IL-17A promotes immune cell recruitment in human esophageal cancers and the infiltrating dendritic cells represent a positive prognostic marker for patient survival

Journal of Immunotherapy

Volumn 36, Issue 8, 2013, Pages 451-458

  Lu, Lin ^a,b   Pan, Ke ^a   Zheng, Hai Xia ^a   Li, Jian Jun ^a   Qiu, Hui Juan ^a   Zhao, Jing Jing ^a   Weng, De Sheng ^a   Pan, Qiu Zhong ^a   Wang, Dan Dan ^a   Jiang, Shan Shan ^a   Chang, Alfred E ^b   Li, Qiao ^b   Xia, Jian Chuan ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

esophageal cancer; IL 17; immune cells recruitment; prognosis

Indexed keywords

CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANZYME B; INTERLEUKIN 17; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; NATURAL KILLER CELL RECEPTOR NKG2D; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER SURVIVAL; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL INFILTRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS CARCINOMA; FLOW CYTOMETRY; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; NATURAL KILLER CELL; OVERALL SURVIVAL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TH17 CELL;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOKINES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; ESOPHAGEAL NEOPLASMS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-17; KILLER CELLS, NATURAL; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84885060563     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3182a802cf     Document Type: Article

References (24)

1. Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004;21:467-476. (Pubitemid 39370503)
2. Tato CM, O'Shea JJ. Immunology: what does it mean to be just 17? Nature. 2006;441:166-168.
3. Tesmer LA, Lundy SK, Sarkar S, et al. Th17 cells in human disease. Immunol Rev. 2008;223:87-113. (Pubitemid 351986173)
4. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 2008;28:454-467. (Pubitemid 351471762)
5. Nakae S, Komiyama Y, Nambu A, et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 2002;17:375-387. (Pubitemid 35279557)
6. Sutton C, Brereton C, Keogh B, et al. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med. 2006; 203:1685-1691. (Pubitemid 44036274)
7. Komiyama Y, Nakae S, Matsuki T, et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol. 2006;177:566-573. (Pubitemid 43939170)
8. Kryczek I, Wei S, SzeligaW, et al. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood. 2009;114: 357-359.
9. Zhang YL, Li J, Mo HY, et al. Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer. 2010;9:4.
10. Kato T, Furumoto H, Ogura T, et al. Expression of IL-17 mRNA in ovarian cancer. Biochem Biophys Res Commun. 2001;282:735-758.
11. Zhang JP, Yan J, Xu J, et al. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol. 2009;50:980-989.
12. Zhang B, Rong G, Wei H, et al. The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun. 2008;374:533-537.
13. Kryczek I, Banerjee M, Cheng P, et al. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood. 2009;114:1141-1149.
14. Martin-Orozco N, Muranski P, Chung Y, et al. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity. 2009;31:787-798.
15. Chen JG, Xia JC, Liang XT, et al. Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients. Int J Biol Sci. 2011;7:53-60.
16. Lv L, Pan K, Li XD, et al. The accumulation and prognosis value of tumor infiltrating IL-17 producing cells in esophageal squamous cell carcinoma. PLoS One. 2011;6:e18219.
17. Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133-1141. (Pubitemid 41541791)
18. Wang W, Lv L, Pan K, et al. Reduced expression of transcription factor AP-2a is associated with gastric adenocarcinoma prognosis. PLoS One. 2011;6:e24897.
19. Muranski P, Boni A, Antony PA, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112:362-373.
20. Muranski P, Borman ZA, Kerkar SP, et al. Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity. 2011;35:972-985.
21. Kryczek I, Zhao E, Liu Y, et al. Human TH17 cells are longlived effector memory cells. Sci Transl Med. 2011;3:104ra100.
22. Muranski P, Restifo NP. Essentials of Th17 cell commitment and plasticity. Blood. 2013;121:2402-2414.
23. Hirota K, Yoshitomi H, Hashimoto M, et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med. 2007;204:2803-2812. (Pubitemid 350179551)
24. Ghannam S, Dejou C, Pedretti N, et al. CCL20 and b-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions. J Immunol. 2011;186: 1411-1420.