-
1
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
-
16847063 10.1074/jbc.M600933200 1:CAS:528:DC%2BD28XhtVahsb%2FI
-
Anderson JP et al (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem 281:29739-29752
-
(2006)
J Biol Chem
, vol.281
, pp. 29739-29752
-
-
Anderson, J.P.1
-
2
-
-
0028036142
-
Recombinant human casein kinase II. A study with the complete set of subunits (alpha, alpha′ and beta), site-directed autophosphorylation mutants and a bicistronically expressed holoenzyme
-
8119294 10.1111/j.1432-1033.1994.tb18622.x 1:CAS:528:DyaK2cXitFWntLg%3D
-
Bodenbach L et al (1994) Recombinant human casein kinase II. A study with the complete set of subunits (alpha, alpha′ and beta), site-directed autophosphorylation mutants and a bicistronically expressed holoenzyme. Eur J Biochem 220:263-273
-
(1994)
Eur J Biochem
, vol.220
, pp. 263-273
-
-
Bodenbach, L.1
-
3
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
12498954 10.1016/S0197-4580(02)00065-9
-
Braak H et al (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24:197-211
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
-
4
-
-
84861064848
-
α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease
-
22499677
-
Braithwaite SP et al (2012) α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease. Rev Neurosci 23:191-198
-
(2012)
Rev Neurosci
, vol.23
, pp. 191-198
-
-
Braithwaite, S.P.1
-
5
-
-
67650496503
-
Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: Relevance to Parkinson's disease pathogenesis
-
19493164 10.1111/j.1471-4159.2009.06191.x 1:CAS:528:DC%2BD1MXptlensLo%3D
-
Chau KY et al (2009) Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis. J Neurochem 110:1005-1013
-
(2009)
J Neurochem
, vol.110
, pp. 1005-1013
-
-
Chau, K.Y.1
-
6
-
-
32544432029
-
Non-motor symptoms of Parkinson's disease: Diagnosis and management
-
16488379 10.1016/S1474-4422(06)70373-8
-
Chaudhuri KR et al (2006) Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 5:235-245
-
(2006)
Lancet Neurol
, vol.5
, pp. 235-245
-
-
Chaudhuri, K.R.1
-
7
-
-
64349083816
-
Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment
-
19375664 10.1016/S1474-4422(09)70068-7 1:CAS:528:DC%2BD1MXlsVajsb0%3D
-
Chaudhuri KR, Schapira AH (2009) Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8:464-474
-
(2009)
Lancet Neurol
, vol.8
, pp. 464-474
-
-
Chaudhuri, K.R.1
Schapira, A.H.2
-
8
-
-
70149084131
-
Mitochondrial kinases in Parkinson's disease: Converging insights from neurotoxin and genetic models
-
19563915 10.1016/j.mito.2009.06.001 1:CAS:528:DC%2BD1MXhtFGqtrnL
-
Dagda RK, Zhu J, Chu CT (2009) Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. Mitochondrion 9:289-298
-
(2009)
Mitochondrion
, vol.9
, pp. 289-298
-
-
Dagda, R.K.1
Zhu, J.2
Chu, C.T.3
-
9
-
-
71949090833
-
Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases
-
19619643 10.1016/j.bbadis.2009.07.007 1:CAS:528:DC%2BD1MXhsFanurjO
-
Devi L, Anandatheerthavarada HK (2010) Mitochondrial trafficking of APP and alpha synuclein: relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases. Biochim Biophys Acta 1802:11-19
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 11-19
-
-
Devi, L.1
Anandatheerthavarada, H.K.2
-
10
-
-
28744439018
-
Dopamine D3 receptor-preferring agonists induce neurotrophic effects on mesencephalic dopamine neurons
-
16307585 10.1111/j.1460-9568.2005.04438.x
-
