Silicone-based scar therapy: A review of the literature

Aesthetic Plastic Surgery

Volumn 34, Issue 5, 2010, Pages 646-651

  Stavrou, Demetris ^a   Weissman, Oren ^a   Winkler, Eyal ^a   Yankelson, Lior ^a   Millet, Eran ^a   Mushin, Oren Paul ^a   Liran, Alon ^a   Haik, Joseph ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Hypertrophic scar; Keloid scar; Silicone elastomer; Silicone based scar therapy; Topical silicone therapy

Indexed keywords

BIOMATERIAL; SILASTIC; SILICONE DERIVATIVE;

HUMAN; REVIEW; SCAR; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; BIOCOMPATIBLE MATERIALS; CICATRIX; HUMANS; SILICONE ELASTOMERS; SILICONES;

EID: 77957755715     PISSN: 0364216X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00266-010-9496-8     Document Type: Article

References (60)

1. RS Ward 1991 Pressure therapy for the control of hypertrophic scar formation after burn injury: A history and review J Burn Care Rehabil 12 257 262 1:STN:280:DyaK3MzlvVGhtA%3D%3D 10.1097/00004630-199105000-00011 1885644
2. FB Niessen PH Spauwen J Schalkwijk M Kon 1999 On the nature of hypertrophic scars and keloids: A review Plast Reconstr Surg 104 1435 1458 1:STN:280:DyaK1Mvkt1Sruw%3D%3D 10.1097/00006534-199910000-00031 10513931 (Pubitemid 29466295)
3. A Fette 2006 Influence of silicone on abnormal scarring Plast Surg Nurs 26 87 92 16783182
4. E Van den Kerckhove K Stappaerts W Boeckx B Van den Hof S Monstrey A Van der Kelen, et al. 2001 Silicones in the rehabilitation of burns: A review and overview Burns 27 205 214 10.1016/S0305-4179(00)00102-9 11311512 (Pubitemid 32328299)
5. WH Lindsey PT Davis 1997 Facial keloids: A 15-year experience Arch Otolaryngol Head Neck Surg 123 397 400 1:STN:280:DyaK2s3mtl2itw%3D%3D 9109787
6. RS English PD Shenefelt 1999 Keloids and hypertrophic scars Dermatol Surg 25 631 638 1:STN:280:DyaK1Mvit1Sktw%3D%3D 10.1046/j.1524-4725.1999.98257.x 10491047 (Pubitemid 29383470)
7. MH Gold 1993 Topical silicone gel sheeting in the treatment of hypertrophic scars and keloids: A dermatologic experience J Dermatol Surg Oncol 19 912 916 1:STN:280:DyaK2c%2Fhtlyjsg%3D%3D 8408909
8. TA Mustoe RD Cooter MH Gold FD Hobbs AA Ramelet PG Shakespeare, et al. 2002 International clinical recommendations on scar management Plast Reconstr Surg 110 560 571 10.1097/00006534-200208000-00031 12142678
9. K Perkins RB Davey KA Wallis 1983 Silicone gel: A new treatment for burn scars and contractures Burns 9 201 204 1:STN:280:DyaL3s7lsVygtQ%3D%3D 10.1016/0305-4179(83)90039-6
10. L O' Brien A Pandit 2006 Silicon gel sheeting for preventing and treating hypertrophic and keloid scars Cochrane Database Syst Rev 1 CD003826
11. JE Sproat A Dalcin N Weitauer RS Roberts 1992 Hypertrophic sternal scars: silicone gel sheet versus Kenalog injection treatment Plast Reconstr Surg 90 988 992 1:STN:280:DyaK3s%2FnvFentA%3D%3D 10.1097/00006534-199212000-00008 1448534
12. SA Carney CG Cason JP Gowar JH Stevenson J McNee AR Groves, et al. 1994 Cica-Care gel sheeting in the management of hypertrophic scarring Burns 20 163 167 1:STN:280:DyaK2c3lslWnsA%3D%3D 10.1016/S0305-4179(06)80016-1 8198723
