Investigating the role of BDNF and CCK system genes in suicidality in a familial bipolar cohort

Journal of Affective Disorders

Volumn 151, Issue 2, 2013, Pages 611-617

  Sears, Catherine ^a   Wilson, Julia ^a   Fitches, Alison ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Association study; BDNF; Bipolar disorder; CCK; CCKBR; Suicide

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLECYSTOKININ; CHOLECYSTOKININ BETA RECEPTOR; CHOLECYSTOKININ RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BIPOLAR DISORDER; COHORT ANALYSIS; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PEDIGREE; PHENOTYPE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SAMPLE SIZE; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT;

ASSOCIATION STUDY; BDNF; BIPOLAR DISORDER; CCK; CCKBR; SUICIDE;

BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLECYSTOKININ; FEMALE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, CHOLECYSTOKININ B; RETROSPECTIVE STUDIES; SUICIDE;

EID: 84885482333     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2013.07.006     Document Type: Article

References (60)

1. R.J. Baldessarini, and J. Hennen Genetics of suicide: an overview Harvard Review of Psychiatry 12 1 2004 1 13
2. J.C. Barrett, B. Fry, J. Maller, and M.J. Daly Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 2 2005 263 265
3. J. Bradwejn, D. Koszycki, and G. Meterissian Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder Canadian Journal of Psychiatry 35 1 1990 83 85
4. D.A. Brent, and J.J. Mann Family genetic studies, suicide, and suicidal behavior American Journal of Medical Genetics Part C Seminars in Medical Genetics 133C 1 2005 13 24
5. D.A. Brent, M. Oquendo, B. Birmaher, L. Greenhill, D. Kolko, B. Stanley, J. Zelazny, B. Brodsky, J. Bridge, S. Ellis, J.O. Salazar, and J.J. Mann Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters Archives of General Psychiatry 59 9 2002 801 807
6. J. Brezo, T. Klempan, and G. Turecki The genetics of suicide: a critical review of molecular studies Psychiatric Clinics of North America 31 2 2008 179 203
7. J. Brezo, J. Paris, F. Vitaro, M. Hebert, R.E. Tremblay, and G. Turecki Predicting suicide attempts in young adults with histories of childhood abuse British Journal of Psychiatry 193 2 2008 134 139
8. Z.Y. Chen, D. Jing, K.G. Bath, A. Ieraci, T. Khan, C.J. Siao, D.G. Herrera, M. Toth, C. Yang, B.S. McEwen, B.L. Hempstead, and F.S. Lee Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior Science 314 5796 2006 140 143
9. (de) C. Montigny Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers. Preliminary findings Archives of General Psychiatry 46 6 1989 511 517
10. Y. Dwivedi, A.C. Mondal, H.S. Rizavi, and R.R. Conley Suicide brain is associated with decreased expression of neurotrophins Biological Psychiatry 58 4 2005 315 324
11. Y. Dwivedi, H.S. Rizavi, R.R. Conley, R.C. Roberts, C.A. Tamminga, and G.N. Pandey Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects Archives of General Psychiatry 60 8 2003 804 815
12. M.F. Egan, M. Kojima, J.H. Callicott, T.E. Goldberg, B.S. Kolachana, A. Bertolino, E. Zaitsev, B. Gold, D. Goldman, M. Dean, B. Lu, and D.R. Weinberger The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 2 2003 257 269
13. S.B. Gabriel, S.F. Schaffner, H. Nguyen, J.M. Moore, J. Roy, B. Blumenstiel, J. Higgins, M. DeFelice, A. Lochner, M. Faggart, S.N. Liu-Cordero, C. Rotimi, A. Adeyemo, R. Cooper, R. Ward, E.S. Lander, M.J. Daly, and D. Altshuler The structure of haplotype blocks in the human genome Science 296 5576 2002 2225 2229
