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Volumn 45, Issue 9, 2013, Pages 2007-2011

Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics

Author keywords

Drug drug interactions; Efflux transporter; Multidrug and toxin extrusion; Pharmacokinetics

Indexed keywords

ACICLOVIR; CAPTOPRIL; CEFALEXIN; CEFRADINE; CETIRIZINE; CIMETIDINE; CISPLATIN; DILTIAZEM; FAMOTIDINE; FEXOFENADINE; GANCICLOVIR; IMATINIB; INDINAVIR; LEVOFLOXACIN; MESNA; METFORMIN; MULTIDRUG AND TOXIN EXTRUSION PROTEIN; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 2; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 2K; MULTIDRUG AND TOXIN EXTRUSION PROTEIN1; ORGANIC CATION TRANSPORTER; OXALIPLATIN; PROCAINAMIDE; PROTEIN; QUINIDINE; QUININE; RITONAVIR; SLC47A1 PROTEIN; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84885114750     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.06.022     Document Type: Short Survey
Times cited : (65)

References (33)
  • 1
    • 84865396291 scopus 로고    scopus 로고
    • Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3)and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat
    • Ahmadimoghaddam D, Hofman J, Zemankova L., Nachtigal P, Dolezelova E, Cerveny L., et al Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3)and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat. Toxicological Sciences 2012; 128:471-81.
    • (2012) Toxicological Sciences , vol.128 , pp. 471-481
    • Ahmadimoghaddam, D.1    Hofman, J.2    Zemankova, L.3    Nachtigal, P.4    Dolezelova, E.5    Cerveny, L.6
  • 2
    • 84876709243 scopus 로고    scopus 로고
    • Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein
    • Ahmadimoghaddam D, Staud F. Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein. Reproductive Toxicology 2013; 39:17-22.
    • (2013) Reproductive Toxicology , vol.39 , pp. 17-22
    • Ahmadimoghaddam, D.1    Staud, F.2
  • 3
    • 84876737773 scopus 로고    scopus 로고
    • Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: Expression profile and fetus protective role at different stages ofgestation
    • Ahmadimoghaddam D, Zemankova L, Nachtigal P., Dolezelova E, Neumanova Z, Cer-veny L, et al Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: expression profile and fetus protective role at different stages ofgestation. Biology of Reproduction 2013; 88:55.
    • (2013) Biology of Reproduction , vol.88 , pp. 55
    • Ahmadimoghaddam, D.1    Zemankova, L.2    Nachtigal, P.3    Dolezelova, E.4    Neumanova, Z.5    Cer-Veny, L.6
  • 5
    • 84861540616 scopus 로고    scopus 로고
    • Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K
    • Astorga B, Ekins S, Morales M., Wright SH Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K. Journal of Pharmacology and Experimental Therapeutics 2012; 341:743-55.
    • (2012) Journal of Pharmacology and Experimental Therapeutics , vol.341 , pp. 743-755
    • Astorga, B.1    Ekins, S.2    Morales, M.3    Wright, S.H.4
  • 6
    • 62749133967 scopus 로고    scopus 로고
    • Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: A preliminary study
    • Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. Diabetes 2009; 58:745-9.
    • (2009) Diabetes , vol.58 , pp. 745-749
    • Becker, M.L.1    Visser, L.E.2    Van Schaik, R.H.3    Hofman, A.4    Uitterlinden, A.G.5    Stricker, B.H.6
  • 7
    • 80054935612 scopus 로고    scopus 로고
    • Mammalian MATE (SLC47A) transport proteins: Impact on efflux of endogenous substrates and xenobiotics
    • Damme K, Nies AT, Schaeffeler E, Schwab M. Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics. Drug Metabolism Reviews 2011; 43:499-523.
    • (2011) Drug Metabolism Reviews , vol.43 , pp. 499-523
    • Damme, K.1    Nies, A.T.2    Schaeffeler, E.3    Schwab, M.4
  • 8
    • 79955641199 scopus 로고    scopus 로고
