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Volumn 223, Issue 5, 2013, Pages 474-488

Attenuation of bone morphogenetic protein signaling during amphibian limb development results in the generation of stage-specific defects

Author keywords

Bone morphogenetic protein; Growth and differentiation factor (GDF); Limb development; N1 transgenic line; Noggin; Xenopus laevis

Indexed keywords

ASPARAGINE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; GROWTH DIFFERENTIATION FACTOR 10; GROWTH DIFFERENTIATION FACTOR 5; GROWTH DIFFERENTIATION FACTOR 6; HEAT SHOCK PROTEIN 70; NOGGIN; OSTEOGENIC PROTEIN 1;

EID: 84885435504     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/joa.12098     Document Type: Article
Times cited : (14)

References (58)
  • 1
    • 78650837422 scopus 로고    scopus 로고
    • The secreted integrin ligand nephronectin is necessary for forelimb formation in Xenopus tropicalis
    • Abu-Daya A, Nishimoto S, Fairclough L, et al. (2011) The secreted integrin ligand nephronectin is necessary for forelimb formation in Xenopus tropicalis. Dev Biol 349, 204-212.
    • (2011) Dev Biol , vol.349 , pp. 204-212
    • Abu-Daya, A.1    Nishimoto, S.2    Fairclough, L.3
  • 2
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    • Akiyama H, Chaboissier MC, Martin JF, et al. (2002) The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16, 2813-2828.
    • (2002) Genes Dev , vol.16 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.C.2    Martin, J.F.3
  • 3
    • 34247517336 scopus 로고    scopus 로고
    • Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice
    • Akiyama H, Stadler HS, Martin JF, et al. (2007) Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol 26, 224-233.
    • (2007) Matrix Biol , vol.26 , pp. 224-233
    • Akiyama, H.1    Stadler, H.S.2    Martin, J.F.3
  • 4
    • 0030725130 scopus 로고    scopus 로고
    • Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb
    • Altabef M, Clarke JD, Tickle C (1997) Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb. Development 124, 4547-4556.
    • (1997) Development , vol.124 , pp. 4547-4556
    • Altabef, M.1    Clarke, J.D.2    Tickle, C.3
  • 5
    • 33845971522 scopus 로고    scopus 로고
    • Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    • Bandyopadhyay A, Tsuji K, Cox K, et al. (2006) Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet 2, e216.
    • (2006) PLoS Genet , vol.2
    • Bandyopadhyay, A.1    Tsuji, K.2    Cox, K.3
  • 6
    • 66349109329 scopus 로고    scopus 로고
    • Overexpression of the transcription factor Msx1 is insufficient to drive complete regeneration of refractory stage Xenopus laevis hindlimbs
    • Barker DM, Beck CW (2009) Overexpression of the transcription factor Msx1 is insufficient to drive complete regeneration of refractory stage Xenopus laevis hindlimbs. Dev Dyn 238, 1366-1378.
    • (2009) Dev Dyn , vol.238 , pp. 1366-1378
    • Barker, D.M.1    Beck, C.W.2
  • 7
    • 0032033028 scopus 로고    scopus 로고
    • Analysis of the developing Xenopus tail bud reveals separate phases of gene expression during determination and outgrowth
    • Beck CW, Slack JM (1998) Analysis of the developing Xenopus tail bud reveals separate phases of gene expression during determination and outgrowth. Mech Dev 72, 41-52.
    • (1998) Mech Dev , vol.72 , pp. 41-52
    • Beck, C.W.1    Slack, J.M.2
  • 8
    • 0042196121 scopus 로고    scopus 로고
    • Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate
    • Beck CW, Christen B, Slack JM (2003) Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate. Dev Cell 5, 429-439.
    • (2003) Dev Cell , vol.5 , pp. 429-439
    • Beck, C.W.1    Christen, B.2    Slack, J.M.3
  • 9
    • 33748848292 scopus 로고    scopus 로고
    • Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles
    • Beck CW, Christen B, Barker D, et al. (2006) Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles. Mech Dev 123, 674-688.
