High-intensity interval exercise improves vagal tone and decreases arrhythmias in chronic heart failure

Medicine and Science in Sports and Exercise

Volumn 45, Issue 10, 2013, Pages 1861-1867

  Guiraud, Thibaut ^a,b   Labrunee, Marc ^a,c,d   Gaucher Cazalis, Kevin ^a   Despas, Fabien ^a,c,d   Meyer, Philippe ^e   Bosquet, Laurent ^f   Gales, Celine ^a   Vaccaro, Angelica ^a   Bousquet, Marc ^b   Galinier, Michel ^a,c   Sénard, Jean Michel ^a,c,d   Pathak, Atul ^a,c,d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Clinic of Saint Orens Cardiovascular and Pulmonary Rehabilitation Center   (France)

^c UNIVERSITÉ PAUL SABATIER   (France)

^d TOULOUSE UNIVERSITY HOSPITAL   (France)

^e GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^f UNIVERSITÉ DE POITIERS   (France)

Author keywords

Heart failure; High intensity; HR variability; Interval

Indexed keywords

ADULT; AGED; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CHRONIC DISEASE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; ELECTROCARDIOGRAPHY; EXERCISE; FEMALE; HEART ARRHYTHMIA; HEART CONTRACTION; HEART FAILURE; HEART RATE; HUMAN; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ARRHYTHMIAS, CARDIAC; AUTONOMIC NERVOUS SYSTEM; CHRONIC DISEASE; CROSS-OVER STUDIES; ELECTROCARDIOGRAPHY, AMBULATORY; EXERCISE; FEMALE; HEART FAILURE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION;

EID: 84885020305     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e3182967559     Document Type: Article

References (39)

