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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 21, 2013, Pages 5814-5820

Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription

(7) Zeller, Jörg a Turbiak, Anjanette J b Powelson, Ian A a,b Lee, Surin a Sun, Duxin b Showalter, H D Hollis b Fearon, Eric R a,b

a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL (United States)

b UNIVERSITY OF MICHIGAN (United States)

Author keywords

Catenin; Small molecule antagonists; T cell factor (TCF); Wnt signaling

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 3 ARYL PYRIMIDO[5,4 E ][1,2,4]TRIAZINE 5,7 DIONE DERIVATIVE; ANTINEOPLASTIC AGENT; APC PROTEIN; AXIN; AXIN 5; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CATENIN; CALPHOSTIN C; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; WNT3A PROTEIN; XANTHOTHRICIN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; COLORECTAL CANCER; DOSE RESPONSE; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MOLECULAR WEIGHT; NONHUMAN; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UBIQUITINATION;

HUMAN ECHOVIRUS 1; RATTUS;

SMALL MOLECULE ANTAGONISTS; T-CELL FACTOR (TCF); WNT SIGNALING; Β-CATENIN;

ANIMALS; BETA CATENIN; CELL LINE; EPITHELIAL CELLS; RATS; SMALL MOLECULE LIBRARIES; TCF TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRIAZINES; WNT SIGNALING PATHWAY;

EID: 84885183994 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.08.111 Document Type: Article

Times cited : (12)

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