    • (2006) Mech Dev , vol.123 , pp. 674-688
    • Beck, C.W.1    Christen, B.2    Barker, D.3
  • 10
    • 0031003272 scopus 로고    scopus 로고
    • Sox9 directly regulates the type-II collagen gene
    • Bell DM, Leung KK, Wheatley SC, et al. (1997) Sox9 directly regulates the type-II collagen gene. Nat Genet 16, 174-178.
    • (1997) Nat Genet , vol.16 , pp. 174-178
    • Bell, D.M.1    Leung, K.K.2    Wheatley, S.C.3
  • 11
    • 70549110151 scopus 로고    scopus 로고
    • Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system
    • Benazet JD, Zeller R (2009) Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb Perspect Biol 1, a001339.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Benazet, J.D.1    Zeller, R.2
  • 12
    • 60749101583 scopus 로고    scopus 로고
    • A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning
    • Benazet JD, Bischofberger M, Tiecke E, et al. (2009) A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science 323, 1050-1053.
    • (2009) Science , vol.323 , pp. 1050-1053
    • Benazet, J.D.1    Bischofberger, M.2    Tiecke, E.3
  • 13
    • 0033231553 scopus 로고    scopus 로고
    • Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin
    • Capdevila J, Tsukui T, Rodriquez Esteban C, et al. (1999) Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol Cell 4, 839-849.
    • (1999) Mol Cell , vol.4 , pp. 839-849
    • Capdevila, J.1    Tsukui, T.2    Rodriquez Esteban, C.3
  • 14
    • 0035881926 scopus 로고    scopus 로고
    • Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    • Chiang C, Litingtung Y, Harris MP, et al. (2001) Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol 236, 421-435.
    • (2001) Dev Biol , vol.236 , pp. 421-435
    • Chiang, C.1    Litingtung, Y.2    Harris, M.P.3
  • 15
    • 0031573802 scopus 로고    scopus 로고
    • FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus
    • Christen B, Slack JMW (1997) FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus. Dev Biol 192, 455-466.
    • (1997) Dev Biol , vol.192 , pp. 455-466
    • Christen, B.1    Slack, J.M.W.2
  • 16
    • 0032541514 scopus 로고    scopus 로고
    • All limbs are not the same
    • Christen B, Slack JMW (1998) All limbs are not the same. Nature 395, 230-231.
    • (1998) Nature , vol.395 , pp. 230-231
    • Christen, B.1    Slack, J.M.W.2
  • 17
    • 0037310205 scopus 로고    scopus 로고
    • Regeneration-specific expression pattern of three posterior Hox genes
    • Christen B, Beck CW, Lombardo A, et al. (2003) Regeneration-specific expression pattern of three posterior Hox genes. Dev Dyn 226, 349-355.
    • (2003) Dev Dyn , vol.226 , pp. 349-355
    • Christen, B.1    Beck, C.W.2    Lombardo, A.3
  • 18
    • 84863105886 scopus 로고    scopus 로고
    • Transient downregulation of Bmp signalling induces extra limbs in vertebrates
    • Christen B, Rodrigues AM, Monasterio MB, et al. (2012) Transient downregulation of Bmp signalling induces extra limbs in vertebrates. Development 139, 2557-2565.
    • (2012) Development , vol.139 , pp. 2557-2565
    • Christen, B.1    Rodrigues, A.M.2    Monasterio, M.B.3
  • 19
    • 0028946304 scopus 로고
    • Fibroblast growth factors induce additional limb development from the flank of chick embryos
    • Cohn MJ, Izpisúa-Belmonte JC, Abud H, et al. (1995) Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.
    • (1995) Cell , vol.80 , pp. 739-746
    • Cohn, M.J.1    Izpisúa-Belmonte, J.C.2    Abud, H.3
  • 20
    • 24644503098 scopus 로고    scopus 로고
    • Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research
    • Conesa A, Gotz S, Garcia-Gomez JM, et al. (2005) Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21, 3674-3676.
    • (2005) Bioinformatics , vol.21 , pp. 3674-3676
    • Conesa, A.1    Gotz, S.2    Garcia-Gomez, J.M.3
  • 21
    • 0034698302 scopus 로고    scopus 로고
    • Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling
    • Dahn RD, Fallon JF (2000) Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling. Science 289, 438-441.