14. X. Gonda, M. Pompili, G. Serafini, F. Montebovi, S. Campi, P. Dome, T. Duleba, P. Girardi, and Z. Rihmer Suicidal behavior in bipolar disorder: epidemiology, characteristics and major risk factors Journal of Affective Disorders 143 1-3 2012 16 26
15. M. Gratacos, J. Costas, R. de Cid, M. Bayes, J.R. Gonzalez, E. Baca-Garcia, Y. de Diego, F. Fernandez-Aranda, J. Fernandez-Piqueras, M. Guitart, R. Martin-Santos, L. Martorell, J.M. Menchon, M. Roca, J. Saiz-Ruiz, J. Sanjuan, M. Torrens, M. Urretavizcaya, J. Valero, E. Vilella, X. Estivill, and A. Carracedo Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment American Journal of Medical Genetics Part B Neuropsychiatric Genetics 150B 6 2009 808 816
16. S.P. Hamilton, S.L. Slager, L. Helleby, G.A. Heiman, D.F. Klein, S.E. Hodge, M.M. Weissman, A.J. Fyer, and J.A. Knowles No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder Molecular Psychiatry 6 1 2001 59 65
17. J. Harro, J. Marcusson, and L. Oreland Alterations in brain cholecystokinin receptors in suicide victims European Neuropsychopharmacology 2 1 1992 57 63
18. E. Hattori, K. Yamada, T. Toyota, K. Yoshitsugu, M. Toru, H. Shibuya, and T. Yoshikawa Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects American Journal of Medical Genetics 105 8 2001 779 782
19. B.M. Henry, E. Terrie, Avshalom Caspi, John Langley, Silva, and A. Phil On the "remembrance of things past": a longitudinal evaluation of the retrospective method Psychological Assessment 6 2 1994 92 101
20. C.J. Hong, S.J. Huo, F.C. Yen, C.L. Tung, G.M. Pan, and S.J. Tsai Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior Neuropsychobiology 48 4 2003 186 189
21. S. Horvath, X. Xu, and N.M. Laird The family based association test method: strategies for studying general genotype - phenotype associations European Journal of Human Genetics 9 4 2001 301 306
22. J.P. Hwang, S.J. Tsai, C.J. Hong, C.H. Yang, J.F. Lirng, and Y.M. Yang The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression Neurobiology of Aging 27 12 2006 1834 1837
23. J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi-Shibuya, S. Kinouchi, M. Nakataki, H. Song, K. Hokoishi, H. Tanabe, A. Sano, and T. Ohmori The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients American Journal of Medical Genetics Part B Neuropsychiatric Genetics 144B 8 2007 1003 1006
24. P.R. Joyce, C.J. Doughty, J.E. Wells, A.E. Walsh, A. Admiraal, M. Lill, and R.J. Olds Affective disorders in the first-degree relatives of bipolar probands: results from the South Island Bipolar Study Comprehensive Psychiatry 45 3 2004 168 174
25. F. Karege, G. Vaudan, M. Schwald, N. Perroud, and R. La Harpe Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs Molecular Brain Research 136 1-2 2005 29 37
26. T. Kato, Z.W. Wang, T. Zoega, and R.R. Crowe Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder American Journal of Medical Genetics 67 4 1996 401 405
27. B. Kim, C.Y. Kim, J.P. Hong, S.Y. Kim, C. Lee, and Y.H. Joo Brain-derived neurotrophic factor Val/Met polymorphism and bipolar disorder. Association of the Met allele with suicidal behavior of bipolar patients Neuropsychobiology 58 2 2008 97 103
28. Y.-K. Kim, H.-P. Lee, S.-D. Won, E.-Y. Park, H.-Y. Lee, B.-H. Lee, S.-W. Lee, D. Yoon, C. Han, D.-J. Kim, and S.-H. Choi Low plasma BDNF is associated with suicidal behavior in major depression Progress in Neuro-Psychopharmacology & Biological Psychiatry 31 1 2007 78 85