Du F, Li R, Huang Y, Li X, Le W (2005) Dopamine D3 receptor-preferring agonists induce neurotrophic effects on mesencephalic dopamine neurons. Eur J Neurosci 22:2422-2430
-
(2005)
Eur J Neurosci
, vol.22
, pp. 2422-2430
-
-
Du, F.1
Li, R.2
Huang, Y.3
Li, X.4
Le, W.5
-
11
-
-
77649123090
-
Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole
-
20137065 10.1186/1471-2210-10-2
-
Ferrari-Toninelli G et al (2010) Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole. BMC Pharmacol 10:2
-
(2010)
BMC Pharmacol
, vol.10
, pp. 2
-
-
Ferrari-Toninelli, G.1
-
12
-
-
51449123001
-
Non-dopaminergic treatments in development for Parkinson's disease
-
18848312 10.1016/S1474-4422(08)70214-X 1:CAS:528:DC%2BD1cXht1enu7%2FO
-
Fox SH et al (2008) Non-dopaminergic treatments in development for Parkinson's disease. Lancet Neurol 7:927-938
-
(2008)
Lancet Neurol
, vol.7
, pp. 927-938
-
-
Fox, S.H.1
-
13
-
-
43249120160
-
Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain
-
18162487 10.1096/fj.07-9348com 1:CAS:528:DC%2BD1cXltlWlu7Y%3D
-
Fuchs J et al (2008) Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain. FASEB J 22:1327-1334
-
(2008)
FASEB J
, vol.22
, pp. 1327-1334
-
-
Fuchs, J.1
-
14
-
-
0036174010
-
Alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
11813001 10.1038/ncb841 1:CAS:528:DC%2BD38XhsVKnur4%3D
-
Fujiwara H et al (2002) alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160-164
-
(2002)
Nat Cell Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
-
15
-
-
9744276661
-
Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms
-
15569251 10.1111/j.1471-4159.2004.02804.x 1:CAS:528:DC%2BD2cXhtFSisbfK
-
Gu M et al (2004) Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms. J Neurochem 91:1075-1081
-
(2004)
J Neurochem
, vol.91
, pp. 1075-1081
-
-
Gu, M.1
-
16
-
-
45449092100
-
Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity
-
18555604 10.1016/j.neulet.2008.05.067 1:CAS:528:DC%2BD1cXnsFCltLw%3D
-
Imamura K et al (2008) Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity. Neurosci Lett 440:97-102
-
(2008)
Neurosci Lett
, vol.440
, pp. 97-102
-
-
Imamura, K.1
-
17
-
-
33645101158
-
Pramipexole protects against MPTP toxicity in non-human primates
-
16464239 10.1111/j.1471-4159.2005.03625.x 1:CAS:528:DC%2BD28XivFSrur0%3D
-
Iravani MM et al (2006) Pramipexole protects against MPTP toxicity in non-human primates. J Neurochem 96:1315-1321
-
(2006)
J Neurochem
, vol.96
, pp. 1315-1321
-
-
Iravani, M.M.1
-
18
-
-
47349086173
-
Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response
-
18571649 10.1016/j.expneurol.2008.04.037 1:CAS:528:DC%2BD1cXptVCjtL8%3D
-
Iravani MM et al (2008) Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response. Exp Neurol 212:522-531
-
(2008)
Exp Neurol
, vol.212
, pp. 522-531
-
-
Iravani, M.M.1
-
19
-
-
33846649595
-
Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity
-
17161393 10.1016/j.ejphar.2006.11.011 1:CAS:528:DC%2BD2sXhtlWiu7w%3D
-
Izumi Y et al (2007) Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity. Eur J Pharmacol 557:132-140
-
(2007)
Eur J Pharmacol
, vol.557
, pp. 132-140
-
-
Izumi, Y.1
-
20
-
-
0035815285
-
Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole
-
11301060 10.1016/S0014-2999(01)00902-5 1:CAS:528:DC%2BD3MXis1Sjs7g%3D
-
Kakimura J et al (2001) Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole. Eur J Pharmacol 417:59-67