    • (2000) Science , vol.289 , pp. 438-441
    • Dahn, R.D.1    Fallon, J.F.2
  • 22
    • 64149103056 scopus 로고    scopus 로고
    • Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2
    • Dathe K, Kjaer KW, Brehm A, et al. (2009) Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2. Am J Hum Genet 84, 483-492.
    • (2009) Am J Hum Genet , vol.84 , pp. 483-492
    • Dathe, K.1    Kjaer, K.W.2    Brehm, A.3
  • 23
    • 0002335529 scopus 로고
    • Limb regeneration in larvae and metamorphosing individuals of the South African clawed toad
    • Dent JN (1962) Limb regeneration in larvae and metamorphosing individuals of the South African clawed toad. J Morphol 110, 61-78.
    • (1962) J Morphol , vol.110 , pp. 61-78
    • Dent, J.N.1
  • 24
    • 0028137737 scopus 로고
    • Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb
    • Francis PH, Richardson MK, Brickell PM, et al. (1994) Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Development 120, 209-218.
    • (1994) Development , vol.120 , pp. 209-218
    • Francis, P.H.1    Richardson, M.K.2    Brickell, P.M.3
  • 25
    • 77952350426 scopus 로고    scopus 로고
    • Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development
    • Galli A, Robay D, Osterwalder M, et al. (2010) Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet 6, e1000901.
    • (2010) PLoS Genet , vol.6
    • Galli, A.1    Robay, D.2    Osterwalder, M.3
  • 26
    • 79960264362 scopus 로고    scopus 로고
    • Full-length transcriptome assembly from RNA-Seq data without a reference genome
    • Grabherr MG, Haas BJ, Yassour M, et al. (2011) Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol 29, 644-652.
    • (2011) Nat Biotechnol , vol.29 , pp. 644-652
    • Grabherr, M.G.1    Haas, B.J.2    Yassour, M.3
  • 27
    • 0037743636 scopus 로고    scopus 로고
    • Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning
    • Khokha MK, Hsu D, Brunet LJ, et al. (2003) Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet 34, 303-307.
    • (2003) Nat Genet , vol.34 , pp. 303-307
    • Khokha, M.K.1    Hsu, D.2    Brunet, L.J.3
  • 28
    • 0030907433 scopus 로고    scopus 로고
    • Expression of radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation
    • Laufer E, Dahn R, Orozco OE, et al. (1997) Expression of radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation. Nature 386, 366-373.
    • (1997) Nature , vol.386 , pp. 366-373
    • Laufer, E.1    Dahn, R.2    Orozco, O.E.3
  • 29
    • 0142027776 scopus 로고    scopus 로고
    • Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2
    • Lehmann K, Seemann P, Stricker S, et al. (2003) Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Proc Natl Acad Sci USA 100, 12277-12282.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12277-12282
    • Lehmann, K.1    Seemann, P.2    Stricker, S.3
  • 30
    • 34547753518 scopus 로고    scopus 로고
    • A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN
    • Lehmann K, Seemann P, Silan F, et al. (2007) A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Am J Hum Genet 81, 388-396.
    • (2007) Am J Hum Genet , vol.81 , pp. 388-396
    • Lehmann, K.1    Seemann, P.2    Silan, F.3
  • 31
    • 0033673531 scopus 로고    scopus 로고
    • Fgf8 signalling from the AER is essential for normal limb development
    • Lewandoski M, Sun X, Martin GR (2000) Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26, 460-463.
    • (2000) Nat Genet , vol.26 , pp. 460-463
    • Lewandoski, M.1    Sun, X.2    Martin, G.R.3
  • 32
    • 79955031869 scopus 로고    scopus 로고
    • Expression of key retinoic acid modulating genes suggests active regulation during development and regeneration of the amphibian limb
    • McEwan J, Lynch J, Beck CW (2011) Expression of key retinoic acid modulating genes suggests active regulation during development and regeneration of the amphibian limb. Dev Dyn 240, 1259-1270.
    • (2011) Dev Dyn , vol.240 , pp. 1259-1270
    • McEwan, J.1    Lynch, J.2    Beck, C.W.3
  • 33
    • 0033662330 scopus 로고    scopus 로고
    • Fgf8 is required for outgrowth and patterning of the limbs
    • Moon AM, Capecchi MR (2000) Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet 26, 455-459.
