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Volumn 65, Issue , 2013, Pages 67-75

Myocardial glycophagy - A specific glycogen handling response to metabolic stress is accentuated in the female heart

Author keywords

Autophagy; Cardiac; Fasting; Gender; Sex

Indexed keywords

GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE B; PROTEIN P62; REGULATOR PROTEIN; STARCH BINDING PROTEIN DOMAIN 1; UNCLASSIFIED DRUG;

EID: 84885543075     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.09.014     Document Type: Article
Times cited : (64)

References (56)
  • 2
    • 0018764335 scopus 로고
    • Diabetes and cardiovascular disease. The Framingham study
    • Kannel W.B., McGee D.L. Diabetes and cardiovascular disease. The Framingham study. Jama 1979, 241:2035-2038.
    • (1979) Jama , vol.241 , pp. 2035-2038
    • Kannel, W.B.1    McGee, D.L.2
  • 3
    • 4944237210 scopus 로고    scopus 로고
    • 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling
    • Patten R.D., Pourati I., Aronovitz M.J., Baur J., Celestin F., Chen X., et al. 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circ Res 2004, 95:692-699.
    • (2004) Circ Res , vol.95 , pp. 692-699
    • Patten, R.D.1    Pourati, I.2    Aronovitz, M.J.3    Baur, J.4    Celestin, F.5    Chen, X.6
  • 4
    • 0005808585 scopus 로고
    • The effect of insulin on pathologic glycogen deposits in diabetes mellitus
    • Warren S. The effect of insulin on pathologic glycogen deposits in diabetes mellitus. Am J Med Sci 1930, 179:482-488.
    • (1930) Am J Med Sci , vol.179 , pp. 482-488
    • Warren, S.1
  • 5
    • 2342533184 scopus 로고    scopus 로고
    • Exercise training attenuated the PKB and GSK-3 dephosphorylation in the myocardium of ZDF rats
    • Lajoie C., Calderone A., Trudeau F., Lavoie N., Massicotte G., Gagnon S., et al. Exercise training attenuated the PKB and GSK-3 dephosphorylation in the myocardium of ZDF rats. J Appl Physiol 2004, 96:1606-1612.
    • (2004) J Appl Physiol , vol.96 , pp. 1606-1612
    • Lajoie, C.1    Calderone, A.2    Trudeau, F.3    Lavoie, N.4    Massicotte, G.5    Gagnon, S.6
  • 6
    • 79751535965 scopus 로고    scopus 로고
    • The effect of losartan treatment on the response of diabetic cardiomyocytes to ATP depletion
    • Alfarano C., Suffredini S., Fantappie O., Mugelli A., Cerbai E., Manni M.E., et al. The effect of losartan treatment on the response of diabetic cardiomyocytes to ATP depletion. Pharmacol Res 2011, 63:225-232.
    • (2011) Pharmacol Res , vol.63 , pp. 225-232
    • Alfarano, C.1    Suffredini, S.2    Fantappie, O.3    Mugelli, A.4    Cerbai, E.5    Manni, M.E.6
  • 8
    • 71049149280 scopus 로고    scopus 로고
    • Changes of glycogen content in liver, skeletal muscle, and heart from fasted rats
    • Kokubun E., Hirabara S.M., Fiamoncini J., Curi R., Haebisch H. Changes of glycogen content in liver, skeletal muscle, and heart from fasted rats. Cell Biochem Funct 2009, 27:488-495.
    • (2009) Cell Biochem Funct , vol.27 , pp. 488-495
    • Kokubun, E.1    Hirabara, S.M.2    Fiamoncini, J.3    Curi, R.4    Haebisch, H.5
  • 10
    • 21644475161 scopus 로고    scopus 로고
    • Glycogen autophagy in the liver and heart of newborn rats. The effects of glucagon, adrenalin or rapamycin
    • Kondomerkos D.J., Kalamidas S.A., Kotoulas O.B., Hann A.C. Glycogen autophagy in the liver and heart of newborn rats. The effects of glucagon, adrenalin or rapamycin. Histol Histopathol 2005, 20:689-696.
