Zinc, insulin, and the liver: A ménage à trois

Journal of Clinical Investigation

Volumn 123, Issue 10, 2013, Pages 4136-4139

  O'Halloran, Thomas V ^a   Kebede, Melkam ^b   Philips, Steven J ^a   Attie, Alan D ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN ZINC SUSPENSION; INSULINASE; TRANSITION ELEMENT; ZINC; ZINC TRANSPORTER;

CELL MATURATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; LIVER CLEARANCE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CATION TRANSPORT PROTEINS; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; LIVER; MALE;

EID: 84885042171     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI72325     Document Type: Review

References (20)

1. Kim AM, et al. Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs. ACS Chem Biol. 2011;6(7):716-723.
2. Outten CE, O'Halloran TV. Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science. 2001;292(5526):2488-2492.
3. Tamaki M, et al. The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest. 2013;123(10):4513-4524.
4. Chimienti F, Devergnas S, Favier A, Seve M. Identification and cloning of a β-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes. 2004;53(9):2330-2337.
5. Wenzlau JM, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A. 2007;104(43):17040-17045.
6. Sladek R, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445(7130):881-885.
7. Qian WJ, Gee KR, Kennedy RT. Imaging of Zn2+ release from pancreatic β-cells at the level of single exocytotic events. Anal Chem. 2003;75(14):3468-3475.
8. Cheng-Xue R, et al. Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K (ATP) channels from both á-cells and α-cells. Diabetes. 2013;62(5):1612-1622.
9. Nicolson TJ, et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 2009;58(9):2070-2083.
10. Pound LD, et al. The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PLoS One. 2012;7(7):e40972.
11. Pound LD, et al. Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J. 2009;421(3):371-376.
12. Lemaire K, et al. Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci U S A. 2009;106(35):14872-14877.
13. Wijesekara N, et al. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia. 2010;53(8):1656-1668.
14. Hardy AB, et al. Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8. Am J Physiol Endocrinol Metab. 2012;302(9):E1084-E1096.
15. Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF. Severe block in processing of proinsulin to insulin accompanied by elevation of des-64, 65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci U S A. 2002;99(16):10299-10304.
16. Menting JG, et al. How insulin engages its primary binding site on the insulin receptor. Nature. 2013;493(7431):241-245.
17. Beintema JJ, Campagne RN. Molecular evolution of rodent insulins. Mol Biol Evol. 1987;4(1):10-18.
18. Bancila V, et al. Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel. J Biol Chem. 2005;280(10):8793-8799.
19. Goodarzi MO, et al. Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. Diabetologia. 2013;56(6):1282-1290.
20. Goodarzi MO, Cui J, Chen YD, Hsueh WA, Guo X, Rotter JI. Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. Am J Physiol Endocrinol Metab. 2011;301(2):E402-E408.