메뉴 건너뛰기




Volumn 383, Issue 1-2, 2013, Pages 201-211

Overexpression of β-NGF promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathway

Author keywords

BMSCs; Cell differentiation; Neuron; NGF

Indexed keywords

ADENOVIRUS VECTOR; BRAIN NATRIURETIC PEPTIDE; CASPASE 3; MERCAPTOETHANOL; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLSERINE; PROTEIN KINASE B;

EID: 84885431534     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1768-6     Document Type: Article
Times cited : (34)

References (29)
  • 1
    • 41149142446 scopus 로고    scopus 로고
    • Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms
    • 10.1002/jnr.21572 18030676 10.1002/jnr.21572 1:CAS:528: DC%2BD1cXksVGqsbs%3D
    • Hokari M, Kuroda S, Shichinohe H, Yano S, Hida K, Iwasaki Y (2008) Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms. J Neurosci Res 86:1024-1035. doi: 10.1002/jnr.21572
    • (2008) J Neurosci Res , vol.86 , pp. 1024-1035
    • Hokari, M.1    Kuroda, S.2    Shichinohe, H.3    Yano, S.4    Hida, K.5    Iwasaki, Y.6
  • 2
    • 0017103248 scopus 로고
    • Precursor cells of mechanocytes
    • 11195 10.1016/S0074-7696(08)60092-3 1:STN:280:DyaE2s%2FltVyhsg%3D%3D
    • Friedenstein AJ (1976) Precursor cells of mechanocytes. Int Rev Cytol 47:327-359
    • (1976) Int Rev Cytol , vol.47 , pp. 327-359
    • Friedenstein, A.J.1
  • 3
    • 3142663241 scopus 로고    scopus 로고
    • Mesenchymal stem cells and their potential as cardiac therapeutics
    • 10.1161/01.RES.0000135902.99383.6f 15242981 10.1161/01.RES.0000135902. 99383.6f 1:CAS:528:DC%2BD2cXlt1Cqsrw%3D
    • Pittenger MF, Martin BJ (2004) Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 95:9-20. doi: 10.1161/01.RES.0000135902. 99383.6f
    • (2004) Circ Res , vol.95 , pp. 9-20
    • Pittenger, M.F.1    Martin, B.J.2
  • 4
    • 62649107775 scopus 로고    scopus 로고
    • Down-regulation of CD105 is associated with multi-lineage differentiation in human umbilical cord blood-derived mesenchymal stem cells
    • 10.1016/j.bbrc.2009.02.118 19250924 10.1016/j.bbrc.2009.02.118 1:CAS:528:DC%2BD1MXjvVOqs7s%3D
    • Jin HJ, Park SK, Oh W, Yang YS, Kim SW, Choi SJ (2009) Down-regulation of CD105 is associated with multi-lineage differentiation in human umbilical cord blood-derived mesenchymal stem cells. Biochem Biophys Res Commun 381:676-681. doi: 10.1016/j.bbrc.2009.02.118
    • (2009) Biochem Biophys Res Commun , vol.381 , pp. 676-681
    • Jin, H.J.1    Park, S.K.2    Oh, W.3    Yang, Y.S.4    Kim, S.W.5    Choi, S.J.6
  • 5
    • 0037106144 scopus 로고    scopus 로고
    • Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis
    • 10.1002/jnr.10365 12205683 10.1002/jnr.10365 1:CAS:528: DC%2BD38XntFGnurw%3D
    • Woodbury D, Reynolds K, Black IB (2002) Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res 69:908-917. doi: 10.1002/jnr.10365
    • (2002) J Neurosci Res , vol.69 , pp. 908-917
    • Woodbury, D.1    Reynolds, K.2    Black, I.B.3
  • 6
    • 33646009967 scopus 로고    scopus 로고
    • Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury
    • 10.1016/j.neulet.2005.12.053 16455199 10.1016/j.neulet.2005.12.053 1:CAS:528:DC%2BD28Xjs1ahsbg%3D
    • Lu J, Moochhala S, Moore XL, Ng KC, Tan MH, Lee LK, He B, Wong MC, Ling EA (2006) Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury. Neurosci Lett 398:12-17. doi: 10.1016/j.neulet.2005.12.053
    • (2006) Neurosci Lett , vol.398 , pp. 12-17
    • Lu, J.1    Moochhala, S.2    Moore, X.L.3    Ng, K.C.4    Tan, M.H.5    Lee, L.K.6    He, B.7    Wong, M.C.8    Ling, E.A.9
  • 8
    • 0032874061 scopus 로고    scopus 로고
    • Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains
    • 10485891 10.1073/pnas.96.19.10711 1:CAS:528:DyaK1MXmtFKjsro%3D
    • Kopen GC, Prockop DJ, Phinney DG (1999) Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 96:10711-10716