1. Abraham WT. Beta-blockers: the new standard of therapy for mild heart failure. Arch Intern Med. 2000;160(9):1237-47. (Pubitemid 30252769)
2. Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science. 1981; 213(4504):220-2. (Pubitemid 11060568)
3. Arai Y, Saul JP, Albrecht P, et al. Modulation of cardiac autonomic activity during and immediately after exercise. Am J Physiol. 1989;256(1 Pt 2):H132-41.
4. Barretto AC, Santos AC, Munhoz R, et al. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Int J Cardiol. 2009;135(3):302-7.
5. Buch AN, Coote JH, Townend JN. Mortality, cardiac vagal control and physical training-what's the link? Exp Physiol. 2002; 87(4):423-35. (Pubitemid 34814570)
6. Buys S, Smih F, Pathak A, et al. Adrenomedullin upregulates M2-muscarinic receptors in cardiomyocytes from P19 cell line. Br J Pharmacol. 2003;139(6):1219-27. (Pubitemid 36920686)
7. Chowdhary S, Townend JN. Role of nitric oxide in the regulation of cardiovascular autonomic control. Clin Sci (Lond). 1999; 97(1):5-17. (Pubitemid 29353890)
8. Cornish AK, Broadbent S, Cheema BS. Interval training for patients with coronary artery disease: a systematic review. Eur J Appl Physiol. 2011;111(4):579-89.
9. De Ferrari GM, Crijns HJ, Borggrefe M, et al. Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur Heart J. 2011;32(7):847-55.
10. Fagard R, Grauwels R, Groeseneken D, et al. Plasma levels of renin, angiotensin II, and 6-ketoprostaglandin F1 alpha in endurance athletes. J Appl Physiol. 1985;59(3):947-52. (Pubitemid 16223426)
11. Floras JS. Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. J Am Coll Cardiol. 2009;54(5):375-85.
12. Galinier M, Pathak A, Fourcade J, et al. Depressed low frequency power of heart rate variability as an independent predictor of sudden death in chronic heart failure. Eur Heart J. 2000; 21(6):475-82. (Pubitemid 30122135)
13. Guiraud T, Juneau M, Nigam A, et al. Optimization of high intensity interval exercise in coronary heart disease. Eur J Appl Physiol. 2010;108(4):733-40.
14. Guiraud T, Nigam A, Gremeaux V, Meyer P, Juneau M, Bosquet L. High-intensity interval training in cardiac rehabilitation. Sports Med. 2012;42(7):587-605.
15. Guiraud T, Nigam A, Juneau M, Meyer P, Gayda M, Bosquet L. Acute responses to high-intensity intermittent exercise in CHD patients. Med Sci Sports Exerc. 2011;43(2):211-7.
16. Hadase M, Azuma A, Zen K, et al. Very low frequency power of heart rate variability is a powerful predictor of clinical prognosis in patients with congestive heart failure. Circ J. 2004;68(4):343-7. (Pubitemid 38470709)
17. Helgerud J, Hoydal K, Wang E, et al. Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc. 2007;39(4):665-71. (Pubitemid 46555794)
18. Le VV,Mitiku T, Hadley D,Myers J, Froelicher VF. Rest premature ventricular contractions on routine ECG and prognosis in heart failure patients. Ann Noninvasive Electrocardiol. 2010;15(1):56-62.
19. Liu JL, Kulakofsky J, Zucker IH. Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure. J Appl Physiol. 2002;92(6):2403-8. (Pubitemid 34666365)
20. Malfatto G, Branzi G, Riva B, Sala L, Leonetti G, Facchini M. Recovery of cardiac autonomic responsiveness with low-intensity physical training in patients with chronic heart failure. Eur J Heart Fail. 2002;4(2):159-66. (Pubitemid 34233502)
21. Malik M. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 1996;17(3):354-81.
22. Massion PB, Dessy C, Desjardins F, et al. Cardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction. Circulation. 2004;110(17):2666-72. (Pubitemid 39453017)
23. Meyer K, Samek L, Schwaibold M, et al. Interval training in patients with severe chronic heart failure: analysis and recommendations for exercise procedures. Med Sci Sports Exerc. 1997; 29(3):306-12. (Pubitemid 27123703)
24. Meyer P, Normandin E, Gayda M, et al. High-intensity interval exercise in chronic heart failure: protocol optimization. J Card Fail. 2012;18(2):126-33.
25. Munk PS, Staal EM, Butt N, Isaksen K, Larsen AI. High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation A randomized controlled trial evaluating the relationship to endothelial function and inflammation. Am Heart J. 2009;158(5): 734-41.
26. Normandin E, Nigam A, Meyer P, et al. Acute responses to intermittent and continuous exercise in heart failure patients. Can J Cardiol. 2013;29(4):466-71.
27. Piepoli MF, Conraads V, Corra U, et al. Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation. Eur J Heart Fail. 2011; 13(4):347-57.
28. Pina IL, Apstein CS, Balady GJ, et al. Exercise and heart failure: a statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation. 2003;107(8): 1210-25. (Pubitemid 36297217)
29. Routledge FS, Campbell TS, McFetridge-Durdle JA, Bacon SL. Improvements in heart rate variability with exercise therapy. Can J Cardiol. 2011;26(6):303-12.
30. Roveda F, Middlekauff HR, Rondon MU, et al. The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. J Am Coll Cardiol. 2003;42(5):854-60. (Pubitemid 37059744)
31. Sabbah HN, Ilsar I, Zaretsky A, Rastogi S, Wang M, Gupta RC. Vagus nerve stimulation in experimental heart failure. Heart Fail Rev. 2011;16(2):171-8.
32. Swedberg K, Komajda M, Bohm M, et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebocontrolled study. Lancet. 2010;376(9744):875-85.
33. Tanaka M, Kitamura K, Ishizaka Y, et al. Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects. Intern Med. 1995;34(8):728-33.
34. Taylor JA, Carr DL, Myers CW, Eckberg DL. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation. 1998;98(6):547-55. (Pubitemid 28371253)
35. Taylor JA, Studinger P. Counterpoint: cardiovascular variability is not an index of autonomic control of the circulation. J Appl Physiol. 2006;101(2):678-81; discussion 81.
36. Townend JN, al-Ani M, West JN, Littler WA, Coote JH. Modulation of cardiac autonomic control in humans by angiotensin II. Hypertension. 1995;25(6):1270-5.
37. Vona M, Rossi A, Capodaglio P, et al. Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction. Am Heart J. 2004;147(6):1039-46. (Pubitemid 38880961)
38. Wisloff U, Ellingsen O, Kemi OJ. High-intensity interval training to maximize cardiac benefits of exercise training? Exerc Sport Sci Rev. 2009;37(3):139-46.
39. Wisloff U, Stoylen A, Loennechen JP, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study Circulation. 2007;115(24):3086-94. (Pubitemid 46956498)