in nonsmall- cell lung cancer. J Clin Oncol 2007;25: 587-95.
    • (2007) J Clin Oncol , vol.25 , pp. 587-595
    • Sequist, L.V.1    Bell, D.W.2    Lynch, T.J.3    Haber, D.A.4
  • 13
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. Plos Med 2005;2: 225-35.
    • (2005) Plos Med , vol.2 , pp. 225-235
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 15
    • 3442891161 scopus 로고    scopus 로고
    • Dualagent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
    • Huang S, Armstrong EA, Benavente S, Chinnaiyan P, Harari PM. Dualagent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res 2004;64: 5355-62.
    • (2004) Cancer Res , vol.64 , pp. 5355-5362
    • Huang, S.1    Armstrong, E.A.2    Benavente, S.3    Chinnaiyan, P.4    Harari, P.M.5
  • 16
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting
    • Matar P, Rojo F, Cassia R, Moreno-Bueno G, Di Cosimo S, Tabernero J, et al. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res 2004;10: 6487-501.
    • (2004) Clin Cancer Res , vol.10 , pp. 6487-6501
    • Matar, P.1    Rojo, F.2    Cassia, R.3    Moreno-Bueno, G.4    Di Cosimo, S.5    Tabernero, J.6
  • 17
    • 43249110958 scopus 로고    scopus 로고
    • Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): A phase i study
    • Ramalingam S, Forster J, Naret C, Evans T, Sulecki M, Lu H, et al. Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study. J Thorac Oncol 2008;3: 258-64.
    • (2008) J Thorac Oncol , vol.3 , pp. 258-264
    • Ramalingam, S.1    Forster, J.2    Naret, C.3    Evans, T.4    Sulecki, M.5    Lu, H.6
  • 18
    • 79954586068 scopus 로고    scopus 로고
    • Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib
    • Janjigian YY, Azzoli CG, Krug LM, Pereira LK, Rizvi NA, Pietanza MC, et al. Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib. Clin Cancer Res 2011;17: 2521-7.
    • (2011) Clin Cancer Res , vol.17 , pp. 2521-2527
    • Janjigian, Y.Y.1    Azzoli, C.G.2    Krug, L.M.3    Pereira, L.K.4    Rizvi, N.A.5    Pietanza, M.C.6
  • 19
    • 84874574262 scopus 로고    scopus 로고
    • An umbrella protocol for histology-independent, phase i modular study based on EGFR mutation status: Using erlotinib alone or in combination with cetuximab, bortezomib, or dasatinib to overcome resistance
    • (suppl; abstr 2536)
    • Fok J, Kurzrock R, Tsimberidou AM,WenS, Naing A, Hong DS, et al. An umbrella protocol for histology-independent, phase I modular study based on EGFR mutation status: Using erlotinib alone or in combination with cetuximab, bortezomib, or dasatinib to overcome resistance. J Clin Oncol 29: 2011 (suppl; abstr 2536).
    • (2011) J Clin Oncol , vol.29
    • Fok, J.1    Kurzrock, R.2    Tsimberidou, A.M.3    Wen, S.4    Naing, A.5    Hong, D.S.6
  • 21
    • 33646783722 scopus 로고    scopus 로고
    • National Cancer Institute
    • National Cancer Institute. Common terminology criteria for adverse events v3.0 (CTCAE); 2006. Available from: http://ctep.cancer.gov/ protocolDevelopment/electronic-applications/docs/ctcaev3.pdf
    • (2006) Common Terminology Criteria for Adverse Events v3.0 (CTCAE)
  • 22
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92: 205-16.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3    Wanders, J.4    Kaplan, R.S.5    Rubinstein, L.6
  • 23
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, Stadler WM, Flaherty KT, Kaye SB, Rosner GL, et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24: 2505-12.
    • (2006) J Clin Oncol , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3    Flaherty, K.T.4    Kaye, S.B.5    Rosner, G.L.6
  • 25
    • 42949176742 scopus 로고    scopus 로고
    • Survival of cancer cells is maintained by EGFR independent of its kinase activity
    • Weihua Z, Tsan R, HuangWC,WuQ, Chiu CH, Fidler IJ, et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008;13: 385-93.
    • (2008) Cancer Cell , vol.13 , pp. 385-393
    • Weihua, Z.1    Tsan, R.2    Huang, W.C.3    Wu, Q.4    Chiu, C.H.5    Fidler, I.J.6
  • 26
    • 84873820021 scopus 로고    scopus 로고
    • Sensitivity to EGFR inhibitors based on location of EGFR exon 20 insertion mutations within the tyrosine kinase domain of EGFR
    • (suppl; abstr 7523)
    • Costa DB, Yasuda H, Sng NJ, Yeo WL, de Figueiredo Pontes LL, Tenen DG, et al. Sensitivity to EGFR inhibitors based on location of EGFR exon 20 insertion mutations within the tyrosine kinase domain of EGFR. J Clin Oncol 30: 2012 (suppl; abstr 7523).
    • (2012) J Clin Oncol , vol.30
    • Costa, D.B.1    Yasuda, H.2    Sng, N.J.3    Yeo, W.L.4    De Figueiredo Pontes, L.L.5    Tenen, D.G.6
  • 27
    • 84855310079 scopus 로고    scopus 로고
    • EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications
    • Yasuda H, Kobayashi S, Costa DB. EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol 2012;13:e23-31.
