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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 21, 2013, Pages 6015-6018

4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor

(9) Mimori, Seisuke a Ohtaka, Hiroyasu a Koshikawa, Yukari a Kawada, Koichi a Kaneko, Masayuki b Okuma, Yasunobu a Nomura, Yasuyuki c Murakami, Yasuoki a Hamana, Hiroshi a

a CHIBA INSTITUTE OF SCIENCE (Japan)

b GIFU PHARMACEUTICAL UNIVERSITY (Japan)

c KURUME UNIVERSITY SCHOOL OF MEDICINE (Japan)

Author keywords

4 phenylbutyric acid (4 PBA); Acetyl histone; Chemical chaperone; Endoplasmic reticulum (ER) stress; H3; Histone deacetylase (HDAC)

Indexed keywords

4 PHENYLBUTYRIC ACID; CHAPERONE; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE INHIBITOR;

ARTICLE; BINDING SITE; CELL ACTIVITY; CELL PROTECTION; CELL VIABILITY; CHEMICAL STRUCTURE; DRUG PROTEIN BINDING; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; NERVE CELL NECROSIS; OXIDATIVE STRESS; UNFOLDED PROTEIN RESPONSE;

4-PHENYLBUTYRIC ACID (4-PBA); ACETYL HISTONE H3; CHEMICAL CHAPERONE; ENDOPLASMIC RETICULUM (ER) STRESS; HISTONE DEACETYLASE (HDAC);

ANIMALS; CELL DEATH; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HISTONE DEACETYLASE INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR CHAPERONES; PHENYLBUTYRATES; PROTECTIVE AGENTS; PROTEIN CONFORMATION;

EID: 84885188725 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.08.001 Document Type: Article

Times cited : (53)

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