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Volumn 14, Issue 7, 2013, Pages 4235-4238

Sulforaphane is Superior to Glucoraphanin in Modulating Carcinogen-Metabolising Enzymes in Hep G2 Cells

Author keywords

Chemoprevention; Glucoraphanin; Glucosinolate; Isothiocyanate; Sulforaphane

Indexed keywords

ANTINEOPLASTIC AGENT; GLUCORAPHANIN; GLUCOSINOLATE; GLUTATHIONE TRANSFERASE; GLYCOSIDASE; IMIDOESTER; ISOTHIOCYANIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAFAN; THIOGLUCOSIDASE;

EID: 84885448423     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.7.4235     Document Type: Article
Times cited : (18)

References (27)
  • 1
    • 77957876664 scopus 로고    scopus 로고
    • Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables.
    • Abdull Razis AF, Bagatta M, De Nicola GR, et al (2010). Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables. Toxicol, 277, 74-85.
    • (2010) Toxicol , vol.277 , pp. 74-85
    • Abdull Razis, A.F.1    Bagatta, M.2    De Nicola, G.R.3
  • 2
    • 79955416779 scopus 로고    scopus 로고
    • The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.
    • Abdull Razis AF, Iori R, Ioannides C (2011). The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer, 128, 2775-82.
    • (2011) Int J Cancer , vol.128 , pp. 2775-2782
    • Abdull Razis, A.F.1    Iori, R.2    Ioannides, C.3
  • 3
    • 2442587889 scopus 로고    scopus 로고
    • Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype.
    • Ambrosone CB, McCann SE, Freudenheim JL, et al (2004). Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr, 134, 1134-8.
    • (2004) J Nutr , vol.134 , pp. 1134-1138
    • Ambrosone, C.B.1    McCann, S.E.2    Freudenheim, J.L.3
  • 4
    • 58549090733 scopus 로고    scopus 로고
    • Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa1c1c7 cells and HepG2 cells.
    • Anwar-Mohamed A, El-Kadi AOS (2009). Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa1c1c7 cells and HepG2 cells. Cancer Lett, 275, 93-101.
    • (2009) Cancer Lett , vol.275 , pp. 93-101
    • Anwar-Mohamed, A.1    El-Kadi, A.O.S.2
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding.
    • Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem, 72, 248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 6
    • 0016333916 scopus 로고
    • Ethoxyresorufin; direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.
    • Burke MD, Mayer RT (1974). Ethoxyresorufin; direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab Disp, 2, 583-8.
    • (1974) Drug Metab Disp , vol.2 , pp. 583-588
    • Burke, M.D.1    Mayer, R.T.2
  • 7
    • 0032948428 scopus 로고    scopus 로고
    • Conversion of isothiocyanates in humans after ingestion of cooked watercress.
    • Getahun SM, Chung F-L (1999). Conversion of isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol Biomark Prev, 8, 447-51.
    • (1999) Cancer Epidemiol Biomark Prev , vol.8 , pp. 447-451
    • Getahun, S.M.1    Chung, F.-L.2
  • 8
    • 0016275313 scopus 로고
    • Glutathione S-transferase, the first enzymic step in mercapturic acid formation.
    • Habig WH, Pabst MJ, Jakoby WB (1974). Glutathione S-transferase, the first enzymic step in mercapturic acid formation. J Biol Chem, 249, 7130-9.
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 9
    • 69049120201 scopus 로고    scopus 로고
    • Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers.
    • Hanlon N, Coldham N, Gielbert A, et al (2009a). Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers. Cancer Lett, 284, 15-20.
    • (2009) Cancer Lett , vol.284 , pp. 15-20
    • Hanlon, N.1    Coldham, N.2    Gielbert, A.3
  • 10
    • 57649184041 scopus 로고    scopus 로고
    • Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane.
    • Hanlon N, Coldham N, Sauer MJ, et al (2009b). Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane. Chem-Biol Inter, 177, 115-20.
    • (2009) Chem-Biol Inter , vol.177 , pp. 115-120
    • Hanlon, N.1    Coldham, N.2    Sauer, M.J.3
  • 11
    • 52649162392 scopus 로고    scopus 로고
    • Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane.
    • Hanlon N, Okpara M, Coldham N, et al (2008). Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane. J Agric Food Chem, 56, 7866-71.
    • (2008) J Agric Food Chem , vol.56 , pp. 7866-7871
    • Hanlon, N.1    Okpara, M.2    Coldham, N.3
  • 12
    • 0034538640 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by isothiocyanates.
    • Hecht SS (2000). Inhibition of carcinogenesis by isothiocyanates. Drug Met Rev, 32, 395-411.
    • (2000) Drug Met Rev , vol.32 , pp. 395-411
    • Hecht, S.S.1
  • 13
    • 0037740965 scopus 로고    scopus 로고
    • Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats.
    • Hintze KJ, Keck A-S, Finley JW, et al (2003). Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats. J Nutr Biochem, 14, 173-9.
    • (2003) J Nutr Biochem , vol.14 , pp. 173-179
    • Hintze, K.J.1    Keck, A.-S.2    Finley, J.W.3
  • 14
    • 10844224317 scopus 로고    scopus 로고
    • Cytochrome P450 in the bioactivation of chemicals.
    • Ioannides C, Lewis DF (2004). Cytochrome P450 in the bioactivation of chemicals. Curr Top Med Chem, 4, 1767-88.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1767-1788