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10711-10716
    • Kopen, G.C.1    Prockop, D.J.2    Phinney, D.G.3
  • 9
    • 0035088373 scopus 로고    scopus 로고
    • Adult bone marrow transplantation after stroke in adult rats
    • 11294470 1:CAS:528:DC%2BD38Xkt1w%3D
    • Li Y, Chen J, Chopp M (2001) Adult bone marrow transplantation after stroke in adult rats. Cell Transplant 10:31-40
    • (2001) Cell Transplant , vol.10 , pp. 31-40
    • Li, Y.1    Chen, J.2    Chopp, M.3
  • 10
    • 0033844402 scopus 로고    scopus 로고
    • Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice
    • 10.1097/00004647-200009000-00006 10994853 10.1097/00004647-200009000- 00006 1:STN:280:DC%2BD3cvksVCkuw%3D%3D
    • Li Y, Chopp M, Chen J, Wang L, Gautam SC, Xu YX, Zhang Z (2000) Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab 20:1311-1319. doi: 10.1097/00004647-200009000-00006
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1311-1319
    • Li, Y.1    Chopp, M.2    Chen, J.3    Wang, L.4    Gautam, S.C.5    Xu, Y.X.6    Zhang, Z.7
  • 11
    • 0034637810 scopus 로고    scopus 로고
    • Spinal cord injury in rat: Treatment with bone marrow stromal cell transplantation
    • 11006983 10.1097/00001756-200009110-00035 1:STN:280: DC%2BD3cvltFaqtw%3D%3D
    • Chopp M, Zhang XH, Li Y, Wang L, Chen J, Lu D, Lu M, Rosenblum M (2000) Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. NeuroReport 11:3001-3005
    • (2000) NeuroReport , vol.11 , pp. 3001-3005
    • Chopp, M.1    Zhang, X.H.2    Li, Y.3    Wang, L.4    Chen, J.5    Lu, D.6    Lu, M.7    Rosenblum, M.8
  • 12
    • 0034663515 scopus 로고    scopus 로고
    • Adult rat and human bone marrow stromal cells differentiate into neurons
    • 10931522 10.1002/1097-4547(20000815)61:4<364: AID-JNR2>3.0.CO;2-C 1:CAS:528:DC%2BD3cXlsFCrt78%3D
    • Woodbury D, Schwarz EJ, Prockop DJ, Black IB (2000) Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364-370
    • (2000) J Neurosci Res , vol.61 , pp. 364-370
    • Woodbury, D.1    Schwarz, E.J.2    Prockop, D.J.3    Black, I.B.4
  • 13
    • 0035495740 scopus 로고    scopus 로고
    • Brain from bone: Efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent
    • 11776476 10.1046/j.1432-0436.2001.680411.x 1:STN:280: DC%2BD38%2Fks1Kqsg%3D%3D
    • Kohyama J, Abe H, Shimazaki T, Koizumi A, Nakashima K, Gojo S, Taga T, Okano H, Hata J, Umezawa A (2001) Brain from bone: efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent. Differentiation 68:235-244
    • (2001) Differentiation , vol.68 , pp. 235-244
    • Kohyama, J.1    Abe, H.2    Shimazaki, T.3    Koizumi, A.4    Nakashima, K.5    Gojo, S.6    Taga, T.7    Okano, H.8    Hata, J.9    Umezawa, A.10
  • 14
    • 1642309517 scopus 로고    scopus 로고
    • Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors
    • 10.1016/j.bbrc.2004.02.111 15033464 10.1016/j.bbrc.2004.02.111
    • García R, Aguiar J, Alberti E, de la Cuétara K, Pavón N (2004) Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors. Biochem Biophys Res Commun 316:753-754. doi: 10.1016/j.bbrc.2004.02.111
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 753-754
    • García, R.1    Aguiar, J.2    Alberti, E.3    De La Cuétara, K.4    Pavón, N.5
  • 15
    • 10744229598 scopus 로고    scopus 로고
    • BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model
    • 10.1016/j.ymthe.2003.10.012 14759803 10.1016/j.ymthe.2003.10.012 1:CAS:528:DC%2BD2cXptVWrtQ%3D%3D
    • Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, Honmou O, Houkin K, Date I, Hamada H (2004) BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther 9:189-197. doi: 10.1016/j.ymthe.2003.10.012
    • (2004) Mol Ther , vol.9 , pp. 189-197
