Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Ren, Zhenhua ^a,b   Wang, Jiayin ^a   Wang, Shuyan ^a   Zou, Chunlin ^a   Li, Xiaobo ^a,c   Guan, Yunqian ^a   Chen, Zhiguo ^a   Zhang, Y Alex ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c NORTHERN JIANGSU PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOGENIC AMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; TECHNETIUM COMPLEX; TECHNETIUM TC 99M TRODAT 1; TECHNETIUM TC 99M TRODAT-1; TROPANE DERIVATIVE;

ANIMAL; ARTICLE; AUTOTRANSPLANTATION; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GENE ORDER; GENETICS; INTOXICATION; MACACA FASCICULARIS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; MOTOR ACTIVITY; SUBSTANTIA NIGRA;

ANIMALS; BIOGENIC MONOAMINES; CORPUS STRIATUM; DOPAMINERGIC NEURONS; GENE EXPRESSION; GENE ORDER; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MACACA FASCICULARIS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MOTOR ACTIVITY; MPTP POISONING; ORGANOTECHNETIUM COMPOUNDS; SUBSTANTIA NIGRA; TRANSPLANTATION, AUTOLOGOUS; TROPANES;

EID: 84885128563     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02786     Document Type: Article

References (51)

1. de Rijk, M. C. et al. Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54, S21-23 (2000). (Pubitemid 30390601)
2. Choi-Lundberg, D. L. et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 275, 838-841 (1997). (Pubitemid 27074886)
3. Gash, D. M. et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380, 252-255 (1996). (Pubitemid 26090648)
4. Tomac, A. et al. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373, 335-339 (1995).
5. Tomac, A. et al. Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc Natl Acad Sci USA 92, 8274-8278 (1995).
6. Gill, S. S. et al.Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 9, 589-595 (2003). (Pubitemid 36597106)
7. Slevin, J. T. et al. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell linederived neurotrophic factor. J Neurosurg 102, 216-222 (2005). (Pubitemid 43194069)
8. Patel, N. K. et al. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Ann Neurol 57, 298-302 (2005). (Pubitemid 40179870)
9. Lang, A. E. et al. Randomized controlled trial of intraputamenal glial cell linederived neurotrophic factor infusion in Parkinson disease. Ann Neurol 59, 459-466 (2006). (Pubitemid 43358066)
10. Sherer, T. B., Fiske, B. K., Svendsen, C. N., Lang, A. E. & Langston, J. W. Crossroads in GDNF therapy for Parkinson's disease. Mov Disord 21, 136-141 (2006).
11. Nutt, J. G. et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60, 69-73 (2003). (Pubitemid 36070646)
12. Kordower, J. H. et al.Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773 (2000).
13. Eslamboli, A. et al. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. J Neurosci 25, 769-777 (2005). (Pubitemid 40170991)
14. Emborg, M. E. et al. GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. Cell Transplant 17, 383-395 (2008). (Pubitemid 351717341)
15. Behrstock, S. et al. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther 13, 379-388 (2006).
16. Grealish, S. et al. The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease. Brain 133, 482-495 (2010).
17. Chen, Z. et al. MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts. PLoS One 6, e14787, http://dx.doi.org/10.1371/journal. pone.0014787 (2011).
18. Chen, Z. & Palmer, T. D. Cellular repair of CNS disorders: an immunological perspective. Hum Mol Genet 17, R84-92 (2008).
19. Dauer, W. & Przedborski, S. Parkinson's disease: mechanisms and models. Neuron 39, 889-909 (2003). (Pubitemid 37130207)
20. Foley, P. & Riederer, P. Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson's disease. J Neurol 247 Suppl 2, II82-94 (2000).
21. Le Blanc, K. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 5, 485-489 (2003). (Pubitemid 38028708)
22. Keyser, K. A., Beagles, K. E. & Kiem, H. P. Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation. Cell Transplant 16, 555-562 (2007). (Pubitemid 351448291)
23. Chen, M. F. et al. The sensitivity of human mesenchymal stem cells to ionizing radiation. Int J Radiat Oncol Biol Phys 66, 244-253 (2006).
24. Valle-Prieto, A. & Conget, P. A. Human mesenchymal stem cells efficiently manage oxidative stress. Stem Cells Dev 19, 1885-1893 (2010).
