Design and discovery of novel quinazolinedione-based redox modulators as therapies for pancreatic cancer

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 1, 2014, Pages 332-343

  Pathania, Divya ^a   Sechi, Mario ^b   Palomba, Michele ^b   Sanna, Vanna ^b   Berrettini, Francesco ^c   Sias, Angela ^b   Taheri, Laleh ^a   Neamati, Nouri ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

Anticancer compounds; Oxidative stress in cancer cells; Redox regulation; ROS mediated cell death; Small molecule drug discovery

Indexed keywords

11 METHYLPYRIMIDO[4,5 B]ACRIDINE 5,12 DIONE; 6 [(2 ACETYLPHENYL)AMINO]QUINAZOLINE 5,8 DIONE; 6 [(3 ACETYLPHENYL)AMINO]QUINAZOLINE 5,8 DIONE; 6 [(4 ACETYLPHENYL)AMINO]QUINAZOLINE 5,8 DIONE; 6 [[2 (PHENYLCARBONYL)PHENYL]AMINO]QUINAZOLINE 5,8 DIONE; 6 [[3 (PHENYLCARBONYL)PHENYL]AMINO]QUINAZOLINE 5,8 DIONE; 6 [[4 (PHENYLCARBONYL)PHENYL]AMINO]QUINAZOLINE 5,8 DIONE; ANTINEOPLASTIC AGENT; CYTOCHROME C; ERLOTINIB; GEMCITABINE; QUINAZOLINE DERIVATIVE; RESVERATROL; THIOCTIC ACID; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL METABOLISM; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SAFETY; ENZYME SYNTHESIS; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PANCREAS CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1,5-BIS{[2-(DI-METHYLAMINO) ETHYL]AMINO}-4,8-DIHYDROXYANTHRACENE-9,10-DIONE; 3-NITROOXYPHENYL ACETYLSALICYLATE; 5-CHLOROMETHYLFLUORESCEIN DIACETATE; ANTICANCER COMPOUNDS; C-JUN N-TERMINAL KINASE; CMFDA; DEOXYRIBONUCLEIC ACID; DIMETHYL SULFOXIDE; DMEM; DMSO; DNA; DPBS; DRAQ5®; DULBECCO'S MODIFIED EAGLE MEDIUM; DULBECCO'S PHOSPHATE BUFFERED SALINE; EDTA; ETHYLENE DIAMINETETRAACETIC ACID; FORKHEAD BOX TRANSCRIPTION FACTOR 3A; FOXO3A; GAPDH; GLUTATHIONE (REDUCED); GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE; GSH; JNK; MANGANESE SUPEROXIDE DISMUTASE, MTT, 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; MNSOD; N-ACETYLCYSTEINE; NAC; NAD(P)H DEHYDROGENASE (QUINONE) 1; NADPH; NADPH OXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED); NO-ASA; NOX1; NQO1; OCR; OXIDATIVE STRESS IN CANCER CELLS; OXYGEN CONSUMPTION RATE; RADIO-IMMUNOPRECIPITATION ASSAY BUFFER; REACTIVE OXYGEN SPECIES; REDOX REGULATION; RIPA BUFFER; ROS; ROS-MEDIATED CELL DEATH; ROSWELL PARK MEMORIAL INSTITUTE-1640; RPMI-1640; SMALL MOLECULE DRUG DISCOVERY;

APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; DRUG DESIGN; ENERGY METABOLISM; HUMANS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINONES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 84885337123     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.08.005     Document Type: Article

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