    • Effects of metabolic acidosis on expression levels of renal drug transporters
    • Gaowa A, Motohashi H, Katsura T, Inui K. Effects of metabolic acidosis on expression levels of renal drug transporters. Pharmaceutical Research 2011; 28:1023-30.
    • (2011) Pharmaceutical Research , vol.28 , pp. 1023-1030
    • Gaowa, A.1    Motohashi, H.2    Katsura, T.3    Inui, K.4
  • 10
    • 83655183203 scopus 로고    scopus 로고
    • Interaction of human multidrug and toxin extrusion 1 (MATE1) transporter with antineoplastic agents
    • Grottker J, Rosenberger A, Burckhardt G, Hagos Y. Interaction of human multidrug and toxin extrusion 1 (MATE1) transporter with antineoplastic agents. Drug Metabolism and Drug Interactions 2011; 26:181-9.
    • (2011) Drug Metabolism and Drug Interactions , vol.26 , pp. 181-189
    • Grottker, J.1    Rosenberger, A.2    Burckhardt, G.3    Hagos, Y.4
  • 12
    • 70349742624 scopus 로고    scopus 로고
    • Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1
    • Ha Choi J., Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, et al Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenetics and Genomics 2009; 19:770-80.
    • (2009) Pharmacogenetics and Genomics , vol.19 , pp. 770-780
    • Ha Choi, J.1    Wah Yee, S.2    Kim, M.J.3    Nguyen, L.4    Ho Lee, J.5    Kang, J.O.6
  • 14
    • 84867869728 scopus 로고    scopus 로고
    • N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K)
    • Ito S, Kusuhara H, Kumagai Y., Moriyama Y, Inoue K, Kondo T., et al N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K). Clinical Pharmacology and Therapeutics 2012a; 92:635-41.
    • (2012) Clinical Pharmacology and Therapeutics , vol.92 , pp. 635-641
    • Ito, S.1    Kusuhara, H.2    Kumagai, Y.3    Moriyama, Y.4    Inoue, K.5    Kondo, T.6
  • 15
    • 84855995429 scopus 로고    scopus 로고
    • Ompetitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
    • Ito S, Kusuhara H, Yokochi M., Toyoshima J, Inoue K, Yuasa H, et al. ompetitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. Journal of Pharmacology and Experimental Therapeutics 2012b; 340:393-403.
    • (2012) Journal of Pharmacology and Experimental Therapeutics , vol.340 , pp. 393-403
    • Ito, S.1    Kusuhara, H.2    Yokochi, M.3    Toyoshima, J.4    Inoue, K.5    Yuasa, H.6
  • 18
    • 79956333806 scopus 로고    scopus 로고
    • Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects
    • Kusuhara H, Ito S, Kumagai Y., Jiang M, Shiroshita T, Moriyama Y., et al Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects. Clinical Pharmacology and Therapeutics 2011; 89:837-44.
    • (2011) Clinical Pharmacology and Therapeutics , vol.89 , pp. 837-844
    • Kusuhara, H.1    Ito, S.2    Kumagai, Y.3    Jiang, M.4    Shiroshita, T.5    Moriyama, Y.6
  • 19
    • 78549256786 scopus 로고    scopus 로고
    • Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha
    • Lu H, Gonzalez FJ, Klaassen C. Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicological Sciences 2010; 118:380-90.
    • (2010) Toxicological Sciences , vol.118 , pp. 380-390
    • Lu, H.1    Gonzalez, F.J.2    Klaassen, C.3
  • 20
    • 79955092770 scopus 로고    scopus 로고
    • Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins
    • Minematsu T, Giacomini KM Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins. Molecular Cancer Therapeutics 2011; 10:531-9.
    • (2011) Molecular Cancer Therapeutics , vol.10 , pp. 531-539
    • Minematsu, T.1    Giacomini, K.M.2
  • 22
    • 33947394472 scopus 로고    scopus 로고
    • Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats
    • DOI 10.1016/j.bcp.2006.12.034, PII S0006295207000032
    • Nishihara K, Masuda S, Ji L., Katsura T, Inui K. Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats. Biochemical Pharmacology 2007; 73:1482-90. (Pubitemid 46452587)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.9 , pp. 1482-1490