-
(2001)
Eur J Pharmacol
, vol.417
, pp. 59-67
-
-
Kakimura, J.1
-
21
-
-
65649140858
-
{alpha}-Synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells
-
19203998 10.1074/jbc.M809671200 1:CAS:528:DC%2BD1MXjvFKksb4%3D
-
Kragh CL et al (2009) {alpha}-Synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells. J Biol Chem 284:10211-10222
-
(2009)
J Biol Chem
, vol.284
, pp. 10211-10222
-
-
Kragh, C.L.1
-
22
-
-
77957577806
-
Neuroprotection of pramipexole in UPS impairment induced animal model of Parkinson's disease
-
20635141 10.1007/s11064-010-0214-3 1:CAS:528:DC%2BC3cXovFCnsrY%3D
-
Li C et al (2010) Neuroprotection of pramipexole in UPS impairment induced animal model of Parkinson's disease. Neurochem Res 35:1546-1556
-
(2010)
Neurochem Res
, vol.35
, pp. 1546-1556
-
-
Li, C.1
-
23
-
-
0037269847
-
Protein kinase CK2: Structure, regulation and role in cellular decisions of life and death
-
12396231 10.1042/BJ20021469 1:CAS:528:DC%2BD38XpsFSht78%3D
-
Litchfield DW (2003) Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J 369:1-15
-
(2003)
Biochem J
, vol.369
, pp. 1-15
-
-
Litchfield, D.W.1
-
24
-
-
78650356896
-
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner
-
20959456 10.1074/jbc.M110.141952 1:CAS:528:DC%2BC3cXhsFynsLjM
-
Machiya Y et al (2010) Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner. J Biol Chem 285:40732-40744
-
(2010)
J Biol Chem
, vol.285
, pp. 40732-40744
-
-
Machiya, Y.1
-
25
-
-
77449113371
-
Phosphorylation of synucleins by members of the Polo-like kinase family
-
19889641 10.1074/jbc.M109.081950 1:CAS:528:DC%2BC3cXlvFCruw%3D%3D
-
Mbefo MK et al (2010) Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem 285:2807-2822
-
(2010)
J Biol Chem
, vol.285
, pp. 2807-2822
-
-
Mbefo, M.K.1
-
26
-
-
79957974579
-
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein
-
21489994 10.1074/jbc.M110.213538 1:CAS:528:DC%2BC3MXmvFCgtbY%3D
-
Nakamura K et al (2011) Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem 286:20710-20726
-
(2011)
J Biol Chem
, vol.286
, pp. 20710-20726
-
-
Nakamura, K.1
-
27
-
-
77953229747
-
Missing pieces in the Parkinson's disease puzzle
-
20495568 10.1038/nm.2165 1:CAS:528:DC%2BC3cXmsVWmt7k%3D
-
Obeso JA et al (2010) Missing pieces in the Parkinson's disease puzzle. Nat Med 16:653-661
-
(2010)
Nat Med
, vol.16
, pp. 653-661
-
-
Obeso, J.A.1
-
28
-
-
58349122472
-
Why have we failed to achieve neuroprotection in Parkinson's disease?
-
19127580 1:CAS:528:DC%2BD1MXhsFKjs78%3D
-
Olanow CW et al (2008) Why have we failed to achieve neuroprotection in Parkinson's disease? Ann Neurol 64(Suppl 2):S101-S110
-
(2008)
Ann Neurol
, vol.64
, Issue.SUPPL. 2
-
-
Olanow, C.W.1
-
29
-
-
5044238005
-
Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4- phenylpyridinium in terminally differentiated SH-SY5Y cells
-
15473989 10.1016/j.expneurol.2004.06.021 1:CAS:528:DC%2BD2cXotlClsLo%3D
-
Presgraves SP et al (2004) Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells. Exp Neurol 190:157-170
-
(2004)
Exp Neurol
, vol.190
, pp. 157-170
-
-
Presgraves, S.P.1
-
30
-
-
46749144187
-
Genomic investigation of alpha-synuclein multiplication and parkinsonism
-
18571778 10.1002/ana.21380 1:CAS:528:DC%2BD1cXptFegur0%3D
-
Ross OA et al (2008) Genomic investigation of alpha-synuclein multiplication and parkinsonism. Ann Neurol 63:743-750
-
(2008)
Ann Neurol
, vol.63
