Medical and ethical considerations in uterus transplantation

International Journal of Gynecology and Obstetrics

Volumn 123, Issue 2, 2013, Pages 173-177

  Benagiano, Giuseppe ^a   Landeweerd, Laurens ^b,c   Brosens, Ivo ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Immunosuppressive therapy; Medical ethics; Pregnancy; Pregnancy complications; Uterus transplantation

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ARTERIOLE; ARTICLE; BLOOD VESSEL SHUNT; CHILDBIRTH; DECIDUA; DECIDUALIZATION; EMBRYO DEVELOPMENT; GESTATIONAL AGE; GRAFT RECIPIENT; HEALTH HAZARD; HUMAN; MEDICAL ETHICS; NIDATION; NONHUMAN; ORGAN TRANSPLANTATION; PREGNANCY; PRIORITY JOURNAL; REPRODUCTION; UTERUS; UTERUS BLOOD FLOW; UTERUS TRANSPLANTATION;

IMMUNOSUPPRESSIVE THERAPY; MEDICAL ETHICS; PREGNANCY; PREGNANCY COMPLICATIONS; UTERUS TRANSPLANTATION;

ETHICS, MEDICAL; FEMALE; HUMANS; ORGAN TRANSPLANTATION; PREGNANCY; PREGNANCY OUTCOME; REPRODUCTIVE TECHNIQUES, ASSISTED; TREATMENT OUTCOME; UTERUS;

EID: 84885176109     PISSN: 00207292     EISSN: 18793479     Source Type: Journal    
DOI: 10.1016/j.ijgo.2013.05.010     Document Type: Article

References (44)

