A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway

Human Pathology

Volumn 44, Issue 11, 2013, Pages 2494-2500

  Cimino Mathews, Ashley ^a   Hicks, Jessica L ^a   Sharma, Rajni ^a   Vang, Russell ^a   Illei, Peter B ^a   De Marzo, Angelo ^a   Emens, Leisha A ^a   Argani, Pedram ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Breast; Fibroepithelial neoplasm; p16; Phyllodes tumor; Rb

Indexed keywords

KI 67 ANTIGEN; PROTEIN P16; RETINOBLASTOMA PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BREAST FIBROADENOMA; CANCER ADJUVANT THERAPY; CANCER CELL; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURGERY; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTOSARCOMA PHYLLOIDES; CYTOPLASM; HIGH RISK PATIENT; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MASTECTOMY; PARTIAL MASTECTOMY; PHENOTYPE; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TISSUE SECTION; TUMOR GROWTH; WART VIRUS;

BREAST; FIBROEPITHELIAL NEOPLASM; P16; PHYLLODES TUMOR; RB;

ADULT; AGED; BREAST NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KI-67 ANTIGEN; MIDDLE AGED; NEOPLASMS, FIBROEPITHELIAL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PHYLLODES TUMOR; RETINOBLASTOMA PROTEIN; STROMAL CELLS; TISSUE ARRAY ANALYSIS; YOUNG ADULT;

EID: 84885572222     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.06.009     Document Type: Article

References (38)