    • (2005) Histol Histopathol , vol.20 , pp. 689-696
    • Kondomerkos, D.J.1    Kalamidas, S.A.2    Kotoulas, O.B.3    Hann, A.C.4
  • 12
    • 80053338210 scopus 로고    scopus 로고
    • Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1
    • Jiang S., Wells C.D., Roach P.J. Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1. Biochem Biophys Res Commun 2011, 413:420-425.
    • (2011) Biochem Biophys Res Commun , vol.413 , pp. 420-425
    • Jiang, S.1    Wells, C.D.2    Roach, P.J.3
  • 13
    • 78049409236 scopus 로고    scopus 로고
    • Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism
    • Jiang S., Heller B., Tagliabracci V.S., Zhai L., Irimia J.M., DePaoli-Roach A.A., et al. Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism. J Biol Chem 2010, 285:34960-34971.
    • (2010) J Biol Chem , vol.285 , pp. 34960-34971
    • Jiang, S.1    Heller, B.2    Tagliabracci, V.S.3    Zhai, L.4    Irimia, J.M.5    DePaoli-Roach, A.A.6
  • 14
    • 0027395256 scopus 로고
    • Identification and characterization of an early estrogen-regulated RNA in cultured guinea-pig endometrial cells
    • Pellerin I., Vuillermoz C., Jouvenot M., Ordener C., Royez M., Adessi G.L. Identification and characterization of an early estrogen-regulated RNA in cultured guinea-pig endometrial cells. Mol Cell Endocrinol 1993, 90:R17-R21.
    • (1993) Mol Cell Endocrinol , vol.90
    • Pellerin, I.1    Vuillermoz, C.2    Jouvenot, M.3    Ordener, C.4    Royez, M.5    Adessi, G.L.6
  • 15
    • 43949109275 scopus 로고    scopus 로고
    • Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle
    • Mammucari C., Schiaffino S., Sandri M. Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy 2008, 4:524-526.
    • (2008) Autophagy , vol.4 , pp. 524-526
    • Mammucari, C.1    Schiaffino, S.2    Sandri, M.3
  • 17
    • 79952395789 scopus 로고    scopus 로고
    • Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle
    • Hunter R.W., Treebak J.T., Wojtaszewski J.F., Sakamoto K. Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle. Diabetes 2011, 60:766-774.
    • (2011) Diabetes , vol.60 , pp. 766-774
    • Hunter, R.W.1    Treebak, J.T.2    Wojtaszewski, J.F.3    Sakamoto, K.4
  • 18
    • 84866061320 scopus 로고    scopus 로고
    • AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
    • Mack H.I., Zheng B., Asara J.M., Thomas S.M. AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization. Autophagy 2012, 8:1197-1214.
    • (2012) Autophagy , vol.8 , pp. 1197-1214
    • Mack, H.I.1    Zheng, B.2    Asara, J.M.3    Thomas, S.M.4
  • 19
    • 80053432592 scopus 로고    scopus 로고
    • Autophagy anomalies in the diabetic myocardium
    • Mellor K.M., Reichelt M.E., Delbridge L.M. Autophagy anomalies in the diabetic myocardium. Autophagy 2011, 7:1263-1267.
    • (2011) Autophagy , vol.7 , pp. 1263-1267
    • Mellor, K.M.1    Reichelt, M.E.2    Delbridge, L.M.3
  • 20
    • 79955658311 scopus 로고    scopus 로고
    • Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
    • Mellor K.M., Bell J.R., Young M.J., Ritchie R.H., Delbridge L.M. Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J Mol Cell Cardiol 2011, 50:1035-1043.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 1035-1043
    • Mellor, K.M.1    Bell, J.R.2    Young, M.J.3    Ritchie, R.H.4    Delbridge, L.M.5
  • 21
    • 84875228858 scopus 로고    scopus 로고
    • Autophagic predisposition in the insulin resistant diabetic heart
    • Mellor K.M., Reichelt M.E., Delbridge L.M. Autophagic predisposition in the insulin resistant diabetic heart. Life Sci 2012, 92:616-620.
