MRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay

Nature Structural and Molecular Biology

Volumn 20, Issue 10, 2013, Pages 1214-1222

  Gong, Chenguang ^a,b   Tang, Yalan ^a,b   Maquat, Lynne E ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RNA HELICASE;

3' UNTRANSLATED REGION; ARTICLE; BASE PAIRING; CELL MIGRATION; NONSENSE MEDIATED MRNA DECAY; PRIORITY JOURNAL; RNA STRUCTURE; STAU1 MEDIATED MRNA DECAY;

3' UNTRANSLATED REGIONS; CYTOSKELETAL PROTEINS; HUMANS; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 84885420883     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2664     Document Type: Article

References (34)

1. Gong, C., Kim, Y.K., Woeller, C.F., Tang, Y. & Maquat, L.E. SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev. 23, 54-66 (2009).
2. Gong, C. & Maquat, L.E. lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements. Nature 470, 284-288 (2011).
3. Cho, H. et al. Staufen1-mediated mRNA decay functions in adipogenesis. Mol. Cell 46, 495-506 (2012).
4. Park, E. & Maquat, L.E. Staufen-mediated mRNA decay. Wiley Interdiscip. Rev. RNA 4, 423-435 (2013).
5. Kim, Y.K. et al. Staufen1 regulates diverse classes of mammalian transcripts. EMBO J. 26, 2670-2681 (2007). (Pubitemid 46884281)
6. Eferl, R. & Wagner, E.F. AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer 3, 859-868 (2003). (Pubitemid 37383716)
7. Shaulian, E. & Karin, M. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4, E131-E136 (2002). (Pubitemid 34521026)
8. Kim, Y.K., Furic, L., DesGroseillers, L. & Maquat, L.E. Mammalian Staufen1 recruits Upf1 to specifc mRNA 3′ UTRs so as to elicit mRNA decay. Cell 120, 195-208 (2005).
9. Miyazawa, Y. et al. CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation. Cancer Res. 70, 5136-5146 (2010).
10. Schmitz, J. SINEs as driving forces in genome evolution. Genome Dyn. 7, 92-107 (2012).
11. Wang, J., Gong, C. & Maquat, L.E. Control of myogenesis by rodent SINE-containing lncRNAs. Genes Dev. 27, 793-804 (2013).
12. Maquat, L.E., Tarn, W.Y. & Isken, O. The pioneer round of translation: features and functions. Cell 142, 368-374 (2010).
13. Park, E., Gleghorn, M.L. & Maquat, L.E. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc. Natl. Acad. Sci. USA 110, 405-412 (2013).
14. Chamieh, H., Ballut, L., Bonneau, F. & Le Hir, H. NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat. Struct. Mol. Biol. 15, 85-93 (2008).
15. Melero, R. et al. The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3′ end. Nat. Struct. Mol. Biol. 19, 498-505 (2012).
16. Gehring, N.H. et al. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol. Cell 20, 65-75 (2005). (Pubitemid 41396563)
17. Kunz, J.B., Neu-Yilik, G., Hentze, M.W., Kulozik, A.E. & Gehring, N.H. Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA 12, 1015-1022 (2006). (Pubitemid 43788120)
18. Gleghorn, M.L., Gong, C., Kielkopf, C.L. & Maquat, L.E. Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat. Struct. Mol. Biol. 20, 515-524 (2013).
19. Martel, C. et al. Multimerization of Staufen1 in live cells. RNA 16, 585-597 (2010).
20. Reuter, J.S. & Mathews, D.H. RNAstructure: software for RNA secondary structure prediction and analysis. BMC Bioinformatics 11, 129 (2010).
21. Gong, C., Popp, M.W. & Maquat, L.E. Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes. Methods 58, 88-93 (2012).
22. Huang, L. & Wilkinson, M.F. Regulation of nonsense-mediated mRNA decay. Wiley Interdiscip. Rev. RNA 3, 807-828 (2012).
23. Lipson, S.E. & Hearst, J.E. Psoralen cross-linking of ribosomal RNA. Methods Enzymol. 164, 330-341 (1988). (Pubitemid 19067604)
24. Gong, C. & Maquat, L.E. "Alu"strious long ncRNAs and their role in shortening mRNA half-lives. Cell Cycle 10, 1882-1883 (2011).
25. Ingolia, N.T., Lareau, L.F. & Weissman, J.S. Ribosome profling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell 147, 789-802 (2011).
26. Sato, H. & Maquat, L.E. Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin β. Genes Dev. 23, 2537-2550 (2009).
27. Cesana, M. et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 147, 358-369 (2011).
28. Karreth, F.A. et al. In vivo identifcation of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147, 382-395 (2011).
29. Rubio-Somoza, I., Weigel, D., Franco-Zorilla, J.M., García, J.A. & Paz-Ares, J. ceRNAs: miRNA target mimic mimics. Cell 147, 1431-1432 (2011).
30. Sumazin, P. et al. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell 147, 370-381 (2011).
31. Tay, Y. et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147, 344-357 (2011).
32. Di Giammartino, D.C., Nishida, K. & Manley, J.L. Mechanisms and consequences of alternative polyadenylation. Mol. Cell 43, 853-866 (2011).
33. Elbarbary, R.A., Li, W., Tian, B. & Maquat, L.E. STAU1 binding to 3′ UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes Dev. 27, 1495-1510 (2013).
34. Marión, R.M., Fortes, P., Beloso, A., Dotti, C. & Ortín, J. A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Mol. Cell. Biol. 19, 2212-2219 (1999). (Pubitemid 29098279)