1. Murray JE, Merrill JP, Harrison JH, Wilson RE, Dammin GJ. Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. N Engl J Med 1963;268:1315-23.
2. Toledo-Pereyra LH, Sutherland DE. Richard Carlton Lillehei: transplant and shock surgical pioneer. J Invest Surg 2011;24(2):49-52.
3. Starzl TE, Groth CG, Brettschneider L, Penn I, Fulginiti VA, Moon JB, et al. Orthotopic homotransplantation of the human liver. Ann Surg 1968;168(3):392-415.
4. Barnard CN. What we have learned about heart transplants. J Thorac Cardiovasc Surg 1968;56(4):457-68.
5. Gatti RA,Meuwissen HJ, Allen HD, Hong R, Good RA. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 1968;2(7583): 1366-9.
6. Starzl TE. Organ transplantation: A practical triumph and epistemologic collapse. Proc Am Philos Soc 2003;147(3):226-45.
7. Watson CJ, Dark JH. Organ transplantation: historical perspective and current practice. Br J Anaesth 2012;108(SUPPL. 1):i29-42.
8. Ohe H, Li Y, Nafady-Hego H, Kayo W, Sakaguchi S,Wood K, et al. Minimal but essential doses of immunosuppression: A more realistic approach to improve long-term outcomes for pediatric living-donor liver transplantation. Transplantation 2011;91(7): 808-10.
9. Starzl TE. Chimerism and tolerance in transplantation. Proc Natl Acad Sci U S A 2004;101(SUPPL. 2):14607-14. (Pubitemid 39346731)
10. Starzl TE, Rao AS, TruccoM, Fontes P, Fung JJ, Demetris AJ. Explanation for loss of the HLA matching effect. Transplant Proc 1995;27(1):57-60.
11. Donnez J, DolmansMM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet 2004;364(9443): 1405-10. (Pubitemid 39370715)
12. Andersen CY, Silber SJ, Bergholdt SH, Jorgensen JS, Ernst E. Long-term duration of function of ovarian tissue transplants: case reports. Reprod Biomed Online 2012;25(2):128-32.
13. Kandela P. Uterine transplantation failure causes Saudi Arabian government clampdown. Lancet 2000;356(9232):838.
14. Fageeh W. Apology to Dr Wafa Mohammed Khalil Fageeh, obstetrician and gynaecologist and assistant professor at King Abdilaziz University, and her medical team. Lancet 2001;358(9287):1076.
15. FageehW, Raffa H, Jabbad H, Marzouki A. Transplantation of the human uterus. Int J Gynecol Obstet 2002;76(3):245-51. (Pubitemid 34203648)
16. Hansen A. Swedish surgeons report world's first uterus transplantations from mother to daughter. BMJ 2012;345:e6357.
17. Ozkan O, Akar ME, Ozkan O, Erdogan O, Hadimioglu N, Yilmaz M, et al. Preliminary results of the first human uterus transplantation from a multiorgan donor. Fertil Steril 2013;99(2):470-6.
18. Brosens I, Pijnenborg R, Benagiano G. Risk of Obstetrical Complications in Organ Transplant Recipient Pregnancies. Transplantation 2013
19. in press.
20. McKay DB, Josephson MA. Pregnancy after kidney transplantation. Clin J Am Soc Nephrol 2008;3(SUPPL. 2):S117-25.
21. Deshpande NA, James NT, Kucirka LM, Boyarsky BJ, Garonzik-Wang JM,Montgomery RA, et al. Pregnancy outcomes in kidney transplant recipients: A systematic review and meta-analysis. Am J Transplant 2011;11(11):2388-404.
22. Deshpande NA, James NT, Kucirka LM, Boyarsky BJ, Garonzik-Wang JM, Cameron AM, et al. Pregnancy outcomes of liver transplant recipients: A systematic review and meta-analysis. Liver Transpl 2012;18(6):621-9.
23. Kociszewska-Najman B, Pietrzak B, Cyganek A, Szpotanska-Sikorska M, Schreiber- Zamora J, Jabiry-Zieniewicz Z, et al. Intrauterine hypotrophy and premature births in neonates delivered by female renal and liver transplant recipients. Transplant Proc 2011;43(8):3048-51.
24. Catsanos R, Rogers W, Lotz M. The ethics of uterus transplantation. Bioethics 2013;27(2): 65-73.
25. Lefkowitz A, Edwards M, Balayla J. The Montreal Criteria for the Ethical Feasibility of Uterine Transplantation. Transpl Int 2012;25(4):439-47.
26. Brosens I, Ghaem-Maghami S, Pijnenborg R. Uterus transplantation in the human: A complex surgical, medical and ethical challenge. Hum Reprod 2013;28(2): 292-3.
27. Saso S, Ghaem-Maghami S, Chatterjee J, Brewig N, Ungar L, Smith JR, et al. Immunology of uterine transplantation: A review. Reprod Sci 2012;19(2):123-34.
28. Br?nnstr?m M, Diaz-Garcia C, Hanafy A, Olausson M, Tzakis A. Uterus transplantation: Animal research and human possibilities. Fertil Steril 2012;97(6):1269-76.
29. Petruzzo P, Lanzetta M, Dubernard JM, Landin L, Cavadas P, Margreiter R, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation 2010;90(12):1590-4.
30. Wranning CA, Akhi SN, Diaz-Garcia C, Br?nnstr?m M. Pregnancy after syngeneic uterus transplantation and spontaneous mating in the rat. Hum Reprod 2011;26(3):553-8.
31. Enskog A, Johannesson L, Chai DC, Dahm-K?hler P,Marcickiewicz J, Nyachieo A, et al. Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation. Hum Reprod 2010;25(8):1980-7.
32. Mihara M, Kisu I,HaraH, Iida T, Yamamoto T, Araki J, et al. Uterus autotransplantation in cynomolgus macaques: intraoperative evaluation of uterine blood flow using indocyanine green. Hum Reprod 2011;26(11):3019-27.
33. Kisu I, Mihara M, Banno K, Hara H, Yamamoto T, Araki J, et al. A new surgical technique of uterine auto-transplantation in cynomolgus monkey: Preliminary report about two cases. Arch Gynecol Obstet 2012;285(1):129-37.
34. Johannesson L, Enskog A, Dahm-K?hler P, Hanafy A, Chai DC,Mwenda JM, et al. Uterus transplantation in a non-human primate: long-term follow-up after autologous transplantation. Hum Reprod 2012;27(6):1640-8.
35. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol 2011;204(3): 193-201.
36. Brosens IA, RobertsonWB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1972;1:177-91.
37. Pijnenborg R, Bland JM, Robertson WB, Brosens I. Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta 1983;4(4):397-413. (Pubitemid 13005635)
38. Brosens JJ, Pijnenborg R, Brosens IA. The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: A review of the literature.Am J Obstet Gynecol 2002;187(5):1416-23. (Pubitemid 35397496)
39. Kimball Watson J. The Womb and Reproductive Technologies: Telos and Integrity. http://culture-of-life.org/womb-and-reproductive-technologies-telos- and-integrity. Published December 28, 2010.
40. Teklenburg G, Salker M, Molokhia M, Lavery S, Trew G, Aojanepong T, et al. Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One 2010;5(4):e10258.
41. Pijnenborg R, Vercruysse L, Brosens I. Deep placentation. Best Pract Res Clin Obstet Gynaecol 2011;25(3):273-85.
42. Khong Y, Brosens I. Defective deep placentation. Best Pract Res Clin Obstet Gynaecol 2011;25(3):301-11.
43. Myatt L. Placental adaptive responses and fetal programming. J Physiol 2006;572(Pt 1):25-30.
44. Milliez J. Uterine transplantation FIGO Committee for the Ethical Aspects of Human Reproduction and Women's Health. Int J Gynecol Obstet 2009;106(3): 270.