Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 21, 2013, Pages 5975-5979

  Kato, Yuko ^a   Fuchi, Nobuhiro ^a   Saburi, Hajime ^a   Nishimura, Yutaka ^a   Watanabe, Ayano ^a   Yagi, Mai ^a   Nakadera, Yasuhito ^a   Higashi, Eriko ^a   Yamada, Masateru ^a   Aoki, Takumi ^a  

^a TORAY INDUSTRIES INC   (Japan)

Author keywords

Hypertension; Mean blood pressure; sEH inhibitor; Spirocyclic diamine; Spontaneously hypertensive rat; Urea

Indexed keywords

EPOXIDE HYDROLASE; HYDROLASE INHIBITOR; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE; CRYSTAL STRUCTURE; HUMAN; HYPERTENSION; MOUSE; NONHUMAN; RAT; STEREOSPECIFICITY;

MURINAE; RATTUS;

HYPERTENSION; MEAN BLOOD PRESSURE; SEH INHIBITOR; SPIROCYCLIC DIAMINE; SPONTANEOUSLY HYPERTENSIVE RAT; UREA;

ALKANES; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; EPOXIDE HYDROLASES; HUMANS; HYPERTENSION; MOLECULAR DOCKING SIMULATION; RATS; RATS, INBRED SHR; UREA;

EID: 84885180648     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.054     Document Type: Article

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