Modafinil increases reward salience in a slot machine game in low and high impulsivity pathological gamblers

Neuropharmacology

Volumn 73, Issue , 2013, Pages 66-74

  Smart, Kelly ^a,b   Desmond, Renée C ^a   Poulos, Constantine X ^b   Zack, Martin ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Dopamine; Modafinil; Pathological gambling; Reward; Salience

Indexed keywords

MODAFINIL; PLACEBO;

ADULT; ARTICLE; CALIBRATION; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CUMULATIVE WINNINGS; DISEASE CLASSIFICATION; FEMALE; GAMBLING; GAME; HUMAN; IMPULSIVENESS; MACHINE; MALE; PATHOLOGICAL GAMBLING; PAYOFF BET SIZE CORRELATION; PHASE TRANSITION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REGRESSION ANALYSIS; REWARD; SCORING SYSTEM; SLOT MACHINE; STIMULUS RESPONSE;

DOPAMINE; MODAFINIL; PATHOLOGICAL GAMBLING; REWARD; SALIENCE;

ADULT; BENZHYDRYL COMPOUNDS; DOUBLE-BLIND METHOD; FEMALE; GAMBLING; HUMANS; IMPULSIVE BEHAVIOR; MALE; NOOTROPIC AGENTS; PSYCHOMOTOR PERFORMANCE; REWARD;

EID: 84885127994     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.05.015     Document Type: Article

References (50)