    • Nishihara, K.1    Masuda, S.2    Ji, L.3    Katsura, T.4    Inui, K.-I.5
  • 24
    • 51249105551 scopus 로고    scopus 로고
    • Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1
    • Sato T, Masuda S, Yonezawa A., Tanihara Y, Katsura T, Inui K. Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. Biochemical Pharmacology 2008; 76:894-903.
    • (2008) Biochemical Pharmacology , vol.76 , pp. 894-903
    • Sato, T.1    Masuda, S.2    Yonezawa, A.3    Tanihara, Y.4    Katsura, T.5    Inui, K.6
  • 26
    • 84871937263 scopus 로고    scopus 로고
    • Phar-macogenomic association between a variant in SLC47A1 gene and therapeutic response to metformin in type 2 diabetes
    • Tkac I, Klimcakova L, Javorsky M., Fabianova M, Schroner Z, Hermanova H, et al. Phar-macogenomic association between a variant in SLC47A1 gene and therapeutic response to metformin in type 2 diabetes. Diabetes, Obesity and Metabolism 2012; 15:189-91.
    • (2012) Diabetes, Obesity and Metabolism , vol.15 , pp. 189-191
    • Tkac, I.1    Klimcakova, L.2    Javorsky, M.3    Fabianova, M.4    Schroner, Z.5    Hermanova, H.6
  • 28
    • 66849142125 scopus 로고    scopus 로고
    • Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin
    • Tsuda M, Terada T, Mizuno T., Katsura T, Shimakura J, Inui K. Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. Molecular Pharmacology 2009; 75:1280-6.
    • (2009) Molecular Pharmacology , vol.75 , pp. 1280-1286
    • Tsuda, M.1    Terada, T.2    Mizuno, T.3    Katsura, T.4    Shimakura, J.5    Inui, K.6
  • 29
    • 69449098951 scopus 로고    scopus 로고
    • The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin
    • Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clinical Pharmacology and Therapeutics 2009; 86:299-306.
    • (2009) Clinical Pharmacology and Therapeutics , vol.86 , pp. 299-306
    • Tzvetkov, M.V.1    Vormfelde, S.V.2    Balen, D.3    Meineke, I.4    Schmidt, T.5    Sehrt, D.6
  • 30
    • 84873928187 scopus 로고    scopus 로고
    • Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling
    • Wittwer MB, Zur AA, Khuri N, Kido Y., Kosaka A, Zhang X, et al Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of Medicinal Chemistry 2013; 56:781-95.
    • (2013) Journal of Medicinal Chemistry , vol.56 , pp. 781-795
    • Wittwer, M.B.1    Zur, A.A.2    Khuri, N.3    Kido, Y.4    Kosaka, A.5    Zhang, X.6
  • 31
    • 34250764918 scopus 로고    scopus 로고
    • Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity
    • DOI 10.1016/j.bcp.2007.03.004, PII S0006295207001487
    • Yokoo S, Yonezawa A, Masuda S., Fukatsu A, Katsura T, Inui K. Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochemical Pharmacology 2007; 74:477-87. (Pubitemid 46963232)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.3 , pp. 477-487
    • Yokoo, S.1    Yonezawa, A.2    Masuda, S.3    Fukatsu, A.4    Katsura, T.5    Inui, K.-I.6
  • 32
    • 81355124801 scopus 로고    scopus 로고
    • Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharma-cogenomics
    • Yonezawa A, Inui K. Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharma-cogenomics. BritishJournal of Pharmacology 2011; 164:1817-25.
    • (2011) BritishJournal of Pharmacology , vol.164 , pp. 1817-1825
    • Yonezawa, A.1    Inui, K.2
  • 33
    • 84864987301 scopus 로고    scopus 로고
    • Twelve transmembrane helices form the functional core of Mammalian MATE1 (multidrug and toxin extruder 1) protein
    • Zhang X, He X, Baker J., Tama F, Chang G, Wright SH Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. Journal of Biological Chemistry 2012; 287:27971-82.
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 27971-27982
    • Zhang, X.1    He, X.2    Baker, J.3    Tama, F.4    Chang, G.5    Wright, S.H.6


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