Scar management by means of occlusion and hydration: A comparative study of silicones versus a hydrating gel-cream

Burns

Volumn 39, Issue 7, 2013, Pages 1437-1448

  Hoeksema, Henk ^a   De Vos, Marie ^a   Verbelen, Jozef ^a   Pirayesh, Ali ^a   Monstrey, Stan ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Fluid silicone gel; Hydrating gel cream; Hydration; Moisturizers; Occlusion; Scar; Scar treatment; Silicone; Silicone gel; Silicone gel sheets; Trans epidermal water loss

Indexed keywords

SILICONE; GEL; SILICONE DERIVATIVE; SKIN CREAM;

ADULT; ARTICLE; COMPARATIVE STUDY; CREAM; FOREARM; GEL; HUMAN; HUMAN EXPERIMENT; HUMIDIFIER; HYDRATION; NORMAL HUMAN; OCCLUSION; SCAR; STRATUM CORNEUM; WATER LOSS; BIOLOGICAL MODEL; BODY WATER; CICATRIX, HYPERTROPHIC; CLINICAL TRIAL; EPIDERMIS; FEMALE; FOREARM INJURIES; MALE; MIDDLE AGED; OCCLUSIVE DRESSING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; THERMOREGULATION; TOPICAL DRUG ADMINISTRATION; YOUNG ADULT;

ADMINISTRATION, TOPICAL; ADULT; BODY WATER; CICATRIX, HYPERTROPHIC; EPIDERMIS; FEMALE; FOREARM INJURIES; GELS; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; OCCLUSIVE DRESSINGS; PROSPECTIVE STUDIES; SILICONES; SKIN CREAM; WATER LOSS, INSENSIBLE; YOUNG ADULT;

EID: 84885425459     PISSN: 03054179     EISSN: 18791409     Source Type: Journal    
DOI: 10.1016/j.burns.2013.03.025     Document Type: Article

References (75)