1. Bakken, I.J., Gotestam, K.G., Grawe, R.W., Wenzel, H.G., Oren, A., 2009. Gambling behavior and gambling problems in Norway 2007. Scand. J. Psychol. 50, 333-339.
2. Beaudoin, C.M., Cox, B.J., 1999. Characteristics of problem gambling in a Canadian context: a preliminary study using a DSM-IV-based questionnaire. Can. J. Psychiatry 44, 483-487.
3. Berridge, K.C., 2007. The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl) 191, 391-431.
4. Clark, L., Lawrence, A.J., Astley-Jones, F., Gray, N., 2009. Gambling near-misses enhance motivation to gamble and recruit win-related brain circuitry. Neuron 61, 481-490.
5. Dackis, C.A., Kampman, K.M., Lynch, K.G., Pettinati, H.M., O'Brien, C.P., 2005. A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology 30, 205-211.
6. Dannon, P.N., Lowengrub, K., Musin, E., Gonopolski, Y., Kotler, M., 2005. Sustained-release bupropion versus naltrexone in the treatment of pathological gambling: a preliminary blind-rater study. J. Clin. Psychopharmacol. 25, 593-596.
7. Dayan, P., Balleine, B.W., 2002. Reward, motivation, and reinforcement learning. Neuron 36, 285-298.
8. de Wit, H., Crean, J., Richards, J.B., 2000. Effects of d-amphetamine and ethanol on a measure of behavioral inhibition in humans. Behav. Neurosci. 114, 830-837.
9. Di Russo, F., Zaccara, G., Ragazzoni, A., Pallanti, S., 2000. Abnormal visual event-related potentials in obsessive-compulsive disorder without panic disorder or depression comorbidity. J. Psychiatr. Res. 34, 75-82.
10. Dixon, M.J., Harrigan, K.A., Sandhu, R., Collins, K., Fugelsang, J.A., 2010. Losses disguised as wins in modern multi-line video slot machines. Addiction 105, 1819-1824.
11. el-Guebaly, N., Patten, S.B., Currie, S., Williams, J.V., Beck, C.A., Maxwell, C.J., Wang, J.L., 2006. Epidemiological associations between gambling behavior, substance use & mood and anxiety disorders. J. Gambl Stud. 22, 275-287.
12. Eysenck, S.B.G., Pearson, P.R., Easting, G., Allsopp, J.F., 1985. Age norms for impulsiveness, venturesomeness, and empathy in adults. Person Individ. Diff. 6, 613-619.
13. Gamo, N.J., Wang, M., Arnsten, A.F., 2010. Methylphenidate and atomoxetine enhance prefrontal function through alpha2-adrenergic and dopamine D1 receptors. J. Am. Acad. Child. Adolesc. Psychiatry 49, 1011-1023.
14. Goudriaan, A.E., Oosterlaan, J., De Beurs, E., Van Den Brink, W., 2008. The role of self-reported impulsivity and reward sensitivity versus neurocognitive measures of disinhibition and decision-making in the prediction of relapse in pathological gamblers. Psychol. Med. 38, 41-50.
15. Grall-Bronnec, M., Wainstein, L., Feuillet, F., Bouju, G., Rocher, B., Venisse, J.L., Sebille-Rivain, V., 2012. Clinical profiles as a function of level and type of impulsivity in a sample group of at-risk and pathological gamblers seeking treatment. J. Gambl Stud. 28, 239-252.
16. Grant, J.E., Chamberlain, S.R., Odlaug, B.L., Potenza, M.N., Kim, S.W., 2010. Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study. Psychopharmacology (Berl) 212, 603-612.
17. Grant, J.E., Odlaug, B.L., Schreiber, L.R., 2012. Pharmacological treatments in pathological gambling. Br. J. Clin. Pharmacol. http://dx.doi.org/10.1111/j.1365-2125.2012.04457.x. [Epub ahead of print].
18. Hamilton, M., 1959. The assessment of anxiety states by rating. Br. J. Med. Psychol. 32, 50-55.
19. Hamilton, M., 1960. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23, 56-62.
20. Hewig, J., Kretschmer, N., Trippe, R.H., Hecht, H., Coles, M.G., Holroyd, C.B., Miltner, W.H., 2010. Hypersensitivity to reward in problem gamblers. Biol. Psychiatry 67, 781-783.
21. Hikosaka, O., Bromberg-Martin, E., Hong, S., Matsumoto, M., 2008. New insights on the subcortical representation of reward. Curr. Opin. Neurobiol. 18, 203-208.
22. Hodgins, D.C., Schopflocher, D.P., Martin, C.R., El-Guebaly, N., Casey, D.M., Currie, S.R., Smith, G.J., Williams, R.J., 2012. Disordered gambling among higher-frequency gamblers: who is at risk? Psychol. Med., 1-12.
23. Kahbazi, M., Ghoreishi, A., Rahiminejad, F., Mohammadi, M.R., Kamalipour, A., Akhondzadeh, S., 2009. A randomized, double-blind and placebo-controlled trial of modafinil in children and adolescents with attention deficit and hyperactivity disorder. Psychiatry Res. 168, 234-237.