    • (2000) Nat Genet , vol.26 , pp. 455-459
    • Moon, A.M.1    Capecchi, M.R.2
  • 34
    • 0030002141 scopus 로고    scopus 로고
    • The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation
    • Mortlock DP, Post LC, Innis JW (1996) The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation. Nat Genet 13, 284-289.
    • (1996) Nat Genet , vol.13 , pp. 284-289
    • Mortlock, D.P.1    Post, L.C.2    Innis, J.W.3
  • 35
    • 0020724823 scopus 로고
    • Thiosemicarbazide-induced osteolathyrism in metamorphosing Xenopus laevis
    • Newman SM Jr, Dumont JN (1983) Thiosemicarbazide-induced osteolathyrism in metamorphosing Xenopus laevis. J Exp Zool 225, 411-421.
    • (1983) J Exp Zool , vol.225 , pp. 411-421
    • Newman Jr, S.M.1    Dumont, J.N.2
  • 37
    • 33745923817 scopus 로고    scopus 로고
    • BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning
    • Ovchinnikov DA, Selever J, Wang Y, et al. (2006) BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning. Dev Biol 295, 103-115.
    • (2006) Dev Biol , vol.295 , pp. 103-115
    • Ovchinnikov, D.A.1    Selever, J.2    Wang, Y.3
  • 38
    • 0035199029 scopus 로고    scopus 로고
    • BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb
    • Pizette S, Abate-Shen C, Niswander L (2001) BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 128, 4463-4474.
    • (2001) Development , vol.128 , pp. 4463-4474
    • Pizette, S.1    Abate-Shen, C.2    Niswander, L.3
  • 39
    • 42449091159 scopus 로고    scopus 로고
    • Brachydactyly type A2 associated with a defect in proGDF5 processing
    • Ploger F, Seemann P, Schmidt-von Kegler M, et al. (2008) Brachydactyly type A2 associated with a defect in proGDF5 processing. Hum Mol Genet 17, 1222-1233.
    • (2008) Hum Mol Genet , vol.17 , pp. 1222-1233
    • Ploger, F.1    Seemann, P.2    Schmidt-von Kegler, M.3
  • 40
    • 0034650211 scopus 로고    scopus 로고
    • Severe limb defects in Hypodactyly mice result from the expression of a novel, mutant HOXA13 protein
    • Post LC, Margulies EH, Kuo A, et al. (2000) Severe limb defects in Hypodactyly mice result from the expression of a novel, mutant HOXA13 protein. Dev Biol 217, 290-300.
    • (2000) Dev Biol , vol.217 , pp. 290-300
    • Post, L.C.1    Margulies, E.H.2    Kuo, A.3
  • 41
    • 66349117431 scopus 로고    scopus 로고
    • BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation
    • Retting KN, Song B, Yoon BS, et al. (2009) BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development 136, 1093-1104.
    • (2009) Development , vol.136 , pp. 1093-1104
    • Retting, K.N.1    Song, B.2    Yoon, B.S.3
  • 42
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle RD, Johnson RL, Laufer E, et al. (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3
  • 43
    • 0029773647 scopus 로고    scopus 로고
    • Cellular analysis of limb development in the mouse mutant hypodactyly
    • Robertson KE, Chapman MH, Adams A, et al. (1996) Cellular analysis of limb development in the mouse mutant hypodactyly. Dev Genet 19, 9-25.
    • (1996) Dev Genet , vol.19 , pp. 9-25
    • Robertson, K.E.1    Chapman, M.H.2    Adams, A.3
  • 44
    • 33845369677 scopus 로고    scopus 로고
    • Characterization of Xenopus digits and regenerated limbs of the froglet
    • Satoh A, Endo T, Abe M, et al. (2006) Characterization of Xenopus digits and regenerated limbs of the froglet. Dev Dyn 235, 3316-3326.
    • (2006) Dev Dyn , vol.235 , pp. 3316-3326
    • Satoh, A.1    Endo, T.2    Abe, M.3
  • 45
    • 84924843883 scopus 로고
    • The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm
    • Saunders JW Jr (1948) The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J Exp Zool 108, 363-403.
