N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats

Clinical Science

Volumn 126, Issue 1, 2014, Pages 85-94

  González, Germán E ^a,b   Rhaleb, Nour Eddine ^a,c   Nakagawa, Pablo ^a   Liao, Tang Dong ^a   Liu, Yunhe ^a   Leung, Pablo ^a   Dai, Xiangguo ^a   Yang, Xiao Ping ^a   Carretero, Oscar A ^a  

^a HENRY FORD HOSPITAL   (United States)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin II; Collagen; Fibrosis; Inflammation; Lymphocyte; Lysyl oxidase (LOX); N acetyl seryl aspartyl lysyl proline (Ac SDKP); Nuclear factor B (NF B)

Indexed keywords

ANGIOTENSIN II; COLLAGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; N ACETYL SERYL ASPARTYL LYSYL PROLINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS LINKING; DOWN REGULATION; EXTRACELLULAR MATRIX; HEART LEFT VENTRICLE FAILURE; HYPERTENSION; HYPERTROPHY; HYPOTENSION; INFLAMMATION; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID OXIDOREDUCTASES; ANGIOTENSIN II; ANIMALS; BODY WEIGHT; CARDIOMEGALY; CD4-POSITIVE T-LYMPHOCYTES; COLLAGEN; EXTRACELLULAR MATRIX; HYPERTENSION; INFLAMMATION; LUNG; MALE; NF-KAPPA B; OLIGOPEPTIDES; ORGAN SIZE; PROTEIN-LYSINE 6-OXIDASE; RATS; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84885062062     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120619     Document Type: Article

References (12)

1. Prunier, F., Gaertner, R., Louedec, L., Michel, J.-B., Mercadier, J.-J. and Escoubet, B. (2002) Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats. Am. J. Physiol. Heart Circ. Physiol. 283, H346-H352
2. Liu, Y. H., D'Ambrosio, M., Liao, T. D., Peng, H., Rhaleb, N. E., Sharma, U., André, S., Gabius, H. J. and Carretero, O. A. (2009) N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin. Am. J. Physiol. Heart Circ. Physiol. 296, H404-H412
3. Garcia, M. J., Firstenberg, M. S., Greenberg, N. L., Smedira, N., Rodriguez, L., Prior, D. and Thomas, J. D. (2001) Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans. Am. J. Physiol. Heart Circ. Physiol. 280, H554-H561
4. Liao, T. D., Yang, X. P., D'Ambrosio, M., Zhang, Y., Rhaleb, N.-E. and Carretero, O. A. (2010) N-acetyl-seryl-aspartyl-lysyl-proline attenuates renal injury and dysfunction in hypertensive rats with reduced renal mass: Council for High Blood Pressure Research. Hypertension 55, 459-467
5. Cavallero, S., Gonzalez, G. E., Seropian, I. M., Cerrudo, C. S., Matorra, F., Morales, C., Morales, C., Hertig, C. M., Puyó, A. M., Fernández, B. E. and Gelpi, R. J. (2010) Ventricular function and natriuretic peptides in sequentially combined models of hypertension. Am. J. Physiol. Heart Circ. Physiol. 298, H1290-H1299
6. Gonzalez, G. E., Seropian, I. M., Krieger, M. L., Palleiro, J., Lopez Verrilli, M. A., Gironacci, M. M., Cavallero, S., Wilensky, L., Tomasi, V. H., Gelpi, R. J. and Morales, C. (2009) Effect of early versus late AT1 receptor blockade with losartan on postmyocardial infarction ventricular remodeling in rabbits. Am. J. Physiol. Heart Circ. Physiol. 297, H375-H386
7. Mukherjee, D. and Sen, S. (1993) Alteration of cardiac collagen phenotypes in hypertensive hypertrophy: role of blood pressure. J. Mol. Cell. Cardiol. 25, 185-196
8. Woodiwiss, A. J., Tsotetsi, O. J., Sprott, S., Lancaster, E. J., Mela, T., Chung, E. S., Meyer, T. E. and Norton, G. R. (2001) Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction. Circulation 103, 155-160
9. Rhaleb, N.-E., Peng, H., Harding, P., Tayeh, M., LaPointe, M. C. and Carretero, O. A. (2001) Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts. Hypertension 37, 827-832
10. Rhaleb, N.-E., Peng, H., Yang, X. P., Liu, Y. H., Mehta, D., Ezan, E. and Carretero, O. A. (2001) Long-term effect of N-acetyl-seryl-aspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension. Circulation 103, 3136-3141
11. Winer, J., Jung, C. K., Shackel, I. and Williams, P. M. (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal. Biochem. 270, 41-49
12. Zibadi, S., Vazquez, R., Moore, D., Larson, D. F. and Watson, R. R. (2009) Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome. Am. J. Physiol. Heart Circ. Physiol. 297, H976-H982