Uterus transplantation in the human: A complex surgical, medical and ethical challenge

Human Reproduction

Volumn 28, Issue 2, 2013, Pages 292-293

  Brosens, Ivo ^a,b   Ghaem Maghami, Sadaf ^c   Pijnenborg, Robert ^d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b LEUVEN INSTITUTE FOR FERTILITY AND EMBRYOLOGY   (Belgium)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIRTH WEIGHT; BLOOD VESSEL SHUNT; DOPPLER ECHOGRAPHY; ETHICS; HUMAN; HYSTERECTOMY; IMMUNOSUPPRESSIVE TREATMENT; MEDICAL RESEARCH; NONHUMAN; NOTE; ORGAN TRANSPLANTATION; PREGNANCY; REPRODUCTION; SURGICAL INJURY; UTERUS TRANSPLANTATION; VASCULARIZATION;

EID: 84872540042     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des407     Document Type: Note

References (14)

1. Brännström M, Diaz-Garcia C, Hanafy A, Olausson M, Tzakis A. Uterus transplantation: animal research and human possibilities. Fertil Steril 2012;97: 1269-1276.
2. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The 'Great Obstetrical Syndromes' are associated with disorders of deep placentation. Am J Obstet Gynecol 2011;204: 193-201.
3. Dahm-Kahler P, Wranning C, Lundmark C, Enskog A, Molne J, Marcickiewicz J, El-Akouri RR, McCracken J, Brännström M. Transplantation of the uterus in sheep: methodology and early reperfusion events. J Obstet Gynaecol Res 2008;34: 784-793.
4. Del Priore G, Saso S, Meslin EM, Tzakis A, Brännström M, Clarke A, Vianna R, Sawyer R, Smith JR. Uterine transplantation-a real possibility? The Indianapolis consensus. Hum Reprod 2012. doi: 10.1093/humrep/des406.
5. Enskog A, Johannesson L, Chai DC, Dahm-Kahler P, Marcickiewicz J, Nyachieo A, Mwenda JM, Brännström M. Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation. Hum Reprod 2010;25: 1980-1987.
6. Fageeh W, Raffa H, Jabbad H, Marzouki A. Transplantation of the human uterus. Int J Gynecol Obstet 2002;76: 245-251.
7. Hansen A. Swedish surgeons report world's first uterus transplantations from mother to daughter. BMJ 2012;345: e6357.
8. Johannesson L, Enskog A, Dahm-Kahler P, Hanafy A, Chai DC, Mwenda JM, Diaz-Garcia C, Olausson M, Brännström M. Uterus transplantation in a non-human primate: long-term follow-up after autologous transplantation. Hum Reprod 2012;27: 1640-1648.
9. Kisu I, Mihara M, Banno K, Hara H, Yamamoto T, Araki J, Iida T, Hayashi Y, Moriguchi H, Aoki D. A new surgical technique of uterine auto-transplantation in cynomolgus monkey: preliminary report about two cases. Archiv Gynecol Obstet 2012;285: 129-137.
10. Mihara M, Kisu I, Hara H, Iida T, Yamamoto T, Araki J, Hayashi Y, Moriguchi H, Narushima M, Banno K. Uterus autotransplantation in cynomolgus macaques: intraoperative evaluation of uterine blood flow using indocyanine green. Hum Reprod 2011;26: 3019-3027.
11. Pijnenborg R, Bland JM, Robertson WB, Brosens I. Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta 1983;4: 397-413.
12. Sieunarine K, Boyle DCM, Corless DJ, Noakes DE, Ungar L, Marr CE, Lindsay I, Del Priore G, Smith JR. Pelvic vascular prospects for uterine transplantation. Int Surgery 2006;91: 217-222.
13. Tendron A, Gouyon J-B, Decramer S. In utero exposure to immunosuppressive drugs: experimental and clinical studies. Pediatr Nephrol 2002;17: 121-130.
14. Wranning CA, Akhi SN, Diaz-Garcia C, Brännström M. Pregnancy after syngeneic uterus transplantation and spontaneous mating in the rat. Hum Reprod 2011;26: 553-558.