    • (1948) J Exp Zool , vol.108 , pp. 363-403
    • Saunders Jr, J.W.1
  • 46
    • 73649136476 scopus 로고    scopus 로고
    • Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN
    • Seemann P, Brehm A, Konig J, et al. (2009) Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN. PLoS Genet 5, e1000747.
    • (2009) PLoS Genet , vol.5
    • Seemann, P.1    Brehm, A.2    Konig, J.3
  • 47
    • 28244497832 scopus 로고    scopus 로고
    • Of chicken wings and frog legs: a smorgasbord of evolutionary variation in mechanisms of tetrapod limb development
    • Stopper GF, Wagner GP (2005) Of chicken wings and frog legs: a smorgasbord of evolutionary variation in mechanisms of tetrapod limb development. Dev Biol 288, 21-39.
    • (2005) Dev Biol , vol.288 , pp. 21-39
    • Stopper, G.F.1    Wagner, G.P.2
  • 48
    • 0016309037 scopus 로고
    • A quantitative analysis of the effect of excision of the AER from the chick limb-bud
    • Summerbell D (1974) A quantitative analysis of the effect of excision of the AER from the chick limb-bud. J Embryol Exp Morph 32, 651-660.
    • (1974) J Embryol Exp Morph , vol.32 , pp. 651-660
    • Summerbell, D.1
  • 49
    • 33750450038 scopus 로고    scopus 로고
    • Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity
    • Tarchini B, Duboule D, Kmita M (2006) Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity. Nature 443, 985-988.
    • (2006) Nature , vol.443 , pp. 985-988
    • Tarchini, B.1    Duboule, D.2    Kmita, M.3
  • 51
    • 0016609565 scopus 로고
    • Positional signalling and the specification of digits in chick limb morphogenesis
    • Tickle C, Summerbell D, Wolpert L (1975) Positional signalling and the specification of digits in chick limb morphogenesis. Nature 254, 199-202.
    • (1975) Nature , vol.254 , pp. 199-202
    • Tickle, C.1    Summerbell, D.2    Wolpert, L.3
  • 52
    • 62349111082 scopus 로고    scopus 로고
    • Growing models of vertebrate limb development
    • Towers M, Tickle C (2009) Growing models of vertebrate limb development. Development 136, 179-190.
    • (2009) Development , vol.136 , pp. 179-190
    • Towers, M.1    Tickle, C.2
  • 53
    • 48349106444 scopus 로고    scopus 로고
    • An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth
    • Verheyden JM, Sun X (2008) An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature 454, 638-641.
    • (2008) Nature , vol.454 , pp. 638-641
    • Verheyden, J.M.1    Sun, X.2
  • 54
    • 23344431857 scopus 로고    scopus 로고
    • Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability
    • Williams TM, Williams ME, Heaton JH, et al. (2005) Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability. Nucleic Acids Res 33, 4475-4484.
    • (2005) Nucleic Acids Res , vol.33 , pp. 4475-4484
    • Williams, T.M.1    Williams, M.E.2    Heaton, J.H.3
  • 55
    • 17044364765 scopus 로고    scopus 로고
    • Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
    • Yoon BS, Ovchinnikov DA, Yoshii I, et al. (2005) Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci USA 102, 5062-5067.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5062-5067
    • Yoon, B.S.1    Ovchinnikov, D.A.2    Yoshii, I.3
  • 56
    • 70449805406 scopus 로고    scopus 로고
    • Vertebrate limb bud development: moving towards integrative analysis of organogenesis
    • Zeller R, Lopez-Rios J, Zuniga A (2009) Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat Rev Genet 10, 845-858.
    • (2009) Nat Rev Genet , vol.10 , pp. 845-858
    • Zeller, R.1    Lopez-Rios, J.2    Zuniga, A.3
  • 57
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman LB, De Jesus-Escobar JM, Harland RM (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86, 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesus-Escobar, J.M.2    Harland, R.M.3
  • 58
    • 0041030051 scopus 로고    scopus 로고
    • Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds
    • Zuniga A, Haramis AP, McMahon AP, et al. (1999) Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature 401, 598-602.
    • (1999) Nature , vol.401 , pp. 598-602
    • Zuniga, A.1    Haramis, A.P.2    McMahon, A.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.