    • (2012) Life Sci , vol.92 , pp. 616-620
    • Mellor, K.M.1    Reichelt, M.E.2    Delbridge, L.M.3
  • 23
    • 84857029289 scopus 로고    scopus 로고
    • Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness
    • Mellor K.M., Wendt I.R., Ritchie R.H., Delbridge L.M. Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness. Am J Physiol Heart Circ Physiol 2012, 302:H964-H972.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302
    • Mellor, K.M.1    Wendt, I.R.2    Ritchie, R.H.3    Delbridge, L.M.4
  • 24
    • 0017613512 scopus 로고
    • A simplification of the protein assay method of Lowry et al. which is more generally applicable
    • Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 1977, 83:346-356.
    • (1977) Anal Biochem , vol.83 , pp. 346-356
    • Peterson, G.L.1
  • 25
    • 70350205612 scopus 로고    scopus 로고
    • Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations
    • Ryu J.H., Drain J., Kim J.H., McGee S., Gray-Weale A., Waddington L., et al. Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations. Int J Biol Macromol 2009, 45:478-482.
    • (2009) Int J Biol Macromol , vol.45 , pp. 478-482
    • Ryu, J.H.1    Drain, J.2    Kim, J.H.3    McGee, S.4    Gray-Weale, A.5    Waddington, L.6
  • 26
    • 84873133391 scopus 로고    scopus 로고
    • Ca2+-dependent proteolysis of junctophilin 1 and junctophilin 2 in skeletal and cardiac muscle
    • Murphy R.M., Dutka T.L., Horvath D., Bell J.R., Delbridge L.M., Lamb G.D. Ca2+-dependent proteolysis of junctophilin 1 and junctophilin 2 in skeletal and cardiac muscle. J Physiol 2012, 591:719-729.
    • (2012) J Physiol , vol.591 , pp. 719-729
    • Murphy, R.M.1    Dutka, T.L.2    Horvath, D.3    Bell, J.R.4    Delbridge, L.M.5    Lamb, G.D.6
  • 29
    • 0344200489 scopus 로고
    • Histochemically demonstrable glycogen in the human heart, with special reference to glycogen storage disease and diabetes mellitus
    • Mowry R.W., Bangle R. Histochemically demonstrable glycogen in the human heart, with special reference to glycogen storage disease and diabetes mellitus. Am J Pathol 1951, 27:611-625.
    • (1951) Am J Pathol , vol.27 , pp. 611-625
    • Mowry, R.W.1    Bangle, R.2
  • 30
    • 65649120436 scopus 로고    scopus 로고
    • Functional significance and morphological characterization of starvation-induced autophagy in the adult heart
    • Kanamori H., Takemura G., Maruyama R., Goto K., Tsujimoto A., Ogino A., et al. Functional significance and morphological characterization of starvation-induced autophagy in the adult heart. Am J Pathol 2009, 174:1705-1714.
    • (2009) Am J Pathol , vol.174 , pp. 1705-1714
    • Kanamori, H.1    Takemura, G.2    Maruyama, R.3    Goto, K.4    Tsujimoto, A.5    Ogino, A.6
  • 31
    • 0023202056 scopus 로고
    • Protein synthesis and degradation during starvation-induced cardiac atrophy in rabbits
    • Samarel A.M., Parmacek M.S., Magid N.M., Decker R.S., Lesch M. Protein synthesis and degradation during starvation-induced cardiac atrophy in rabbits. Circ Res 1987, 60:933-941.
    • (1987) Circ Res , vol.60 , pp. 933-941
    • Samarel, A.M.1    Parmacek, M.S.2    Magid, N.M.3    Decker, R.S.4    Lesch, M.5
  • 32
    • 0023943184 scopus 로고
    • Effect of fasting on myocardial substrates in male and female rats
    • Arnall D.A., Palmer W.K., Miller W.C., Oscai L.B. Effect of fasting on myocardial substrates in male and female rats. Am J Physiol 1988, 254:C560-C563.
    • (1988) Am J Physiol , vol.254
    • Arnall, D.A.1    Palmer, W.K.2    Miller, W.C.3    Oscai, L.B.4
  • 33
    • 0022393563 scopus 로고
    • Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle
    • Zorzano A., Balon T.W., Brady L.J., Rivera P., Garetto L.P., Young J.C., et al. Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle. Biochem J 1985, 232:585-591.