1. K. Perkins, R.B. Davey, and K.A. Wallis Silicone gel: a new treatment for burn scars and contractures Burns 9 3 1983 201 204
2. S.T. Ahn, W.W. Monafo, and T.A. Mustoe Topical silicone gel: a new treatment for hypertrophic scars Surgery 106 4 1989 781 786 discussion 6-7
3. S.A. Carney, C.G. Cason, J.P. Gowar, J.H. Stevenson, J. McNee, and A.R. Groves Cica-Care gel sheeting in the management of hypertrophic scarring Burns 20 2 1994 163 167
4. S.M. Lee, C.K. Ngim, Y.Y. Chan, and M.J. Ho A comparison of Sil-K and Epiderm in scar management Burns 22 6 1996 483 487
5. G.V. de Oliveira, T.A. Nunes, L.A. Magna, M.L. Cintra, G.T. Kitten, and S. Zarpellon Silicone versus nonsilicone gel dressings: a controlled trial Dermatol Surg 27 8 2001 721 726
6. J.I. Colom Majan Evaluation of a self-adherent soft silicone dressing for the treatment of hypertrophic postoperative scars J Wound Care 15 5 2006 193 196
7. G.P. Wittenberg, B.G. Fabian, J.L. Bogomilsky, L.R. Schultz, E.J. Rudner, and M.L. Chaffins Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment Archiv Dermatol 135 9 1999 1049 1055
8. C.W.P. Li-Tsang, J.C.M. Lau, J. Choi, C.C.C. Chan, and L. Jianan A prospective randomized clinical trial to investigate the effect of silicone gel sheeting (Cica-Care) on post-traumatic hypertrophic scar among the Chinese population Burns 32 6 2006 678 683
9. N. Wessling, C.M. Ehleben, V. Chapman, S.R. May, and J.M. Still Jr. Evidence that use of a silicone gel sheet increases range of motion over burn wound contractures J Burn Care Rehabil 6 6 1985 503 505
10. K.J. Quinn Silicone gel in scar treatment Burns 13 Suppl. 1987 S33 S40
11. S. Ohmori Effectiveness of silastic sheet coverage in the treatment of scar keloid (hypertrophic scar) Aesthet Plast Surg 12 2 1988 95 99
12. D.W. Mercer, G.S. Smith, J.M. Cross, D.H. Russell, L. Chang, and J. Cacioppo Effects of lipopolysaccharide on intestinal injury; potential role of nitric oxide and lipid peroxidation J Surg Res 63 1 1996 185 192
13. S.T. Ahn, W.W. Monafo, and T.A. Mustoe Topical silicone gel for the prevention and treatment of hypertrophic scar Archiv Surg 126 4 1991 499 504
14. M.H. Gold Topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. A dermatologic experience J Dermatol Surg Oncol 19 10 1993 912 916
15. B. Hirshowitz, Y. Ullmann, Y. Harshai, A. Vilenski, and I.J. Peled Silicone occlusive sheeting (Sos) in the management of hypertrophic and keloid scarring, including the possible mode of action of silicone, by static electricity Eur J Plast Surg 16 1 1993 5 9
16. M.H. Gold A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids J Am Acad Dermatol 30 3 1994 506 507
17. J.E. Fulton Jr. Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars Dermatol Surg 21 11 1995 947 951
18. B. Berman, and F. Flores Comparison of a silicone gel-filled cushion and silicon gel sheeting for the treatment of hypertrophic or keloid scars Dermatol Surg 25 6 1999 484 486
19. K. Eishi, S.J. Bae, F. Ogawa, Y. Hamasaki, K. Shimizu, and I. Katayama Silicone gel sheets relieve pain and pruritus with clinical improvement of keloid: possible target of mast cells J Dermatol Treat 14 4 2003 248 252
20. M. Murison, and W. James Preliminary evaluation of the efficacy of Dermatix silicone gel in the reduction of scar elevation and pigmentation J Plast Reconstr Aesthet 59 4 2006 437 439
21. W.G. Chernoff, H. Cramer, and S. Su-Huang The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema Aesthet Plast Surg 31 5 2007 495 500
22. H. Karagoz, F. Yuksel, E. Ulkur, and R. Evinc Comparison of efficacy of silicone gel, silicone gel sheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars Burns 35 8 2009 1097 1103
23. S.H. Rhee, S.H. Koh, D.W. Lee, B.Y. Park, and Y.O. Kim Aesthetic effect of silicone gel on surgical scars in Asians J Craniofac Surg 21 3 2010 706 710
24. P. Muangman, P. Aramwit, S. Palapinyo, S. Opasanon, and A. Chuangsuwanich Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury Afr J Pharm Pharmacol 5 3 2011 442 446
25. L. O'Brien, and A. Pandit Silicon gel sheeting for preventing and treating hypertrophic and keloid scars Cochrane Database Syst Rev 1 2006
26. C.W.P. Li-Tsang, Y.P. Zheng, and J.C.M. Lau A randomized clinical trial to study the effect of silicone gel dressing and pressure therapy on posttraumatic hypertrophic scars J Burn Care Res 31 3 2010 448 457
