Cerebral blood flow measured by arterial-spin labeling MRI: A useful biomarker for characterization of minimal hepatic encephalopathy in patients with cirrhosis

European Journal of Radiology

Volumn 82, Issue 11, 2013, Pages 1981-1988

  Zheng, Gang ^a,b   Zhang, Long Jiang ^a   Zhong, Jianhui ^c   Wang, Ze ^d   Qi, Rongfeng ^a   Shi, Donghong ^a   Lu, Guang Ming ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY OF AERONAUTICS AND ASTRONAUTICS   (China)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Arterial spin labeling; Cerebral blood flow; Cirrhosis; Hepatic encephalopathy

Indexed keywords

AMMONIA; BIOLOGICAL MARKER;

ADULT; ALCOHOL LIVER CIRRHOSIS; AMMONIA BLOOD LEVEL; ARTICLE; BILIARY CIRRHOSIS; BRAIN BLOOD FLOW; BRAIN DISEASE; BRAIN REGION; CHILD PUGH SCORE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENDER; GRAY MATTER; HEPATIC ENCEPHALOPATHY; HUMAN; INFORMED CONSENT; MALE; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PUTAMEN; RECEIVER OPERATING CHARACTERISTIC; SPIN LABELING; SUPERIOR TEMPORAL GYRUS; SUPRAMARGINAL GYRUS;

ARTERIAL SPIN LABELING; ARTERIAL-SPIN LABELING; ASL; CBF; CEREBRAL BLOOD FLOW; CIRRHOSIS; DIGIT SYMBOL TEST; DST; HE; HEPATIC ENCEPHALOPATHY; MCC; MEDIAN CINGULATE CORTEX; MHE; MINIMAL HEPATIC ENCEPHALOPATHY; NCT-A; NON HEPATIC ENCEPHALOPATHY; NON-HE; NUMBER-CONNECTION TEST TYPE A; OHE; OVERT HEPATIC ENCEPHALOPATHY; PET; POSITRON EMISSION TOMOGRAPHY; RECEIVER OPERATOR CHARACTERISTIC; ROC; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPECT; TIPS; TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT.;

BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; FEMALE; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER CIRRHOSIS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPIN LABELS;

EID: 84885178159     PISSN: 0720048X     EISSN: 18727727     Source Type: Journal    
DOI: 10.1016/j.ejrad.2013.06.002     Document Type: Article

References (38)