    • Kurozumi, K.1    Nakamura, K.2    Tamiya, T.3    Kawano, Y.4    Kobune, M.5    Hirai, S.6    Uchida, H.7    Sasaki, K.8    Ito, Y.9    Kato, K.10    Honmou, O.11    Houkin, K.12    Date, I.13    Hamada, H.14
  • 16
    • 0036174607 scopus 로고    scopus 로고
    • Adenoviral gene therapy
    • 11854546 10.1634/theoncologist.7-1-46 1:CAS:528:DC%2BD38XitVChtL4%3D
    • Vorburger SA, Hunt KK (2002) Adenoviral gene therapy. Oncologist 7:46-59
    • (2002) Oncologist , vol.7 , pp. 46-59
    • Vorburger, S.A.1    Hunt, K.K.2
  • 17
    • 80052034804 scopus 로고    scopus 로고
    • Enhancement of angiogenic effect of co-transfection human NGF and VEGF genes in rat bone marrow mesenchymal stem cells
    • 10.1016/j.gene.2011.06.027 21782908 10.1016/j.gene.2011.06.027 1:CAS:528:DC%2BC3MXhtVygs7fI
    • Fan BS, Lou JY (2011) Enhancement of angiogenic effect of co-transfection human NGF and VEGF genes in rat bone marrow mesenchymal stem cells. Gene 485:167-171. doi: 10.1016/j.gene.2011.06.027
    • (2011) Gene , vol.485 , pp. 167-171
    • Fan, B.S.1    Lou, J.Y.2
  • 18
    • 49849087101 scopus 로고    scopus 로고
    • Effects of pcDNA3-beta-NGF gene-modified BMSC on the rat model of Parkinson's disease
    • 10.1007/s12031-007-9032-8 18273710 10.1007/s12031-007-9032-8 1:CAS:528:DC%2BD1cXmsFKjs7c%3D
    • Wang TH, Feng ZT, Wei P, Li H, Shi ZJ, Li LY (2008) Effects of pcDNA3-beta-NGF gene-modified BMSC on the rat model of Parkinson's disease. J Mol Neurosci 35:161-169. doi: 10.1007/s12031-007-9032-8
    • (2008) J Mol Neurosci , vol.35 , pp. 161-169
    • Wang, T.H.1    Feng, Z.T.2    Wei, P.3    Li, H.4    Shi, Z.J.5    Li, L.Y.6
  • 19
    • 79958110929 scopus 로고    scopus 로고
    • Targeting NGF pathway for developing neuroprotective therapies for multiple sclerosis and other neurological diseases
    • 21701990
    • Colafrancesco V, Villoslada P (2011) Targeting NGF pathway for developing neuroprotective therapies for multiple sclerosis and other neurological diseases. Arch Ital Biol 149:183-192
    • (2011) Arch Ital Biol , vol.149 , pp. 183-192
    • Colafrancesco, V.1    Villoslada, P.2
  • 20
    • 78650225880 scopus 로고    scopus 로고
    • Effects of nerve growth factor and Noggin-modified bone marrow stromal cells on stroke in rats
    • 10.1002/jnr.22535 21162129 10.1002/jnr.22535 1:CAS:528: DC%2BC3cXhsFKjur%2FO
    • Ding J, Cheng Y, Gao S, Chen J (2011) Effects of nerve growth factor and Noggin-modified bone marrow stromal cells on stroke in rats. J Neurosci Res 89:222-230. doi: 10.1002/jnr.22535
    • (2011) J Neurosci Res , vol.89 , pp. 222-230
    • Ding, J.1    Cheng, Y.2    Gao, S.3    Chen, J.4
  • 21
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • 10.1080/14653240600855905 16923606 10.1080/14653240600855905 1:STN:280:DC%2BD28vpvFSjsA%3D%3D
    • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315-317. doi: 10.1080/ 14653240600855905
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6    Deans, R.7    Keating, A.8    Prockop, D.9    Horwitz, E.10
  • 22
    • 0344961120 scopus 로고    scopus 로고
    • Murine marrow-derived mesenchymal stem cell: Isolation, in vitro expansion, and characterization
    • 10.1046/j.1365-2141.2003.04669.x
    • Meirelles LaS, Nardi NB (2003) Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br J Haematol 123:702-711
    • (2003) Br J Haematol , vol.123 , pp. 702-711
    • Meirelles, L.1    Nardi, N.B.2
  • 23
    • 68849092642 scopus 로고    scopus 로고
    • Treatment of injured neurons with bone marrow stem cells cotransfected by hTERT and Ad-BDNF in vitro
    • 10.1007/s12031-009-9208-5 19459071 10.1007/s12031-009-9208-5 1:CAS:528:DC%2BD1MXmvFSisrY%3D
    • Wang Z, Deng Q, Zhang X, Zhang J (2009) Treatment of injured neurons with bone marrow stem cells cotransfected by hTERT and Ad-BDNF in vitro. J Mol Neurosci 38:265-272. doi: 10.1007/s12031-009-9208-5
