Conjugated linoleic acid targets β2 integrin expression to suppress monocyte adhesion

Journal of Immunology

Volumn 191, Issue 8, 2013, Pages 4326-4336

  De Gaetano, Monica ^a   Dempsey, Eugene ^a   Marcone, Simone ^a   James, William G ^a   Belton, Orina ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CONJUGATED LINOLEIC ACID; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELL ACTIVATION; CELL POLARITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ANIMALS; ANTIGENS, CD18; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CXCL12; ENDOTHELIUM; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES; LINOLEIC ACIDS, CONJUGATED; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; PLAQUE, ATHEROSCLEROTIC; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4;

EID: 84885465469     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300990     Document Type: Article

References (49)

1. Cunningham, K. S., and A. I. Gotlieb. 2005. The role of shear stress in the pathogenesis of atherosclerosis. Lab. Invest. 85: 9-23.
2. Mehdizadeh, A., and A. Norouzpour. 2009. New insights in atherosclerosis: endothelial shear stress as promoter rather than initiator. Med. Hypotheses 73: 989-993.
3. Hahn, C., and M. A. Schwartz. 2009. Mechanotransduction in vascular physiology and atherogenesis. Nat. Rev. Mol. Cell Biol. 10: 53-62.
4. Jonasson, L., J. Holm, O. Skalli, G. Bondjers, and G. K. Hansson. 1986. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 6: 131-138.
5. Hansson, G. K., L. Jonasson, B. Lojsthed, S. Stemme, O. Kocher, and G. Gabbiani. 1988. Localization of T lymphocytes and macrophages in fibrous and complicated human atherosclerotic plaques. Atherosclerosis 72: 135-141.
6. Moore, K. J., and I. Tabas. 2011. Macrophages in the pathogenesis of atherosclerosis. Cell 145: 341-355.
7. Woollard, K. J., and F. Geissmann. 2010. Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol 7: 77-86.
8. Gerszten, R. E., E. A. Garcia-Zepeda, Y. C. Lim, M. Yoshida, H. A. Ding, M. A. Gimbrone, Jr., A. D. Luster, F. W. Luscinskas, and A. Rosenzweig. 1999. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398: 718-723.
9. Chan, J. R., S. J. Hyduk, and M. I. Cybulsky. 2001. Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration. J. Exp. Med. 193: 1149-1158.
10. Luo, B. H., C. V. Carman, and T. A. Springer. 2007. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25: 619-647.
11. Diamond, M. S., D. E. Staunton, A. R. de Fougerolles, S. A. Stacker, J. Garcia-Aguilar, M. L. Hibbs, and T. A. Springer. 1990. ICAM-1 (CD54): a counterreceptor for Mac-1 (CD11b/CD18). J. Cell Biol. 111: 3129-3139.
12. Sumagin, R., H. Prizant, E. Lomakina, R. E. Waugh, and I. H. Sarelius. 2010. LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. J. Immunol. 185: 7057-7066.
13. Park, Y., J. M. Storkson, K. J. Albright, W. Liu, and M. W. Pariza. 1999. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34: 235-241.
14. Nagao, K., N. Inoue, Y. M. Wang, and T. Yanagita. 2003. Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats. Biochem. Biophys. Res. Commun. 310: 562-566.
15. Navarro, V., A. Zabala, M. T. Macarulla, A. Fernández-Quintela, V. M. Rodríguez, E. Simón, and M. P. Portillo. 2003. Effects of conjugated linoleic acid on body fat accumulation and serum lipids in hamsters fed an atherogenic diet. J. Physiol. Biochem. 59: 193-199.
16. Kritchevsky, D., S. A. Tepper, S. Wright, P. Tso, and S. K. Czarnecki. 2000. Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J. Am. Coll. Nutr. 19: 472S-477S.
17. Lee, K. N., D. Kritchevsky, and M. W. Pariza. 1994. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108: 19-25.
18. O'Shea, M., J. Bassaganya-Riera, and I. C. Mohede. 2004. Immunomodulatory properties of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6, Suppl.)1199S-1206S.
19. Churruca, I., A. Fernández-Quintela, and M. P. Portillo. 2009. Conjugated linoleic acid isomers: differences in metabolism and biological effects. Biofactors 35: 105-111.
20. Toomey, S., B. Harhen, H. M. Roche, D. Fitzgerald, and O. Belton. 2006. Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis 187: 40-49.
21. McClelland, S., C. Cox, R. O'Connor, M. de Gaetano, C. McCarthy, L. Cryan, D. Fitzgerald, and O. Belton. 2010. Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell. Atherosclerosis 211: 96-102.
22. Yu, Y., P. H. Correll, and J. P. Vanden Heuvel. 2002. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim. Biophys. Acta 1581: 89-99.
23. Stachowska, E., J. Kijowski, V. Dziedziejko, A. Siennicka, and D. Chlubek. 2011. Conjugated linoleic acid regulates phosphorylation of PPARg by modulation of ERK 1/2 and p38 signaling in human macrophages/fatty acid-laden macrophages. J. Agric. Food Chem. 59: 11846-11852.
24. Perdomo, M. C., J. E. Santos, and L. Badinga. 2011. Trans-10, cis-12 conjugated linoleic acid and the PPAR-g agonist rosiglitazone attenuate lipopolysaccharideinduced TNF-A production by bovine immune cells. Domest. Anim. Endocrinol. 41: 118-125.