25. Kurozumi, K. et al. Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol Ther 11, 96-104 (2005). (Pubitemid 40012003)
26. Cova, L. et al. Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease. Brain Res 1311, 12-27 (2010).
27. Venkataramana, N. K. et al. Open-labeled study of unilateral autologous bonemarrow-derived mesenchymal stem cell transplantation in Parkinson's disease. Transl Res 155, 62-70 (2010).
28. Ke, H. et al. Derivation, characterization and gene modification of cynomolgus monkey mesenchymal stem cells. Differentiation 77, 256-262 (2009).
29. Jones-Engel, L. et al. Sensitive assays for simian foamy viruses reveal a high prevalence of infection in commensal, free-ranging Asian monkeys. J Virol 81, 7330-7337 (2007). (Pubitemid 47047822)
30. Lee, C. C., Ye, F. & Tarantal, A. F. Comparison of growth and differentiation of fetal and adult rhesus monkey mesenchymal stem cells. Stem Cells Dev 15, 209-220 (2006). (Pubitemid 43726499)
31. Iversen, L. L. Role of transmitter uptake mechanisms in synaptic neurotransmission. Br J Pharmacol 41, 571-591 (1971).
32. Beck, K. D. et al. GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Neuron 16, 665-673 (1996). (Pubitemid 26101115)
33. German, D. C., Manaye, K., Smith, W. K., Woodward, D. J. & Saper, C. B. Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization. Ann Neurol 26, 507-514 (1989). (Pubitemid 19247226)
34. Ren, Z. et al. Spontaneous transformation of adult mesenchymal stem cells from cynomolgus macaques in vitro. Exp Cell Res 317, 2950-2957 (2011).
35. Ren, Z., Zhang, Y. A. & Chen, Z. Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysis. Exp Cell Res 318, 435-440 (2012).
36. Switzer, W. M. et al. Ancient co-speciation of simian foamy viruses and primates. Nature 434, 376-380 (2005). (Pubitemid 40469179)
37. Lindvall, O. et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247, 574-577 (1990).
38. Olanow, C. W. et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 54, 403-414 (2003). (Pubitemid 37072046)
39. Freed, C. R. et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344, 710-719 (2001). (Pubitemid 32204988)
40. Kim, B. S. et al. Growth, differentiation, and biochemical signatures of rhesus monkey mesenchymal stem cells. Stem Cells Dev 17, 185-198 (2008). (Pubitemid 351271609)
41. Ye, Z., Yu, X. & Cheng, L. Lentiviral gene transduction of mouse and human stem cells. Methods Mol Biol 430, 243-253 (2008).
42. Kim, S. H., Lee, W. J., Lim, H. K. & Park, C. K. SPIO-enhanced MRI findings of well-differentiated hepatocellular carcinomas: correlation with MDCT findings. Korean J Radiol 10, 112-120 (2009).
43. Bezard, E., Imbert, C., Deloire, X., Bioulac, B. & Gross, C. E. A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey. Brain Res 766, 107-112 (1997). (Pubitemid 27431440)
44. Stephenson, D. T. et al. The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-treated squirrel monkeys. J Pharmacol Exp Ther 314, 1257-1266 (2005). (Pubitemid 41205992)
45. Kurlan, R., Kim, M. H. & Gash, D. M. Oral levodopa dose-response study in MPTP-induced hemiparkinsonian monkeys: assessment with a new rating scale for monkey parkinsonism. Mov Disord 6, 111-118 (1991).
46. Gash, D. M. et al. An automated movement assessment panel for upper limb motor functions in rhesusmonkeys and humans. J Neurosci Methods 89, 111-117 (1999). (Pubitemid 29361505)
47. Maswood, N. et al. Effects of chronic intraputamenal infusion of glial cell linederived neurotrophic factor (GDNF) in aged Rhesus monkeys. Neurobiol Aging 23, 881-889 (2002). (Pubitemid 35217713)
48. Zhang, Z. et al. Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging. J Gerontol A Biol Sci Med Sci 55, B473-480 (2000). (Pubitemid 32010283)
49. Huang, W. S. et al. 99mTc-TRODAT-1 SPECT in healthy and 6-OHDA lesioned parkinsonian monkeys: comparison with 18F-FDOPA PET. Nucl Med Commun 24, 77-83 (2003).
50. Geng, Y. et al. Investigating the role of 99mTc-TRODAT-1 SPECT imaging in idiopathic Parkinson's disease. J Zhejiang Univ Sci B 6, 22-27 (2005).
51. Davidson, C., Coomber, B., Gibson, C. L. & Young, A. M. Effect of pre-ischaemic conditioning on hypoxic depolarization of dopamine efflux in the rat caudate brain slice measured in real-time with fast cyclic voltammetry. Neurochem Int 59, 714-721 (2011).