Arrhythmia risk stratification based on QT interval instability: An intracardiac electrocardiogram study

Heart Rhythm

Volumn 10, Issue 6, 2013, Pages 875-880

  Chen, Xiaozhong ^a   Tereshchenko, Larisa G ^b   Berger, Ronald D ^b   Trayanova, Natalia A ^a  

^a Johns Hopkins University   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Arrhythmia; Implantable cardioverter defibrillator; QT interval electrocardiography; Risk stratification; Sudden death

Indexed keywords

ANTIARRHYTHMIC AGENT;

ADULT; ALGORITHM; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAM; FEMALE; HEALTH STATUS INDICATOR; HEART ARRHYTHMIA; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QT INTERVAL; RECEIVER OPERATING CHARACTERISTIC; RISK ASSESSMENT; RR INTERVAL; SURVIVAL;

AGED; ALGORITHMS; ARRHYTHMIAS, CARDIAC; DEFIBRILLATORS, IMPLANTABLE; ELECTROCARDIOGRAPHY; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; RISK FACTORS; ROC CURVE;

EID: 84885385517     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2013.02.014     Document Type: Article

References (33)

1. Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart Disease and Stroke Statistics 2010 Update: A report from the American Heart Association. Circulation 2010;121:e46-e215.
2. Huikuri H, Castellanos A, Myerburg R. Sudden death due to cardiac arrhythmias. N Engl J Med 2001;345: 1473-1482.
3. Muller D, Agrawal R, Arntz H. How sudden is sudden cardiac death? Circulation 2006;114: 1146-1150.
4. Luna ABd, Coumel P, Leclercq JF. Ambulatory sudden cardiac death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J 1989;117: 151-159.
5. Moss AJ, Zareba W, Hall WJ, et al. for the Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002;346: 877-883.
6. Connolly S, Hallstrom A, Cappato R, et al. Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. AVID, CASH and CIDS studies. Antiarrhythmics vs Implantable Defibrillator study. Cardiac Arrest Study Hamburg. Canadian Implantable Defibrillator Study. Eur Heart J 2000;21: 2071-2078.
7. Ezekowitz JA, Armstrong PW, McAlister FA. Implantable cardioverter defib-rillators in primary and secondary prevention: a systematic review of randomized, controlled trials. Ann Intern Med 2003;138: 445-452.
8. Parkes J, Bryant J, Milne R. Implantable cardioverter-defibrillators in arrhythmias: a rapid and systematic review of effectiveness. Heart 2002;87: 438-442.
9. Sanders GD, Hlatky MA, Owens DK. Cost-effectiveness of implantable cardioverter-defibrillators. N Engl J Med 2005;353: 1471-1480.
10. Strickberger SA, Hummel JD, Bartlett TG, et al. Amiodarone versus implantable cardioverter-defibrillator: randomized trial in patients with nonischemicdilated cardiomyopathy and asymptomaticnonsustained ventricular tachycardia- AMIOVIRT. J Am Coll Cardiol 2003;41: 1707-1712.
11. Owens DK, Sanders GD, Harris RA, et al. Cost-effectiveness of implantable cardioverter defibrillators relative to amiodarone for prevention of sudden cardiac death. Ann Intern Med 1997;126: 1-12.
12. Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987;59: 256-262.
13. La Rovere MT, Pinna GD, Hohnloser SH, et al. ATRAMI Investigators. Autonomic Tone and Reflexes After Myocardial Infarcton. Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials. Circulation 2001;103: 2072-2077.
14. Lown B, Wolf M. Approaches to sudden death from coronary heart disease. Circulation 1971;44: 130-142.
15. Rabkin S, Mathewson F, Tate R. Relationship of ventricular ectopy in men without apparent heart disease to occurrence of ischemic heart disease and sudden death. Am Heart J 1981;101: 135-142.
16. Lanza G, Guido V, Galeazzi M, Mustilli M, Natali R, Ierardi C. Prognostic role of heart rate variability in patients with a recent acute myocardial infarction. Am J Cardiol 1998;82: 1323-1328.
17. Schulze R, Strauss H, Pitt B. Sudden death in the year following myocardial infarction: relation to ventricular premature contractions in the late hospital phase and left ventricular ejection fraction. Am J Cardiol 1977;62: 192-199.
18. Grimm W, Herzum I, Müller H-H, Christ M. Value of heart rate variability to predict ventricular arrhythmias in recipients of prophylactic defibrillators with idiopathic dilated cardiomyopathy. Pacing Clin Electrophysiol 2003;26: 411-415.
19. Grimm W, Christ M, Bach J, Müller H, Maisch B. Noninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg cardiomyopathy study. Circulation 2003;108: 2883-2891.
20. Kennedy H, Whitlock J, Sprague M, Kennedy L, Buckingham T, Goldberg R. Long-term follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. N Engl J Med 1985;312: 193-197.
21. Gilmour RF, Riccio ML, Locati EH, Maison-Blanche P, Coumel P, Schwartz PJ. Time- and rate-dependent alterations of the QT interval precede the onset of torsade de pointes in patients with acquired QT prolongation. J Am Coll Cardiol 1997;30: 209-217.
22. Fossa AA, Wisialowski T, Crimin K, et al. Analyses of dynamic beat-to-beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of torsades de pointes during QT prolongation caused by sotalol. Ann Noninvasive Electrocardiol 2007;12: 338-348.
23. Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF. Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 1997;96: 1557-1565.
24. Tereshchenko LG, Fetics BJ, Domitrovich PP, Lindsay BD, Berger RD. Prediction of ventricular tachyarrhythmias by intracardiac repolarization variability analysis. Circ Arrhythm Electrophysiol 2009;2: 276-284.
25. Atiga WL, Calkins H, Lawrence JH, Tomaselli GF, Smith JM, Berger RD. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J Cardiovasc Electrophysiol 1998;9: 899-908.
26. Schmidt G, Malik M, Barthel P, et al. Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet 1999;353: 1390-1396.
27. Chen X, Trayanova NA. A novel methodology for assessing the bounded-input bounded-output instability in QT interval dynamics: application to clinical ECG with ventricular tachycardia. IEEE Trans Biomed Eng 2012;59: 2111-2117.
28. Nolasco JB, Dahlen RW. A graphic method for the study of alternation in cardiac action potentials. J Appl Physiol 1968;25: 191-196.
29. Koller ML, Riccio ML, Gilmour RF. Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. Am J Physiol 1998;275:H1635-H1642.
30. Chen X, Hu Y, Berger RD, Fetics BJ, Trayanova NA. Unstable QT interval dynamics precedes VT onset in patients with acute myocardial infarction: a novel approach to detect instability in QT interval dynamics from clinical ECG. Circ Arrhythm Electrophysiol 2011;4: 858-866.
31. Chen X, Fenton FH, Gray RA. Head-tail interactions in numerical simulations of reentry in a ring of cardiac tissue. Heart Rhythm 2005;2: 1038-1046.
32. Qu Z, Garfinkel A, Chen PS, Weiss JN. Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue. Circulation 2000;102: 1664-1670.
33. Garfinkel A, Kim Y, Voroshilovsky O, et al. Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci U S A 2000;97: 6061-6066.