    • (2012) Lancet Oncol , vol.13
    • Yasuda, H.1    Kobayashi, S.2    Costa, D.B.3
  • 28
    • 84857087591 scopus 로고    scopus 로고
    • Clarifying the spectrum of driver oncogene mutations in biomarkerverified squamous carcinoma of lung: Lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations
    • Rekhtman N, Paik PK, Arcila ME, Tafe LJ, Oxnard GR, Moreira AL, et al. Clarifying the spectrum of driver oncogene mutations in biomarkerverified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations. Clin Cancer Res 2012;18: 1167-76.
    • (2012) Clin Cancer Res , vol.18 , pp. 1167-1176
    • Rekhtman, N.1    Paik, P.K.2    Arcila, M.E.3    Tafe, L.J.4    Oxnard, G.R.5    Moreira, A.L.6
  • 30
    • 84879492481 scopus 로고    scopus 로고
    • Correlation between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors and EGFR mutations in advanced squamous cell lung cancer
    • Duan JC, An TT, Wu MN, Yang L, Bai H, Wang ZJ, et al. [Correlation between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors and EGFR mutations in advanced squamous cell lung cancer]. Zhonghua Jie He He Hu Xi Za Zhi 2012;35: 323-8.
    • (2012) Zhonghua Jie He He Hu Xi Za Zhi , vol.35 , pp. 323-328
    • Duan, J.C.1    An, T.T.2    Wu, M.N.3    Yang, L.4    Bai, H.5    Wang, Z.J.6
  • 31
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced nonsmall- cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, et al. Cetuximab plus chemotherapy in patients with advanced nonsmall- cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009;373: 1525-31.
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3    Von Pawel, J.4    Krzakowski, M.5    Ramlau, R.6
  • 33
    • 51049116207 scopus 로고    scopus 로고
    • Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
    • Wu JY, Wu SG, Yang CH, Gow CH, Chang YL, Yu CJ, et al. Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin Cancer Res 2008;14: 4877-82.
    • (2008) Clin Cancer Res , vol.14 , pp. 4877-4882
    • Wu, J.Y.1    Wu, S.G.2    Yang, C.H.3    Gow, C.H.4    Chang, Y.L.5    Yu, C.J.6
  • 34
    • 84885668867 scopus 로고    scopus 로고
    • Cetuximab resistance associated with dimerization-independence of oncogenic EGFR mutants
    • Cho J, Chen L, Sangji N, Du J, Okabe T, Yonesaka K, et al. Cetuximab resistance associated with dimerization-independence of oncogenic EGFR mutants. Mol Cancer Ther 2009;8(12 Suppl):A177.
    • (2009) Mol Cancer Ther , vol.8 , Issue.12 SUPPL.
    • Cho, J.1    Chen, L.2    Sangji, N.3    Du, J.4    Okabe, T.5    Yonesaka, K.6
  • 35
  • 36
    • 80755128256 scopus 로고    scopus 로고
    • Retreatment with erlotinib: Regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment
    • Becker A, Crombag L, Heideman DA, Thunnissen FB, van Wijk AW, Postmus PE, et al. Retreatment with erlotinib: regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment. Eur J Cancer 2011; 47: 2603-6.
    • (2011) Eur J Cancer , vol.47 , pp. 2603-2606
    • Becker, A.1    Crombag, L.2    Heideman, D.A.3    Thunnissen, F.B.4    Van Wijk, A.W.5    Postmus, P.E.6
  • 37
    • 84877926446 scopus 로고    scopus 로고
    • Dodging a dogma: Is treating beyond progression beneficial?
    • Naing A, Kurzrock R. Dodging a dogma: is treating beyond progression beneficial? Cancer Chemother Pharmacol 2013;71: 1385-6.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 1385-1386
    • Naing, A.1    Kurzrock, R.2
  • 39
    • 84865201590 scopus 로고    scopus 로고
    • Therapeutic effect of gamma-secretase inhibition in KRAS G12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK
    • Maraver A, Fernandez-Marcos PJ, Herranz D, Canamero M, Munoz-Martin M, Gomez-Lopez G, et al. Therapeutic effect of gamma-secretase inhibition in KRAS G12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell 2012;22: 222-34.
    • (2012) Cancer Cell , vol.22 , pp. 222-234
    • Maraver, A.1    Fernandez-Marcos, P.J.2    Herranz, D.3    Canamero, M.4    Munoz-Martin, M.5    Gomez-Lopez, G.6
  • 40
    • 84873677937 scopus 로고    scopus 로고
    • Activity of afatinib/cetuximab in patients (Pts) with EGFR-mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors
    • Janjigian YY, Smit EF, Horn L, Groen HJM, Camidge DR, Gettinger S, et al. Activity of afatinib/cetuximab in patients (Pts) with EGFR-mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors. Ann Oncol 2012;23:401.
    • (2012) Ann Oncol , vol.23 , pp. 401
    • Janjigian, Y.Y.1    Smit, E.F.2    Horn, L.3    Groen, H.J.M.4    Camidge, D.R.5    Gettinger, S.6
  • 41
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Jackman D, Pao W, Riely GJ, Engelman JA, Kris MG, Janne PA, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol 2010;28: 357-60.
    • (2010) J Clin Oncol , vol.28 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3    Engelman, J.A.4    Kris, M.G.5    Janne, P.A.6


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