13. CW Li-Tsang JC Lau J Choi CC Chan L Jianan 2006 A prospective randomized clinical trial to investigate the effect of silicone gel sheeting (Cica-Care) on posttraumatic hypertrophic scar among the Chinese population Burns 32 678 683 10.1016/j.burns.2006.01.016 16837136 (Pubitemid 44293058)
14. KJ Quinn JH Evans JM Courtney JD Gaylor WH Reid 1985 Nonpressure treatment of hypertrophic scars Burns 12 102 108 1:STN:280:DyaL287jt1yhsA%3D%3D 10.1016/0305-4179(85)90035-X (Pubitemid 16174197)
15. Y Sawada K Sone 1992 Hydration and occlusion treatment for hypertrophic scars and keloids Br J Plast Surg 45 599 603 1:STN:280:DyaK3s7ltlClsw%3D%3D 10.1016/0007-1226(92)90027-U 1493533
16. C Chang Y Kuo H Chiu J Lee T Wong S Jee 1995 Hydration, not silicone modulates the effects of keratinocytes on fibroblasts J Surg Res 59 705 711 1:STN:280:DyaK287jtVWhsw%3D%3D 10.1006/jsre.1995.1227 8538169 (Pubitemid 26013892)
17. DW Thomas ID O'Neill KG Harding JP Shepherd 1995 Cutaneous wound healing: a current perspective J Oral Maxillofac Surg 53 442 447 1:STN:280: DyaK2M3htlymsA%3D%3D 10.1016/0278-2391(95)90721-1 7699500
18. Winter GD (1962) Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 193:293-294
19. M Dyson S Young CL Pendle DF Webster SM Lang 1988 Comparison of the effects of moist and dry conditions on dermal repair J Invest Dermatol 91 434 939 1:STN:280:DyaL1M%2FgvF2mtw%3D%3D 10.1111/1523-1747.ep12476467 3171219
20. DT Gault 1999 Scars and contractures Surgery 4 73 75
21. GV de Oliveira TA Nunes LA Magna ML Cintra GT Kitten S Zarpellon, et al. 2001 Silicone versus nonsilicone gel dressings: a controlled trial Dermatol Surg 27 721 726 10.1046/j.1524-4725.2001.00345.x 11493295 (Pubitemid 32738241)
22. TJ Phillips AD Gerstein V Lordan 1996 A randomized controlled trial of hydrocolloid dressing in the treatment of hypertrophic scars and keloids Dermatol Surg 22 775 778 1:STN:280:DyaK2s%2FivVGisA%3D%3D 10.1016/S1076-0512(96) 00343-3 8874525
23. HC Bieley B Berman 1996 Effects of a water-impermeable, nonsilicone-based occlusive dressing on keloids J Am Acad Dermatol 35 113 114 1:STN:280:DyaK283nt12rsw%3D%3D 10.1016/S0190-9622(96)90521-6 8682947 (Pubitemid 26231338)
24. BE Katz 1995 Silicone gel sheeting in scar therapy Cutis 56 65 67 1:STN:280:DyaK28%2Fls1Shtg%3D%3D 7555106
25. JT Beranek 1990 Why does topical silicone gel improve hypertrophic scars? A hypothesis Surgery 108 122 1:STN:280:DyaK3c3ps1aqsw%3D%3D 2360183
26. V Moulin 1995 Growth factors in skin wound healing Eur J Cell Biol 68 1 7 1:CAS:528:DyaK2MXoslKlsbs%3D 10.1016/S0006-3495(95)80233-X 8549585
27. TH Gilman 2003 Silicone sheet for treatment and prevention of hypertrophic scar: a new proposal for the mechanism of efficacy Wound Repair Regen 11 235 236 10.1046/j.1524-475X.2003.11313.x 12753606 (Pubitemid 36648883)
28. NJ Brown EA Smyth SS Cross MW Reed 2002 Angiogenesis induction and regression in human surgical wounds Wound Repair Regen 10 245 251 10.1046/j.1524-475X.2002.10408.x 12191007 (Pubitemid 35006786)
29. Y Sawada K Sone 1990 Treatment of scars and keloids with a cream containing silicone oil Br J Plast Surg 43 683 688 1:STN:280: DyaK3M%2FnslKhtw%3D%3D 10.1016/0007-1226(90)90189-7 2104531