25. Nakaya, H., B. D. Summers, A. C. Nicholson, A. M. Gotto, Jr., D. P. Hajjar, and J. Han. 2009. Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone. Am. J. Pathol. 174: 2007-2014.
26. Bernhagen, J., R. Krohn, H. Lue, J. L. Gregory, A. Zernecke, R. R. Koenen, M. Dewor, I. Georgiev, A. Schober, L. Leng, T. Kooistra, et al. 2007. MIF is a noncognate ligand of CXC chemokine receptors in ininflammatory and atherogenic cell recruitment. Nat. Med. 13: 587-596.
27. Kuligowski, M. P., A. R. Kitching, and M. J. Hickey. 2006. Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol. 176: 6991-6999.
28. McCarthy, C., P. O'Gaora, W. G. James, M. de Gaetano, S. McClelland, D. J. Fitzgerald, and O. Belton. 2010. SorLA modulates atheroprotective properties of CLA by regulating monocyte migration. Atherosclerosis 213: 400-407.
29. Dransfield, I., C. Cabañas, A. Craig, and N. Hogg. 1992. Divalent cation regulation of the function of the leukocyte integrin LFA-1. J. Cell Biol. 116: 219-226.
30. Verma, N. K., E. Dempsey, M. Freeley, C. H. Botting, A. Long, D. Kelleher, and Y. Volkov. 2011. Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells. J. Cell. Physiol. 226: 1489-1498.
31. McCarthy, C., M. M. Duffy, D. Mooney, W. G. James, M. D. Griffin, D. J. Fitzgerald, and O. Belton. 2013. IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis. FASEB J. 27: 499-510.
32. Geissmann, F., S. Jung, and D. R. Littman. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19: 71-82.
33. Evans, M., J. Brown, and M. McIntosh. 2002. Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J. Nutr. Biochem. 13: 508.
34. Platt, I., and A. El-Sohemy. 2009. Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes. Lipids Health Dis. 8: 15-18.
35. Stachowska, E., M. Baskiewicz-Masiuk, V. Dziedziejko, I. Gutowska, I. Baranowska-Bosiacka, M. Marchlewicz, B. Dołegowska, B. Wiszniewska, B. Machaliński, and D. Chlubek. 2008. Conjugated linoleic acid increases intracellular ROS synthesis and oxygenation of arachidonic acid in macrophages. Nutrition 24: 187-199.
36. Arbonés-Mainar, J. M., M. A. Navarro, S. Acín, M. A. Guzmán, C. Arnal, J. C. Surra, R. Carnicer, H. M. Roche, and J. Osada. 2006. Trans-10, cis-12-And cis-9, trans-11-conjugated linoleic acid isomers selectively modify HDLapolipoprotein composition in apolipoprotein E knockout mice. J. Nutr. 136: 353-359.
37. Stachowska, E., A. Siennicka, M. Baskiewcz-Hałasa, J. Bober, B. Machalinski, and D. Chlubek. 2012. Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. Int. J. Food Sci. Nutr. 63: 30-35.
38. Huang, C., and T. A. Springer. 1997. Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit. Proc. Natl. Acad. Sci. USA 94: 3162-3167.
39. Hirasawa, H., T. Chiba, S. Ueki, Y. Kamada, W. Ito, M. Takeda, M. Fujita, H. Kato, H. Kayaba, and J. Chihara. 2008. The synthetic PPARgamma agonist troglitazone inhibits eotaxin-enhanced eosinophil adhesion to ICAM-1-coated plates. Int. Arch. Allergy Immunol. 146(Suppl. 1): 11-15.
40. Bleul, C. C., R. C. Fuhlbrigge, J. M. Casasnovas, A. Aiuti, and T. A. Springer. 1996. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med. 184: 1101-1109.
41. Abi-Younes, S., A. Sauty, F. Mach, G. K. Sukhova, P. Libby, and A. D. Luster. 2000. The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques. Circ. Res. 86: 131-138.
42. Wang, P. S., F. S. Chou, L. Porchia, M. Saji, and J. J. Pinzone. 2008. Troglitazone inhibits cell migration, adhesion, and spreading by modulating cytoskeletal rearrangement in human breast cancer cells. Mol. Carcinog. 47: 905-915.
43. Stachowska, E., J. Kijowski, V. Dziedziejko, A. Siennicka, and D. Chlubek. 2011. Conjugated linoleic acid regulates phosphorylation of PPARg by modulation of ERK 1/2 and p38 signaling in human macrophages/fatty acid-laden macrophages. J. Agric. Food Chem. 59: 11846-11852 .
44. Cheng, W. L., C. K. Lii, H. W. Chen, T. H. Lin, and K. L. Liu. 2004. Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathway. J. Agric. Food Chem. 52: 71-78.
45. Geissmann, F., C. Auffray, R. Palframan, C. Wirrig, A. Ciocca, L. Campisi, E. Narni-Mancinelli, and G. Lauvau. 2008. Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of Tcell responses. Immunol. Cell Biol. 86: 398-408.
46. Auffray, C., D. Fogg,M. Garfa, G. Elain, O. Join-Lambert, S. Kayal, S. Sarnacki, A. Cumano, G. Lauvau, and F. Geissmann. 2007. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science 317: 666-670.
47. Swirski, F. K., P. Libby, E. Aikawa, P. Alcaide, F. W. Luscinskas, R. Weissleder, and M. J. Pittet. 2007. Ly-6Chi monocytes dominate hypercholesterolemiaassociated monocytosis and give rise to macrophages in atheromata. J. Clin. Invest. 117: 195-205.
48. Stöger, J. L., M. J. Gijbels, S. van der Velden, M. Manca, C. M. van der Loos, E. A. Biessen, M. J. Daemen, E. Lutgens, and M. P. de Winther. 2012. Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis 225: 461-468.
49. Mantovani, A., C. Garlanda, and M. Locati. 2009. Macrophage diversity and polarization in atherosclerosis: a question of balance. Arterioscler. Thromb. Vasc. Biol. 29: 1419-1423.