Methanolic leaf extract of Parkia biglobosa protects against doxorubicin-induced cardiotoxicity in rats

International Journal of Applied Research in Natural Products

Volumn 6, Issue 3, 2013, Pages 39-47

  Komolafe, K ^a   Akinmoladun, A C ^a   Olaleye, M T ^a  

^a FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

Author keywords

Antihyperlipidemic; Antioxidants; Cardiotoxicity; Doxorubicin; Parkia biglobosa

Indexed keywords

ALKALOID; ANTHRAQUINONE; ASPARTATE AMINOTRANSFERASE; CARDIAC GLYCOSIDE; CREATINE KINASE MB; DOXORUBICIN; FLAVONOID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; METHANOL; PARKIA BIGLOBOSA EXTRACT; PHENOL DERIVATIVE; PHLOBATANNIN; PLANT EXTRACT; RAMIPRIL; SAPONIN; SUPEROXIDE DISMUTASE; TANNIN DERIVATIVE; TERPENOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARDIOTOXICITY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DRUG EFFECT; DRUG SCREENING; DYSLIPIDEMIA; ENZYME ACTIVITY; FEMALE; HEART PROTECTION; IN VITRO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; MALE; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; PARKIA BIGLOBOSA; PHYTOCHEMISTRY; PLANT LEAF; RAT;