, pp. 743-750
-
-
Ross, O.A.1
-
31
-
-
33744982893
-
Etiology of Parkinson's disease
-
16717248 10.1212/WNL.66.10-suppl-4.S10
-
Schapira AH (2006) Etiology of Parkinson's disease. Neurology 66:S10-S23
-
(2006)
Neurology
, vol.66
-
-
Schapira, A.H.1
-
32
-
-
41049099938
-
Progress in neuroprotection in Parkinson's disease
-
18353131 10.1111/j.1468-1331.2008.02055.x
-
Schapira AH (2008) Progress in neuroprotection in Parkinson's disease. Eur J Neurol 15(Suppl 1):5-13
-
(2008)
Eur J Neurol
, vol.15
, Issue.SUPPL. 1
, pp. 5-13
-
-
Schapira, A.H.1
-
33
-
-
61949458087
-
Molecular and clinical pathways to neuroprotection of dopaminergic drugs in Parkinson disease
-
19221314 10.1212/WNL.0b013e3181990438 1:CAS:528:DC%2BD1MXhslygsL8%3D
-
Schapira AH (2009a) Molecular and clinical pathways to neuroprotection of dopaminergic drugs in Parkinson disease. Neurology 72:S44-S50
-
(2009)
Neurology
, vol.72
-
-
Schapira, A.H.1
-
34
-
-
58149131277
-
Neurobiology and treatment of Parkinson's disease
-
19042040 10.1016/j.tips.2008.10.005 1:CAS:528:DC%2BD1MXktlygsA%3D%3D
-
Schapira AH (2009b) Neurobiology and treatment of Parkinson's disease. Trends Pharmacol Sci 30:41-47
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 41-47
-
-
Schapira, A.H.1
-
35
-
-
70349235644
-
Perspectives on recent advances in the understanding and treatment of Parkinson's disease
-
19723294 10.1111/j.1468-1331.2009.02793.x 1:STN:280: DC%2BD1MnjslGgsw%3D%3D
-
Schapira AH et al (2009) Perspectives on recent advances in the understanding and treatment of Parkinson's disease. Eur J Neurol 16:1090-1099
-
(2009)
Eur J Neurol
, vol.16
, pp. 1090-1099
-
-
Schapira, A.H.1
-
36
-
-
77955831301
-
Rationale for delayed-start study of pramipexole in Parkinson's disease: The PROUD study
-
20544810 10.1002/mds.23143
-
Schapira AH et al (2010) Rationale for delayed-start study of pramipexole in Parkinson's disease: the PROUD study. Mov Disord 25:1627-1632
-
(2010)
Mov Disord
, vol.25
, pp. 1627-1632
-
-
Schapira, A.H.1
-
37
-
-
77954862456
-
Molecular and clinical prodrome of Parkinson disease: Implications for treatment
-
20479780 10.1038/nrneurol.2010.52 1:CAS:528:DC%2BC3cXntFSntbg%3D
-
Schapira AH, Tolosa E (2010) Molecular and clinical prodrome of Parkinson disease: implications for treatment. Nat Rev Neurol 6:309-317
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 309-317
-
-
Schapira, A.H.1
Tolosa, E.2
-
38
-
-
77949478474
-
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
-
19880420 10.1093/hmg/ddp501 1:CAS:528:DC%2BD1MXhs1WisLfP
-
Sha D et al (2010) Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet 19:352-363
-
(2010)
Hum Mol Genet
, vol.19
, pp. 352-363
-
-
Sha, D.1
-
39
-
-
34249794256
-
Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein
-
17465029 10.1002/jnr.21310 1:CAS:528:DC%2BD2sXmsFeqt7w%3D
-
Wakamatsu M et al (2007) Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein. J Neurosci Res 85:1819-1825
-
(2007)
J Neurosci Res
, vol.85
, pp. 1819-1825
-
-
Wakamatsu, M.1
-
40
-
-
43249108653
-
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein
-
18451726 10.1097/NEN.0b013e3186fc995 1:CAS:528:DC%2BD1cXmsFehtbg%3D
-
Waxman EA, Giasson BI (2008) Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein. J Neuropathol Exp Neurol 67:402-416
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 402-416
-
-
Waxman, E.A.1
Giasson, B.I.2
|