30. TW Wong HC Chiu CH Chang LJ Lin CC Liu JS Chen 1996 Silicone cream occlusive dressing: a novel noninvasive regimen in the treatment of keloid Dermatology 192 329 333 1:STN:280:DyaK2s%2FhslOmsg%3D%3D 10.1159/000246405 8864367
31. ST Ahn WW Monafo TA Mustoe 1989 Topical silicone gel: a new treatment for hypertrophic scars Surgery 106 781 786 1:STN:280:DyaK3c%2FhvF2kug%3D%3D 2529659 discussion 6-7
32. B Hirshowits Y Ullmann Y Har-Shai, et al. 1993 Silicone occlusive sheeting (SOS) in the management of hypertrophic and keloid scarring, including the possible mode of action of silicone by static electricity Eur J Plast Surg 16 8 14
33. DS Weiss WH Eaglstein V Falanga 1989 Exogenous electric current can reduce the formation of hypertrophic scars J Dermatol Surg Oncol 15 1272 1275 1:STN:280:DyaK3c%2FnvVyhsA%3D%3D 2592666
34. Y Har-Shai E Lindenbaum M Tendler A Gamliel-Lazarovich L Feitelberg B Hirshowitz 1999 Negatively charged static electricity stimulation as a possible mechanism for enhancing the involution of hypertrophic and keloid scars IMAJ Israel Med Assoc J 1 203 205 1:STN:280:DC%2BD3c7pt1egsg%3D%3D
35. B Hirshowitz E Lindenbaum Y Har-Shai L Feitelberg M Tendler D Katz 1998 Static-electric field induction by a silicone cushion for the treatment of hypertrophic and keloid scars Plast Reconstr Surg 101 1173 1183 1:STN:280:DyaK1c7ovVSnug%3D%3D 10.1097/00006534-199804050-00001 9529199 (Pubitemid 28152689)
36. G Amicucci M Schietroma M Rossi C Mazzotta 2005 Silicone occlusive sheeting vs silicone cushion for the treatment of hypertrophic and keloid scars: a prospective-randomized study Ann Ital Chir 76 79 83 1:STN:280: DC%2BD2MznvVWlsw%3D%3D 16035676
37. Peat J, Mellis C, Williams K, Xuan W (2002) Health science research: a handbook of quantitative methods. Sage Publications, London
38. SM Lee CK Ngim YY Chan MJ Ho 1996 A comparison of Sil-K and Epiderm in scar management Burns 22 483 487 1:STN:280:DyaK2s%2FjvVCitQ%3D%3D 10.1016/0305-4179(95)00165-4 8884011 (Pubitemid 26306114)
39. JI Majan 2006 Evaluation of a self-adherent soft silicone dressing for the treatment of hypertrophic postoperative scars J Wound Care 15 193 196 16711171
40. CW Li-Tsang JC Lau SK Liu 2003 Validation of an objective scar pigmentation measurement by using a spectrocolorimeter Burns 29 779 784 10.1016/S0305-4179(03)00165-7 14636751 (Pubitemid 37433912)
41. JC Lau CW Li-Tsang YP Zheng 2005 Application of tissue ultrasound palpation system (TUPS) in objective scar evaluation Burns 31 445 452 10.1016/j.burns.2004.07.016 15896506 (Pubitemid 40724481)
42. M Momeni F Hafezi H Rahbar H Karimi 2008 Effects of silicone gel on burn scars Burns 35 1 70 74 10.1016/j.burns.2008.04.011 18672332
43. B Palmieri G Gozzi G Palmieri 1995 Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids Int J Dermatol 34 506 509 1:STN:280:DyaK28%2Fmsl2jsA%3D%3D 10.1111/j.1365-4362.1995.tb00628.x 7591421
44. J Scott EC Huskisson 1979 Accuracy of subjective measurements made with or without previous scores: an important source of error in serial measurement of subjective states Ann Rheum Dis 38 558 559 1:STN:280:DyaL3c7lt1emtQ%3D%3D 10.1136/ard.38.6.558 317238
45. HP Ehrlich H Tarver TK Hunt 1972 Inhibitory effects of vitamin E on collagen synthesis and wound repair Ann Surg 175 235 240 1:CAS:528: DyaE38XktFCjurk%3D 10.1097/00000658-197202000-00013 5059607