27. L. Steinstraesser, E. Flak, B. Witte, A. Ring, D. Tilkorn, and J. Hauser Pressure garment therapy alone and in combination with silicone for the prevention of hypertrophic scarring: randomized controlled trial with intraindividual comparison Plast Reconstruct Surg 128 4 2011 e306 e313
28. F.B. Niessen, P.H.M. Spauwen, P.H. Robinson, V. Fidler, and M. Kon The use of silicone occlusive sheeting (Sil-K) and silicone occlusive gel (epiderm) in the prevention of hypertrophic scar formation Plast Reconstruct Surg 102 6 1998 1962 1972
29. T.H. Gilman Silicone sheet for treatment and prevention of hypertrophic scar: a new proposal for the mechanism of efficacy Wound Repair Regen 11 3 2003 235 236
30. C.H. Ricketts, L. Martin, D.T. Faria, G.M. Saed, and D.P. Fivenson Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings Dermatol Surg 22 11 1996 955 959
31. N.I. Cruz-Korchin Effectiveness of silicone sheets in the prevention of hypertrophic breast scars Ann Plast Surg 37 4 1996 345 348
32. M.M. Nikkonen, J.M. Pitkanen, and M.M. Al-Qattan Problems associated with the use of silicone gel sheeting for hypertrophic scars in the hot climate of Saudi Arabia Burns 27 5 2001 498 501
33. T.A. Mustoe Evolution of silicone therapy and mechanism of action in scar management Aesthet Plast Surg 32 1 2008 82 92
34. K.Y. Chan, C.L. Lau, S.M. Adeeb, S. Somasundaram, and M. Nasir-Zahari A randomized, placebo-controlled, double-blind, prospective clinical trial of silicone gel in prevention of hypertrophic scar development in median sternotomy wound Plast Reconstruct Surg 116 4 2005 1013 1020
35. M. Signorini, and M.T. Clementoni Clinical evaluation of a new self-drying silicone gel in the treatment of scars: a preliminary report Aesthet Plast Surg 31 2 2007 183 187
36. M.B. van der Wal, P.P. van Zuijlen, P. van de Ven, and E. Middelkoop Topical silicone gel versus placebo in promoting the maturation of burn scars: a randomized controlled trial Plast Reconstruct Surg 126 2 2010 524 531
37. V. de Giorgi, S. Sestini, F. Mannone, F. Papi, B. Alfaioli, and A. Gori The use of silicone gel in the treatment of fresh surgical scars: a randomized study Clin Exp Dermatol 34 6 2009 688 693
38. Y. Sawada, and K. Sone Treatment of scars and keloids with a cream containing silicone oil Br J Plast Surg 43 6 1990 683 688
39. M.A. Musgrave, N. Umraw, J.S. Fish, M. Gomez, and R.C. Cartotto The effect of silicone gel sheets on perfusion of hypertrophic burn scars J Burn Care Rehabil 23 3 2002 208 214
40. D.S. Weiss, W.H. Eaglstein, and V. Falanga Exogenous electric-current can reduce the formation of hypertrophic scars J Dermatol Surg Oncol 15 12 1989 1272 1275
41. Y. Har-Shai, E. Lindenbaum, M. Tendler, A. Gamliel-Lazarovich, L. Feitelberg, and B. Hirshowitz Negatively charged static electricity stimulation as a possible mechanism for enhancing the involution of hypertrophic and keloid scars Isr Med Assoc J 1 3 1999 203 205
42. G. Amicucci, M. Schietroma, M. Rossi, and C. Mazzotta Silicone occlusive sheeting vs silicone cushion for the treatment of hypertrophic and keloid scars. A prospective-randomized study Ann Ital Chir 76 1 2005 79 83 Bendaggio occlusivo al silicone vs cuscino al silicone nel trattamento delle cicatrici ipertrofiche e cheloidee. Studio prospettico-randomizzato.
43. E. Van den Kerckhove, K. Stappaerts, W. Boeckx, B. Van den Hof, S. Monstrey, and A. Van der Kelen Silicones in the rehabilitation of burns: a review and overview Burns 27 3 2001 205 214
44. T.J. Phillips, A.D. Gerstein, and V. Lordan A randomized controlled trial of hydrocolloid dressing in the treatment of hypertrophic scars and keloids Dermatol Surg 22 9 1996 775 778
45. H.C. Bieley, and B. Berman Effects of a water-impermeable, non-silicone-based occlusive dressing on keloids J Am Acad Dermatol 35 1 1996 113 114
46. T. Suetake, S. Sasai, Y.X. Zhen, and H. Tagami Effects of silicone gel sheet on the stratum corneum hydration Br J Plast Surg 53 6 2000 503 507
47. O. Kloeters, A. Tandara, and T.A. Mustoe Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction Wound Repair Regen 15Suppl1 2007 S40 S45
48. C.C. Chang, Y.F. Kuo, H.C. Chiu, J.L. Lee, T.W. Wong, and S.H. Jee Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts J Surg Res 59 6 1995 705 711
