Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits

Journal of Clinical Biochemistry and Nutrition

Volumn 53, Issue 2, 2013, Pages 114-121

  Fukuda, Naoki ^a   Ito, Tsunekata ^b   Ohwada, Kazuo ^a,b   Fujii, Junichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

Author keywords

Fatty acid synthase; Hepatic triglyceride lipase; Metabolic syndrome; Postprandial hypertriglyceridemia

Indexed keywords

FATTY ACID; MESSENGER RNA; TRIACYLGLYCEROL LIPASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; GENE; HYPERTRIGLYCERIDEMIA; LIPID HYDROLYSIS; LIPID METABOLISM; MALE; NONHUMAN; PATHOGENESIS; PLASMA; POLYMERASE CHAIN REACTION; POSTPRANDIAL HYPERTRIGLYCERIDEMIA; POSTPRANDIAL STATE; RABBIT; UPREGULATION;

EID: 84885095077     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.13-21     Document Type: Article

References (25)

1. United Nations, Demographic Yearbook System: Demographic Yearbook 2004. (http://unstats.un.org/unsd/demographic/products/dyb/dyb2004.htm)
2. Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004; 116: 337-350. (Pubitemid 38167322)
3. Metabolic syndrome Criteria Study Group. Definition and criteria for metabolic syndrome. JJpn Soc Intern Med 2005; 94: 188-213.
4. Brousseau ME, Hoeg JM. Transgenic rabbits as models for atherosclerosis research. J Lipid Res 1999; 40: 365-375. (Pubitemid 29116139)
5. Shiomi M, Ito T. The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe. Atherosclerosis 2009; 207: 1-7.
6. Kawai T, Ito T, Ohwada K, Mera Y, Matsushita M, Tomoike H. Hereditary postprandial hypertriglyceridemic rabbit exhibits insulin resistance and central obesity: A novel model of metabolic syndrome. Arterioscler Thromb Vase Biol 2006; 26: 2752-2757.
7. Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW. Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science 1986; 232: 1230-1237. (Pubitemid 16065997)
8. Mitsuguchi Y, Ito T, Ohwada K. Pathologic findings in rabbit models of hereditary hypertriglyceridemia and hereditary postprandial hypertriglyceridemia. Comp Med 2008; 58:465-480.
9. Hata M, Ito T, Ohwada K. Kinetic analysis of apolipoproteins in postprandial hypertriglyceridaemia rabbits. Lab Anim 2009; 43: 174-181.
10. Rozen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132: 365-386.
11. Coenen KR, Gruen ML, Hasty AH. Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-deficient mice. J Nutr Biochem 2007; 18: 727-735. (Pubitemid 47600650)
12. Abumrad NA, Davidson NO. Role of the gut in lipid homeostasis. Physiol Rev 2012; 92: 1061-1085.
13. Perret B, Mabile L, Martinez L, Tercc5 F, Barbaras R, Collet X. Hepatic lipase: structure/function relationship, synthesis, and regulation. J Lipid Res 2002; 43: 1163-1169. (Pubitemid 34988164)
14. Jones DR, Schmidt RJ, Pickard RT, Foxworthy PS, Eacho PL Estrogen receptor-mediated repression of human hepatic lipase gene transcription. J Lipid Res 2002; 43: 383-391. (Pubitemid 34252268)
15. Horton JD, Goldstein JL, Brown MS. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-1131. (Pubitemid 34496588)
16. Bertile F, Raclot T. mRNA levels of SREBP-lc do not coincide with the changes in adipose lipogenic gene expression. Biochem Biophys Res Commun 2004; 325: 827-834. (Pubitemid 39487947)
17. Claycombe KJ, Jones BH, Standridge MK, et al. Insulin increases fatty acid synthase gene transcription in human adipocytes. Am J Physiol 1998; 274: R1253-R1259.
18. Mead JR, Irvine SA, Ramji DP. Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med 2002; 80: 753-769. (Pubitemid 35478124)
19. Fan J, Wang J, Bensadoun A, et al. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc Natl Acad Sci USA 1994;91:8724-8728. (Pubitemid 24273737)
20. Chatterjee C, Sparks DL. Hepatic lipase, high-density lipoproteins, and hypertriglyceridemia. Am J Pathol 2011; 178: 1429-1433.
21. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232: 34-47. (Pubitemid 16037973)
22. Sheng Z, Otani H, Brown MS, Goldstein JL. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci USA 1995;92:935-938.
23. Takahashi S, Sakai J, Fujino T, et al. The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor. JAtheroscler Thromb 2004; 11: 200-208.
24. Nakayama T, Soma M, Saito S, et al. Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction. Am Heart J 2002; 143: 797-801. (Pubitemid 34595335)
25. Jansen H, Verhoeven AJ, Weeks L, et al. Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients. Arterioscler Thromb Vase Biol 1997;17:2837-2842. (Pubitemid 28016029)