    • (2009) J Mol Neurosci , vol.38 , pp. 265-272
    • Wang, Z.1    Deng, Q.2    Zhang, X.3    Zhang, J.4
  • 24
    • 77954259784 scopus 로고    scopus 로고
    • Noggin induces human bone marrow-derived mesenchymal stem cells to differentiate into neural and photoreceptor cells
    • 20795361 1:CAS:528:DC%2BC3cXovV2rtbw%3D
    • Tao YX, Xu HW, Zheng QY, FitzGibbon T (2010) Noggin induces human bone marrow-derived mesenchymal stem cells to differentiate into neural and photoreceptor cells. Indian J Exp Biol 48:444-452
    • (2010) Indian J Exp Biol , vol.48 , pp. 444-452
    • Tao, Y.X.1    Xu, H.W.2    Zheng, Q.Y.3    Fitzgibbon, T.4
  • 25
    • 2442460088 scopus 로고    scopus 로고
    • Role of mitochondrial membrane permeabilization in apoptosis and cancer
    • 10.1038/sj.onc.1207534 15077148 10.1038/sj.onc.1207534 1:CAS:528:DC%2BD2cXivFKmsb4%3D
    • Henry-Mowatt J, Dive C, Martinou JC, James D (2004) Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 23:2850-2860. doi: 10.1038/sj.onc.1207534
    • (2004) Oncogene , vol.23 , pp. 2850-2860
    • Henry-Mowatt, J.1    Dive, C.2    Martinou, J.C.3    James, D.4
  • 26
    • 84863229605 scopus 로고    scopus 로고
    • In vitro differentiation of rat bone marrow mesenchymal stem cells into hepatocytes
    • 10.5754/hge11220 22024079 10.5754/hge11220 1:CAS:528:DC%2BC38XjvFOlu78%3D
    • Feng Z, Li C, Jiao S, Hu B, Zhao L (2011) In vitro differentiation of rat bone marrow mesenchymal stem cells into hepatocytes. Hepatogastroenterology 58:2081-2086. doi: 10.5754/hge11220
    • (2011) Hepatogastroenterology , vol.58 , pp. 2081-2086
    • Feng, Z.1    Li, C.2    Jiao, S.3    Hu, B.4    Zhao, L.5
  • 27
    • 34247092489 scopus 로고    scopus 로고
    • Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT
    • 10.1016/j.ejphar.2007.01.071 17341418 10.1016/j.ejphar.2007.01.071 1:CAS:528:DC%2BD2sXksV2ktLg%3D
    • Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ (2007) Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. Eur J Pharmacol 563:49-60. doi: 10.1016/j.ejphar.2007.01.071
    • (2007) Eur J Pharmacol , vol.563 , pp. 49-60
    • Ou, Y.C.1    Yang, C.R.2    Cheng, C.L.3    Raung, S.L.4    Hung, Y.Y.5    Chen, C.J.6
  • 28
    • 26944489046 scopus 로고    scopus 로고
    • Bone marrow stromal cells increase astrocyte survival via upregulation of phosphoinositide 3-kinase/threonine protein kinase and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways and stimulate astrocyte trophic factor gene expression after anaerobic insult
    • 10.1016/j.neuroscience.2005.06.091 16198497 10.1016/j.neuroscience.2005. 06.091 1:CAS:528:DC%2BD2MXhtFersrjE
    • Gao Q, Li Y, Chopp M (2005) Bone marrow stromal cells increase astrocyte survival via upregulation of phosphoinositide 3-kinase/threonine protein kinase and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways and stimulate astrocyte trophic factor gene expression after anaerobic insult. Neuroscience 136:123-134. doi: 10.1016/j.neuroscience.2005.06. 091
    • (2005) Neuroscience , vol.136 , pp. 123-134
    • Gao, Q.1    Li, Y.2    Chopp, M.3
  • 29
    • 33845313280 scopus 로고    scopus 로고
    • Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons
    • 10.1016/j.neuint.2006.08.007 17050038 10.1016/j.neuint.2006.08.007 1:CAS:528:DC%2BD28Xht12msrbJ
    • Isele NB, Lee HS, Landshamer S, Straube A, Padovan CS, Plesnila N, Culmsee C (2007) Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons. Neurochem Int 50:243-250. doi: 10.1016/j.neuint.2006.08.007
    • (2007) Neurochem Int , vol.50 , pp. 243-250
    • Isele, N.B.1    Lee, H.S.2    Landshamer, S.3    Straube, A.4    Padovan, C.S.5    Plesnila, N.6    Culmsee, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.