    • (1985) Biochem J , vol.232 , pp. 585-591
    • Zorzano, A.1    Balon, T.W.2    Brady, L.J.3    Rivera, P.4    Garetto, L.P.5    Young, J.C.6
  • 34
    • 10644268528 scopus 로고    scopus 로고
    • Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium
    • Han X., Cheng H., Mancuso D.J., Gross R.W. Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium. Biochemistry 2004, 43:15584-15594.
    • (2004) Biochemistry , vol.43 , pp. 15584-15594
    • Han, X.1    Cheng, H.2    Mancuso, D.J.3    Gross, R.W.4
  • 35
    • 0020623557 scopus 로고
    • Comparison of carbohydrate and lipid metabolism in mice and rats during fasting
    • Menahan L.A., Sobocinski K.A. Comparison of carbohydrate and lipid metabolism in mice and rats during fasting. Comp Biochem Physiol B 1983, 74:859-864.
    • (1983) Comp Biochem Physiol B , vol.74 , pp. 859-864
    • Menahan, L.A.1    Sobocinski, K.A.2
  • 36
    • 2542463869 scopus 로고    scopus 로고
    • Genome-wide identification of high-affinity estrogen response elements in human and mouse
    • Bourdeau V., Deschenes J., Metivier R., Nagai Y., Nguyen D., Bretschneider N., et al. Genome-wide identification of high-affinity estrogen response elements in human and mouse. Mol Endocrinol 2004, 18:1411-1427.
    • (2004) Mol Endocrinol , vol.18 , pp. 1411-1427
    • Bourdeau, V.1    Deschenes, J.2    Metivier, R.3    Nagai, Y.4    Nguyen, D.5    Bretschneider, N.6
  • 37
    • 0015010679 scopus 로고
    • Effect of pregnancy and exercise on actomyosin, nucleic acid, and glycogen content of the rat heart
    • Blake C.A., Hazelwood R.L. Effect of pregnancy and exercise on actomyosin, nucleic acid, and glycogen content of the rat heart. Proc Soc Exp Biol Med 1971, 136:632-636.
    • (1971) Proc Soc Exp Biol Med , vol.136 , pp. 632-636
    • Blake, C.A.1    Hazelwood, R.L.2
  • 39
    • 0035947744 scopus 로고    scopus 로고
    • Myocardial Akt activation and gender: increased nuclear activity in females versus males
    • Camper-Kirby D., Welch S., Walker A., Shiraishi I., Setchell K.D., Schaefer E., et al. Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 2001, 88:1020-1027.
    • (2001) Circ Res , vol.88 , pp. 1020-1027
    • Camper-Kirby, D.1    Welch, S.2    Walker, A.3    Shiraishi, I.4    Setchell, K.D.5    Schaefer, E.6
  • 42
    • 79954427751 scopus 로고    scopus 로고
    • Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice
    • Andres A.M., Ratliff E.P., Sachithanantham S., Hui S.T. Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice. FEBS Lett 2011, 585:1223-1230.
    • (2011) FEBS Lett , vol.585 , pp. 1223-1230
    • Andres, A.M.1    Ratliff, E.P.2    Sachithanantham, S.3    Hui, S.T.4
  • 43
    • 0019408984 scopus 로고
    • Effect of fasting on hormones and metabolites in plasma of fast-growing, lean and slow-growing obese pigs
    • Wangsness P.J., Acker W.A., Burdette J.H., Krabill L.F., Vasilatos R. Effect of fasting on hormones and metabolites in plasma of fast-growing, lean and slow-growing obese pigs. J Anim Sci 1981, 52:69-74.
    • (1981) J Anim Sci , vol.52 , pp. 69-74
    • Wangsness, P.J.1    Acker, W.A.2    Burdette, J.H.3    Krabill, L.F.4    Vasilatos, R.5
  • 44
    • 84860326574 scopus 로고    scopus 로고
    • Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase
    • Wu J.W., Wang S.P., Casavant S., Moreau A., Yang G.S., Mitchell G.A. Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase. Endocrinology 2012, 153:2198-2207.
