Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6466-6476

  Guo, Xiaoke ^a   Yang, Qian ^a   Xu, Jing ^a   Zhang, Li ^a   Chu, Hongxi ^a   Yu, Peng ^a   Zhu, Yingying ^a   Wei, Jinglian ^a   Chen, Weilin ^a   Zhang, Yaozhong ^a   Zhang, Xiaojin ^a   Sun, Haopeng ^a   Tang, Yiqun ^a   You, Qidong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Atrial fibrillation (AF); Kv1.5 Indole derivatives; Structure activity relationship (SAR)

Indexed keywords

1H INDOLE 3 CARBALDEHYDE; 2 (1H INDOL 3 YL)ETHANAMINE; 2 CHLORO N (2,4 DIMETHYLPHENYL)ACETAMIDE; 2 CHLORO N (4 CHLOROPHENYL)ACETAMIDE; 2 CHLORO N (4 METHOXYPHENYL)ACETAMIDE; 2 CHLORO N PHENYLACETAMIDE; 3 (2 NITROETHYL) 1H INDOLE; 3 (2 NITROVINYL) 1H INDOLE; 4 (CYCLOPENTYLOXY)BENZENE 1 SULFONYL CHLORIDE; 4 BUTOXYBENZENE 1 SULFONYL CHLORIDE; 4 ISOBUTOXYBENZENE 1 SULFONYL CHLORIDE; 4 ISOPROPOXYBENZENE 1 SULFONYL CHLORIDE; 5 METHOXY 1H INDOLE 3 CARBALDEHYDE; INDOLE DERIVATIVE; METHYL 2 AMINO 3 (1H INDOL 3 YL)PROPANOATE; METHYL 2 AMINO 3 PHENYLPROPANOATE; N (2,4 DIFLUOROPHENYL) 2 [3 [(2 TOSYLHYDRAZONO)METHYL]1H INDOL 1 YL]ACETAMIDE; N (4 CHLOROPHENYL) 2 [5 METHOXY 3 [(2 TOSYLHYDRAZONO)METHYL]1H INDOL 1 YL]ACETAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 4 BUTOXYBENZENESULFONAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 4 METHOXYBENZENESULFONAMIDE; N [2 (1H INDOL 3 YL)ETHYL] 4 METHYLBENZENESULFONAMIDE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.5; POTASSIUM CHANNEL KV1.5 INHIBITOR; SODIUM 4 (CYCLOPENTYLOXY)BENZENESULFONATE; SODIUM 4 BUTOXYBENZENESULFONATE; SODIUM 4 ISOBUTOXYBENZENESULFONATE; SODIUM 4 ISOPROPOXYBENZENESULFONATE; SODIUM CHANNEL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EVENT RELATED POTENTIAL; GUINEA PIG; IN VITRO STUDY; ISOLATED HEART; MALE; NONHUMAN; PATCH CLAMP; PHARMACODYNAMICS; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

RATTUS;

ATRIAL FIBRILLATION (AF); INDOLE DERIVATIVES; KV1.5; STRUCTURE-ACTIVITY RELATIONSHIP (SAR);

ANIMALS; DRUG DESIGN; HALF-LIFE; HEART; HEK293 CELLS; HUMANS; HYDRAZONES; INDOLES; KV1.5 POTASSIUM CHANNEL; MALE; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885177366     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.041     Document Type: Article

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