46. JV Quinn GA Wells 1998 An assessment of clinical wound evaluation scales Acad Emerg Med 5 583 586 1:STN:280:DyaK1czitFOhsw%3D%3D 10.1111/j.1553-2712. 1998.tb02465.x 9660284
47. Nguyen DQ, Potokar T, Price P (2008) A review of current objective and subjective scar assessment tools. J Wound Care 17:101-102, 104-106
48. PP van Zuijlen AP Angeles RW Kreis KE Bos E Middelkoop 2002 Scar assessment tools: Implications for current research Plast Reconstr Surg 109 1108 1122 10.1097/00006534-200203000-00052 11884845
49. JA Duncan JS Bond T Mason A Ludlow P Cridland S O'Kane, et al. 2006 Visual analogue scale scoring and ranking: a suitable and sensitive method for assessing scar quality? Plast Reconstr Surg 118 909 918 1:CAS:528: DC%2BD2sXmtVShsg%3D%3D 10.1097/01.prs.0000232378.88776.b0 16980850 (Pubitemid 44412923)
50. PT Truong F Abnousi CM Yong A Hayashi JA Runkel T Phillips, et al. 2005 Standardized assessment of breast cancer surgical scars integrating the Vancouver Scar Scale, Short-Form McGill Pain Questionnaire, and patients' perspectives Plast Reconstr Surg 116 1291 1299 1:CAS:528:DC%2BD2sXkvVCjtg%3D%3D 10.1097/01.prs.0000181520.87883.94 16217470 (Pubitemid 41456498)
51. NI Cruz-Korchin 1996 Effectiveness of silicone sheets in the prevention of hypertrophic breast scars Ann Plast Surg 37 345 348 1:STN:280: DyaK2s%2FmtV2qtg%3D%3D 10.1097/00000637-199610000-00001 8905040
52. Bland M, Peacock J (2004) Statistical questions in evidence-based medicine. Oxford University Press, New York
53. MH Gold TD Foster MA Adair K Burlison T Lewis 2001 Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting Dermatol Surg 27 641 644 1:STN:280:DC%2BD3MzovVygtw%3D%3D 10.1046/j.1524-4725.2001.00356.x 11442615 (Pubitemid 32652393)
54. FB Niessen PH Spauwen PH Robinson V Fidler M Kon 1998 The use of silicone occlusive sheeting (Sil-K) and silicone occlusive gel (Epiderm) in the prevention of hypertrophic scar formation Plast Reconstr Surg 102 1962 1972 1:STN:280:DyaK1M%2FislWitQ%3D%3D 10.1097/00006534-199811000-00023 9810992
55. O'Brien L, Pandit A (2006) Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev 1:CD003826
56. TA Mustoe 2008 Evolution of silicone therapy and mechanism of action in scar management Aesthetic Plast Surg 32 82 92 10.1007/s00266-007-9030-9 17968615
57. WG Chernoff H Cramer S Su-Huang 2007 The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and postlaser exfoliation erythema Aesthetic Plast Surg 31 495 500 10.1007/s00266-006-0218-1 17700980 (Pubitemid 47437499)
58. ST Ahn WW Monafo TA Mustoe 1991 Topical silicone gel for the prevention and treatment of hypertrophic scar Arch Surg 126 499 504 1:STN:280: DyaK3M7otF2qtQ%3D%3D 2009067
59. B Berman OA Perez S Konda BE Kohut MH Viera S Delgado, et al. 2007 A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management Dermatol Surg 33 1291 1302 1:CAS:528:DC%2BD2sXhtlartrrF 10.1111/j.1524-4725. 2007.33280.x 17958580 discussion 302-303
60. CJ van den Helder JJ Hage 1994 Sense and nonsense of scar creams and gels Aesthetic Plast Surg 18 307 313 10.1007/BF00449800 7976767 (Pubitemid 24266335)