49. W.L. Garner Epidermal regulation of dermal fibroblast activity Plast Reconstr Surg 102 1 1998 135 139
50. B.J. Nickoloff, and Y. Naidu Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin J Am Acad Dermatol 30 4 1994 535 546
51. C.A. Harrison, F. Gossiel, A.J. Bullock, T. Sun, A. Blumsohn, and S. Mac Neil Investigation of keratinocyte regulation of collagen I synthesis by dermal fibroblasts in a simple in vitro model Br J Dermatol 154 3 2006 401 410
52. B.E. Katz Silicone gel sheeting in scar therapy Cutis 56 1 1995 65 67
53. J.T. Beranek Why does topical silicone gel improve hypertrophic scars - a hypothesis Surgery 108 1 1990 122
54. T.A. Mustoe, R.D. Cooter, M.H. Gold, F.D. Hobbs, A.A. Ramelet, and P.G. Shakespeare International clinical recommendations on scar management Plast Reconstr Surg 110 2 2002 560 571
55. D. Stavrou, O. Weissman, E. Winkler, L. Yankelson, E. Millet, and O.P. Mushin Silicone-based scar therapy: a review of the literature Aesthet Plast Surg 34 5 2010 646 651
56. W. Wigger-Alberti, M. Kuhlmann, D. Wilhelm, U. Mrowietz, K. Eichhorn, and J. Ortega Efficacy of a polyurethane dressing versus a soft silicone sheet on hypertrophic scars J Wound Care 18 5 2009 208 214
57. A.S. Saulis, J.D. Chao, A. Telser, J.E. Mogford, and T.A. Mustoe Silicone occlusive treatment of hypertrophic scar in the rabbit model Aesthet Surg J/Am Soc Aesthet Plast Surg 22 2 2002 147 153
58. Courage + Khazaka electronic GmbH. Information and Operating Instruction for the Corneometer Stand-alone and with software, 2010.
59. V. Rogiers EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences Skin Pharmacol Physiol 14 2001 117 128
60. T. Suetake, S. Sasai, Y.X. Zhen, T. Ohi, and H. Tagami Functional analyses of the stratum corneum in scars: sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars Archiv Dermatol 132 1996 1453 1458
61. S.J. Park, J.M. Kim, C.H. Lee, and C.J. Lee Evaluation of the skin barrier function by TEWL measurement in hypertrophic scars and keloids [in Korean] Korean J Dermatol 38 2000 176 182
62. Y.J. Kim, M.Y. Kim, P.K. Lee, H.O. Kim, and Y.M. Park Evaluation of natural change of skin function in split-thickness skin grafts by noninvasive bioengineering methods Dermatol Surg 32 11 2006 1358 1363
63. J.J. Escobar-Chávez, V. Merino-Sanjuán, M. López-Cervantes, Z. Urban-Morlan, E. Piñón-Segundo, and D. Quintanar-Guerrero The tape-stripping technique as a method for drug quantification in skin J Pharm Pharm Sci 11 1 2008 104 130
64. H. Löffler, F. Dreher, and H.I. Maibach Stratum corneum adhesive stripping: influence of anatomical site, application pressure, duration and removal Br J Dermatol 151 2004 746 752
65. ®: TM210 and TM300 Int J Cosmet Sci 27 2005 237 241
66. ® Skin Res Technol 11 2005 61 69
67. T. Roelandt, W.D. Roseeu, and J.P. Hachem Practical use and significance of transepidermal water loss measurements J.W. Fluhr, Practical aspects of cosmetic testing 1st ed. 2011 Springer Germany
68. S.L. Hester, C.A. Rees, R.A. Kennis, D.L. Zoran, K.E. Bigley, and S.A. Wright Evaluation of corneometry (skin hydration) and transepidermal water-loss measurements in two canine breeds Am Soc Nutr Sci 134 8 2004 2110S 2113S
69. K.D. O'Shaughnessy, M. De La Garza, N.K. Roy, and T.A. Mustoe Homeostasis of the epidermal barrier layer: a theory of how occlusion reduces hypertrophic scarring Wound Repair Regen 17 September-October (5) 2009 700 708
70. A. Rougier, D. Dupuis, C. Lotte, R. Roguet, and H. Schaefer In vivo correlation between stratum corneum reservoir function and percutaneous absorption J Invest Dermatol 81 1983 275 278
71. M. Lodén The clinical benefit of moisturizers J Eur Acad Dermatol Venereol 19 6 2005 672 688
72. T.C. Flynn, J. Petros, R.E. Clark, and G.E. Viehman Dry skin and moisturizers Clin Dermatol 19 4 2001 387 392
73. D. Harte, J. Gordon, M. Shaw, M. Stinson, and A. Porter-Armstrong The use of pressure and silicone in hypertrophic scar management in burns patients: a pilot randomized controlled trial J Burn Care Res 30 4 2009 632 642
74. Z.D. Draelos Therapeutic moisturizers Dermatol Clin 18 4 2000 597 607
75. E.M. Jackson Moisturizers: adjunct therapy and advising patients Am J Contact Dermat 7 4 1996 247 250