1. P.P. Rosen Fibroepithelial neoplasms P.P. Rosen, Rosen's Breast Pathology 3rd ed. 2009 Lippincott Williams & Wilkins Philadelphia, PA 187 229
2. P.H. Tan, G. Tse, and A. Lee Fibroepithelial tumours S.R. Lakhani, I.O. Ellis, S.K. Schnitt, World Health Organization Classification of Tumours of the Breast 2012 IARC Press Lyon, France 142 147
3. C.G. Kleer, T.J. Giordano, T. Braun, and H.A. Oberman Pathologic, immunohistochemical, and molecular features of benign and malignant phyllodes tumors of the breast Mod Pathol 14 2001 185 190
4. A. Niezabitowski, B. Lackowska, and J. Rys Prognostic evaluation of proliferative activity and DNA content in the phyllodes tumor of the breast: immunohistochemical and flow cytometric study of 118 cases Breast Cancer Res Treat 65 2001 77 85
5. B. Shpitz, Y. Bomstein, and A. Sternberg Immunoreactivity of p53, Ki-67, and c-erbB-2 in phyllodes tumors of the breast in correlation with clinical and morphologic features J Surg Oncol 79 2002 86 92
6. A. Kuijper, R.A. de Vos, J.H. Lagendijk, E. van der Wall, and P.J. van Diest Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors Am J Clin Pathol 123 2005 690 698
7. N.N. Esposito, D. Mohan, and A. Brufsky Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases Arch Pathol Lab Med 130 2006 1516 1521
8. J. Massagué G1 cell-cycle control and cancer Nature 432 2004 298 306
9. R.Z. Karim, R.A. Scolyer, and G.M. Tse Pathogenic mechanisms in the initiation and progression of mammary phyllodes tumours Pathology 41 2009 105 117
10. J. Li, M.J. Poi, and M.D. Tsai Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer Biochemistry 50 2011 5566 5582
11. E.A. Dublin, N.K. Patel, and C.E. Gillett Retinoblastoma and p16 proteins in mammary carcinoma: their relationship to cyclin D1 and histopathological parameters Int J Cancer 79 1998 71 75
12. A.P. Subhawong, T. Subhawong, and H. Nassar Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically Am J Surg Pathol 33 2009 163 175
13. R.Z. Karim, S.K. Gerega, and Y.H. Yang p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours Histopathology 56 2010 868 875
14. M. Laé, A. Vincent-Salomon, and A. Savignoni Phyllodes tumors of the breast segregate in two groups according to genetic criteria Mod Pathol 20 2007 435 444
15. A.M. Jones, R. Mitter, and R. Springall A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence J Pathol 214 2008 533 544
16. A. Kuijper, A.M. Snijders, and E.M. Berns Genomic profiling by array comparative genomic hybridization reveals novel DNA copy number changes in breast phyllodes tumours Cell Oncol 31 2009 31 39
17. A. Cimino-Mathews, A.P. Subhawong, and H. Elwood Neural crest transcription factor Sox10 is preferentially expressed in triple negative and metaplastic breast carcinomas Hum Pathol 44 2013 1341 1349
18. A. Cimino-Mathews, A.P. Subhawong, and P.B. Illei GATA-3 expression in breast carcinoma: utility in triple negative sarcomatoid and metastatic carcinomas Hum Pathol 44 2013 1341 1349
19. R. Klaes, T. Friedrich, and D. Spitkovsky Overexpression of p16(INK4a) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri Int J Cancer 92 2001 276 284
20. A. Cimino-Mathews, R. Sharma, and P.B. Illei Detection of human papillomavirus in small cell carcinomas of the anus and rectum Am J Surg Pathol 36 2012 1087 1092
21. A.H. Lee Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast Histopathology 52 2008 45 57
22. D. Giri Recurrent challenges in the evaluation of fibroepithelial lesions Arch Pathol Lab Med 133 2009 713 721
23. E.J. Sawyer, A.M. Hanby, and P. Ellis Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal components Am J Pathol 156 2000 1093 1098
24. R.P. McCarthy, S. Zhang, and D.G. Bostwick Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate Am J Pathol 165 2004 1395 1400
25. C.J. Moffat, S.E. Pinder, and A.R. Dixon Phyllodes tumours of the breast: a clinicopathological review of thirty-two cases Histopathology 27 1995 205 218
26. P.H. Tan, T. Jayabaskar, and K.L. Chuah Phyllodes tumors of the breast: the role of pathologic parameters Am J Clin Pathol 123 2005 529 540
27. J. Ben Hassouna, T. Damak, and A. Gamoudi Phyllodes tumors of the breast: a case series of 106 patients Am J Surg 192 2006 141 147
28. S. Noguchi, K. Motomura, H. Inaji, S. Imaoka, and H. Koyama Clonal analysis of fibroadenoma and phyllodes tumor of the breast Cancer Res 53 1993 4071 4074
29. S. Noguchi, H. Yokouchi, and T. Aihara Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysis Cancer 76 1995 1779 1785
30. A. Kuijper, H. Buerger, and R. Simon Analysis of the progression of fibroepithelial tumours of the breast by PCR-based clonality assay J Pathol 197 2002 575 581
31. K.B. Hodges, F.W. Abdul-Karim, and M. Wang Evidence for transformation of fibroadenoma of the breast to malignant phyllodes tumor Appl Immunohistochem Mol Morphol 17 2009 345 350
32. D. Parry, S. Bates, D.J. Mann, and G. Peters Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product EMBO J 14 1995 503 511
33. D.M. Muirhead, H.T. Hoffman, and R.A. Robinson Correlation of clinicopathological features with immunohistochemical expression of cell cycle regulatory proteins p16 and retinoblastoma: distinct association with keratinisation and differentiation in oral cavity squamous cell carcinoma J Clin Pathol 59 2006 711 715
34. S. Lv, Y. Niu, and L. Wei Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study Breast Cancer Res Treat 112 2008 411 418
35. K.J. Jee, G. Gong, S.H. Ahn, J.M. Park, and S. Knuutila Gain in 1q is a common abnormality in phyllodes tumours of the breast Anal Cell Pathol 25 2003 89 93
36. E.S. Knudsen, and K.E. Knudsen Tailoring to RB: tumour suppressor status and therapeutic response Nat Rev Cancer 8 2008 714 724
37. A. Ertel, J.L. Dean, and H. Rui RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response Cell Cycle 9 2010 4153 4163
38. A.K. Witkiewicz, A. Ertel, and J. McFalls RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer Clin Cancer Res 18 2012 5110 5122