24. Kalechstein, A.D., Fong, T., Rosenthal, R.J., Davis, A., Vanyo, H., Newton, T.F., 2007. Pathological gamblers demonstrate frontal lobe impairment consistent with that of methamphetamine-dependent individuals. J. Neuropsychiatry Clin. Neurosci. 19, 298-303.
25. Lesieur, H.R., Blume, S.B., 1987. The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers. Am. J. Psychiatry 144, 1184-1188.
26. McNichol, D., 1972. A Primer of Signal Detection Theory. George Allen & Unwin, London.
27. Minzenberg, M.J., Carter, C.S., 2008. Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33, 1477-1502.
28. Muller, C.A., Banas, R., Heinz, A., Hein, J., 2011. Treatment of pathological gambling with disulfiram: a report of 2 cases. Pharmacopsychiatry 44, 81-83.
29. Niv, Y., 2007. Cost, benefit, tonic, phasic: what do response rates tell us about dopamine and motivation? Ann. N. Y Acad. Sci. 1104, 357-376.
30. Niv, Y., Daw, N.D., Joel, D., Dayan, P., 2007. Tonic dopamine: opportunity costs and the control of response vigor. Psychopharmacology (Berl) 191, 507-520.
31. Oberg, S.A., Christie, G.J., Tata, M.S., 2011. Problem gamblers exhibit reward hypersensitivity in medial frontal cortex during gambling. Neuropsychologia 49, 3768-3775.
32. Paterson, N.E., Fedolak, A., Olivier, B., Hanania, T., Ghavami, A., Caldarone, B., 2010. Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents. Pharmacol. Biochem. Behav. 95, 449-456.
33. Pessiglione, M., Seymour, B., Flandin, G., Dolan, R.J., Frith, C.D., 2006. Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 442, 1042-1045.
34. Petry, N.M., 2003. A comparison of treatment-seeking pathological gamblers based on preferred gambling activity. Addiction 98, 645-655.
35. Petry, N.M., Stinson, F.S., Grant, B.F., 2005. Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J. Clin. Psychiatry 66, 564-574.
36. Robbins, T.W., Everitt, B.J., 2007. A role for mesencephalic dopamine in activation: commentary on Berridge (2006). Psychopharmacology (Berl) 191, 433-437.
37. Robertson Jr., P., Hellriegel, E.T., 2003. Clinical pharmacokinetic profile of modafinil. Clin. Pharmacokinet. 42, 123-137.
38. Saez-Abad, C., Bertolin-Guillen, J.M., 2008. Personality traits and disorders in pathological gamblers versus normal controls. J. Addict. Dis. 27, 33-40.
39. Shao, R., Read, J., Behrens, T.E., Rogers, R.D., 2013. Shifts in reinforcement signalling while playing slot-machines as a function of prior experience and impulsivity. Transl. Psychiatry 3, e235.
40. Skinner, H.A., Allen, B.A., 1982. Alcohol dependence syndrome: measurement and validation. J. Abnorm. Psychol. 91, 199-209.
41. Sobell, L.C., Sobell, M.B., 1992. Timeline followback: a technique for assessing self-reported alcohol consumption. In: Litten, R.Z., Allen, J. (Eds.), Measuring Alcohol Consumption: Psychosocial and Biological Methods. Humana Press., Totowa, New Jersey, pp. 41-72.
42. Sofuoglu, M., DeVito, E.E., Waters, A.J., Carroll, K.M., 2012. Cognitive enhancement as a treatment for drug addictions. Neuropharmacology 64, 452-463.
43. Spencer, R.C., Klein, R.M., Berridge, C.W., 2012. Psychostimulants act within the prefrontal cortex to improve cognitive function. Biol. Psychiatry 72, 221-227.
44. Stoops, W.W., Lile, J.A., Fillmore, M.T., Glaser, P.E., Rush, C.R., 2005. Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration. Psychopharmacology (Berl) 182, 186-193.
45. Sugam, J.A., Day, J.J., Wightman, R.M., Carelli, R.M., 2012. Phasic nucleus accumbens dopamine encodes risk-based decision-making behavior. Biol. Psychiatry 71, 199-205.
46. Tremblay, A.M., Desmond, R.C., Poulos, C.X., Zack, M., 2011. Haloperidol modifies instrumental aspects of slot machine gambling in pathological gamblers and healthy controls. Addict. Biol. 16, 467-484.
47. Turner, N.E., Wiebe, J., Falkowski-Ham, A., Kelly, J., Skinner, W., 2005. Public awareness of responsible gambling and gambling behaviours in Ontario. Int. Gambl. Stud. 5, 95-112.
48. Volkow, N.D., Fowler, J.S., Logan, J., Alexoff, D., Zhu, W., Telang, F., Wang, G.J., Jayne, M., Hooker, J.M., Wong, C., Hubbard, B., Carter, P., Warner, D., King, P., Shea, C., Xu, Y., Muench, L., Apelskog-Torres, K., 2009. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 301, 1148-1154.
49. Volkow, N.D., Wang, G.J., Fowler, J.S., Ding, Y.S., 2005. Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol. Psychiatry 57, 1410-1415.
50. Zack, M., Poulos, C.X., 2009. Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivity. J. Psychopharmacol. 23, 660-671.