EID: 84885038017     PISSN: None     EISSN: 19406223     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Akindahunsi AA.Olaleye MT. 2003. Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffa L. J Ethnopharm. 89: 161-164.
2. Akinmoladun AC, Obuotor EM, Barthwal MK, Dikshit M, Farombi EO. 2010. Ramipril-like activity of Spondias mombin Linn against no-flow ischemia and isoproterenol-induced cardiotoxicity in rat heart. Cardiovasc Toxicol. 10 (4): 295-305.
3. Akinmoladun AC, Ibukun EO, Afor E, Akinrinlola, BL, Onibon TR, Akinboboye AO, Obuotor EM, Farombi EO. 2007. Chemical constituents and antioxidant activity of Alstonia boonei. Afr. J. Biotechnol. 6(10): 1197-1201.
4. Beutler E, Duron O, Kelly BM. 1963. Improved method for the determination of blood glutathione. J lab Clin Med 61: 882-888.
5. Byrne JA, Grieve DJ, Cave AC, Shah AM. 2003. Oxidative stress and heart failure. Arch Mal Coeur. 96:214-21
6. Chen YF, Kobayashi S, Chen J. 2008. Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. J. Molecul Cellul Cardiology. 44(1): 180-187.
7. Crowwell WL, Otvos JD. 2004. Low density lipoprotein particles number and risk for cardiovascular disease. Curr Artheroscler Rep 6: 381-387.
8. Dahanukar SA, Kulkarni RA, Rege NN. 2000. Pharmacology of medicinal plants and natural products. Indian J Pharmacol. 32: 581-5118.
9. Dalloz F, Maingon P, Cottin Y, Briot F, Horiot JC, Rochette L. 1999. Effects of combined irradiation and doxorubicin treatment on cardiac function and antioxidant defenses in the rat. Free Radic Biol Med 26:785-800.
10. Deavall DG, Martin EA, Horner JM, Roberts R. 2012. Drug-induced oxidative stress and toxicity. J. Toxicol. Article ID 645460, 13 pages. doi:10.1155/2012/645460
11. Dewanto V, Wu XZ, Adom KK, Liu RH. 2002. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J Agric Food Chem 50:3010-3014.
12. Doroshow JH, Esworthy RS. 1992. The role of antioxidant defenses in the cardiotoxicity of anthracycline. In: Muggia FM, editors. Cancer Treatment and the Heart. 2nd ed. Baltimore: Johns Hopkins University Press. p.47-58.
13. Gianni L, Myers CE. 1992. The role of free radical formation in the cardiotoxicity of anthracycline. In: Muggia FM, editors. Cancer Treatment and the Heart. 2nd ed. Baltimore: Johns Hopkins University Press. p 9-46.
14. Habig WH, Pabst MJ, Jacoby WB 1974. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation, J Biol Chem 249: 7130-7139.
15. Injac R, Radic N, Govedarica B. 2009. Acute doxorubicin pulmotoxicity in rats with malignant neoplasm is effectively treated with fullerenol C60(OH)24 through inhibition of oxidative stress. Pharmacol Rep 61(2): 335-342.
16. Kessler M, Ubeaud G, Jung L. 2003. Anti- and pro-oxidant activity of rutin and quercetin derivatives. J Pharm Pharmacol 55: 131-142.
17. Komolafe K, Olaleye MT, Fasan TI, Elekofehinti OO, Saliu JA, Akindahunsi AA. 2013. Lipid-lowering effect of Parkia biglobosa leaf saponins in Triton-X 1339-induced hyperlipidemic rats. RJPBCS 4(1): 576-585.
18. Li T, Singal PK. 2000. Adriamycin induced early changes in myocardial antioxidant enzymes and their modulation by probucol. Circulation. 102:2105-2110.
19. Lonn E, Gerstein HC, Smieja MJ, Mann FE, Yusuf S. 2003. Mechanisms of cardiovascular risk reduction with ramipril: insights from HOPE and HOPE substudies. Eur Heart J Suppl 5: 43-48.
20. Millogo-Kone H, Guissou IP, Nacoulma O, Traore AS. 2008. Comparative Study of leaf and stem bark extracts of Parkia Biglobosa against enterobacteria. Afr J Tradit Complement Altern Med. 5:238-243.
21. Misra HP, Fridovich I. 1972. The univalent reduction of oxygen by reduced flavins and quinines. J Bio Chem 247: 188-192.
22. Mukherjee R, Burman AC. 2008. Protective effects of Terminalia arjuna against Doxorubicin-induced cardiotoxicity. J Ethnopharmacol 117: 123-129.
23. Ohkawa H, Ohishi N, Yagi K.. 1979. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95: 351-358.
24. Olaleye MT, Komolafe K, Akindahunsi AA. 2013. Effect of methanolic leaf extract of Parkia biglobosa on some biochemical indices and hemodynamic parameters in rats. J Chem Pharm Res 5:213-220.
25. Pessah IN. 1992. Calcium release channel of sarcoplasmic reticulum: an important target for doxorubicin-mediated cardiotoxicity. Adv Exp Med Biol 311:409-410.
26. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hofeman DG, Hoekstra WG. 1973. Selenium: biochemical role as a component of glutathione peroxidase. Science. 179 (73): 588-590.
27. Salah AM, Gathumbi J, Vierling W. 2002. Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats. Phytother Res. 16: 283-285.
28. Seo HJ, Jeong KS, Lee MK. 2003. Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. Life Sci. 73 (7): 933-946.
29. Šimùnek T, Štìrba M, Popelová O, Adamcová M, Hrdina R, Geršl V. 2009. Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacological Reports. 61: 154-171.
30. Singal PK, Li T, Kumar D, Danelisen I, Iliskovic N. 2000. Adriamycin-induced heart failure: mechanism and modulation. Mol. Cell Biochem 207: 77-86.
31. Singh G, Singh AT, Abraham A, Bhat B, Mukherjee A, Verma R, Agarwal SK, Jha S,Sofowora A. 1993. Medicinal plants and Traditional medicine in Africa. Spectrum Books Ltd, Ibadan.
32. Somova LI, Shode FO, Ramnanan P, Nadar A. 2003. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies of africana leaves. J. Ethnopharm. 84: 299-305.
33. Thippeswamy BS, Thakker SP, Tubachi S, Kalyani GA, Netra MK, Patil U, Desai S, Gavimath CC Veerapur VP. 2009. Cardioprotective Effect of Cucumis trigonus Roxb on isoproterenol-induced myocardial infarction in rat. Am J Pharmacol Toxicol. 4:29-37.
34. Tokarska-Schlattner M, Zaugg M, Zuppinger C, Wallimann T, Schlattner U. 2008. New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics. J Mol Cell Cardiol 41(3): 389-405.
35. Topping DL, Storer GB, Calvert GD, Illman RJ, Oakenfull DG, Weller RA 1980. Effects of dietary saponins on fecal bile acids and neutral sterols, plasma lipids and lipoprotein turnover in the pig. Am J Clin Nutr 33: 783-786.
36. Vinson JA, Jang J, Dabbagh YA, Serry MM, Cai S. 1995a. Plant phenols exhibit lipoprotein-bound antioxidant activity using an in vitro model for heart disease. J Agric Food Chem 43:2798-2799.
37. Weiss RB. 1992. The anthracyclines: will we ever find a better doxorubicin? Semin Oncol 19(6): 670-686.
38. Wilson PW, Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. 1998. Prediction of coronary heart disease using risk factor categories. Circulation 97: 1837-1847.
39. World Health Organization. 2007. Prevention of cardiovascular diseases: Guidelines for assessment and management of cardiovascular risk. Geneva.
40. Yagmurca M, Fadillioglu E, Erdogan H, Ucar M, Sogut S, Irmak MK. 2003. Erdosteine prevents doxorubicin-induced cardiotoxicity in rats. Pharmacol Res. 48(4): 377-382.
41. Zhang L, Yang Y, Yu L, Wang Y, Liu L, Fan, X. 2011. Cardioprotective effects of Glycyrrhiza uralensis extract against Doxorubicin-induced toxicity. Int J Toxicol 30(2):181-189.