    • Ioannides, C.1    Lewis, D.F.2
  • 15
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: a comprehensive review.
    • Juge N, Mithen RF, Traka M (2007). Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci, 64, 1105-27.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 16
    • 0037420961 scopus 로고    scopus 로고
    • Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/HepG2 assay.
    • Kassie F, Laky B, Gminski R, et al (2003). Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/HepG2 assay. Chem-Biol Inter, 142, 285-96.
    • (2003) Chem-Biol Inter , vol.142 , pp. 285-296
    • Kassie, F.1    Laky, B.2    Gminski, R.3
  • 17
    • 33746701934 scopus 로고    scopus 로고
    • Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
    • Kuroiwa Y, Nishikawa A, Kitamura Y, et al (2006). Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Cancer Lett, 241, 275-80.
    • (2006) Cancer Lett , vol.241 , pp. 275-280
    • Kuroiwa, Y.1    Nishikawa, A.2    Kitamura, Y.3
  • 18
    • 58349089802 scopus 로고    scopus 로고
    • Cruciferous vegetable consumption and lung cancer risk: a systematic review.
    • Lam TK, Gallicchio L, Lindsley K, et al (2009). Cruciferous vegetable consumption and lung cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev, 18, 184-95.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 184-195
    • Lam, T.K.1    Gallicchio, L.2    Lindsley, K.3
  • 19
    • 80051838367 scopus 로고    scopus 로고
    • Cytotoxic and antioxidant activit of 4-263 methylthio-3-butenyl isothiocyanate from Raphanus Sativus L. (Kaiware Daikon) sprouts.
    • Papi A, Orlandi M, Bartolini G, et al (2008). Cytotoxic and antioxidant activit of 4-263 methylthio-3-butenyl isothiocyanate from Raphanus Sativus L. (Kaiware Daikon) sprouts. J Agric Food Chem, 56, 875-83.
    • (2008) Agric Food Chem , vol.56 , pp. 875-883
    • Papi, A.1    Orlandi, M.2    Bartolini, G.3
  • 20
    • 33244477386 scopus 로고    scopus 로고
    • Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces Phase-I xenobiotic metabolising enzymes and increases free radical generation in rat liver.
    • Perocco P, Bronzetti G, Canistro D, et al (2006). Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces Phase-I xenobiotic metabolising enzymes and increases free radical generation in rat liver. Mut Res, 595, 125-36.
    • (2006) Mut Res , vol.595 , pp. 125-136
    • Perocco, P.1    Bronzetti, G.2    Canistro, D.3
  • 21
    • 0023930873 scopus 로고
    • Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers.
    • Prohaska HJ, Santamaria AB (1988). Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal Biochem, 169, 328-36.
    • (1988) Anal Biochem , vol.169 , pp. 328-336
    • Prohaska, H.J.1    Santamaria, A.B.2
  • 22
    • 80051910138 scopus 로고    scopus 로고
    • Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53.
    • Rudolf E, Cervinka M (2011). Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. Toxicol in vitro, 25, 1302-9.
    • (2011) Toxicol in vitro , vol.25 , pp. 1302-1309
    • Rudolf, E.1    Cervinka, M.2
  • 23
    • 79955040533 scopus 로고    scopus 로고
    • Raphasatin is a more potent inducer of the detoxification enzymes than its degradation products.
    • Scholl C, Eshelman BD, Barnes DM, et al (2011). Raphasatin is a more potent inducer of the detoxification enzymes than its degradation products. J Food Sci, 76, 504-11.
    • (2011) J Food Sci , vol.76 , pp. 504-511
    • Scholl, C.1    Eshelman, B.D.2    Barnes, D.M.3
  • 24
    • 79956040609 scopus 로고    scopus 로고
    • Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells.
    • Sharma C, Sadrieh L, Priyani A, et al (2011). Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells. Cancer Epidemiol, 35, 272-8.
    • (2011) Cancer Epidemiol , vol.35 , pp. 272-278
    • Sharma, C.1    Sadrieh, L.2    Priyani, A.3
  • 25
    • 67649238683 scopus 로고    scopus 로고
    • Glucosinolates in Brassica vegetables: the influence of the food supply chain on intake, bioavailability and human health.
    • Verkerk R, Schreiner M, Krumbein A, et al (2009). Glucosinolates in Brassica vegetables: the influence of the food supply chain on intake, bioavailability and human health. Mol Nutr Food Res, 53, 219-65.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 219-265
    • Verkerk, R.1    Schreiner, M.2    Krumbein, A.3
  • 26
    • 0001923588 scopus 로고
    • Isolation and Identification of trans-4-(methylthio)-3-butenyl-glucosinolate from radish roots (Raphanus sativus L.)
    • Visentin M, Tava A, Iori R, et al (1992). Isolation and Identification of trans-4-(methylthio)-3-butenyl-glucosinolate from radish roots (Raphanus sativus L.). J Agric Food Chem, 40, 1687-91.
    • (1992) J Agric Food Chem , vol.40 , pp. 1687-1691
    • Visentin, M.1    Tava, A.2    Iori, R.3
  • 27
    • 5144230473 scopus 로고    scopus 로고
    • Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.
    • Zhang Y (2004). Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res, 555, 173-90.
    • (2004) Mutat Res , vol.555 , pp. 173-190
    • Zhang, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.