29. P. Koefoed, D.P. Woldbye, T.O. Hansen, E.S. Hansen, G.M. Knudsen, T.G. Bolwig, and J.F. Rehfeld Gene variations in the cholecystokinin system in patients with panic disorder Psychiatric Genetics 20 2 2010 59 64
30. D. Koszycki, J. Copen, and J. Bradwejn Sensitivity to cholecystokinin-tetrapeptide in major depression Journal of Affective Disorders 80 2-3 2004 285 290
31. B.-H. Lee, and Y.-K. Kim BDNF mRNA expression of peripheral blood mononuclear cells was decreased in depressive patients who had or had not recently attempted suicide Journal of Affective Disorders 125 1-3 2010 369 373
32. J. Licinio, C. Dong, and M.L. Wong Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response Archives of General Psychiatry 66 5 2009 488 497
33. L. Liu, T. Foroud, X. Xuei, W. Berrettini, W. Byerley, W. Coryell, R. El-Mallakh, E.S. Gershon, J.R. Kelsoe, W.B. Lawson, D.F. MacKinnon, M. McInnis, F.J. McMahon, D.L. Murphy, J. Rice, W. Scheftner, P.P. Zandi, F.W. Lohoff, A.B. Niculescu, E.T. Meyer, H.J. Edenberg, and J.I. Nurnberger Jr. Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder Psychiatric Genetics 18 6 2008 267 274
34. P.C. Maisonpierre, M.M. Le Beau, R. Espinosa 3rd, N.Y. Ip, L. Belluscio, S.M. de la Monte, S. Squinto, ME. Furth, and G.D. Yancopoulos Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations Genomics 10 3 1991 558 568
35. J.J. Mann, C. Waternaux, G.L. Haas, and K.M. Malone Toward a clinical model of suicidal behavior in psychiatric patients American Journal of Psychiatry 156 2 1999 181 189
36. E. Maron, T. Nikopensius, S. Koks, S. Altmae, E. Heinaste, K. Vabrit, V. Tammekivi, P. Hallast, K. Koido, A. Kurg, A. Metspalu, E. Vasar, V. Vasar, and J. Shlik Association study of 90 candidate gene polymorphisms in panic disorder Psychiatric Genetics 15 1 2005 17 24
37. F.S. Neves, L. Malloy-Diniz, M.A. Romano-Silva, S.B. Campos, D.M. Miranda, L. De Marco, P.G. Figueira, M.O. Krebs, and H. Correa The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities Journal of Affective Disorders 131 1-3 2011 307 311
38. M. Neves-Pereira, J.K. Cheung, A. Pasdar, F. Zhang, G. Breen, P. Yates, M. Sinclair, C. Crombie, N. Walker St.; and D.M. Clair BDNF gene is a risk factor for schizophrenia in a Scottish population Molecular Psychiatry 10 2 2005 208 212
39. New Zealand Ministry of Health, G. 2012. Suicide Facts: Deaths and intentional self-harm hospitalisations, Wellington.
40. F. Noble, and B.P. Roques CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology Progress in Neurobiology 58 4 1999 349 379
41. J.I. Nurnberger Jr.; M.C. Blehar, C.A. Kaufmann, C. York-Cooler, S.G. Simpson, J. Harkavy-Friedman, J.B. Severe, D. Malaspina, and T. Reich Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative Archives of General Psychiatry 51 11 1994 849 859 (discussion 863-844)
42. N. Perroud, P. Courtet, I. Vincze, I. Jaussent, F. Jollant, F. Bellivier, M. Leboyer, P. Baud, C. Buresi, and A. Malafosse Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt Genes Brain Behav 7 3 2008 314 322
43. P. Pregelj, G. Nedic, A.V. Paska, T. Zupanc, M. Nikolac, J. Balazic, M. Tomori, R. Komel, D.M. Seler, and N. Pivac The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide Journal of Affective Disorders 128 3 2011 287 290
