Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy- 2-methylpropanamide] in rats

Xenobiotica

Volumn 43, Issue 11, 2013, Pages 993-1009

  Kim, Juhyun ^a   Wang, Ronghua ^b   Veverka, Karen A ^a   Dalton, James T ^a  

^a GTx Inc   (United States)

^b QPS LLC   (United States)

Author keywords

Mass balance; Pharmacokinetics; Quantitative whole body autoradiography

Indexed keywords

ALCOHOL; AMIDE; CARBON 14; DRUG METABOLITE; ENOBOSARM; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG OXIDATION; DRUG URINE LEVEL; FEMALE; HALF LIFE TIME; MALE; NONHUMAN; PLASMA CLEARANCE; RADIOACTIVITY; RAT; SINGLE DRUG DOSE; TISSUE DISTRIBUTION;

ABSORPTION; ADMINISTRATION, ORAL; AMIDES; ANIMALS; AUTORADIOGRAPHY; BIOTRANSFORMATION; FECES; FEMALE; MALE; MASS SPECTROMETRY; METABOLOMICS; RADIOACTIVITY; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84885152692     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2013.788233     Document Type: Article

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