    • (2012) Endocrinology , vol.153 , pp. 2198-2207
    • Wu, J.W.1    Wang, S.P.2    Casavant, S.3    Moreau, A.4    Yang, G.S.5    Mitchell, G.A.6
  • 45
    • 40649104960 scopus 로고    scopus 로고
    • Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage
    • Ofir M., Arad M., Porat E., Freimark D., Chepurko Y., Vidne B.A., et al. Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage. Biochem Pharmacol 2008, 75:1482-1491.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1482-1491
    • Ofir, M.1    Arad, M.2    Porat, E.3    Freimark, D.4    Chepurko, Y.5    Vidne, B.A.6
  • 46
    • 0036167225 scopus 로고    scopus 로고
    • Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
    • Arad M., Benson D.W., Perez-Atayde A.R., McKenna W.J., Sparks E.A., Kanter R.J., et al. Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J Clin Invest 2002, 109:357-362.
    • (2002) J Clin Invest , vol.109 , pp. 357-362
    • Arad, M.1    Benson, D.W.2    Perez-Atayde, A.R.3    McKenna, W.J.4    Sparks, E.A.5    Kanter, R.J.6
  • 47
    • 33846850210 scopus 로고    scopus 로고
    • Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium
    • Bito V., van der Velden J., Claus P., Dommke C., Van Lommel A., Mortelmans L., et al. Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium. Circ Res 2007, 100:229-237.
    • (2007) Circ Res , vol.100 , pp. 229-237
    • Bito, V.1    van der Velden, J.2    Claus, P.3    Dommke, C.4    Van Lommel, A.5    Mortelmans, L.6
  • 48
    • 0026099413 scopus 로고
    • Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy
    • Schaper J., Froede R., Hein S., Buck A., Hashizume H., Speiser B., et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 1991, 83:504-514.
    • (1991) Circulation , vol.83 , pp. 504-514
    • Schaper, J.1    Froede, R.2    Hein, S.3    Buck, A.4    Hashizume, H.5    Speiser, B.6
  • 49
    • 77951948911 scopus 로고    scopus 로고
    • Impaired organization and function of myofilaments in single muscle fibers from a mouse model of Pompe disease
    • Xu S., Galperin M., Melvin G., Horowits R., Raben N., Plotz P., et al. Impaired organization and function of myofilaments in single muscle fibers from a mouse model of Pompe disease. J Appl Physiol 2010, 108:1383-1388.
    • (2010) J Appl Physiol , vol.108 , pp. 1383-1388
    • Xu, S.1    Galperin, M.2    Melvin, G.3    Horowits, R.4    Raben, N.5    Plotz, P.6
  • 51
    • 58149468046 scopus 로고    scopus 로고
    • When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease
    • Raben N., Baum R., Schreiner C., Takikita S., Mizushima N., Ralston E., et al. When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. Autophagy 2009, 5:111-113.
    • (2009) Autophagy , vol.5 , pp. 111-113
    • Raben, N.1    Baum, R.2    Schreiner, C.3    Takikita, S.4    Mizushima, N.5    Ralston, E.6
  • 52
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H., et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007, 282:24131-24145.
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6
  • 54
    • 70350329383 scopus 로고    scopus 로고
    • Cell sex determines anoikis resistance in vascular smooth muscle cells
    • Straface E., Vona R., Gambardella L., Ascione B., Marino M., Bulzomi P., et al. Cell sex determines anoikis resistance in vascular smooth muscle cells. FEBS Lett 2009, 583:3448-3454.
    • (2009) FEBS Lett , vol.583 , pp. 3448-3454
    • Straface, E.1    Vona, R.2    Gambardella, L.3    Ascione, B.4    Marino, M.5    Bulzomi, P.6
  • 55
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan D.F., Shackelford D.B., Mihaylova M.M., Gelino S., Kohnz R.A., Mair W., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331:456-461.
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5    Mair, W.6
  • 56
    • 80053476420 scopus 로고    scopus 로고
    • The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
    • Egan D., Kim J., Shaw R.J., Guan K.L. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy 2011, 7:643-644.
    • (2011) Autophagy , vol.7 , pp. 643-644
    • Egan, D.1    Kim, J.2    Shaw, R.J.3    Guan, K.L.4


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