44. S. Rodriguez, T.R. Gaunt, and I.N. Day Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies American Journal of Epidemiology 169 4 2009 505 514
45. M. Sarchiapone, V. Carli, A. Roy, L. Iacoviello, C. Cuomo, M.C. Latella, M. di Giannantonio, L. Janiri, M. de Gaetano, and M.N. Janal Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients Neuropsychobiology 57 3 2008 139 145
46. L.C. Schenkel, J. Segal, J.A. Becker, G.G. Manfro, M.M. Bianchin, and S. Leistner-Segal The BDNF Val66Met polymorphism is an independent risk factor for high lethality in suicide attempts of depressed patients Progress in Neuro-Psychopharmacology & Biological Psychiatry 34 6 2010 940 944
47. J. Schumacher, R.A. Jamra, T. Becker, S. Ohlraun, N. Klopp, E.B. Binder, T.G. Schulze, M. Deschner, C. Schmal, S. Hofels, A. Zobel, T. Illig, P. Propping, F. Holsboer, M. Rietschel, M.M. Nothen, and S. Cichon Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression Biological Psychiatry 58 4 2005 307 314
48. C. Sears, D. Markie, R. Olds, and A. Fitches Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene Bipolar Disorder 13 7-8 2011 630 637
49. T. Sherrin, K.Y. Heng, Y.Z. Zhu, Y.M. Tang, G. Lau, and C.H. Tan Cholecystokinin-B receptor gene expression in cerebellum, pre-frontal cortex and cingulate gyrus and its association with suicide Neuroscience Letters 357 2 2004 107 110
50. S. Shindo, and N. Yoshioka Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan Forensic Science International 150 1 2005 85 90
51. J.J. Vanderhaeghen, J.C. Signeau, and W. Gepts New peptide in the vertebrate CNS reacting with antigastrin antibodies Nature 257 5527 1975 604 605
52. I. Vincze, N. Perroud, C. Buresi, P. Baud, F. Bellivier, B. Etain, C. Fournier, F. Karege, M.L. Matthey, M. Preisig, M. Leboyer, and A. Malafosse Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene Bipolar Disorder 10 5 2008 580 587
53. Z. Wang, J. Valdes, R. Noyes, T. Zoega, and R.R. Crowe Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder American Journal of Medical Genetics 81 3 1998 228 234
54. M.J. Webster, C.S. Weickert, M.M. Herman, and J.E. Kleinman BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex Developmental Brain Research 139 2 2002 139 150
55. WHO Causes of Death 2008: Data Sources and Methods Department of Health Statistics and Informatics 2011 World Health Organization Geneva
56. J. Wilson Genetics of Panic and Anxiety, Department of Pathology 2013 Dunedin, University of Otago (Ph.D, (in preparation)
57. J. Wilson, D. Markie, and A. Fitches Cholecystokinin system genes: associations with panic and other psychiatric disorders Journal of Affective Disorders 136 3 2012 902 908
58. K. Yamada, E. Hattori, M. Shimizu, A. Sugaya, H. Shibuya, and T. Yoshikawa Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder Journal of Neural Transmission 108 7 2001 837 848
59. C.C. Zai, M. Manchia, V. De Luca, A.K. Tiwari, N.I. Chowdhury, G.C. Zai, R.P. Tong, Z. Yilmaz, S.A. Shaikh, J. Strauss, and J.L. Kennedy The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis International Journal of Neuropsychopharmacology 15 8 2012 1037 1042
60. F. Zarrilli, A. Angiolillo, G. Castaldo, L. Chiariotti, S. Keller, S. Sacchetti, A. Marusic, T. Zagar, V. Carli, A. Roy, and M. Sarchiapone Brain derived neurotrophic factor (BDNF) genetic polymorphism (Val66Met) in suicide: a study of 512 cases American Journal of Medical Genetics Part B Neuropsychiatric Genetics 150B 4 2009 599 600