1. J.S. Bajaj, J.B. Wade, and A.J. Sanyal Spectrum of neurocognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy Hepatology 50 6 2009 2014 2021
2. A.H. Lockwood, E.W. Yap, and H.M. Rhoades Altered cerebral blood flow and glucose metabolism in patients with liver disease and minimal encephalopathy J Cereb Blood Flow Metab 11 2 1991 331 336
3. A.M. Qadr, B.O. Ogunwale, and K.D. Mullen Can we ignore minimal hepatic encephalopathy any longer? Hepatology 45 3 2007 547 548
4. J.S. Bajaj, M. Hafeezullah, and R.G. Hoffmann Minimal hepatic encephalopathy: a vehicle for accidents and traffic violations Am J Gastroenterol 102 9 2007 1903 1909
5. J.S. Bajaj, K. Saeian, and M.D. Verber Inhibitory control test is a simple method to diagnose minimal hepatic encephalopathy and predict development of overt hepatic encephalopathy Am J Gastroenterol 102 4 2007 754 760
6. J.S. Bajaj, A. Etemadian, and M. Hafeezullah Testing for minimal hepatic encephalopathy in the United States: an AASLD survey Hepatology 45 3 2007 833 834
7. P. Ferenci, A. Lockwood, and K. Mullen Hepatic encephalopathy - definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 Hepatology 35 2 2002 716 721
8. I. Ciecko-Michalska, J. Wojcik, and M. Wyczesany Cognitive evoked response potentials in patients with liver cirrhosis without diagnosis of minimal or overt hepatic encephalopathy. A pilot study J Physiol Pharmacol. 63 3 2012 271 276
9. A. Goldbecker, K. Weissenborn, and G. Hamidi Shahrezaei Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates Gut 7 January 2013 10.1136/gutjnl-2012-303262
10. P. Amodio, A. Pellegrini, and E. Ubiali The EEG assessment of low-grade hepatic encephalopathy: comparison of an artificial neural network-expert system (ANNES) based evaluation with visual EEG readings and EEG spectral analysis Clin Neurophysiol 117 10 2006 2243 2251
11. A. Singhal, R. Nagarajan, and C.H. Hinkin Two-dimensional MR spectroscopy of minimal hepatic encephalopathy and neuropsychological correlates in vivo J Magn Reson Imaging 32 1 2010 35 43
12. A.M. Catafau, J. Kulisevsky, and L. Berna Relationship between cerebral perfusion in frontal-limbic-basal ganglia circuits and neuropsychologic impairment in patients with subclincal hepatic encephalopathy J Nucl Med 41 3 2000 405 410
13. R.E. O'Carroll, P.C. Hayes, and K.P. Ebmeier Regional cerebral blood flow and cognitive function in patients with chronic liver disease Lancet 337 8752 1991 1250 1253
14. R. Testa, G. Rodriguez, and F. Arvigo Cerebral blood flow and plasma free tryptophan in cirrhotics with and without hepatic encephalopathy Ital J NeurolSci 10 4 1989 415 421
15. T. Li, X. Li, and W. Zhou Dynamic susceptibility contrast-enhanced first-pass perfusion MR imaging in patients with subclinical hepatic encephalopathy J Neuroradiol 39 5 2012 290 294
16. J.A. Detre, J. Wang, and Z. Wang Arterial spin-labeled perfusion MRI in basic and clinical neuroscience Curr Opin Neurol 22 2009 348 355
17. R.P. Bokkers, J.P. Bremmer, and B.N. Berckel Arterial spin labeling perfusion MRI at multiple delay times: a correlative study with H(2)(15)O positron emission tomography in patients with symptomatic carotid artery occlusion J Cereb Blood Flow Metab 30 2010 222 229
18. Y. Lim, Y. Cho, and S. Shamim Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy Epilepsy Res 82 2-3 2008 183 189
19. Z. Wang, G.K. Aguirre, and H.Y. Rao Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx Magn Reson Imaging 26 2 2008 261 269
20. Z. Wang Improving cerebral blood flow quantification for arterial spin labeled perfusion MRI by removing residual motion artifacts and global signal fluctuations Magn Reson Imaging 30 10 2012 1409 1415
21. J. Wang, Z. Wang, and G.K. Aguirre To smooth or not to smooth? ROC analysis of perfusion fMRI data Magn Reson Imaging 23 1 2005 75 81
22. M. Donahue, H. Lu, and C. Jones An account of the discrepancy between MRI and PET cerebral blood flow measures. A high-field MRI investigation NMR Biomed 19 8 2006 1043 1054
23. N. Tzourio-Mazoyer, B. Landeau, and D. Papathanassiou Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain NeuroImage 15 1 2002 273 289
24. A.M. Campbell, and C. Beaulieu Comparison of multislice and single-slice acquisitions for pulsed arterial spin labeling measurements of cerebral perfusion Magn Reson Imaging 24 7 2006 869 876
25. S.X.F. Aslan, P.L. Wang, and J. Uh Estimation of labeling efficiency in pseudo-continuous arterial spin labeling Magn Reson Med 63 3 2010 765 771
26. G. Zheng, L.J. Zhang, and Z. Wang Changes in cerebral blood flow after transjugular intrahepatic portosystemic shunt can help predict the development of hepatic encephalopathy: an arterial spin labeling MR study Eur J Radiol 81 12 2012 3851 3856
27. S. Møller, and J.H. Henriksen Cardiovascular complications of cirrhosis Gut 57 2 2008 268 278
28. D. Haussinger Low grade cerebral edema in the pathogenesis of hepatic encephalopathy in cirrhosis Hepatology 43 6 2006 1187 1190
29. L.J. Zhang, G.M. Lu, and J.Z. Yin Metabolic changes of anterior cingulate cortex in patients with hepatic cirrhosis: a magnetic resonance spectroscopy study Hepatol Res 40 8 2010 777 785
30. F. Miese, G. Kircheis, and H.J. Wittsack 1H-MR spectroscopy, magnetization transfer, and diffusion-weighted imaging in alcoholic and nonalcoholic patients with cirrhosis with hepatic encephalopathy AJNR Am J Neuroradiol 27 5 2006 1019 1026
31. H. Sugimoto, R.C. Koehler, and D.A. Wilson Methionine sulfoximine, a glutamine synthetase inhibitor, attenuates increased extracellular potassium activity during acute hyperammonemia J Cereb Blood Flow Meiab 17 1 1997 44 49
32. A.S. Bender, and M.D. Norenberg Effects of ammonia and L-methionine-DL-sulfoximine on K+ and Cl- fluxes in cultured astrocytes Soc Neurosci Abstr 19 1993 688
33. O.B. Paulson, and E.A. Newman Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science 237 4817 1987 896 898
34. M.D. Norenberg Astroglial dysfunction in hepatic encephalopathy Metab Brain Dis 13 4 1998 319 336
35. S. Master, J. Gottstein, and A.T. Blei Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis Hepatology 30 4 1999 876 880
36. V.L. Rao, R.M. Audet, and R.F. Butterworth Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis Brain Res 765 1 1997 169 172
37. T.N. Nagaraja, and N. Brookes Intracellular acidification induced by passive and active transport of ammonium ions in astrocytes Am J Physiol 274 4 Pt 1 1998 883 891
38. M. Iwasa, M. Kaito, and Y. Adachi Cerebral blood flow in basal ganglia is correlated with clinical signs of hepatic encephalopathy in patients with liver cirrhosis Am J Gastroenterol 97 3 2002 763 764